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All Journal Medicina journal of internal medicine Sport and Fitness Journal Buletin Udayana Mengabdi E-Jurnal Medika Udayana Althea Medical Journal Jurnal Kesehatan Jurnal Kesehatan Andalas Majalah Obat Tradisional Journal of Medicine and Health ISM (Intisari Sains Medis) : Jurnal Kedokteran Bali Dermatology and Venereology Journal Essential: Essence of Scientific Medical Journal Bali Dental Journal Physical Therapy Journal of Indonesia Bali Dermatology Venereology and Aesthetic Journal Indonesian Journal of Biomedicine and Clinical Sciences Journal of Medicine and Health
Desak Made Wihandani
Bagian Biokimia, Fakultas Kedokteran Universitas Udayana
Biochemistry, Genetics & Molecular Biology Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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The role of flaxseed (Linum usitatissimum) in improving plasma lipid profiles: a literature review Marcella, Marzha; Desak Made Wihandani; I Gusti Ayu Artini
Indonesian Journal of Biomedicine and Clinical Sciences Vol 57 No 2 (2025)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v57i2.16550

Abstract

Several major risk factors contribute to cardiovascular diseases. One of these is dyslipidemia, an imbalance of plasma lipids such as total cholesterol (TC), low-density lipoprotein (LDL), triglycerides (TG), and high-density lipoprotein (HDL). While medications to lower lipids are widely used to improve lipid profiles, they have some limitations. Flaxseed is rich in ɑ-linolenic acid, phytosterols, and lignans, which can improve lipid profiles. This study aimed to review the potential effects of flaxseed on lipid metabolism. Data was gathered from research databases such as Google Scholar, PubMed, Science Direct, and Springer for the past 5 yr. About 1,527 scientific articles were found, but after eliminating duplicates and screening of title and abstract, only 45 full-text articles were assessed, with 16 selected. The result showed that ɑ-linolenic acid, phytosterols, lignans, and fibers in flaxseed improve TC, LDL, TG, and HDL through various mechanisms. In conclusion, flaxseed shows promise as a natural therapy for dyslipidemia, improving TC, LDL, VLDL, and TG levels, though HDL effects vary. Disparities are linked to demographics, form, dosage, and duration, highlighting the need for standardized research.
Focus on the dabrafenib, vemurafenib, and trametinib in the clinical outcome of melanoma: A systematic review and meta-analysis Ida Ayu Widya Anjani; Anak Agung Bagus Putra Indrakusuma; I Gede Krisna Arim Sadeva; Putri Ayu Wulandari; Luh Made Mas Rusyanti; Prima Sanjiwani Saraswati Sudarsa; I Gede Putu Supadmanaba; Desak Made Wihandani
Bali Dermatology Venereology and Aesthetic Journal BDVJ - Vol. 3 No. 2 (December 2020)
Publisher : Explorer Front

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/myphje28

Abstract

Background: Melanoma is the most severe lethal skin cancer, affecting melanin producer cells (melanocytes). Surgery is the most common treatment, whereas, for the advanced stage, the development of treatment is recommended. BRAF (Dabrafenib and Vemurafenib) inhibitor or MEK inhibitor (Trametinib) is the most frequently targeted melanoma therapy due to more than 80% of patients with positive BRAF mutation. In this review, those treatments will be investigated systematically to identify their clinical outcome. Method: This systematic literature review (SLR) was performed from Cochrane, Science Direct, Google Scholar, and Pubmed. Cochrane Risk-of-Bias Tool RoB2 is used to assess RCT studies and New-castle Ottawa Scale Assessment to assess cohort studies by three different assessors. Data analysis was carried out by using Review Manager (RevMan 5.4). Heterogenicity test was assessed by I2 and Chi2 statistic Result: There are 20 studies used in this article (13 RCT and seven cohorts). The overall survival (OS) and progression-free survival (PFS) of the survey that using targeted therapy (vemurafenib, trametinib, or dabrafenib) compare other treatments (chemotherapy, immunotherapy, etc.) showed risk ratio (RR) was 1.12 (95%CI 1.07,1.17; I2=100%; p<0,00001). The OS and PFS with monotherapy compare of vemurafenib, trametinib, or dabrafenib with combination therapy showed RR was 1.09 (95%CI.06,1.13; I2=99%; p<0,00001). Conclusion: BRAF and MEK targeted therapy has a good prognosis for a patient with a positive BRAF gene mutation and could be combined with other treatments for better clinical outcomes rather than monotherapy.
Does omega-3 supplementation added to exercise attenuate inflammaging? Effects on circulating interleukin-6 in older adults: A meta-analysis of randomized controlled trials Hartaningsih, Ni Made Dian; Wihandani, Desak Made; Ruma, I Made Winarsa; Prabawa, I Putu Yuda
Physical Therapy Journal of Indonesia Vol. 7 No. 1 (2026): Inpress January-June 2026
Publisher : Universitas Udayana dan Diaspora Taipei Medical University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/ptji.v7i1.398

Abstract

Background: Low-grade systemic inflammation (inflammaging) characterizes older adults, with circulating interleukin-6 (IL-6) as a key biomarker linked to frailty, physical decline, and cardiometabolic risk. Exercise repeatedly elicits anti-inflammatory myokine responses, while long-chain omega-3 (eicosapentaenoic Acid (EPA)/ docosahexaenoic acid (DHA)) promotes resolution of inflammation via membrane remodelling and specialized pro-resolving mediators. This study aimed to determine whether adding omega-3 supplementation to structured exercise reduces resting IL-6 more than exercise alone in older adults. Methods: A systematic search was undertaken in PubMed using a pre-specified medical subject headings (MeSH) strategy that combined terms for long-chain omega-3 fatty acids, structured exercise/physical activity, Interleukin-6, the aged population, and randomized/clinical trial filters; animal-only studies were excluded. This search yielded 22 records. Complementary searches in Scopus (14 records) and ResearchGate (18 records) were pooled with PubMed results and deduplicated prior to screening. Four RCTs (duration 8–18 weeks) met all criteria. Pooled effects were estimated with a random-effects model using restricted maximum likelihood (REML). Between-study heterogeneity was summarized by Q, I², and τ² summarized between-study heterogeneity. Potential small-study effects were explored visually using a funnel plot. Results: Pooled analysis using a REML model shows that post-intervention IL-6 was lower by 0.77 pg/mL when omega-3 supplementation was added to exercise versus exercise alone (MD = −0.77 pg/mL; 95% CI −1.46 to −0.08; p = 0.03; k = 4), indicating a statistically significant, directionally consistent attenuation of resting inflammation. Between-study heterogeneity was moderate (Q = 7.04, df = 3, p = 0.07; I² = 55%; τ² = 0.26), suggesting that differences in trial characteristics (e.g., duration 8–18 weeks, exercise mode, and omega-3 dose/form) contributed to variability in effect sizes. Funnel-plot analysis did not reveal marked asymmetry. Conclusion: Across randomized trials in older adults, omega-3 supplementation added to exercise achieves a modest but statistically significant reduction in resting IL-6 versus exercise alone, consistent with attenuation of inflammaging.
Co-Authors Adi Saputra Adioka GM Agung Nova Mahendra AGUS BAGIADA NYOMAN Anak Agung Bagus Putra Indrakusuma Anak Agung Bagus Putra Indrakusuma Anak Agung Gede Eka Septian Utama Anak Agung Istri Shania Kemala Anak Agung Ngurah Krisnanta Adnyana Ananta Kusuma, , I Komang Wira Andrean Heryanto Anjani, Ida AyuWidya Anthony Wijaya Arcana N Arim Sadeva, I Gede Krisna Artha, I Wayan Windi Atmaja, Made Ayu Kurniati Avissia Zivanna Bagus Komang Satriyasa Baiq Rissa Khaerawati Salim Bramantya, Putu Arya Rahadi Christian Chandra Christine Beatrice Amesiella Cokorda Bagus Jaya Lesmana Dady Iskandar Dhananjaya, I Gede Arya Diva Edgar, Christine Gede Andry Nicolas Andry Nicolas Halim, Wilson I A Md Dwi Purwitasari I Dewa Putu Sutjana I G. P. Supadmanaba I Gede Krisna Arim Sadeva I Gede Krisna Arim Sadeva I Gede S Narayana I Gede Wikania Wira Wiguna I Gusti Ayu Artini I Gusti Ayu Stiti Sadvika I Kadek Arya Gangga Permana I Ketut Agus Somia I Komang Wira Ananta Kusuma I Made Adi Widiantara I Made Angga Sayoga I Made Jawi I MADE MULIARTA . I Nyoman Wande I W. Sudarsa I Wayan Gede Sutadarma I Wayan Gede Sutadarma I Wayan Gede Sutadarma I Wayan Gede Sutadarma I Wayan Surudarma I Wayan Weta I Wayan Windi Artha I.A. Pascha Paramurthi Ida Ayu Dewi Wiryanthini Ida Ayu W Anjani Ida Ayu Widya Anjani Ida Ayu Widya Anjani Ida AyuWidya Anjani Ida Sri Iswari Indra Lesmana Indrakusuma, Anak Agung Bagus Putra Janet Tee Jaya, Ni Komang Ayu Amanda Setiari Katrin ** Kausalya Neelamagam Ketut Agus Adrianta Ketut Ayu Hartarani Prasetya Ketut Tirtayasa Komang Erdwin Wicaksana Kusumadewi, Made Dea Avrilia Listya Triandari Luh Made Indah Sri Handari Adiputra Luh Made Mas Rusyanti Luh Made Mas Rusyati Luh Putu Ratna Sundari M.Ali Imron Made Ngurah Arya Diningrat Pinatih Made VW Yani Made Wahyu Krisnandewi Mamangdean, Christo Timothy Marcella, Marzha Muh. Ali Imron Muhammad Ali Imron Muhammad Irfan Muhammad Irfan Ni Kadek Fiora Rena Pertiwi Ni Kadek Yudit Erawati Ni Made Ari Purwaningrum Ni Made Ayu Adnyani Ni Made Dian Hartaningsih Ni Made Dwi Putri Nadi Ni Made Suasti Wulanyani Ni Nyoman Ayu Dewi Ni Nyoman Ayu Dewi Ni Nyoman Ayu Dewi Ni Nyoman Ayu Dewi Ni Nyoman Ayu Dewi Ni Putu Sri Indrani Remitha NN Ayu Dewi NYOMAN AGUS BAGIADA Nyoman Bayu Mahendra Parisya Sasmana, I Gede Aswin Prabawa, I Putu Yuda Prima Saraswati Sanjiwani Sudarsa Purwaningrum, Ni Made Ari Putri Ayu Wulandari Putri Ayu Wulandari Putri Ayu Wulandari, Putri Ayu Putu Anda Tusta Adiputra Putu Astawa Rubahshini Gunaseelan Ruma, I Made Winarsa Sabrina Annamma Philip Sasmana, I Gede Aswin Parisya Shenbagam Mahalingam Sinta Wiranata Sugijanto - Sugijanto - Surudarma, I Wayan Susy Purnawati Sutedja, Jane Carissa Tjokorda Gde Bagus Mahadewa Triana Devy, Anggi Amanda Widya Anjani, Ida Ayu Wijaya, Audrey Rachel Wijaya, Grace Veronika Wiranata, Sinta Yudha Anggoro Kawi