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All Journal BALI MEDICAL JOURNAL (BMJ) Archive of Community Health Sport and Fitness Journal E-Jurnal Medika Udayana Majalah Ilmiah Fisioterapi Indonesia Indonesian Journal of Cancer Journal of Tropical Biodiversity and Biotechnology MNJ (Malang Neurology Journal) IDJP (Indonesian Journal of Pharmaceutics) JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Jurnal Epidemiologi Kesehatan Komunitas Jurnal Ilmu Kefarmasian Indonesia ISM (Intisari Sains Medis) : Jurnal Kedokteran Bali Anatomy Journal Essential: Essence of Scientific Medical Journal Indonesian Archives of Biomedical Research (InABR) Indonesian Journal of Cancer Public Health and Preventive Medicine Archive Journal of Global Pharma Technology Physical Therapy Journal of Indonesia Media Kesehatan Politeknik Kesehatan Makassar Indonesian Journal of Global Health Research
Agung Wiwiek Indrayani
Departemen Farmakologi Dan Terapi, Fakultas Kedokteran Universitas Udayana, Denpasar,Bali
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Dentistry Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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Effectivity of Earthworm (Lumbricus rubellus) Extract as Antidiarrhea Caused by Enteropathogenic Escherichia Coli Irawan, Angeline Aprilia; Putri, Gita Almira; Dhumaranang, Hyangayu Dedari; Indrayani, Agung Wiwiek
Jurnal Epidemiologi Kesehatan Komunitas Vol 9, No 2 : Agustus 2024
Publisher : Master of Epidemiology, Faculty of Public Health, Diponegoro University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jekk.v9i2.9141

Abstract

Background: Diarrhea still becomes a health problem in Indonesia with a high mortality rate among children under five years old. Antibiotics are used in the management of diarrhea caused by Enteropathogenic Escherichia coli, but it can change the intestinal microbiota in children and can cause resistance. Therefore, raw material is needed as an antibacterial.Methods: The sources of the narrative review come from Google Scholar, PubMed, and ResearchGate with keywords such as earthworm, Lumbricus rubellus, earthworm extract, antidiarrhea, and Escherichia coliResult: Earthworms (Lumbricus rubellus) have some active compounds that are useful for fibrinolytic, thrombolytic, antithrombotic, anti-inflammatory, antioxidant, and broad-spectrum antimicrobial properties. The antimicrobial activity of earthworms is due to the presence of Lumbricin-1 content where its activity against Escherichia coli has been proven by various studies.Conclusion : Earthworm (Lumbricus rubellus) extract can inhibit the growth of Escherichia coli bacteria so it has the potential to become an antidiarrheaKeywords: antidiarrheal; earthworm; Lumbricus rubellus; Lumbricin-1; Enteropathogenic Escherichia coli  
The Yoga Practice Frequency, Anxiety Levels, and Quality of Life in Dwijendra High School Adolescents: An Observational Study Dewi, Rani Nafisa; Kamayoga, I Dewa Gede Alit; Indrayani, Agung Wiwiek; Adhitya, I Putu Gde Surya
Majalah Ilmiah Fisioterapi Indonesia Vol 12 No 3 (2024): Majalah Ilmiah Fisioterapi Indonesia
Publisher : Bachelor and Profession of Physiotherapy Study Program, Faculty of Medicine, Udayana University in collaboration with Indonesian Physiotherapy Association (IPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/mifi.2024.v12.i03.p18

Abstract

Introduction: Adolescence is a transitional period marked by physical, cognitive, and psychosocial changes. According to the World Health Organization (WHO), 3.6% of children aged 10-14 and 4.6% of those aged 15-19 experience anxiety disorders. Changes during adolescence, including in physicality, sexuality, cognition, health, and socioemotional aspects, can lead to anxiety, which can disrupt quality of life. Yoga is one method to alleviate anxiety and improve quality of life. Methods: This study aimed to examine the relationship between the frequency of yoga practice, anxiety levels, and quality of life among adolescents at Dwijendra High School. An observational analytic study with a cross-sectional design was conducted. The sample consisted of 106 students aged 16-18 from Dwijendra High School, who practiced yoga at least once a week. Data were collected using a yoga frequency questionnaire, the DASS-21, and the WHOQOL-BREF. Results: Bivariate analysis using Spearman’s Rho revealed a significant relationship between the frequency of yoga practice and anxiety levels (p=0.001, r=-0.585), indicating that more frequent yoga practice is associated with lower anxiety levels. The analysis also showed a significant relationship between the frequency of yoga practice and quality of life (p=0.001, r=0.714), indicating that more frequent yoga practice is associated with a higher quality of life. Correlation values for each variable ranged between 0.5 and 0.75, demonstrating a significant relationship between yoga frequency, anxiety levels, and quality of life in adolescents. Conclusion: There is a significant relationship between the frequency of yoga practice, anxiety levels, and quality of life among adolescents at Dwijendra High School, Denpasar. Keywords: yoga frequency, quality of life, adolescents, anxiety levels
The Hamstring Flexibility and Balance Impact on T Kick Speed in Pencak Silat Athletes in Madiun City: A Cross-Sectional Study Prasetyo, Arsya Hayyu; Kinandana, Gede Parta; Indrayani, Agung Wiwiek; Negara, Anak Agung Gede Angga Puspa
Majalah Ilmiah Fisioterapi Indonesia Vol 12 No 3 (2024): Majalah Ilmiah Fisioterapi Indonesia
Publisher : Bachelor and Profession of Physiotherapy Study Program, Faculty of Medicine, Udayana University in collaboration with Indonesian Physiotherapy Association (IPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/mifi.2024.v12.i03.p19

Abstract

Introduction: Pencak silat is a traditional Indonesian martial art that has been an integral part of Indonesian culture for centuries. Among its various techniques, the T kick is known for its higher effectiveness compared to other kicks. To achieve a fast T kick, biomotor components such as flexibility and balance are essential. Methods: This observational analytic study employed a cross-sectional design. Subjects were selected through purposive sampling, consisting of male pencak silat athletes aged 15-18 years, with a total sample size of 116. The study included three variables: two independent variables (hamstring flexibility and balance) and one dependent variable (T kick speed). Data collection involved measuring hamstring flexibility, balance tests, and kick speed tests. The data were analyzed using the Spearman’s rho correlation test. The aim of this study was to determine the relationship between hamstring flexibility and balance with T kick speed in pencak silat athletes in Madiun City. Results: The non-parametric Spearman’s rho analysis showed a significant relationship between hamstring flexibility and T kick speed, with p=0.000 (p<0.05) and a correlation coefficient of 0.348. Additionally, a significant relationship was found between balance and T kick speed, with p=0.000 (p<0.05) and a correlation coefficient of 0.508. Conclusion: Based on these findings, it can be concluded that there is a relationship between hamstring flexibility and balance with T kick speed in pencak silat athletes in Madiun City. Keywords: Hamstring Flexibility, Balance, Speed, Pencak Silat, T Kick, Madiun City
 Antioxidant Potential of Usnea spp. Extract with Lysozyme Conjugation for the Prevention of Chronic Kidney Disease Progression Junior, Darren; Dewi, Luh Putu Widya Amritha; Indratmo, Novea; Indrayani, Agung Wiwiek
Indonesian Journal of Pharmaceutics Vol 6, Issue 1, Jan - April 2024
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v6i1.57697

Abstract

The prevalence of chronic kidney disease worldwide has been reported to increase every year with hypertension serving as the leading cause. The recommended treatment for chronic kidney disease patients with a history of hypertension is antihypertensive medications, which could cause side effects from prolonged use. Hence, the authors sought out a possible novel modality by implementing antioxidant properties from beard lichen (Usnea spp.) extract. Literature search was conducted on trusted scientific databases, including Google Scholar, PubMed, DOAJ, and Cochrane. The pathophysiology of hypertension in the progression of chronic kidney disease could mainly be attributed to the presence of inflammation and oxidative stress, which could be attenuated by the use of antioxidants. Lichens are a class of complex living organisms resulting from a symbiosis that allows them to synthesize various beneficial phytochemicals. Usnic and stictic acid derived from Usnea spp. are part of phenolic compounds that display strong antioxidant activities. In order for these antioxidants to have a focused effect on the kidneys, a kidney-targeted drug delivery system should be considered with lysozyme conjugation being the most studied method. The combination of Usnea spp. extract’s antioxidant capabilities with lysozyme conjugation could serve as a potential novel modality in the specific prevention of chronic kidney disease progression.                 Keywords: antioxidant; chronic kidney disease; lysozyme conjugation; Usnea                       spp. 
Nano Drug Delivery System with Resveratrol as Promising Novel Adjuvant Therapy for Diabetic Non-Healing Wounds: A Literature Review Sari, Ni Wayan Puspita; Els, Vanessa; Indrayani, Agung Wiwiek
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 13, No 4
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.84181

Abstract

Diabetes mellitus (DM) is a metabolic disease characterized by increased blood sugar levels (hyperglycemia) and is associated with impaired function of β cells. The uncontrolled and prolonged hyperglycemia in DM can cause complications. One of the most common is diabetic non-healing wounds, the leading cause of disability in people with diabetes, therefore adjuvant therapy is needed. Compounds from natural ingredients are currently getting the spotlight in recent studies conducted to prove their effect on non-healing wounds, such as Resveratrol (RSV). This review aims to discuss the potential of RSV as a novel adjuvant therapy and its delivery system strategy in the case of diabetic non-healing wounds. We conducted an extensive search from three online scientific databases such as ScienceDirect, ResearchGate, and PubMed on February-March 2023. Keywords used are "resveratrol", "diabetic wound healing", and "diabetes mellitus". As a result, 86 studies were reviewed, and only 79 selected studies met all inclusion criteria. The formulation of RSV nanoparticles in oral drug delivery systems and topical administration has shown promise to overcome the limitations of RSV as adjuvant therapy in diabetic non-healing wounds. The best option that we found through this literature review is the nano-oral drug delivery system as it could minimize drug metabolism in the gastrointestinal tract, therefore the drug bioavailability and drug concentration on the target site could be maximized, even though the systemic side effects might occur.
Pengaruh Puzzle Terhadap Peningkatan Perkembangan Motorik Halus Anak Prasekolah Di Tk Santo Yoseph Denpasar Ni Kadek Dian Arisanti; Anak Ayu Nyoman Trisna Narta Dewi; Agung Wiwiek Indrayani
Media Kesehatan Politeknik Kesehatan Makassar Vol 19 No 1 (2024): Media Kesehatan
Publisher : Direktorat Politeknik Kesehatan Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32382/medkes.v19i1.550

Abstract

Various things can affect motor development in early childhood, both internal and external factors. Stimulation in the form of puzzles is one of the factors that increase children's fine motor development. The purpose of this study is to prove the effect of offering jigsaw puzzles to improve fine motor development in preschool children. The research method used was experimental with intervention and control groups and using simple random sampling technique with a total of 25 samples. The intervention group consists of 13 children who are given puzzles and the control group, consisting of 12 children, are given freedom to play other games such as playing in the field. The results showed an increase in fine motor development in preschool children at Tk Santo Yoseph Denpasar after being given a puzzle, as evidenced by the Wilcoxon Test results of 0.005 (p<0.05) in the intervention group during the pre- and post-test and the results of the Mann-Whitney Test posttest data of 0.021 (p<0.05). Based on the research that has been conducted, it can be concluded that there is an effect of offering puzzles on children's fine motor development and changes in the level of children's fine motor development in the intervention group after they have been given puzzles.
Efficacy of Solvent Type on Antioxidant Activity of Artocarpus heterophyllus Leaves Extract: A Scoping Review Ida Bagus Ideyogiswara; Bagus Komang Satriyasa; Agung Nova Mahendra; Agung Wiwiek Indrayani; Ketut Agus Adrianta
Indonesian Journal of Global Health Research Vol. 8 No. 4 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i4.2347

Abstract

Jackfruit leaves (Artocarpus heterophyllus) contain various bioactive compounds that have the potential as natural antioxidants. The antioxidant activity of jackfruit leaf extract is influenced by the type of solvent used during the extraction process. Objective to identify the effectiveness of various types of solvents on the antioxidant activity of jackfruit leaf extract. This study used a scoping review method by reviewing articles from PubMed, ScienceDirect, and Google Scholar in 2020–2025 Searching strategy using the keywords "Artocarpus heterophyllus" OR "jackfruit leaves" AND "antioxidant activity" OR "antioxidant capacity" AND solvent OR "solvent type" OR "extraction solvent" . Included articles were English-language primary studies published between 2020 and 2025. A total of 11 articles that met the inclusion criteria were analyzed descriptively. The data were analyzed descriptively and presented in tabular form to identify patterns of findings related to the effectiveness of various solvent types on the antioxidant activity of Artocarpus heterophyllus leaf extrac. Ethanol and hydroethanol solvents showed higher antioxidant activity than other solvents. Strong antioxidant activity is related to the high content of phenolic and flavonoid compounds that were successfully extracted. The type of solvent affects the antioxidant activity of jackfruit leaf extract, with ethanol and hydroethanol being the most effective solvents in extracting bioactive antioxidant compounds.
The Effect of Puzzle-playing on Fine Motor Development in Preschool Children Ni Kadek Dian Arisanti; Anak Ayu Nyoman Trisna Narta Dewi; Agung Wiwiek Indrayani
Physical Therapy Journal of Indonesia Vol. 3 No. 2 (2022): July - December 2022
Publisher : Universitas Udayana dan Diaspora Taipei Medical University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/ptji.v3i2.55

Abstract

Background: Development is developing human maturity and psychological processes that cannot be measured, such as increasing skills. The development speed in children is influenced by various factors such as the environment, health, nutrition, stimulation, and the role of parents. Fine motor development can be improved by applying the learning process and playing with interesting media, so children do not get bored easily. The media should be educative, like a puzzle game. Physiotherapy plays a role in preventing and reducing further complications that do not occur in children who experience fine motor delays. This research aims to determine the effect of giving puzzle games on fine motor development in preschool children. Methods: The method applied is a literature study by looking for theoretical references related to the research carried out. This literature review uses secondary data and information from journals collected from the Google Scholar, PubMed, and ScienceDirect databases over the last ten years as data sources. Results: Four studies discuss the impact of puzzle games on the fine motor development of preschool children. According to all journals, puzzle games impact the fine motor development of preschool-aged children. On average, about 25 children participate in each study. Conclusion: The findings obtained based on the literature that has been reviewed and the discussion state that giving puzzle games affects fine motor development in preschool children. The findings of this research can be used as a basis for puzzle therapy in children and are expected to be used to improve children's fine motor development through other games. There isn’t any clinical implication from this literature review.
The correlation between work posture and lower back pain among tailors Putu Ayu Bintang Anjali; Sayu Aryantari Putri Thanaya; Agung Wiwiek Indrayani; Ni Komang Ayu Juni Antari
Physical Therapy Journal of Indonesia Vol. 5 No. 1 (2024): January-June 2024
Publisher : Universitas Udayana dan Diaspora Taipei Medical University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/ptji.v5i1.198

Abstract

Background: Tailoring is an occupation pursued by a significant portion of the Indonesian population, and it is closely associated with working in a seated position. Tailors often experience rigid work postures and static muscle loads, which, if left unaddressed for extended periods, can increase the risk of work-related illnesses, one of which is lower back pain. Methods: This study employed an analytical observational method with a cross-sectional approach. The research subjects were determined using a total sampling technique. The total number of research subjects involved in this study was 37, adjusted based on inclusion and exclusion criteria. The research data included the level of work posture risk which was measured by the Rapid Upper Limb Assessment (RULA) and lower back pain measured by the Numeric Pain Rating Scale (NPRS). Results: The Spearman's rho hypothesis test was used to analyze the relationship between work posture and the occurrence of lower back pain at the garment in Bali, yielding a result of p = 0.000 (p < 0.05), indicating a significant correlation. Conclusions: This research concluded that a significant correlation between work posture and lower back pain among tailors in Bali.
Co-Authors Adhitya, I Putu Gde Surya Adrian Wiryanata Gorintha Adrian Wiryanata Gorintha Agung Nova Mahendra Agus Eka Darwinata Agus Indra Yudhistira Diva Putra Agus Indra Yudhistira Diva Putra Aloysius Ivander Wirayudha Widjaja Aman, IGM Amaze Grace Davidz Morato Anak Agung Bagus Putra Indrakusuma Anak Agung Bagus Putra Indrakusuma Anak Agung Gde Putra Wiraguna Anak Agung Gede Angga Puspa Negara Anak Agung Gede Eka Septian Utama Anak Agung Gede Eka Septian Utama Anak Ayu Nyoman Trisna Narta Dewi Andrea Ivena Anggi Amanda Triana Devy Ari Wibawa Ari Wibawa Aria Wibawa Bagus Komang Satriyasa Bagus Naibaho Desak Ketut Ernawati Dewa Ayu Putu Sri Ista Dewanti Dewi, Anak Ayu Nyoman Trisna Narta Dewi, Luh Putu Widya Amritha Dewi, Ni Wayan Sucindra Dewi, Rani Nafisa Dhumaranang, Hyangayu Dedari Dyan Amalina Pratiwi Els, Vanessa Emily Devina Kartawijaya Faradilah Destyana Fiqhi Dhamiery Haniefah Effendi Gede Parta Kinandana Hafizh Marin I Dewa Putu Sutjana I Gede Aswin Parisya Sasmana I Gede Krisna Arim Sadeva I Gede Wikania Wira Wiguna I Gede Wikania Wira Wiguna I Gusti Ayu Artini I Gusti Ayu Bulan Sistayani I Gusti Ayu Gita Widyaswari I Gusti Ayu Sitti Sadvika I Made Jawi I Made Krisna Dinata I Made Niko Winaya I Nengah Raka Swastika I Nengah Raka Swastika I Nyoman Adi Putra I P G. Adiatmika I Putu Eka Widyadharma I Putu Gde Surya Adhitya I Putu Yudi Pramana Putra I Wayan Putu Sutirta Yasa I Wayan Sumardika I Wayan Weta Ida Bagus Ideyogiswara Indratmo, Novea Irawan, Angeline Aprilia Isa Cahya Permadi Junior, Darren Kamayoga, I Dewa Gede Alit Ketut Agus Adrianta Komang Githa Pradnyamitha Dewi L. Ade Sintia Devi Luh Putu Happy Sandha Luh Putu Ratna Sundari Luh Putu Ratna Sundari Luh Putu Sudi Wahyuni Made Edwin Sridana Made Hendra Satria Nugraha Made Indira Dianti Sanjiwani Made Indira Dianti Sanjiwani Mardaningrat, Kadek Herdana Vildan Milhanah Milhanah Nanda Putra Wiguna Natasya Pramatya Putri Negara, Anak Agung Gede Angga Puspa Ni Kadek Dian Arisanti Ni Kadek Dian Arisanti Ni Ketut Risitani Ni Ketut Ristiani Ni Ketut Ristiani Ni Komang Ayu Juni Antari Ni Komang Ayu Juni Antari Ni Luh Guantari Ni Luh Nopi Andayani Ni Made Adi Tarini Ni Made Dwi Sandhiutami Ni Made Intansari Tri Buana Ni Made Maya Risna Ayu Ni Made Wira Tania Astarini Ni Nyoman Tri Eka Buanasari Ni Putu Sri Indrani Remitha Ni Putu Venaya Sidarthayani Ni Wayan Melyani Indahswari Ni Wayan Mutiara Warmasari Ni Wayan Sinta Devi Arini Ni Wayan Sri Wahyuni Sri Wahyuni Ni Wayan Sucindra Dewi Ni Wayan Tianing Ni Wayan Tianing Nila Wahyuni Nila Wahyuni Nugraha, Boya Nyoman Budhi Wirananda Setiawan Nyoman Budhi Wirananda Setiawan Nyoman Ririn Chandrika Sari Prasetyo, Arsya Hayyu Pratiwi, Kadek Prastiti Surya Putrawan, Ida Bagus Indra Shadnyana Putri Ayu Wulandari Putri, Gita Almira Putri, Kadek Wina Santhya Putu Aprilyanti Aristadewi Putu Ayu Bintang Anjali Putu Ayu Wulan Purnama Dewi Putu Savitri Priutami Putu Sutha Nurmawan Putu Wisnu Arya Wardana Riska Damayanti Sitompul Rizaldy Pinzon Sari, Ni Wayan Puspita Sayu Aryantari Putri Thanaya Sayu Aryantari Putri Thanaya Thomas Eko Purwata Tracey Odella Jiraldi Akemah Tresnayanthi, Kadek Ayu Sri Vania Rau, Chiquita Putri Vidya Rahmayunissa Swandi Putri Vingky Winda Astiti Vittala, Govinda Wimpie I Pangkahila Winanti, Kadek Dinda Ayu Sri Witri Okta Maruli Y, Yudiyanta Yundari, Yundari Zidni Sadati Maulana Aden