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All Journal Biospecies Natural B JOIV : International Journal on Informatics Visualization Jurnal Biologi Tropis Jurnal Akuatiklestari Aquasains : Jurnal Ilmu Perikanan dan Sumberdaya Perairan Jurnal Medika Malahayati Jurnal Ilmiah Biologi Eksperimen dan Keanekaragaman Hayati (J-BEKH) Journal of Tropical Marine Science Akuatikisle: Jurnal Akuakultur, Pesisir dan Pulau-Pulau Kecil Arwana: Jurnal Ilmiah Program Studi Perairan Journal of Energy, Material, and Instrumentation Technology Jurnal Kedokteran Hewan Depik Jurnal Ilmu-Ilmu Perairan, Pesisir dan Perikanan Depik Jurnal Ilmu-Ilmu Perairan, Pesisir, dan Perikanan Jurnal Perikanan Bioma : Jurnal Biologi dan Pembelajaran Biologi IJIS Edu : Indonesian Journal of Integrated Science Education
Susanto, Gregorius Nugroho
Jurusan Biologi Fakultas Matematika Dan Ilmu Pengetahuan Alam Universitas Lampung
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Earth & Planetary Sciences Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Physics Public Health Social Sciences Veterinary Other

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Journal : Natural B

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The Effect of Taurine on Superoxide Dismutase Enzyme Activity, Malondialdehyde And Histology In Liver Mice (Mus Musculus) Male-Induced Herbicide Glyphosate Elfa Verda Puspita; Gregorius Nugroho Susanto; Sumardi Sumardi; Endang Linirin Widiastuti
Natural B, Journal of Health and Environmental Sciences Vol 3, No 3 (2016)
Publisher : Natural B, Journal of Health and Environmental Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (441.762 KB) | DOI: 10.21776/ub.natural-b.2016.003.03.04

Abstract

Glyphosate herbicide widely used by farmers in Indonesia. As a result of exposure to herbicides, the production of free radicals or ROS exceeds the body's defense system called oxidative stress. Therefore, the activity of antioxidant enzymes in the body decline and thus can cause tissue damage and certain organ dysfunction. ROS can be suppressed by administration of antioxidants. One source of the antioxidant is taurine. Taurine has a protective effect against oxidation and free radical capture in a variety of cells and tissues against toxic oxidant component. This study aims to determine the effect of taurine in the liver of mice induced herbicide glyphosate on the activity of the enzyme superoxide dismutase (SOD), malondialdehida (MDA), changes in morphology and structure of liver histology. The research used completely randomized design (CRD). Mice were divided into three treatment groups such as, control group (K0), a group of glyphosate (K1) at a dose of 25 mg /kgBW/day orally for 25 days, and a group of taurine+glyphosate (K2) at a dose of taurine 7800 mg/kgBW/day + glyphosate dose 25 mg/kgBW/day orally for 25 days. Each treatment consisted of 8 mice as replication. Results of analysis with one ways ANOVA (P<0.05) followed by the Tukey test showed taurine dose of 7800 mg/kgBW/day can reduce liver cells of male mice that were treated by the herbicide glyphosate but it not be able to increase the levels of SOD and to decrease MDA levels.
Co-Authors - Damayanti Abdullah Aman Damai Agus Setiawan Agus Setyawan Akmal Junaidi Akmalia Rahmani Alqoriani A, Ostarica Andriyani, Agista Arlanda, Revilarita Arofah, Nur Lailatul Ayu Tiara Fitri Ayuandira, Niken Ayuni, Ubaid Jan Azizah Azizah Banowati, Nurmaya Tri Choirun Nisa Elfa Verda Puspita Endah Setyaningrum Endah Setyaningrum Endang L. Widiastuti Endang Linirin Widiastuti Endang Linirin Widiastuti Endang Linirin Widiastuti Farisi, Salman Gurum Ahmad Pauzi Hendri Busman Hendri Busman Indra Gumay Febryano Irawan, Tazranisa Indy Isni Uswatun Khasanah Juliasih, Ni Luh Gede Ratna Junaidi Junaidi Juriani Juriani Kanedi, Kanedi Kusuma Handayani, Kusuma Lestari, Sepnina Like Lumbanraja, Favorisen R M Husien Ferdiansyah M. Kanedi Madi Hartono Maya Riantini, Maya Mayaguezz, Henky Megawaty, Dyah Ayu Mohammad Kanedi Muhammad Zulhafid Munti Sarida Nababan, Yolanda Nazma, Anya Khalisza Putri Nuning Nurcahyani Nur Lailatul Arofah Nurul Khasanah, Nurul Okta Ferli Suryadi Ostarica Alqoriani A. Pribadie, Aldi Indra Prihadhi, Eka Primasari Pertiwi Priyambodo Priyambodo Puspitaningsih N.W., Rr. Etty Qadar Hasani Ramadhina, Melati Rizki Rani Setiana Revanza, M. Zidan Romaskila, Ulfanida Rr. Etty Puspitaningsih N.W. Sa'diah, Annisa Nurul Salman Alfarisi Sari, Mutiara Pradita Sibarani , Marsya Christyanti Slamet Mulyono Sri Murwani Sumardi . Sumardi, Sumardi Supono Supono Supono Supono Suratman Suratman Suratman Suratman Suratman Umar Sutyarso Sutyarso Sutyarso Sutyarso Sutyarso, - Teguh Ismail Tintin Kurtini Tintin Kurtini Tugiyono Tugiyono Tugiyono Tugiyono Tugiyono Tugiyono Tugiyono Tugiyono Utoyo , Laji Wahid Giantara Widiastuti, Endang Linirin Yolanda Nababan Yudha Trinoegraha Adiputra Yuni Astuti Yuni Astuti Zainal Abidin