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All Journal Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Jurnal Kedokteran Brawijaya The Journal of Experimental Life Sciences (JELS) Biotropika Indonesian Journal of Biotechnology Indonesian Journal of Chemistry Biota Jurnal Riset Biologi dan Aplikasinya JSMARTech : Journal of Smart Bioprospecting and Technology Berkala Penelitian Hayati Tri Dharma Mandiri: Diseminasi dan Hilirisasi Riset Kepada Masyarakat (Jurnal Pengabdian Kepada Masyarakat) Makara Journal of Science
fatchiyah .
Departement Of Biology, Faculty Of Mathematic And Natural Science, Universitas Brawijaya, Malang
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Public Health Social Sciences

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Phytochemical Analysis of Purple Sweet Potatoes (Ipomoea batatas) Roots Extract From Lawang and Kawi Mountain Cultivar, East Java, Indonesia Alam, Fajar Mustika; Kurnianingsih, Nia; Fatchiyah, Fatchiyah
The Journal of Experimental Life Science Vol. 12 No. 1 (2022)
Publisher : Graduate School, Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jels.2022.012.01.03

Abstract

Indonesia has wide cultivation of purple sweet potatoes (PSP) commodities, particularly in East Java province. However, the difference of phytochemical profiles in PSP among geographical regions has not been fully explored. This study aimed to analyze the phytochemicals, anthocyanin, and antioxidant activity profiles from two different cultivars of PSP from Lawang and Kawi Mountain region, East Java, Indonesia. The acidified methanol extract was identified for a phytochemical compound using standard methods. Antioxidant activity was analyzed using a ferric reducing assay. Anthocyanins were screened using ultraviolet-visible spectroscopy and total calculation. Both extracts have positive values in their alkaloid, phenolic, flavonoid, glycoside, and tannin content. Antioxidant activity was high with IC50 value 2.5 and 2.3 µg. mL-1 for Lawang and Kawi Mountain, respectively. Each cultivar has a similar peak at 521 nm at pH 1 and 530 nm at pH 4.5. Total anthocyanin calculation was showed that Lawang has higher anthocyanin content than Kawi Mountain cultivar. We concluded that PSP from Lawang has better anthocyanin content than the Kawi Mountain cultivar. We proposed that PSP from the Lawang cultivar has the potential to be explored in further research and health-related product development.
Virtual Based Screening of Rosmaniric Acid and Its Derivatives as Potential Anticancer Approach Targeting HIF-1a Naufal, Achmad Hanif; Wachid, Nisa Nabila Aufa; Kamila, Fairuz Sarah; Wahyuningsih, Nadia; Ilmiyah, Silvi Zakiyatul; Nafisah, Wirdatun; Fatchiyah, Fatchiyah
Biotropika: Journal of Tropical Biology Vol. 13 No. 1 (2025)
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.biotropika.2025.013.01.03

Abstract

Cancer is one of the leading causes of death in the world. Rosmarinic acid becomes one of the important polyphenolic compounds. It includes derivatives of two amino acids, caffeic acid from phenylalanine and 3,4-dihydroxyphenyl-lactic acid from tyrosine, secondary metabolites found in many herbal plants from the subfamily Lamiaceae and Boraginaceae. Rosmarinic acid works in inhibiting the occurrence of metastases and tumor formation. In this study, we evaluated rosmarinic acid and its derivatives through study literature. The compounds were downloaded from the PubChem database, while the three-dimensional structure of HIF-1a was retrieved from RCSB PDB. The biological activity was analyzed using the PASS server, and the cytotoxic effect was predicted using CLC-Pred., The pharmacological properties of bioactive compounds were analyzed using SwissADME. The compounds and HIF-1a were prepared using PyRx 0.8 version and Discovery Studio software, docked specifically using Autodock Vina, visualized using Discovery Studio software, and molecular dynamic simulation using CABS-flex 2.0. Rosmarinic acid and its derivative showed an inhibition with the highest affinity value of compound against HIF-1a are control (-6.9 kcal/mol), Rosmarinic acid (-6.4 kcal /mol), and Methyl rosmarinate (-6.3 kcal/mol). Rosmarinic acid could be expected to have activity as an inhibitor modulated at the post-translational level. Comprehensive and further analysis is required in future research based in vivo and in vitro for the development of cancer treatments.
Sosialisasi Pemanfaatan Susu Kambing di SD Islam As-Salam Malang Fatchiyah, Fatchiyah; Wihastuti, Titin Andri; Nurdiana, Nurdiana; Rohmah, Rista Nikmatu; Triprisila, Lidwina Faraline; Christianto, Antonius; Hasibuan, Akbar Farid
TRI DHARMA MANDIRI: Dissemination and Downstreaming of Research to the Community (Journal of Community Engagement) Vol 1 No 1 (2021)
Publisher : SMONAGENES Research Center, Univeritas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jtridharma.2021.001.01.11

Abstract

Sebagian besar masyarakat masih belum mengetahui manfaat yang terkandung pada susu kambing, masyarakat masih menganggap bahwa susu sapi merupakan satu-satunya sumber nutrisi hewani yang memiliki kandungan protein, gizi, dan manfaat yang sangat besar bagi kesehatan. Untuk itu perlu dilakukan sosialisasi tentang pemanfaatan susu kambing karena kurangnya pengetahuan masyarakat sehingga menyebabkan rendahnya daya beli masyarakat. Tujuan dari kegiatan ini adalah untuk menjalin rintisan kerjasama dengan sekolah sebagai salah satu tempat pemasaran produk susu kambing serta orang tua siswa-siswi dalam meningkatkan daya konsumen masyarakat terhadap susu kambing dan memberikan informasi yang berlandaskan data ilmiah tentang manfaat susu kambing. Sosialisasi dilaksanakan melalui pemaparan pemateri tentang manfaat dan pentingnya mengonsumsi susu kambing dalam kehidupan sehari-hari serta pemanfaatan susu kambing menjadi produk nutrisi sehat (susu kambing pasteurisasi). Hasil dari kegiatan sosialisasi adalah para guru dan siswa-siswi bertambah pengetahuannya tentang pentingnya mengonsumsi susu kambing sebagai pangan sehat bernutrisi dan antusias dalam membuat produk-produk sehat berbahan dasar susu kambing.
Pemberdayaan Kelompok Ibu PKK Desa dalam Penyuluhan Menu Nutrisi Sehat Berbasis Produk Lokal di Desa Karangwidoro, Kecamatan Dau, Kabupaten Malang Fatchiyah, Fatchiyah; Suyanto, Eko; Wijayanti, Ernanin Dyah; Husnah, Yeni Avidhatul
TRI DHARMA MANDIRI: Dissemination and Downstreaming of Research to the Community (Journal of Community Engagement) Vol 2 No 2 (2022)
Publisher : SMONAGENES Research Center, Univeritas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jtridharma.2022.002.02.70

Abstract

Berdasarkan hasil penelitian riset kesehatan dasar, konsumsi pangan masyarakat Indonesia saat ini sebagian besar belum sesuai nutrisi sehat dan seimbang khususnya konsumsi sayuran dan buah-buahan. Hal ini menimbulkan kurangnya implementasi konsumsi pangan sehat masyarakat desa. Penyuluhan dan edukasi menu nutrisi sehat berbasis produk lokal menjadi penting dilakukan untuk mendukung Gerakan Masyarakat Hidup Sehat (GERMAS) serta pemanfaatan pangan lokal yang bernutrisi sehat. Salah satu desa dengan potensi sumber daya lokal yang melimpah sebagai produk lokal pangan nutrisi sehat adalah Desa Karangwidoro, Kecamatan Dau, Kabupaten Malang. Kegiatan penyuluhan ini merupakan upaya pemenuhan program pengabdian kepada masyarakat DPP/SPP Departemen Biologi, Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Brawijaya Tahun 2022 untuk memberikan edukasi bagi masyarakat khususnya ibu-ibu PKK sebagai penggerak pertama dalam keluarga. Metode pelaksanaan dilakukan dengan 5 tahap yaitu kerangka pemecahan masalah; diskusi; sosialisasi penyuluhan; khalayak sasaran yakni perangkat desa, ketua pokja sandang dan kesehatan, ibu-ibu PKK; serta pelaksanaan kegiatan. Bentuk penyuluhan berupa edukasi pangan sehat, praktik menu sehat dan pengolahannya, serta pemaparan materi. Kegiatan penyuluhan dan edukasi menu sehat berjalan sukses dengan ibu-ibu kader PKK desa yang sangat antusias. Hasil kegiatan pre-test menunjukkan nilai 65–70 sebanyak 33%. Hasil post-test terdapat peningkatan menjadi 91–100 sebanyak 45%. Pendampingan dan pemantauan dilakukan oleh kader PKK kesehatan dan tim pengabdi di masyarakat secara door to door untuk mendukung keberhasilan program.
Pendampingan Penguatan Pemahaman dan Keterampilan Pengujian Aktivitas Antioksidan pada Guru dan Siswa SMA di Wilayah Bali Barat Fatchiyah, Fatchiyah; Suyanto, Eko
TRI DHARMA MANDIRI: Dissemination and Downstreaming of Research to the Community (Journal of Community Engagement) Vol 4 No 1 (2024)
Publisher : SMONAGENES Research Center, Univeritas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jtridharma.2024.004.01.1

Abstract

Keterbatasan fasilitas dan keterampilan pembelajaran di laboratorium sains di lingkungan sekolah menengah (SMA) menjadi permasalahan umum yang dapat menurunkan minat dan pemahaman siswa di bidang sains. Permasalahan ini juga ditemukan di wilayah Bali Barat, di mana keterbatasan alat dan bahan serta keterampilan tenaga pendidik menjadi kendala dalam pembelajaran. Salah satu keterampilan pembelajaran di laboratorium sains yang penting serta membutuhkan alat dan bahan relatif sederhana adalah pengujian aktivitas antioksidan senyawa yang dapat diterapkan dalam pembelajaran di sekolah. Kegiatan pengabdian ini bertujuan untuk menguatkan pemahaman dan keterampilan pengujian aktivitas antioksidan pada guru dan siswa SMA di wilayah Bali Barat. Kegiatan pengabdian dihadiri oleh 40 guru dan 26 siswa dari 6 SMA negeri di wilayah Bali Barat yang dilaksanakan di aula Balai Taman Nasional Bali Barat (TNBB). Metode community-based interaction approach dilakukan melalui penyampaian materi dan diskusi interaktif serta praktikum pengujian aktivitas antioksidan menggunakan metode Ferric Reducing Antioxidant Power (FRAP) menggunakan alat dan bahan yang sederhana. Kegiatan pengabdian ini menguatkan pemahaman dan meningkatkan keterampilan guru dan siswa terkait sumber senyawa antioksidan, kapasitas antioksidan, prinsip dasar, dan praktik pengujian aktivitas antioksidan menggunakan metode FRAP.
Molecular Interaction of Purple Rice Ferulic Acid and Skin Aging-Related Enzymes Wijayanti, Ernanin Dyah; Fatchiyah, Fatchiyah; Safitri, Anna; Siswanto, Dian
Makara Journal of Science Vol. 29, No. 1
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Purple rice is rich in ferulic acid, a phenolic acid abundant in rice. Ferulic acid (FA) has long been recognized for its anti-oxidant properties, which are linked to its skin anti-aging activity owing to its ability to scavenge free radicals and pro-tect cells from damage. Skin anti-aging activity could be assessed by inhibiting skin aging enzymes. However, there was limited information on the mechanism of FA inhibition of these enzymes. This study focused on the molecular interac-tion between purple rice FA and collagenase or tyrosinase, both with and without their substrates. The interaction be-tween FA (CID 445858), collagenase (2Y6I), tyrosinase (5M8M), collagenase substrate (CID 5486160), and tyrosinase substrate (CID 6057) was docked using Hex 8.0.0 Cuda with the default settings. Discovery Studio 2020 and LigPlot software were used to visualize the docking results. Ascorbic acid (CID 54670067) and kojic acid (CID 3840) were used as positive controls for collagenase and tyrosinase, respectively. Molecular docking revealed that FA formed electro-static, hydrogen, and hydrophobic bonds with all aging enzymes, substrates, and enzyme–substrate complexes. FA could bind to both free enzymes and free substrates, consequently attenuating enzyme–substrate bonding, and preventing the substrate from binding appropriately in its normal position. Molecular dynamics simulations demonstrated that FA formed a stable bond with tyrosinase, similar to kojic acid, although the bond with collagenase was less stable. However, the pattern of each parameter during the simulation was comparable with that of ascorbic acid. The current study indicated that the FA from purple rice had the potential to act as an inhibitor of skin aging en-zymes and could be developed as a skin anti-aging candidate
A Comparative Study of the Secondary Metabolite from Talinum triangulare (Jacq.) Willd. Methanolic Extract from Malang and Kediri, East Java Budiarti, Sarah Fadilah; Fatchiyah, Fatchiyah
Biotropika: Journal of Tropical Biology Vol. 10 No. 2 (2022)
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.biotropika.2022.010.02.09

Abstract

Talinum triangulare is a medicinal plant that has been used broadly by the Indonesia community because of its properties. Several studies have proven the components of secondary metabolites in T. triangulare. However, the content of secondary metabolites in each part of T. triangulare is not clearly understood. Therefore, this study aimed to analyse the types of secondary metabolites of leaf, stems, and roots of T. triangulare. The plant from Malang was chosen as the sample source because it is a highland suitable for the life of T. triangulare. The plant from Kediri was chosen as a lowland location. Samples of leaves, stems, and roots of T. triangulare were extracted by maceration method. Phytochemical analyses include phenolics, flavonoids, alkaloids, tannins, saponins, and terpenoids. The absorbance values were measured at different wavelengths. The leaf and stems of T. triangulare contain flavonoid compounds, tannins, phenolics, alkaloids, saponins, and terpenoids with higher levels of secondary metabolites in the leaf. While the roots have the lowest secondary metabolite was only containing steroids. The differential levels and types of secondary metabolites samples obtained from Kediri tend to be lower than samples obtained from Malang. These results indicate that the leaf metabolite secondary of T. triangulare has high potential health benefits for regulating molecular and cellular metabolism.
Genomic Profile of OsCOMT in Indonesian Purple Rice Wijayanti, Ernanin Dyah; Safitri, Anna; Siswanto, Dian; Fatchiyah, Fatchiyah
Biotropika: Journal of Tropical Biology Vol. 10 No. 3 (2022)
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.biotropika.2022.010.03.04

Abstract

The Indonesian purple rice (IPR), a crossbreeding of black and white rice, is a potential source of ferulic acid. Up to this point, the genomic similarity between the crossbreeding and its parentals has not been determined, particularly in genes involved in ferulic acid biosynthesis. In this present work, we analysed the profile of Oryza sativa caffeic acid-O-methyltransferase (OsCOMT) gene in IPR. The genomic DNA was extracted by CTAB method, then amplified with a specific primer of OsCOMT gene. The amplicon was sequenced by Sanger method and confirmed by geneID NC_029259.1. The IPR showed an amplicon of 708 bp sequence of the OsCOMT gene, indicating the gene involved in ferulic acid biosynthesis. The IPR gene profile is similar to the parentals, but there are variations in point mutations that distinguish it from the parentals. Aspartic acid was changed to Glutamine by mutations at positions 52, 69, and 79. We suggest that IPR has a novel OsCOMT gene variant that is unique as it is the crossbreed.
Study of Flavonoid in Apium graveolens L. as a Kirsten Rat Sarcoma Protein Inhibitor in Colorectal Cancer Based on In Silico Study Abdullah, Abdullah; Putri, Nenis Try Melani; Rosyadah, Nuraini; Ramadhani, Putri; Putri, Siti Aqila Kharisma; Widyananda, Muhammad Hermawan; Kurniawan, Nia; Fatchiyah, Fatchiyah
Biotropika: Journal of Tropical Biology Vol. 11 No. 2 (2023)
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.biotropika.2023.011.02.07

Abstract

Colorectal cancer (CRC) is considered the second deadliest cancer, mainly caused by the mutation of Kirsten Rat Sarcoma (KRAS) type G12D; it’s still undruggable. Flavonoids are secondary metabolites in celery, consisting of apigenin, luteolin, quercetin, and kaempferol. This study aims to analyse the most potential flavonoid compounds in Apium graveolens L. as KRAS inhibitors in CRC with in-silico. This study starts by collecting the 3D structure, Compound ID, formula, and canonical SMILES of compounds from PubChem and the 3D structure of KRAS G12D from the RCSB-PDB. Ligand and protein preparations using OpenBabel PyRx and Biovia Discovery Studio 2019. The SwissADME web server is used to analyse drug-likeness, the PassOnline web server is used to analyse biological activity, docked using PyRx VinaWizard, and visualisation by Biovia Discovery Studio 2019. RMSD and RMSF values were obtained by analysing binding stability with the YASARA application. The molecular docking test showed that chrysoeriol, luteolin, and apigenin have the highest binding affinity and advance to molecular dynamic test. Results of the molecular dynamic showed that chrysoeriol could potentially inhibit the KRAS protein drug in CRC since it also had the lowest toxicity and the strongest binding affinity to the KRAS.
Co-Authors Abdullah Abdullah Adhya Dava Aligarh Yahya Adzral Alamsyah Agustin, Diah Eka Ahmad Hafidul Ahkam Akbar Farid Hasibuan Alam, Fajar Mustika Alvionita, Cicin Vinolia Anandari, Risma Nila Andyni, Regina Shania Anna Roosdiana Antonius Christianto Aris Soewondo Aru W Sudoyo Arumsari, Pamuji Lestari Atamimi, Fachrur Rozi Aulanni'am, Aulanni'am Bare, Yohanes Budiarti, Sarah Fadilah Cairns, James Robert Ketudat Choirunil Chotimah Christianto, Antonius Criswahyudianti, Elsa Rahmania Dewi Ratih Tirto Sari Dian Siswanto Djoko Wahono S Eko Suyanto Elan Herlina Elan Herlina, Elan Ernanin Dyah Wijayanti Ezra, Achmad Fadilla, Khalisa Fahmi, Muhamad fajri, wahyu nur laili Farida Rachmawati, Farida Fatma Yona, Hafidza Fauzi Yusuf, Fauzi Firdausi, Lina Gotoh, Takayuki Handono Kalim Harun Al Rasyid Damanik, Harun Al Rasyid Hasibuan, Akbar Farid Hazna Noor Meidinna Hermanto, Feri Eko Hose, Victor Alvianoes Guterez Husnah, Yeni Avidhatul Ilmiyah, Silvi Zakiyatul Iva Himmatul Aliyah Iva Himmatul Aliyyah Kamila, Fairuz Sarah Karuniasari, Nadaa Khairunnisa Hidaya, Amira Kurnianingsih, Nia Lidwina Faraline Triprisila Lidwina Faraline Triprisila Lina Firdausi M Rasjad Indra M Rasjad Indra Maekawa, Tatsuya Maisuroh, Dalilatul Mandai, Kouhei Mantow, Jellyta Pricilla Mardhiyah, Rihadatul Aisy Masruro, Nuri Miggy Uri Karitas Minnah, Siti Khaizatul Miyajima, Katsuhiro Muhammad Darwin P Mulyati Mulyati Muwaffiq Faza, Ahmad Nafisah, Wirdatun Najma Zahira Nakamura, Sanae Narwasthu, Sekararum Nathania, Nina Regina Naufal, Achmad Hanif Nia Kurniawan Nia Kurniawan Nia Kurniawan Nikmah, Istiftakhun Nurdiana Nurdiana Nurdiana Nurdiana Nurmasari, Damai Aulia Ohta, Takashi Ohta, Takeshi Pertiwi, Kadita Octavia Pramudya, Muhammad Alif Imam Pratama, Ardo Cahya Putri Ramadhani, Putri Putri, Nenis Try Melani Putri, Siti Aqila Kharisma Rahmadini, Agnia Fadillah Rahmat Grahadi Rasjad Indra Rasjad Indra Reyhanditya, Davy Rijalullah, Muhammad Asyraf Rista Nikmatu Rohmah Rista Nikmatu Rohmah Rista Nikmatu Rohmah Rista Nikmatu Rohmah, Rista Nikmatu Rivqi Rifa Bia Rizka Vamelia Sulistya Ningrum Rizky Nurdiansyah Robiatul Adawiyah Rofi'i, Ahmad Rosyada, Nabila Nur Rosyadah, Nuraini Safira, Dona Safitri, Anna Sari, Dewi Ratih Tirto Sasase, Tomohiko Shafala Safa, Muhammad Shinohara, Masami Shinozaki, Yuichi Siti Nur Aisyah Soraya Widyasari Soraya Widyasari, Soraya Sri Rahayu Lestari Syafruddin Ilyas Talitha Pangestu, Twistka Tapiory, Adelia Adrianne Titin Andri Wihastuti Turhadi Turhadi Ulfah, Mumtaz Nabila Uno, Kinuko Wachid, Nisa Nabila Aufa Wahyuningsih, Nadia Widadni, Vidya Utami Widyananda, Muhammad Hermawan Yamada, Takahisa Yamaguchi, Ayane Zaidah, Laili Nur Zain, Dhiyaa Syahlaa Bianca Febrinnisa Zyana Fithri Nur Faizah