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I Nyoman Gede Budiana
Gynecology Oncology Division, Obstetrics & Gynecology Department, Sanglah General Hospital
Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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Journal : INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES

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ASSOCIATION OF B-CELL LYMPHOMA PROTEIN-2 AND CASPASE-3 EXPRESSION IN OVARIAN CANCER Budiana, I N. G.
INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES Vol 7 No 2 (2013): IJBS Vol2 No2
Publisher : Udayana University

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Abstract

Ovarian cancer remains a major problem of women’s health in the world, including Indonesia, and is associated with high rates of incidence and mortality. There are many efforts in early diagnosis on ovarian cancer, but until now there have not been found any satisfactory method. On the other hand, knowledge and research in the field of molecular biology become more advance, one of them is a mechanism to control the growth of cells in ovarian cancer through a process of programmed cell death or apoptosis. B-cell lymphoma protein 2 (Bcl-2) and caspase-3 are proteins that play a role on the mechanism of apoptosis. The purpose of this study was to determine the expression of Bcl-2 and caspase-3 and their association with ovarian cancer. Materials and method: The design of this study was a cross-sectional study. Expression of Bcl-2 and caspase-3 examined by immunohistochemistry under light microscope with 400x light power field and expression as a negative when the protein expressed in 10% or less of cells and as a positive when the protein expressed in more than 10% of cells. A number of 45 subjects were recruited in this study. Thirthy one of 45 subjects showed the expression of Bcl-2 positive (68.9%), while the positive expression of caspase-3 present in 20 subjects (44.4%). There was a significant association between the expression of Bcl-2 with the expression of caspase-3 in ovarian cancer patients (p=0.002; lambda=0.4). There was also a significant association between stage of disease with expression of Bcl-2 (p=0.002; lambda=0.3) dan expression of caspase-3 (p=0.001; lambda=0.3). Conclusion: It concluded that there is a significant association between the expression of Bcl-2 and the expression of caspase-3 in ovarian cancer.
Co-Authors Agrifa Eko Albert Sembiring Agung Bagus S. Satyarsa Ahmad, Nurmi Anak A. A. W. P. Dewi Anak Agung Istri Ayu Detritha Sarasmarth Anak Agung Istri Mas Sugiantari Anom Suardika Arlando Martino Anapaku Astawa Pemayun, Tjokorda Gede Bayu Mahendra, I Nyoman Budiono - Budiono -, Budiono Charles Richard Thene Demetria Jesica Lim Dewi, Anak A. A. W. P. Dewi, Putu Pradnya Paramitha Endang Sri Widiyanti Eric Gradiyanto Ongko Ernawati Ernawati Ernawati Ernest T. B. Sianturi Evert Solomon Pangkahila Faroek Hoesin Faroek Hoesin, Faroek FEBIANI, MELINDA FLORENCIA Heni Sunyoto I Gd Ngurah Harry W.S I Gd Ngurah Harry W.S2 I Gde Sastra Winata I Gede Indra Kumara I Gede Mega Putra I Gede Ngurah Harry Wijaya Surya I Ketut Surya Negara I Ketut Suwiyoga I Ketut Tunas I Komang Darma Wijaya I Made Darmayasa I Nyoman Hariyasa Sanjaya I Nyoman Satria Pratama I Wayan Artana Putra I Wayan Megadhana I. Lesmana Ida Ayu Dhitayoni Ida Bagus Arjuna Ida Bagus Gde Fajar Manuaba Ida Bagus Putra Adnyana Ida Bagus Rendra Kurniawan Artha Intan Puspa Jaqueline Sudiman Johan Qalaba K.W.M. Kenwa Kade Yudi Saspriyana Kevin Agastya Duarsa Komang Ayu Kartika Sari Kusuma, Anak Agung Ngurah Jaya L.H. Wirahartato L.P.D. Virayanti Luh Nyoman Mas Amita Luh Seri Ani Made Ayu Prabawaty Indraswari Made Bagus Dwi Aryana Made Yudha Ganesa Wikantyas Widia Mahastya, I Wayan Cahya Marta, Kadek Fajar Melinda Febiani Nara Iswari, Putu Ristya Ni Kadek Ari Chintya Vedantari Ni Kadek Chindy Sarindra Bhavani Ni Kadek Dwi Karlina Nicholas Renata Lazarosony Nyoman Bayu Mahendra Nyoman Damar Widya Dharma Ongko, Eric Gradiyanto P.A.T. Adiputra Pande Kadek Aditya Prayudi Pande Kadek Aditya Prayudi Pande Made Suwanpramana Putra, I Wayan Artana Putra, Wayan Artana Putu Adi Sujana Putra Putu Ayu Indrayathi Putu Doster Mahayasa Putu Harrista Indra Pramana Putu Pradnya Paramitha Dewi Putu Raka Sanistia Sania Savitri Putu Srinata Dampati R. Niruri Rasmaya Niruri Rasmaya Niruri Rasmaya Niruri Rayvany Uil Rini Noviyani Ryan Saktika Mulyana Sagun Chandra Yowani Sari, Komang Ayu Kartika Stefanus K .H Stefanus K.H SUHATNO - SUHATNO -, SUHATNO Surya, I Gede Ngurah Harry Wijaya Suwardewa, Tjokora Gde Agung Tasia Irma Endriani Tjokorda Gde Agung Suwardewa Tjokorda Gede Astawa Pemayun Widi, Made Yudha Ganesa Wikantyas Widyasari, Putu Kartika Wijaya Surya, I Gede Ngurah Harry Wiradnyana, Anak Agung Putra Wulandari, Putu Kintan