Article Per Year (5 Year)
p-Index From 2021 - 2026
2.794
P-Index
This Author published in this journals
All Journal International Journal of Renewable Energy Development JURNAL KIMIA SAINS DAN APLIKASI Journal of Education and Learning (EduLearn) Abdimas Jurnal Inovasi Pendidikan Kimia Jurnal Penelitian Pendidikan Rekayasa: Jurnal Penerapan Teknologi dan Pembelajaran Sainteknol : Jurnal Sains dan Teknologi Jurnal Karya Pendidikan Matematika Jurnal Daya Matematis Indonesian Journal of Chemical Science Indonesian Journal of Chemistry ABDIMAS SILIWANGI JISIP: Jurnal Ilmu Sosial dan Pendidikan Jurnal Pendidikan Jurnal Pengabdian Masyarakat Khatulistiwa Budapest International Research and Critics Institute-Journal (BIRCI-Journal): Humanities and Social Sciences Cokroaminoto Journal of Primary Education Jurnal Bina Desa Bookchapter Alam Universitas Negeri Semarang Bulletin of Chemical Reaction Engineering & Catalysis LEMBARAN PUBLIKASI MINYAK DAN GAS BUMI International Journal of Active Learning Scientific Contributions Oil and Gas
Sri Kadarwati
Unknown Affiliation
Religion Arts Humanities Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Earth & Planetary Sciences Economics, Econometrics & Finance Education Energy Engineering Environmental Science Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Mathematics Public Health Social Sciences Other

Published : 57 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search
Journal : JURNAL KIMIA SAINS DAN APLIKASI

 1 
Performance of HDTMA-Br-Modified Indonesian Zeolite as a Drug Carrier Candidate for Diclofenac Sodium Khafidhotun Naimah; Harjono Harjono; Jumaeri Jumaeri; Sri Kadarwati
Jurnal Kimia Sains dan Aplikasi Vol 24, No 3 (2021): Volume 24 Issue 3 Year 2021
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (4104.288 KB) | DOI: 10.14710/jksa.24.3.91-100

Abstract

Diclofenac sodium is a non-steroidal anti-inflammatory drug with a relatively short release time. This short release time promotes a more frequent drug consumption and could lead to side effects in the stomach, e.g., gastrointestinal disorders, gastrointestinal bleeding, and gastric ulcers. A drug delivery system with a slow-release activity is one of the promising technologies to control the drug amount released to the stomach. A surfactant-modified natural zeolite as a carrier for diclofenac sodium has been used in this study. This study focused on the preparation, characterization, and slow-release performance of HDTMA-modified natural zeolite as a carrier for diclofenac sodium. The zeolite underwent chemical and physical activation, as well as milling prior to use. It was proven that the zeolite used was dominated by mordenite and clinoptilolite with high stability properties towards acid treatments, as indicated by the XRD patterns. A modification of the zeolite surface using HDTMABr was also successfully performed, indicated by the appearance of peaks at wavenumbers of 2923.05 cm-1 and 2853.39 cm-1 (symmetrical and asymmetrical CH2 strains of HDTMA molecules, respectively) in the FTIR spectra. The synthesized HDTMA-modified natural zeolite also showed an excellent surface property such as surface area, pore-volume, and size, as indicated by the BET-BJH isotherms on the nitrogen adsorption. The slow-release performance of the zeolite-based drug delivery system was studied by investigating the adsorption-desorption behavior of HDTMA-modified zeolite towards diclofenac sodium. The HDTMA-modified zeolite adsorbed the diclofenac sodium of 54.01% at a pH of 7.5, the contact time of 60 min, and the initial concentration of 100 ppm. The adsorbed diclofenac sodium of 73.95% could be released from the HDTMA-modified adsorbent for 8 h, mimicking the time length of drug metabolism in the human body.
Co-Authors - Jumaeri A Tri Widodo A Tri Widodo Adinda Hapsari Aditia Nur Bakti Agung Feinnudin Amalina, Nur Dina Anggreani, Ina Annisa, Riska Nurfirda Aprillia Findayani Arma Yoga Astutik, Kasni Atika Wijaya Ayu Nugrahantia, Ayu Azzahra, Elvara Siti Azzahra, Yasmin Bahij, Aida Tika Biluthfil Bakti, Prayoga Bangun Yulianto Cepi Kurniawan Damayanti, Kristina Damayanti, Lutfia Damayanti, Yosephine Debbie Devitra Saka Rani Dewi, Silmi Dalila Millatina Dhian Ekowati Dian Sri Asmorowati Edi Prayitno, Edi Edy Cahyono Eko Budi Susatyo Elsa Ari Astuti Endang Susilaningsih Evalisa Apriliani, Evalisa Evita H. Legowo Fitri Rahmawati Fitri Rahmawati Harjito - Harjito Harjito Hidayah, Aida Nur Hutomo Wahyu Nugroho I Ketut Suada Imam Khabib Imam Kusmaryono Indriana Kartini Isti Hidayah Iswanto, Haifa Firyal Joseph P. Brinkman Junaid Sadrach Kartikasari, Reny Kasmadi Imam Supardi Kasmui -, Kasmui Khaerur Rifqi, Khaerur Khafidhotun Naimah Kolilah, Liluk Lailatul Badriyah Latifah Latifah LENI HERLINA Luluk Amnah Fitriyana, Luluk Amnah M Rafi Antoni M. Udiharto Malik, Septina Praditia Marcelino, Richie Mohammad Alauhdin, Mohammad Mubarak, Dinda Halimah Agrifani Muflikah, Binti Murbangun Nuswowati Nila Ubaidah Noegroho Hadi NOEGROHO HADI HS Noegroho Hadi HS. Nuhyal Ulya Nurhikmah Nurhikmah Nuril Huda Nurul Fadhilah Pertiwi Ayu Pamuji Kurniatun, Pertiwi Ayu Pamuji Pramestia, Rena Aliya Prima Astuti Handayani Puji Eka Rahayu Puji Eka Rahayu Putriana Dewi Rahayu, Sri Astusi Rani, Devitra Saka Rida Farida, Rida Risna Anggraeni Rohmah, Rojaa Maysa Rudiyanto, Aris Rudiyanto, Aris Sadrach, Junaid Saptorini Saptorini Saptorini Saptorini, Saptorini Siddiq Wahyu Hidayat Sigit Priatmoko Soeprodio Soeprodio, Soeprodio Soeprodjo Soeprodjo, Soeprodjo Sri Astusi Rahayu Sri Susilogati Sumarti Sri Wahyuni Sri Wahyuni Sri Wahyuni SRI WARDANI Subiyanto Hadi Saputro Sugihardjo Sugihardjo Sugihardjo Sugihardjo Sulistyaningsih, Nining Sulistyarini, Ika Teguh Budiyanto, Teguh Triyono Triyono Try Astuti Wandah Wibawanto Wara Dyah Pita Rengga Wega Trisunaryanti Witono Basuki, Witono Woro Sumarni Wuwus Ardiatna Zahro, Ainu Ilmiatuz