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All Journal International Journal of Electrical and Computer Engineering IAES International Journal of Artificial Intelligence (IJ-AI) Jurnal Teknologi Dan Industri Pangan Jurnal Pustakawan Indonesia ComEngApp : Computer Engineering and Applications Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences TELKOMNIKA (Telecommunication Computing Electronics and Control) Jurnal Ilmu Komputer dan Agri-Informatika Jurnal Ilmiah Kursor Biogenesis: Jurnal Ilmiah Biologi Jurnal Teknologi Informasi dan Ilmu Komputer Journal of ICT Research and Applications International Journal of Advances in Intelligent Informatics Indonesian Journal of Biotechnology Seminar Nasional Informatika (SEMNASIF) Sosio Konsepsia Khazanah Informatika: Jurnal Ilmu Komputer dan Informatika Jurnal Teknologi dan Sistem Komputer Jurnal RESTI (Rekayasa Sistem dan Teknologi Informasi) INTENSIF: Jurnal Ilmiah Penelitian dan Penerapan Teknologi Sistem Informasi Jurnal Penelitian Pendidikan IPA (JPPIPA) Kinetik: Game Technology, Information System, Computer Network, Computing, Electronics, and Control ILKOM Jurnal Ilmiah Jurnal Nasional Pendidikan Teknik Informatika (JANAPATI) Komputasi: Jurnal Ilmiah Ilmu Komputer dan Matematika Jurnal Jamu Indonesia Journal of Electronics, Electromedical Engineering, and Medical Informatics VISI PUSTAKA: Buletin Jaringan Informasi Antar Perpustakaan JURNAL Al-AZHAR INDONESIA SERI SAINS DAN TEKNOLOGI Indonesian Journal of Electrical Engineering and Computer Science Nusantara Science and Technology Proceedings Bioinformatics and Biomedical Research Journal Jurnal Pustakawan Indonesia Jurnal Nasional Teknik Elektro dan Teknologi Informasi J-Icon : Jurnal Komputer dan Informatika Indonesian Journal of Jamu
Wisnu Ananta Kusuma
Department Of Computer Science, Faculty Of Mathematics And Natural Sciences, IPB University, Jl Meranti Kampus IPB Dramaga, Bogor 16680, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Medicine & Pharmacology Physics Public Health Social Sciences Other

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Journal : Indonesian Journal of Biotechnology

 1 
Analysis using top‐k skyline query of protein‐protein interaction reveals alpha‐synuclein as the most important protein in Parkinson’s disease Mohammad Romano Diansyah; Annisa Annisa; Wisnu Ananta Kusuma
Indonesian Journal of Biotechnology Vol 26, No 4 (2021)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijbiotech.63023

Abstract

Parkinson’s disease is the second‐most‐common neurodegenerative disorder and can reduce patients’ quality of life. The disease is caused by abnormalities in dopaminergic neurons, such as reactive oxygen species (ROS) imbalance leading to programmed cell death, protein misfolding, and vesicle trafficking. Protein‐protein interaction (PPI) analysis has been demonstrated to understand better candidate proteins that might contribute to multifactorial neurodegenerative diseases, particularly in Parkinson’s disease. PPI analysis can be obtained from experiments and computational predictions. However, experiment data is often limited in interactome coverage. Therefore, additional computational prediction methods are required to provide more comprehensive PPI information. PPI can be represented as protein‐protein networks and analyzed based on centrality measures. The previous study has shown that top‐k skyline query, a method using dominance rule‐based centrality measures, reveals important protein candidates in Parkinson’s diseases. This study applied the top‐k skyline query to PPIs containing experiment and prediction data to find important proteins in Parkinson’s disease. The result shows that alpha‐synuclein (SNCA) is the most important protein and is expected to be a potential biomarker candidate for Parkinson’s disease.
Co-Authors Abdul Aziz Abdul Rahman Saleh Adrianus, Albert Afifa, Rizky Maulidya Agus Buono agus Nurrohim Agus Sugiyono Ahmad, Tarmizi Aini Fazriani Aisah Rini Susanti Akhmad Faqih Alami, Tegar Ali Djamhuri Annisa Annisa Annisa , Annisa Annisa Annisa Annisa Annisa Annisa Annisa Annisa Annisa Anton Suryatama Arini Aha Pekuwali Arini Pekuwali Arwan Subakti Ary Prabowo Ary Prabowo Auliatifani, Reza Auliya Ilmiawati Auriza Rahmad Akbar Azizah, Norma Nur Badollahi Mustafa Badrut Tamam Bahrul Ulum Budi Tjahjono Dahrul Syah Diah Handayani Dian Indah Savitri Dian Kartika Utami Essy Harnelly Fadli , Aulia Fahrury Romdendine, Muhammad Farhan Ramadhani , Hilmi Farit Mochamad Afendi Farohaji Kurniawan Fatriani, Rizka Fazriani, Aini Firman Ardiansyah Fithri, Silvy Rahmah Ginoga, Muh Fadhil Al-Haaq Halida Ernita Handayani, Vitri Aprilla Handayani, Vitri Aprilla Hanifah Nuryani Lioe Hardi, Wishnu Hasibuan, Lailan Sahrina Hendra Rahmawan Hendra Rahmawan Hera Dwi Novita Heru Sukoco Hesty, Nurry Widya Imas Sukaesih Sitanggang Indra Astuti Ira Maryati Irfan Wahyudin Irma Herawati Suparto Irman Hermadi Irmanida Batubara Irvan Lewenusa ISKANDAR ZULKARNAEN SIREGAR Isnan Mulia Janti G. Sudjana Jaya Sena Turana Joni Prasetyo Kana Saputra S Kangko, Danang Dwijo Karlisa Priandana Khaydanur Khaydanur Khaydanur, Khaydanur Laela Wulansari Larasati Larasati Lina Herlina Tresnawati Listina Setyarini Lusi Agus Setiani M. Rafi Maggy T. Suhartono Mala Nurilmala Medria Kusuma Dewi Hardhienata Mohamad Rafi Mohamad Rafi Mohamad Rafi Mohammad Romano Diansyah Mohammad Romano Diansyah Muchlishah Rosyadah Muhammad Asyhar Agmalaro Muhammad Subianto Mulyati Mulyati Mushthofa Muttaqin, Muhammad Rafi Nasution, Tegar Alami Nengsih, Nunuk Kurniati Norma Nur Azizah Nunuk Kurniati Nengsih Nur Choiriyati Nurdevi Noviana Ovi Sofia Pramita Andarwati Pranoto, Bono Prihasuti Harsani Priyo Raharjo Pudji Muljono Purnajaya, Akhmad Rezki Purnomo, Tsania Firqin Ramadhanti, Nabila Sekar Ramdan Satra Ratu Mutiara Siregar Refianto Damai Darmawan Refianto Damai Darmawan Resnawati Reza Auliatifani Rif’ati, Lutfah Ronald Marseno Rosy Aldina Rosyadah, Muchlishah Rudi Heryanto SATRIYAS ILYAS Septaningsih, Dewi Anggraini Siti Syahidatul Helma Sony Hartono Wijaya Sri Nurdiati SUHARINI, YUSTINA SRI Sulistyo Basuki Sulistyo Basuki Supriyanto, Arif Syahid Abdullah Syarifah Aini Syarifah Fathimah Azzahra Syukriyansyah Taufik Djatna Toni Afandi Tsania Firqin Purnomo Usman, Muhammad Syafiuddin Wa Ode Rahma Agus Udaya Manarfa Wahjuni, Sri Widya Sari Wijaya, Eko Praja Hamid Wijaya, Prima Trie Wijayanto, Rudi P. Wina Yulianti Wishnu Hardi Wulansari, Laela Yandra Arkeman Yessy Yanitasari Yudhi Trisna Atmajaya yudiartono, yudiartono Yulianah Yulianah Yunita Fauzia Achmad Zulkarnaen, Silvia Alviani