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All Journal International Journal of Public Health Science (IJPHS) Pharmaciana: Jurnal Kefarmasian Indonesian Journal of Urology Indonesian Journal of Cancer Chemoprevention Jurnal Farmasi Klinik Indonesia Mutiara Medika: Jurnal Kedokteran dan Kesehatan JURNAL PENGABDIAN KEPADA MASYARAKAT Science and Technology Indonesia JOURNAL OF HEALTH SCIENCE (JURNAL ILMU KESEHATAN) AKSIOLOGIYA : Jurnal Pengabdian Kepada Masyarakat Window of Health : Jurnal Kesehatan Media Ilmu Kesehatan PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Care : Jurnal Ilmiah Ilmu Kesehatan Health Sciences and Pharmacy Journal Bhamada: Jurnal Ilmu dan Teknologi Kesehatan (E-Journal) Jurnal Ilmiah Permas: Jurnal Ilmiah STIKES Kendal Science Midwifery Jurnal Pembelajaran Pemberdayaan Masyarakat (JP2M) Avicenna : Journal of Health Research Asian Australasian Neuro and Health Science Journal (AANHS-J) Universitas Muhammadiyah Yogyakarta Undergraduate Conference Proceeding Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Prosiding Seminar Nasional Program Pengabdian Masyarakat Dinamika Kesehatan: Jurnal Kebidanan dan Keperawatan Berita Kedokteran Masyarakat Indonesian Health Journal Ibnu Sina: Jurnal Kedokteran dan Kesehatan - Fakultas Kedokteran Universitas Islam Sumatera Utara Journal of Public Health and Pharmacy Jurnal Sains dan Kesehatan Bhamada: Jurnal Ilmu dan Teknologi Kesehatan (E-Journal) Jurnal Penelitian Keperawatan
Titiek Suhardi Haripurnomo Kushadiwijaya Hidayati
2Departemen Epidemiologi, Kesehatan Masyarakat Dan Kedokteran Keluarga, Fakultas Kedokteran Dan Ilmu Kesehatan, Universitas Muhammadiyah Yogyakarta.
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Journal : Science and Technology Indonesia

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Formulation Optimization and In Vitro Antioxidant Evaluation of a Polyherbal Nanosuspension Incorporating Apium graveolens, Centella asiatica, and Orthosiphon stamineus Astuti, Febriana; Akrom; Mustofa; Setianto, Arif Budi; Hidayati, Titiek
Science and Technology Indonesia Vol. 11 No. 1 (2026): January
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2026.11.1.65-83

Abstract

Antioxidants play a crucial role in protecting cells from damage caused by free radicals, particularly reactive oxygen species (ROS). Herbal plants contain various bioactive compounds, such as phenolics, flavonoids, terpenoids, and alkaloids, which exhibit strong antioxidant properties to neutralize these harmful molecules. However, the bioavailability of these compounds is often limited due to their poor water solubility. Nanotechnology offers a promising solution, specifically through the development of nanosuspensions. This approach enhances the solubility of these compounds by reducing their particle size to the nanometer scale, thus improving absorption in the body. In this study, nanosuspensions were formulated using extracts from Apium graveolens, Centella asiatica, and Orthosiphon stamineus through a two-factor optimization approach with Design-Expert® version 13 software. The optimal formulation contained 25 mL of chitosan, 6 g of Tween 80, and 10 mL of sodium tripolyphosphate (Na-TPP), resulting in nanosuspensions with an average particle size of 220.00(1157) nm, a polydispersity index (PDI) of 0.59±0.06, and a zeta potential of −28.27±0.37mV. The antioxidant activity was evaluated using DPPH and ABTS assays. In the DPPH assay, the nanopolyherbal formulation showed an IC50 of 41.780(3064) μgmL−1, while the combined extract had an IC50 of 44.930(2989) μgmL−1. The ABTS assay revealed an IC50 of 28.21 μgmL−1 for the nanosuspension, significantly lower than the combined extract’s 54.22 μgmL−1. These results highlight the superior antioxidant activity of the nanosuspension, emphasizing the potential of nanotechnology to enhance the efficacy of bioactive compounds from herbal plants.
Co-Authors - nurkamila - nurkamila, - - Sagiran Ahmad Hamim Sadewa Akbar, Rizaluddin Akrom Akrom Akrom Akrom Akrom, Akrom Amal, Muhammad Ikhlasul Anwar, Muslih Ardhitapramesti A.H.P. Arif Budi Setianto Arif Santoso Arif Santoso Arya Adiningrat Aryanto, Samsu Ayu Cahyaningtyas azizah khoiriyati Briliian Wahyudi, Rizqy Cahya Ningrum, Windy Astuti Dewi Puspita Dhara Indah Kartika Jati, Dhara Indah Kartika Diaz Habibah, Khalisha Eka Arikensiwi Eka Arikensiwi, Eka Emdat Suprayitno Emdat Suprayitno Endang Darmawan Erviana Erviana Erviana Erviana Fadil Abdillah Fahmy Abdul Haq Falasifah Ani Yuniarti, Falasifah Ani Faradisa Yuanita Fahmi Fathimah Kelrey Febriana Astuti Fuadi, Akhsanul Ginandjar Zukhruf Saputri Ginanjar Zuhruf Saputri Gumson Joshua Tampubolon Halimatusa'diyah, Thoharoh Handa Meru Erio Rakihara Haris, Tauranaswa Farrelabhista Putra Hastin Munifah T.F.F.S. Iffa Karina Permatasari Iffa Karina Permatasari Indrayanti, Indrayanti Indrayanti, Indrayanti Indri Nurasa Indri Nurasa Irna Susiati Kailani, Dzaka Ogan Amirudin Lutfi Khoiriyati, Azizah Kumala Syifa, Amira Kusumo, Mahendro Prasetyo Laela Hayu Nurani Laela Hayu Nurani Laili Apriani Lilis Suryani Lukman Hardia Marsetyawan HNE Soesatyo Mustofa Mustofa Nanik Sulistyani Naylil Mawadda Rohma Neni Probosiwi Nevi Seftaviani Nisa, Aida Novita Kurnisa Sari Nur Isnaini Nur Isnaini, Nur Nurcholid Umam Nurcholid Umam Kurniawan Nurisa Fikriyani L. Nurjanna Nurjanna Nurkhasanah Ogan Amirudin Lutfi, Dzaka Olyvia Wulan Kencana Panji Tutut Anggraeni Pradhana, Muhammad Ilham Satya Prasasti Bintarum Pratiwi, Adinda Aning Purwoko, Akhmad Edy Rachmayani, Tantri Rahmah Rahmah Ratna Indriawati Riska, Erlina Rizma Nurfadjrin Sagiran Sagiran Shabrina Arwi Laily Shiko Indrawan Siti Pandanwangi TW Sri Hesthi Sonyo Subroto, Bramastha Alfanda Sumaryani, Sri Sun, Suny Suprayitno, Emdat Tantri Rachmayani Theodola Baning Rahayujati Thoharoh Halimatusa'diyah Thoharoh Halimatusa’diyah Thosimomia Tamimi, Nia Tri Pitara Mahanggoro Tsai, Mei Ling Vivi Sofia Yuningtyaswari Yuningtyaswari Yuningtyaswari Yuningtyaswari Zuniarto, Ahmad Azrul