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All Journal JURNAL KIMIA SAINS DAN APLIKASI Jurnal Riset Kimia Pharmacon INDONESIAN JOURNAL OF PHARMACY ALCHEMY Jurnal Penelitian Kimia Jurnal Penelitian Farmasi Indonesia Majalah Farmasi dan Farmakologi (Trends in Pharmacy and Pharmaceutical Sciences) JSFK (Jurnal Sains Farmasi & Klinis) JURNAL PHOTON Molekul: Jurnal Ilmiah Kimia Jurnal Hasi Penelitian Dan Pengkajian Ilmiah Eksakta - JPPIE Jurnal Bakti Untuk Negeri Jurnal Farmasi Indonesia Molekul: Jurnal Ilmiah Kimia Inovasi Jurnal Pengabdian Masyarakat (IJPM) Borneo Journal of Pharmacy Jurnal Medika: Medika Journal of Tropical Pharmacy and Chemistry Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Ihsan Ikhtiarudin
Sekolah Tinggi Ilmu Farmasi Riau
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Journal : INDONESIAN JOURNAL OF PHARMACY

 1 
Synthesis and in Silico Studies of a Benzenesulfonyl Curcumin Analogue as a New Anti Dengue Virus Type 2 (DEN2) NS2B/NS3 Ikhtiarudin, Ihsan
Indonesian Journal of Pharmacy Vol 30 No 2, 2019
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1199.428 KB) | DOI: 10.14499/indonesianjpharm30iss2pp84-90

Abstract

Curcumin has been reported can interact with multiple molecular targets involved in a large variety of diseases. Accumulated evidence indicated curcumin plays an inhibitory role against infection of numerous viruses. Some studies have been reported that curcumin can interfere the infection processes of dengue virus. In this work, a benzenesulfonyl curcumin, (3E,5E)-3,5-bis(4-methoxybenzylidene)-1-(phenylsulfonyl)piperidin-4-one (compound 2) has been synthesized by two steps of reactions. The structure of compound 2 has been established based on the interpretation of spectral data include UV, FT-IR, MS/MS, 1H and 13C NMR. Then, the in silico studies have been also performed to predict the potency of compound 2 as inhibitor for dengue virus Type 2 (DEN 2) NS2B/NS3 protease. The in silico studies showed that compound 2 has hydrogen bonding with His51 residue, and amazingly that the other catalytic triad such as Asp75 and Ser135 were also showed interactions with the ligand. It is presumably that this compound showed very good activity against DEN2 and can be developed as a new inhibitor for dengue viruses. 
Co-Authors Abdi Wira Septama Abdi Wira Septama Adel Zamri Adel Zamri Adel Zamri Adel Zamri Adel Zamri Adel Zamri Adriani Susanty agistia, nesa Alpasiri, Ikhsan Mauludi Anggi Fisi Anggita Anggraini, Laurentin Leni BENNI ISKANDAR Dachriyanus Deni Anggraini Deswinda, Intan Ayu Dian Sanita Putri Dira Dira Dwi Andreyas Elsa Natia Emma Susanti Emrizal Enda Mora Fatma Sri Wahyuni Ferdy Firmansyah Fikri Maulana Fikri Maulana, Fikri Furi, Mustika Haiyul Fadhli Harpirabi, T. Herfindo, Nofal Hidayati, Fika Hilwan Y. Teruna Hilwan Yuda Teruna Indah Lestari, Indah Indah Wahyuni Jasma, Jasma Jasril Jasril Lelani - Lestari, Kurnia Dwi M Almurdani Meiriza Djohari, Meiriza Mira Febrina Musyirna Rahmah Nasution Musyirna Rahmah Nst Neni Frimayanti Nofriyanti Nova Tantri Silalahi Noval Herfindo Nurdina Putri Nursinta Al Basit Nurul Susianti Pratiwi, Erniza Pratiwi, Wirahma Indah Putri Lestari Putri Rizki Rahmadani Rabiatul Adawiyah Rahayu Utami Rahayu Utami Rahayu Utami Rahma Dona Rahmi, Helvy Rahmiwati Hilma Ramadhan, Fariz Putra Rasyid, Wildan Rosnita Dewi Rahmawati Sari, Seftika Shafira Melsonia Shelna, Khafiza Silalahi, Nova Tantri Sinata, Novia Sukma, Sukma Tami, Tami Tria Harlianti Tria Harlianti Vella kurnia Wahyuni YANTO Yuharmen - Yum Eryanti Zahira, Rifka