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All Journal HAYATI Journal of Biosciences Jurnal Ilmu Pertanian Indonesia Jurnal Ilmu Dasar BERKALA SAINSTEK Abdimas REKAYASA UNEJ e-Proceeding BIOLINK (Jurnal Biologi Lingkungan, Industri, Kesehatan) Caraka Tani: Journal of Sustainable Agriculture BIOEDUKASI JPSCR : Journal of Pharmaceutical Science and Clinical Research Abdimas Umtas : Jurnal Pengabdian kepada Masyarakat SULUH: Jurnal Abdimas Journal of Natural Sciences Makara Journal of Science InSTEM Jurnal Malikussaleh Mengabdi Life Science and Biotechnology Biosaintifika: Journal of Biology & Biology Education Jurnal Penelitian Sains dan Teknologi Indonesia Biodiversitas Journal of Biological Diversity
Dwi Setyati
Jurusan Biologi, Fakultas Matematika Dan Ilmu Pengetahuan Alam, Universitas Jember
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Control & Systems Engineering Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Environmental Science Immunology & microbiology Industrial & Manufacturing Engineering Library & Information Science Mathematics Physics Public Health Social Sciences Other

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Effect of Colchicine and Bio-catharantin on the DNA Relative Content and Stomatal Structure of Black Rice (Oryza sativa L. var. Jeliteng) Dwi Setyati; Mukhamad Su’udi; Dyah Retno Wulandari; Tri Handoyo; Fuad Bahrul Ulum
Caraka Tani: Journal of Sustainable Agriculture Vol 39, No 2 (2024): October
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/carakatani.v39i2.88279

Abstract

Black rice (Oryza sativa L. var. Jeliteng), known for its health benefits compared to white rice, faces challenges in productivity. Among varieties, this black rice is popular in Indonesia but shows low yield. Research on improving black rice through genetic manipulation with antimitotic substances is limited. Therefore, this study aims to compare the effects of colchicine and Bio-catharantin on the germination rate, DNA relative content, and stomatal structure of O. sativa L. var. Jeliteng. Seeds were treated with colchicine (0.1%, 0.2%, and 0.3%) and Bio-catharantin (0.1%, 0.2%, 0.3%, 0.4%, and 0.5%) at soaking durations of 12, 24, and 48 hours. Germination was assayed, ploidy was determined using flow cytometry, and stomatal traits, including size and density, were examined microscopically. The results showed that Bio-catharantin did not exhibit any toxic effects on germination rates, whereas colchicine reduced germination starting at 0.2% concentration. Both chemical agents modified the DNA relative content of Jeliteng black rice. Colchicine generally increased stomatal length and width while decreasing stomatal density, with significant changes at 0.3% concentration for 24 hours. Bio-catharantin also altered stomatal traits, enhancing length and width in most cases but significantly reducing density under certain conditions. Bio-catharantin emerged as a promising alternative to colchicine for inducing chromosomal mutations in plants, offering benefits in altered stomatal structures without the toxic effects on germination, compared to colchicine.
Antimicrobial and Phytochemistry study of Liparis resupinata Ridl. from Mount Gumitir, East Java, Indonesia Fuad Bahrul Ulum; Dwi Setyati; Moh. Ikmal Alfi Rizqoni; Mukhamad Su'udi
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 8, No 3 (2023)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v8i3.70856

Abstract

Liparis resupinata Ridl. is one of the abundant epiphytic orchids in the Mount Gumitir, Jember Regency with potency for phytopharmacy study. Our study focused on the observation of the species for their antimicrobial and metabolite profiles. This study used Gram-positive and Gram-negative bacteria, i.e., S. aureus, S. typhi, and E. coli with an agar diffusion method for antibacterial activity test. The metabolite profile was generated through GC-MS. The methanolic extract of the leaves of L. resupinata showed positive antibacterial activity. The GC-MS data analysis suggested the presence of antimicrobial substances e.g., (-)-loliolide, nonanoic acid, 1,2-ethanediamine, and hydroxy dimethyl furanone.
Morphological, molecular, and phytochemical characteristics of wild edible fern (Diplazium esculentum) from Jember, East Java, Indonesia YUSRINA RISKY AMALINI; KAHAR MUZAKHAR; MUKHAMAD SU’UDI; DWI SETYATI; EDIA FITRI DWINIANTI; FUAD BAHRUL ULUM
Biodiversitas Journal of Biological Diversity Vol. 26 No. 6 (2025)
Publisher : Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13057/biodiv/d260624

Abstract

Abstract. Amalini YR, Muzakhar K, Su’udi M, Setyati D, Dwinianti EF, Ulum FB. 2025. Morphological, molecular, and phytochemical characteristics of wild edible fern (Diplazium esculentum) from Jember, East Java, Indonesia. Biodiversitas 26: 2794-2805. Diplazium esculentum, an edible pteridophyte with medicinal potential, exhibits morphological variation that risks improper medicinal use. This study aimed to comprehensively characterize D. esculentum from Jember, Indonesia, through an integrative approach, including morphological analysis, DNA barcoding, phytochemical profiling, and antioxidant activity assessment. Fifteen specimens, locally referred to as pakis menir, were collected from a single site within a rubber-mixed coffee plantation in Panti, Jember District, East Java, Indonesia. The examination of morphological traits, molecular identification using the rbcL marker, analysis of phytochemical profiles through GC-MS, prediction of biological activities using PASS online, and evaluation of antioxidant activity using the DPPH assay all pointed to the potential of D. esculentum. Morphological analysis confirmed D. esculentum's diagnostic traits, while rbcL DNA barcoding validated a 100% sequence match with D. esculentum (OL536867.1). GC-MS analysis of young fronds identified 25 bioactive metabolites, including 11 phenolics, 9 terpenoids, and 5 alkaloids, with 96% exhibiting high biological activity (Pa>0.7) according to PASS predictions. The dominant compound, 3,6-dimethylquinoline (12.38%), exhibited significant anticancer potential, while the frond extract showed strong antioxidant activity (IC50: 91.25±7.60 ppm), reflecting its phenolic richness. These results highlight the potential of D. esculentum's phytochemical wealth and pharmacological promise, supporting further exploration in pharmacognosy, nutraceuticals, and bioactive compounds.
Phytochemical and pharmacological evaluation of Vanda tricolor from Gumitir, East Java, Indonesia FUAD BAHRUL ULUM; YUSI ANANDA PUTRI; ABDILLAH MAULANA FARHAN; DWI SETYATI; RANJITHKUMAR RAJAMANI; BAMBANG SUGIHARTO; MUKHAMAD SU’UDI
Biodiversitas Journal of Biological Diversity Vol. 26 No. 9 (2025)
Publisher : Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13057/biodiv/d260947

Abstract

Abstract. Ulum FB, Putri YA, Farhan AM, Setyati D, Rajamani R, Sugiharto B, Su’udi M. 2025. Phytochemical and pharmacological evaluation of Vanda tricolor from Gumitir, East Java, Indonesia. Biodiversitas 26: 4783-4792. Vanda tricolor an epiphytic orchid native to the coffee agroforest of Gumitir, East Java, Indonesia, represents a promising source of pharmacologically active compounds. This study aimed to characterize the bioactive constituents of V. tricolor and evaluate their antioxidant, antimicrobial, and anticancer potential. Methanolic leaf extracts were analyzed using gas chromatography-mass spectrometry (GC-MS) for metabolite profiling. Its biological activities were assessed through the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay, agar well diffusion method, and molecular docking against the antiapoptotic Bcl-2 protein. GC-MS analysis identified 48 metabolites, with 4-butylphenol (7.57%) as the predominant compound. The extract demonstrated very strong antioxidant activity (IC??: 37.25 ppm), along with moderate antibacterial effects against Staphylococcus aureus and Escherichia coli; however, it showed no growth inhibition against Salmonella typhi. Molecular docking revealed that 4-butylphenol exhibited the highest binding affinity toward Bcl-2 (-5.50 kcal/mol), indicating its potential as a lead compound for anticancer therapy. These findings represent the first integrated phytochemical and pharmacological profile of V. tricolor from Gumitir, underscoring its value as a source of natural bioactive agents. The results also provide a scientific basis for further exploration of orchids in drug discovery and contribute to the conservation of this underutilized native species.
Bioactivities and phytochemical profile of Cyclosorus parasiticus from East Java, Indonesia via GC-MS and LC-MS FUAD BAHRUL ULUM; DWI SETYATI; IKA OKTAVIANAWATI; MOH. IKMAL ALFI RIZQONI; ERLIN NOVITA SARI; KAHAR MUZAKHAR; MUKHAMAD SU’UDI
Biodiversitas Journal of Biological Diversity Vol. 27 No. 2 (2026)
Publisher : Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13057/biodiv/d270234

Abstract

Abstract. Ulum FB, Setyati D, Oktavianawati I, Rizqoni MIA, Sari EN, Muzakhar K, Su’udi M. 2026. Bioactivities and phytochemical profile of Cyclosorus parasiticus from East Java, Indonesia via GC-MS and LC-MS. Biodiversitas 27 (2): d270234. https://doi.org/10.13057/biodiv/d270234. Cyclosorus parasiticus is a terrestrial fern abundantly distributed in the area of Gumitir Mountain, East Java, Indonesia. Despite its ecological abundance, its pharmacological potential remains undercharacterised, although leaf tissues from Gumitir populations accumulate relatively high levels of flavonoids and alkaloids. Through an integrative bioassay–metabolomics approach, this study presents the first systematic evaluation of the antibacterial and antioxidant activities, together with comprehensive chemical profiling, of C. parasiticus from the Gumitir region. Metabolite annotation revealed pronounced chemical diversity, with 39 compounds identified by GC-MS and six dominant LC-MS features. Importantly, the diterpene euphornin and the alkaloids canthiumine and haplophytine were detected and are reported here for the first time in a fern, substantially expanding current knowledge of pteridophyte secondary metabolism and highlighting previously overlooked alkaloid diversity in fern taxa. The methanolic extract exhibited concentration-dependent antibacterial inhibition against Staphylococcus aureus, Kocuria rosea, Pseudomonas aeruginosa, and Escherichia coli, with greater susceptibility observed in Gram-positive bacteria. Antioxidant activity measured by the DPPH radical-scavenging assay yielded an IC50 value of 176.66±14.64 ppm, indicating moderate radical-scavenging capacity. Collectively, these findings establish C. parasiticus (Gumitir population) as a chemically rich fern with measurable antibacterial and antioxidant potential, supporting its promise as a natural source of pharmacologically relevant metabolites.
Diversity of Hoya Species across Three Plantation Landscapes in Jember Regency and the Phytochemical and Antioxidant Potential of Hoya lacunosa Blume Fuad bahrul Ulum; Asa Hanifatul Hayyinah; Hari Sulistiyowati; Tri Ratnasari; Mukhamad Su'udi; Edia Fitri Dwinianti; Dwi Setyati
Biosaintifika: Journal of Biology & Biology Education Vol. 17 No. 3 (2025): November 2025
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/biosaintifika.v17i3.22001

Abstract

Jember Regency encompasses several plantation areas characterized by diverse ecological conditions, notably the Gumitir, Garahan, and Tancak plantations. Among the flora in these regions, the genus Hoya is notable for its medicinal potential. This study aimed to characterize the diversity of Hoya species, provide detailed morphological documentation, and evaluate the phytochemical and antioxidant properties of a medicinally used species. Field exploration employed a systematic plot-based design consisting of 150 plots (5 × 5 m²) with 3 m spacing. The most vegetatively dominant species, Hoya lacunosa, was subjected to GC–MS phytochemical analysis and DPPH-based antioxidant evaluation. A total of eleven Hoya species were recorded across the three plantation sites. The Gumitir plantation exhibited the highest diversity, containing ten species., i.e. Hoya burtoniae, H. camphorifolia, H. carnosa, H. cinnamomifolia, H. dennisii, H. fuscomarginata, H. lacunosa, H. micrantha, H. purpureofusca, and two unidentified Hoya spp. In contrast, the Garahan plantation supported only H. dennisii and H. fuscomarginata, while H. lacunosa was exclusively found in Tancak indicating a highly localized distribution. GC-MS profiling on H. lacunosa leaves revealed 26 compounds, comprising 16 secondary metabolites (12 phenolics, 2 alkaloids, and 2 terpenes) and 5 primary metabolites. The methanol extract exhibited strong antioxidant activity (IC₅₀ = 50.89 ppm), reflecting its potential as a natural source of bioactive compounds. These findings demonstrate substantial Hoya diversity in Jember Regency and underscore the potential of H. lacunosa as a valuable source of bioactive metabolites for pharmaceutical development.
Co-Authors A.A. Ketut Agung Cahyawan W ABDILLAH MAULANA FARHAN Adawiyah, Robiyatul Afidah, Yusfi Aini Nurul Ali Murtodo Ana, Daniar Alfi Andiana, Jocelin Anik Suwandari Anik Swandari Ari Satia Nugraha Arif Mohammad Siddiq Arsetyo Rahardianto Arum, Asyifa Yasmin Asa Hanifatul Hayyinah Asyifa Yasmin Ningrum BAMBANG SUGIHARTO Bambang Sugiharto Desy Lutfianasari Dhiyaul Kholis DWI INDAHNING ROHMAH Dwinianti, Edia Dwinianti, Edia Fitri Dwinianti, Edia Fitria Dyah Retno Wulandari El Shania Ravitamala ERLIN NOVITA SARI Esti Utarti Eva Tyas Utami Farhan, Abdillah Maulana Fitri, Edia Fuad Bahrul Ulum Gilani, Noor Azizah Hidayat Teguh Wiyono Ika Oktavianawati KAHAR MUZAKHAR KAHAR MUZAKHAR Khoirunnisa, Gita Ayu Kumalasari, Deris Erlita Luh Putu Ratna Sundari Luthfiah Luthfiah M. Akbar, Salahuddin Miatin Alvin Septianasari MOH. IKMAL ALFI RIZQONI Moh. Ikmal Alfi Rizqoni Monica Paulina Erizcy MUKHAMAD SU’UDI MUKHAMAD SU’UDI Mukhamad Su'udi Mukhamad Su'udi Mukhamad Su'udi Mukhamad Su'udi Mukhamad Su'udi Mukhamad Su'udi MUKHAMAD SU’UDI Mukhamad Su’udi Mustafidah, Qori'atul Nihayah, Husnatun Parawita Dewanti Pining Suwardining Tyas Rajamani, Ranjithkumar RANJITHKUMAR RAJAMANI Ratnasari, Tri Rendy Setiawan Rike Oktarianti Rizqoni, Moh Ikmal Alfi Robi’atul Adawiyah Rosida, Waki'atil Rosyadi, Achmad Saniyah Fatkhul Alim Sattya Arimurti Sa’adah, Kurnia Su'udi, M. Su'udi, Mukhamad Sulistiyowati, Hari Sutoyo Sutoyo Su’udi, Mukhamad Tri Handoyo Tri Ratnasari Tri Ratnasari Tri Ratnasari Tri Ratnasari Tri Ratnasari Umiyah Umiyah Veren Yuliana Saputri Vita Sindiya Waki’atil Rosida Wardatus Sholeha Wasiatur Roziqoh YUSI ANANDA PUTRI YUSRINA RISKY AMALINI