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Hendriati, Hendriati
Fakultas Kedokteran, Universitas Andalas
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Journal : Human Care Journal

 1 
PERUBAHAN NILAI CENTRAL CORNEAL THICKNESS SEBAGAI DETEKSI SEVERITAS RETINOPATI DIABETIKUM PADA PENDERITA DIABETES MELITUS TIPE II Guntur Fazwat; Hendriati Hendriati; Weni Helvinda
HUMAN CARE JOURNAL Vol 6, No 1 (2021): Human Care Journal
Publisher : Universitas Fort De Kock

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32883/hcj.v6i1.960

Abstract

AbstractIntroduction : Hyperglycemia has a toxic effect on almost all cells in the body. Ocular complications due to hyperglycemia can occur in the cornea and retina. Retinal microvascular disorders in patients with type II DM are called diabetic retinopathy. Type II diabetes mellitus has a significant influence on the morphological, metabolic, physiological, and clinical aspects of the cornea that can be evaluated by measuring central corneal thickness (CCT) using Anterior Segment - Optical Coherence Tomography (AS-OCT). Morphological changes occur in corneal epithelium, epithelial basement membrane and basement, stromal and endothelial membrane complexes. CCT changes as changes in the retina of type II DM patients are chronic processes that lead to changes in the structure and biomechanics of the cornea and retina. Method: The subjects of this study consisted of 36 eyes of type II DM patients divided into 4 diabetic retinopathy groups (mild, moderate, severe NPDR and PDR) with GDS> 200mg / dl then CCT values were measured using AS-OCT. Result: CCT degrees in this study: normal 44.4%; thick (33.3%); thin (13.9%); ; very thick CCT (8.3%). There is no statistically significant relationship between the degree of CCT and severity of diabetic retinopathy. Conclusion: The CCT value of DM type II sufferers in the PDR group was higher than in the NPDR group, where there was an increase in CCT value along with an increase in severity of diabetic retinopathy, but the results were statistically not significant. CCT examination is expected to be one of the evaluations to evaluate the progression of hyperglycemic in type II DM against ocular disorders, especially cornea.Keywords: Type II diabetes mellitus, diabetic retinopathy, central corneal thickness, Anterior Segment - Optical Coherence Tomography AbstrakPendahuluan : Hiperglikemia memiliki efek toksik pada hampir semua sel dalam tubuh. Komplikasi okular akibat hiperglikemia dapat terjadi pada kornea dan retina. Gangguan mikrovaskuler retina pada penderita DM tipe II disebut retinopati diabetik. Diabetes melitus tipe II memberikan pengaruh signifikan pada aspek morfologis, metabolik, fisiologis, dan klinis kornea yang dapat dievaluasi  dengan mengukur ketebalan kornea sentral atau central corneal thickness (CCT) menggunakan Anterior Segment – Optical Coherence Tomography (AS-OCT) . Perubahan morfologis terjadi pada epitel kornea, membran basal epitel dan kompleks membran basal, stroma, dan endotelium. Perubahan CCT sebagaimana perubahan pada retina pasien DM tipe II merupakan proses kronis yang berujung pada perubahan struktur dan biomekanik dari kornea dan retina. Metode: Subjek penelitian ini terdiri dari 36 mata penderita DM tipe II yang dibagi dalam 4 kelompok retinopati diabetikum (mild, moderate, severe NPDR dan PDR) dengan GDS > 200mg/dl kemudian diukur nilai CCT menggunakan AS-OCT. Hasil: Derajat CCT pada penelitian ini: normal 44,4%; thick (33,3%); thin (13,9%); very thick CCT (8,3%). Tidak terdapat hubungan yang bermakna secara statistik antara derajat CCT terhadap severitas retinopati diabetikum. Kesimpulan: Nilai CCT penderita DM tipe II kelompok PDR lebih tinggi dari pada kelompok NPDR, dimana tampak peningkatan  nilai CCT seiring dengan peningkatan severitas retinopati diabetikum, namun hasil tersebut secara uji statistik tidak bermakna signifikan. Pemeriksaan CCT diharapkan menjadi salah satu penilaian untuk mengevaluasi progresifitas hiperglikemik pada penyakit DM tipe II terhadap gangguan okular, terutama korneaKata Kunci: Diabetes mellitus tipe II, retinopati diabetik, central corneal thickness, Anterior Segment – Optical Coherence Tomography
ANALISIS FAKTOR RISIKO KEJADIAN DRY EYE DISEASE PADA TENAGA KEPENDIDIKAN FAKULTAS KEDOKTERAN UNIVERSITAS ANDALAS Febiyola Ratu Khairani; Hendriati Hendriati; Husnil Kadri; Kemala Sayuti; Tofrizal Tofrizal; Moestafa Nur
HUMAN CARE JOURNAL Vol 8, No 3 (2023): Human Care Journal
Publisher : Universitas Fort De Kock

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32883/hcj.v8i3.2691

Abstract

ABSTRAKDry eye disease (DED) atau penyakit mata kering merupakan penyakit multifaktorial pada mata yang memengaruhi penglihatan, aktivitas sehari-hari, produktivitas kerja, dan kualitas hidup secara umum sehingga penting untuk mengontrol faktor risiko yang dapat dimodifikasi. Penelitian ini bertujuan untuk mengetahui hubungan antara jenis kelamin, usia, penggunaan komputer, penggunaan ruangan ber-AC serta kebiasaan merokok dengan risiko kejadian dry eye disease pada tenaga kependidikan Fakultas Kedokteran Universitas Andalas. Metode yang digunakan adalah analitik observasional dengan desain penelitian cross sectional menggunakan kuesioner OSDI dengan uji korelasi Mann-Whitney dan Rank Spearman. Hasil penelitian menunjukkan bahwa terdapat hubungan yang signifikan antara usia (p=0,012) dan penggunaan komputer (p=0,000) dengan DED dimana dengan bertambahnya usia dan semakin lama durasi penggunaan komputer maka semakin tinggi risiko DED namun tidak terdapat hubungan yang signifikan antara jenis kelamin (p=0,877), penggunaan AC (p=0,463), dan kebiasaan merokok (p=0,206) dengan DED. ABSTRACTDry eye disease (DED) is a multifactorial disease that occurs on the eye. DED symptoms can affect vision, daily activities, productivity at work and general quality of life therefore the modifiable risk factors is important to control. This study was aimed to determined the relationship between gender, age, use of computers, use of air-conditioner rooms, and smoking habits to the risk of dry eye disease in educational staff at the Faculty of Medicine Universitas Andalas. The method used was an observational analytic with a cross sectional design was using the OSDI questionnaire with the Mann-Whitney correlation test and Spearman Rank correlation test. The results of the study showed that there was a significant relationship between age (p=0,012) and computer use (p=0,000) to DED, increasing age and the longer duration of computer use, the higher risk of suffer from dry eye disease but there was no significant relationship between gender (p=0,877), use of air-conditioner (p=0,463), dan smoking habits (p=0,206) to DED.
Co-Authors Adila Hanna Adrial Adrial Afelita, Tia Afriwardi Afriwardi Agustin Vira Agustin Vira Aisyah Elliyanti Al Hafiz Alhakim, Hafidh Taufiq Alifia Damanil Putri Almurdi Almurdi Andrini Ariesti Andrini Ariesti Anum, Qaira Ariesti, Andrini Arina Widya Murni Astria Rima Rara Yuswir Astria Rima Rara Yuswir Deddy Saputra Deny Wiryulisda Desty Ria Tiffani Dia Rofinda, Zelly Dia Dian Pertiwi Dian Pertiwi Dolly Irfandy Dwitya Elvira, Dwitya Elmatris Sy Ennesta Asri Ennesta Asri Erlina Rustam Erwen, Yolanda Wulandari Febiyola Ratu Khairani Fortuna, Fory Frizki Amalya Putri Gardenia Akhyar Guntur Fazwat Gustia Anugrahwati Hanum, Fathiya Juwita Hasmiwati Heru Ardila Putra Husnil Kadri Husnil Wardiyah Ilahi, Fitratul Ilmiawati, Ilmiawati Indah Indria Sari Indah Indria Sari Indah Syafira Praja Irayanti, Irayanti Irza, Metika Rahmasari Izzati Mujahidah Julita Julita Julita Julita Julizar Julizar Julizar Julizar Kelvin Mandela Kemala Sayuti Khairiah Nevrianty Laila Isrona Lili Irawati lonanda, Gama Agusto Lucyana Lucyana, Lucyana Mahata, Liganda Endo Maralaut, Azhardin Mardijas Efendi Moestafa Nur Muhammad Fadhil Rahmadiansyah Muhammad Hidayat Muhammad Syauqie Nasyayya Akbari Nazar Nelmi Silvia Nesa Pratiwi Noverika Windasari Novian Novian Novian Novian Praja, Fathira Luthfi Nuresa Primasakti, Pattih Raden Mohamad Herdian Bhakti Rahim, Beby Rahmadiansyah, Muhammad Fadhil Rahman, Ardizal Rahman, Ardizal Rahmat Syawqi Rahmat Syawqi Rendra Darma Satria Rendra Darma Satria Rika Desviorita Rika Desviorita Rimelda Aquinas Rina Gustia Rina Gustia Rizanda Machmud Rizki Dwayana Rizki Dwayana Roza, Silvia Rudy Afriant Rustam, Raihana Satya Wydya Yenny Sherly Muchlis Siti Syiehan Muhdalin Suhery, Suhery Sya'diyyah, Lailatul Syafendra, Atika Tofrizal Tofrizal Trisno, Assyifa Azzahra Dwi Tutty Ariani Tutty Ariani Ulya Uti Fasrini Vitresia, Havriza Weni Helvinda Yulistini, Yulistini Zacky Aulia Mursi Zulferza, Jaka