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Increased Dissolution Rate of Solid Dispersion Fenofibric Acid PEG 6000 and In Vivo Study Deni Anggraini; Nesa Agistia; Armon Fernando; Amanda Yulia; Dira Repuja
Journal of Food and Pharmaceutical Sciences Vol 14, No 2 (2026): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.26376

Abstract

Fenofibrate acid is a fibrate drug with high permeability but low water solubility, resulting in limited bioavailability. Solid dispersion using hydrophilic carriers is one strategy to increase solubility. The objective of this study was to improve the solubility of fenofibric acid by converting it into a solid dispersion system using PEG 6000 as a carrier. Preparation of solid dispersion systems by the melting method. The fenofibric acid PEG 6000 weight ratios were F1 (1:1), F2 (1:3), and F5 (1:5). Physicochemical characterization of the solid dispersions included DSC, PXRD, FTIR, and SEM tests, as well as dissolution and bioavailability tests with the determination of pharmacokinetic parameters. Characterization results show that fenofibric acid with PEG 6000 as a carrier still exhibits a crystalline phase but with reduced intensity, resulting in increased solubility and dissolution rate. Dissolution test show that solid dispersion F3 (1:5) dissolves faster (78.7%) than pure fenofibric acid (53.2%). after 60 minutes. Pharmacokinetic parameter determination tests showed no significant difference between pure fenofibric acid and solid dispersion. Solid dispersion of fenofibric acid with PEG 6000 as a carrier can improve the physicochemical performance and dissolution rate of fenofibric acid but pharmacokinetic parameters did not differ significantly.
Co-Authors Adriani Susanty agistia, nesa Agistia, Nesa Agustini, Tiara Tri Ainun Alfatma Allaya, Regina Alpatiqa, Silviana Lufti, Siti Hizra Amanda Yulia Amin, Syahrul Anita Lukman Annisa Safitri Arief, Encik Juliansyah Aulia, Nada Aqilah Azkia Wanudya Rahmadhani Benni Iskandar Buddy Giovanni DAYAR ARBAIN Deni Anggraini Dira Repuja Dwi Winarsih Elsa Safitri Enda Mora Fadhilatun Khoiriyah Farediah Ahmad Farisa, Nayla Al Ferdy Firmansyah Fina Aryani, Fina Fitri Suryani Furi, Mustika Gressy Novita Haiyul Fadhli Hariyani, Widya Hasnah M. Sirat Hayu Lestari Hefriza Putri Husnawati Ihsan Ikhtiarudin Indah Puspita Sari Indri Aprilia, Indri Irfan, Nawwar Ivona Adelin Jannati, Nisa Jumadila, Ikhsal Mukri Kolista Sisilawati M. Almurdani Maryunita, Dinda Mayrade, Salma Yudhistira Meiriza Djohari, Meiriza Melzi Octaviani Meyrika Putri Wandala Milianty, Jesy Muhtadi, Wildan Khairi Musyirna Rahmah Nst Neni Frimayanti Netralis Has Ningrum, Tilar Eka Widia Nofri Hendri Sandi Nurul Elisa Putri Lestari Putri Lestari, Putri Putri, Dhini Fahira Rahayu Utami Rahayu Utami Rahma Dona Rahma, Indah Lutfianti Rahma, Rizqia I’zza Rahmah, Rizka I’zaa Rahmayanı, Wıky Rajeb Fadillah Ramona, Paula Repuja, Dira Rickha Octavia Rusnedy, Rahmayati Sadam Husein Safira, Yola Safitri, Fasri Dian Septi Muharni Suci Bettiza Oktarisma Suhelmi - Suhelmi - Syafutri, Lidiyah Syahbandi, Ilham Syilfia Hasti Tengku Yuni Atika S Tiara Salsabila P.A Tita Adhaha F Venny Wulandari Victriani Sitohang Winda Sari Winda Windiati Wira Noviana, Wira Noviana Yeni Karlina Yulia, Amanda Yulius Mubharroq Zakiyah Manaf