Heri Setiyo Bekti
Department Of Medical Laboratory Technology, Politeknik Kesehatan Kemenkes Denpasar, Denpasar, Bali, Indonesia And Center Of Excelence In Science And Technology, Polytechnic Of Health Denpasar, Bali, Indonesia

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Journal : Medical Laboratory Technology Journal

The Efficacy of Green Grapefruit (Vitis Vinifera L) Extracts on Reducing Blood Glucose in a Diabetic Rat Model Habibah, Nur; Rofi'ah, Lisa Khofidatur; Bekti, Heri Setiyo; Dewi, Ni Nyoman Astika; Wilankrisna, Luh Ade; Posmaningsih, Dewa Ayu Agustini
Medical Laboratory Technology Journal Vol. 10 No. 2 (2024): December
Publisher : Poltekkes Kemenkes Banjarmasin Jurusan Analis Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31964/mltj.v10i2.606

Abstract

Diabetes mellitus (DM) is a chronic disease in which the pancreas cannot produce enough insulin hormone or when the body cannot use the insulin hormones properly. Green grapes contain flavonoids, anthocyanins, tannins, phenolic acids, and resveratrol and are high in antioxidants that are beneficial in lowering blood glucose levels. This study aims to determine the effectiveness of green grapefruit (Vitis vinifera L) extract in reducing blood glucose levels in a diabetic rat model. This research is a true experiment with a post-test-only control group design, using 24 male Wistar white rats aged 8-12 weeks and weighing 130-200 grams. The rats were divided into three groups: the positive control (I), green grapefruit extract (II), and normal group (III). The results showed that green grapefruit extract effectively reduced blood glucose levels in experimental animals by a percentage of 98.4%. The Independent T-Test showed a value of ρ>0.05 (0.533), so there was no significant difference in glucose levels between green grapefruit extract and positive control. This study concludes that green grapefruit extract was effective at 98.4% in reducing blood glucose levels in the diabetic rat model, compared to the positive control. The promising results of this study need to be continued by establishing a standardized optimal dose, assessing long-term effects, and implementing clinical trials to evaluate efficacy and safety.
Co-Authors Ade Dharmawan Agus Sri Lestari Amany, Hana Amirah ANDI UDIN SARANSI Anniwati, Leonita Aprilia Rakhmawati Aprilia Rakhmawati Aprilia Rakhmawati Aprilia Rakhmawati Arjani, Ida Ayu Made Sri Artawa, I Made Budi Arwati, Ketut Lilik Ayu Sukma Wedha Kristyanti Burhannuddin Burhanuddin, Burhannuddin Cahyana, I Made Dwipa Cok Dewi Widhya Hana Sundari Cok Dewi Widhya HS Cok Dewi Widhya HS Cokorda Dewi Widhya Hana Sundari Desak Gede Dwi Agustini Desak Made Lestari Dewi Dewa Ayu Niti Rahayu Putri Dewi, Kadek Indra Trisna Dewi, Ni Km Ayu Kusuma Dewi, Ni Nyoman Astika Dewi, Ni Putu Ditya Prabandari Dewi, Pande Putu Ayu Patria Dharmawaiswari, Anak Agung Ayu Ratih Dharmawati, I Gst Agung Ayu Dwija, Ida Bagus Nyoman Putra Farsida, Farsida Fusvita Merdekawati Ganjar Noviar Hardiyanta, I Made Yogi Haribaik, Anastaysia Annisa Hasfika, Essydhea Husna, Ismalia I Gusti Agung Ayu Dharmawati I Gusti Agung Ayu Dharmawati I Gusti Agung Dewi Sarihati I Gusti Agung Dewi Sarihati I Gusti Ayu Made Wulan Diantari I Gusti Ayu Sri Dhyanaputri I Gusti Ngurah Teja Pratama I Made Krishna Paramartha I Made Suarjana I Made Suarjana I Made Yogi Hardiyanta I Nyoman Jirna I Nyoman Purna I Wayan Karta I Wayan Karta Ida Ayu Krisna Dwipayanti Ida Ayu Sri Arjani Ida Bagus Oka Suyasa Ida Bagus Oka Suyasa Indriyani Indriyani Jannah Sofy Yanty Kadek Ika Surya Cahyani Kosasih, Audia Nizhma Nabila Kurniawan, Surya Bayu Luh Ade Wilan Krisna Luh Ade Wilankrisna Luh Putu Laksmi Mahastuti, Shri Ayu Purnami Mardhia Mardhia Marpaung, Nurasi Lidya E. Mastra , Nyoman Merdekawati, Fusvita Mochamad Choirul Hadi Ni Kadek Wahyu Diana Sari Ni Komang Erny Astiti Ni Komang Juniawati Ni Komang Omik Trianita Udiana Ni Komang Sri Narayanthi Ni Nyoman Astika Dewi Ni Putu Ditya Prabandari Dewi Ni Putu Ditya Prabandari Dewi Ni Putu Intan Maha Ayu Diyanti Ni Putu Lisa Anjani Ni Putu Yulia Rahma Dewi Ni Wayan Rika Kumara Dewi Noviar, Ganjar Nur Habibah Nur Habibah Nyoman Mastra Posmaningsih, Dewa Ayu Agustini Pradnya Yasa, Ni Putu Candra Dewi Prianggandanni, Made Ayu Vita Purwani Ruth, Grace Monica Putu Amrita Paramahita Putu Diah Wahyuni Rakhmawati, Aprilia Rike Syahniar Rinawati, Luh Putu Rindi, Oktavelendi Dhaneta Graha Rofi'ah, Lisa Khofidatur Ruspawan, I Dewa Made Savitri, Ni Putu Ayu Dani Sofi Yanty, Jannah Sudarmanto, I Gede Sudiadnyana, I Wayan Surya Bayu Kurniawan Suwarriana, I Nyoman Astra Suyasa, Ida Bagus Oka Swastini, I Gusti Agung Ayu Putu Tedja, I Gusti Ayu Wiradari Utami, Luh Mitha Ari Wikantari, Ni Made Ayu Kerti Wilankrisna, Luh Ade Yanty, Jannah Sofy