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All Journal PHARMACON Jurnal Mahasiswa Farmasi Fakultas Kedokteran dan Ilmu Kesehatan UNTAN Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) JURNAL PHARMASCIENCE Majalah Obat Tradisional Pharmascience Jurnal Fitofarmaka Indonesia Molecular and Cellular Biomedical Sciences (MCBS) SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Jurnal Farmasi Medica (Pharmacy Medical Journal) PMJ PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Lumbung Farmasi : Jurnal Ilmu Kefarmasian Jurnal Farmasi dan Sains Indonesia (JFSI) Jurnal AFAMEDIS Kaunia: Integration and Interconnection of Islam and Science Journal Pharmaceutical Sciences and Research (PSR) Jurnal Farmasi Sains dan Praktis Gemilang: Jurnal Manajemen dan Akuntansi Jurnal Natural Journal of Tropical Pharmacy and Chemistry JIMEK Journal Pharmacy of Tanjungpura Jurnal Farmasi Ikifa
Sri Wahdaningsih
Department Of Pharmacy, Faculty Of Medicine And Public Health Sciences, Universitas Tanjungpura Pontianak
Religion Agriculture, Biological Sciences & Forestry Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Control & Systems Engineering Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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Pengaruh Pemberian Fraksi Metanol Kulit Buah Naga Merah (Hylocerecus polyhizus) Terhadap Kadar Malondialdehid Pada Tikus (Rattus novergicus) Wistar Yang Mengalami Stres Oksidatif Sri Wahdaningsih; Eka Kartika Untari
Jurnal Pharmascience Vol 3, No 1 (2016): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v3i1.5834

Abstract

ABSTRAK  Produksi radikal bebas berlebihan dalam tubuh dapat menyebabkan stres oksidatif. Salah satu indikator stres oksidatif pada manusia adalah kadar Malondialdehid (MDA). Kulit Hylocereus polyrhizus berpotensi sebagai antioksidan eksogen alami. Tujuan penelitian ini untuk mengetahui efek fraksi metanol kulit H. polyhizus terhadap kadar MDA dan mengetahui dosis fraksi metanol kulit H. polyhizus yang dapat menurunkan kadar MDA. Kulit H. polyhizus dimaserasi menggunakan kloroform p.a, kemudian difraksinasi dengan pelarut metanol. Kadar MDA diukur menggunakan Spektrofotometer UV-Vis pada panjang gelombang 532 nm. Tikus dibagi menjadi 7 kelompok yaitu kontrol normal, kontrol negatif, kontrol positif vitamin E(18 mg/ kgBB), kontrol positif kuersetin (4 mg/ 200gBB), dosis I (5 mg/ 200gBB), Dosis II (10 mg/ 200gBB) dan dosis III (20 mg/ 200gBB). Setiap kelompok terdiri dari 4 ekor tikus dan diberikan stres oksidatif berupa perenangan 10 menit perhari dan puasa pakan selama 5 hari. Analisis data dilakukan dengan menggunakan One way ANOVA dan uji LSD (Least Significant Difference). Hasil analisis data kadar rata-rata MDA pada kelompok normal, negatif, vitamin E, kuersetin, dosis I,II dan III berturut-turut adalah 0,042; 0,051; 0,034; 0,042; 0,037; 0,033; 0,030 µg/ml. Dosis fraksi metanol kulit H. polyhizus berpotensi sebagai antioksidan karena dapat menurunkan kadar malondialdehid pada tikus yang mengalami stres oksidatif.   Kata Kunci : Stres oksidatif, Malondialdehid, Antioksidan, Hylocereus polyrhizus, Metanol ABSTRACT Excessive free radical production will lead to oxidative stress. One of the indicators used to determine stress oxidative is malondialdehyde (MDA). Hylocereus polyhizus peel is potential as natural exogenous antioxidant. The aim of this research was  to study the effect of methanol fraction of H. polyhizus peel on MDA level and  to determine that dose that could  reduce the MDA level. H. polyhizus peel was macerated with chloroform, fractionated with methanol. Measurement of MDA level was used Spectrophotometer UV-Vis in 532 nm.  Rats were divided into 7 groups : normal, negative, positive control vitamin E (18 mg/ kgbw), positive control quercetin (4 mg/200gbw), H. polyhizus peel extract group treated with dose I (5 mg/200gbw), dose II (10 mg/200gbw) and dose III (20 mg/200gbw). Each group consist of 4 rats and induced with oxidative stress by 10 minute swimming each day and food restriction for 5 days. MDA levels were analyzed using One way Anova and LSD test. The data shown that MDA level at normal, negative, vitamin E, kuarsetin, dose I, II, III group is 0.042; 0.051; 0.034; 0.042; 0.037; 0.033; 0,030 µg/ml. The methanol fraction of red dragon fruit peel was a potent antioxidant  because posessing the ability to lowering the MDA level on stress oxidative rats. Key Word : Stress Oxidative, Malondialdehyde, Antioxidant, Hylocereus polyrhizus, Methanol.
Identifikasi Gugus Fungsi Fraksi Etil Asetat dan Fraksi n-Heksan Hylocereus polyrhizus (F.A.C.Weber) Britton & Rose Sri Wahdaningsih; Fajar Nugraha; Hadi Kurniawan; Anis Marselia; Dian Novita Sari
Jurnal Pharmascience Vol 9, No 1 (2022): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v9i1.11192

Abstract

Buah naga merah diketahui memiliki manfaat pada daging maupun kulit buahnya. Kulit buah naga merah yang sering dibuang sebagai limbah ternyata memiliki aktivitas antioksidan yang lebih banyak daripada daging buahnya. Penelitian ini bertujuan untuk mengidentifikasi gugus fungsi yang ada pada fraksi etil asetat dan n-heksan kulit buah naga merah. Analisis gugus fungsi dilakukan dengan menggunakan alat spektrofotometer FTIR dengan metode pelet KBr. Hasil yang diperoleh bersifat kualitatif yaitu berupa spektrum inframerah. Hasil identifikasi gugus fungsi dari fraksi etil asetat kulit buah naga merah adalah gugus fungsi O–H, C–H alkana, C=O, C–O, dan C–H aromatik. Hasil identifikasi gugus fungsi dari fraksi n-heksan kulit buah naga merah adalah gugus fungsi O-H , C-H alkana, C-H alkena, C-O, dan C=O. Senyawa yang terkandung pada fraksi etil asetat kulit buah naga merah adalah fenolik, flavonoid, terpenoid, steroid, dan alkaloid. Senyawa yang terkandung pada fraksi n-heksan kulit buah naga merah adalah flavonoid, terpenoid, dan steroid. Kata Kunci: Kulit Buah Naga Merah, Fraksinasi, Spektrum, Fourier Transform Infrared  Red dragon fruit is known have benefits in the flesh and peel of the fruit. The peel of the red dragon fruit, which is often disposed of as waste, has more antioxidant activity than its flesh. This study aimed to identify the functional groups in the ethyl acetate and n-hexane fractions of red dragon fruit peel. Functional group analysis was done by using FTIR spectrophotometer with KBr pellet method. The results obtained were qualitative in the form of an infrared spectrum. The results of the identification of functional groups from the ethyl acetate fraction of red dragon fruit peel were O–H, C–H alkanes, C=O, C–O, and C–H aromatics functional groups. The results of the identification of functional groups from the n-hexane fraction of red dragon fruit peel were O-H, C-H alkanes, C-H alkenes, C-O, and C=O functional groups. The compounds that contained in the ethyl acetate fraction of red dragon fruit peel are phenolics, flavonoids, terpenoids, steroids, and alkaloids. The compounds that contained in the n-hexane fraction of red dragon fruit peel are flavonoids, terpenoids, and steroids.
Analisis Pengaruh Penggunaan Depot Medroxyprogesterone Acetate Terhadap Kenaikan Berat Badan Akseptor di Puskesmas Perumnas II Pontianak Nurmainah Nurmainah; Sri Wahdaningsih; Syaazaratul Qamelia Innas
Jurnal Pharmascience Vol 7, No 2 (2020): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v7i2.8400

Abstract

Kontrasepsi suntik merupakan salah satu kontrasepsi hormonal yang masih menjadi pilihan akseptor dalam mengatur kehamilan. Namun demikian, penggunaan kontrasepsi suntik Depot Medroxyprogesterone Acetate (DMPA) diketahui dapat meningkatkan berat badan selama pemakaian enam (6) bulan atau lebih. Tujuan penelitian ini dilakukan untuk menganalisis pengaruh penggunaan DMPA terhadap kenaikan berat badan akseptor. Penelitian ini merupakan penelitian observasional dengan rancangan penelitian potong lintang (cross sectional) yang bersifat analitik. Populasi dalam penelitian ini adalah seluruh akseptor baru suntik DMPA di Puskesmas Perumnas II Pontianak pada bulan Januari 2018 hingga Maret 2019. Variabel dari penelitian ialah usia, pekerjaan, paritas, dan kenaikan berat badan. Analisis dilakukan dengan menggunakan analisis paired t-test. Teknik pengambilan sampel yang digunakan ialah purposive sampling. Jumlah sampel yang memenuhi kriteria inklusi dan ekslusi sebanyak 81 akseptor. Dari hasil penelitian ini diperoleh bahwa sebagian besar akseptor berusia 20-35 tahun (71,6%), bekerja sebagai ibu rumah tangga (97,5%), mempunyai 2 anak atau lebih (77,8%), dan memiliki kenaikan berat badan 0-2 kg (44,4%). Berdasarkan hasil analisis paired t-test bahwa penggunaan suntik KB 3 bulan (DMPA) memiliki pengaruh terhadap kenaikan berat badan akseptor dengan nilai p=0,001. Kesimpulan dari penelitian ini bahwa terdapat pengaruh penggunaan DMPA terhadap kenaikan berat badan akseptor. Injectable contraception is a hormonal contraceptive used by acceptors in regulating pregnancy. However, the use of Depot Medroxyprogesterone Acetate (DMPA) is known to increase body weight after six months of use or more.. The purpose of this study was to analysis the effect of using DMPA on weight gain. This study was an observational study with cross sectional analytic study design. The population in this study were all new acceptors who used DMPA at the Perumnas II Pontianak Public Health Care in January 2018 to March 2019. Variables from the study were age, occupation, parity, and weight gain. Analysis was performed using paired t-test analysis. The sampling technique used was purposive sampling, where the number samples that met the inclusion and exclusion criteria were 81 acceptors. The results showed that most of the acceptors were aged 20-35 years (71,6%), work as housewives (97,5%), had 2 or more children (77,8%), and gained weight 0-2  kg (44,4%). Based on the results of paired t-test analysis, the use of DMPA has an effect on the acceptor’s weight gain with a value of p = 0.001. The conclusion of this study is that there is an effect of the use of DMPA on acceptor weight gain.Keywords: Acceptors, DMPA, weigt gain 
The Antibacterial Activity of Red Dragon Fruit Peel (Hylocereus polyrhizus Britton & Rose) Methanolic Fraction Against Staphylococcus epidermidis and Propionibacterium acnes Sri Wahdaningsih; Eka Kartika Untari
Jurnal Pharmascience Vol 8, No 2 (2021): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v8i2.10378

Abstract

Acnes can be caused by Propionibacterium acnes and Staphylococcus epidermidis. Red dragon (Hylocereus polyrhizus B & R) fruit peels is one of natural materials which is assumed to possess an antibacterial activity. The purpose of this study was to determine the antibacterial activity of red dragon fruit peels methanol fraction (RDFPMF) against S. epidermidis and P. acne by disc diffusion Kirby-Bauer method. Red dragon fruit peels were maceration in chloroform and fractionation in methanol. Clindamycin 4µg/disk was used as positive control and DMSO 10% was used as negative control. This research showed that the RDFPMF has antibacterial activity against P. acnes which the average of inhibition zones obtained from the concentrations from 100, 50, and 25 mg/mL respectively were 10.5 ± 0.50 mm, 10.0 ± 0.00 mm, and 8.5 ± 0.50 mm. The RDFPMF has no inhibition zone toward S. epidermidis. The red dragon fruit peels methanol fraction has antibacterial activity on P. acnes by disc diffusion method (Kirby-Bauer test).
ISOLASI DAN IDENTIFIKASI SENYAWA ANTIOKSIDAN DARI BATANG PAKIS (ALSOPHILA GLAUCA J.SM) DENGAN METODE DPPH (2,2-DIFENIL-1- PIKRILHIDRAZIL) Sri Wahdaningsih; Subagus Wahyuono; Erna Prawita Setyowati
Kaunia: Integration and Interconnection Islam and Science Vol. 9 No. 1 (2013)
Publisher : Fakultas Sains dan Teknologi UIN Sunan Kalijaga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/kaunia.1048

Abstract

Oxidative stress induced by the radicals have been known to affect the occurrence of various degenerative disease. As the search for natural antioxidant compounds had been studied the isolation and identification of antioxidant compounds in fern stems (Alsophila glauca J.Sm) using DPPH method (1,1-diphenyl 2-picrylhydrazyl). Fern stem extraction was done by maceration with wasbenzen and metanol. Extracts was obtained by evaporating the wasbenzen solvent with a rotavapor. Material was re-macerated with methanol after all wasbenzen evaporation. The same way was done on  wasbenzen to obtain the metanol extract. These extracts were tested for antioxidant activity using DPPH method with TLC. Active extract was partitioned in 80% methanol. Extracts both soluble and insoluble in methanol 80% were tested their antioxidant activity using DPPH method (TLC). Active extract was fractionated in vacuum liquid chromatography using a mobile phase with different polarity gradient and different concentrations (wasbenzen:chloroform). Active  fraction  was  isolated  by  preparative TLC method and purity of compounds obtained was tested by TLC. Antioxidant activity of isolates obtained were tested by DPPH method using spectrophotometry. Compounds known to had antioxidant activity as radical catcher with IC50 178.4 µg/ml.
FORMULASI DAN EVALUASI UJI MUTU FISIK LOTION EKSTRAK KULIT MANGGIS (Garcinia mangostana L.) Sri Wahdaningsih; Vanny Ade Rahmasari
AFAMEDIS Vol. 1 No. 1 (2020): Jurnal Farmasi Indonesia AFAMEDIS
Publisher : Akademi Farmasi Mitra Sehat Mandiri Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (111.112 KB)

Abstract

Kulit buah manggis (Garcinia mangostana L.) memiliki kandungan xanton yang khasiatnya sebagai antioksidan yang baik untuk kulit. Tujuan penelitian ini adalah untuk membuat formulasi sediaan lotion yang akan di uji mutu fisik dari sediaannya. Ekstrak kulit manggis dibuat dengan cara maserasi menggunakan etanol 70% dengan rendemen yang dihasilkan 23.36 %. Konsentrasi yang digunakan pada sediaan lotion ini adalah 3%, 5% dan 7%. Evaluasi uji mutu fisik lotion meliputi pengamatan organoleptis, uji Ph, uji homogenitas, uji daya sebar, uji daya lekat dan identifikasi tipe emulsi. Dari hasil penelitian uji mutu fisik lotion beraroma khas, berwarna coklat muda hingga coklat tua, tekstur halus pada Formulasi 3% dan 5% sedangkan pada formulasi 7% terdapat butiran ekstrak, pH 6-6,5, daya sebar 3-7 cm, daya lekat formulasi 3% 3 menit formulasi 5% dan 7% 5 menit, dan tipe emulsi minyak dalam air.
Lymphocyte Proliferation and Nitric Oxide-Producing Activities of Lupeol Isolated From Red Dragon Fruit (Hylocereus polyrhizus) Extract Sri Wahdaningsih; Subagus Wahyuono; Sugeng Riyanto; Retno Murwanti
Molecular and Cellular Biomedical Sciences Vol 5, No 1 (2021)
Publisher : Cell and BioPharmaceutical Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21705/mcbs.v5i1.166

Abstract

Background: Hylocereus polyrhizus has activities as antimicrobial agent, anti-hypercholesterolemia, anti-diabetic (diabetes mellitus), cardiovascular risk reduction, health supplement, and melanoma cell suppression. The extracts from the peels of H. polyrhizus were able to increase phagocytic ability, cell numbers and leukocytes and to influence relative spleen weights in the formation of body immune system in male rats. The fruit peels contained phenolics, flavonoids, carotenoids, and anthocyanins. This study investigated the active compounds of H. polyrhizus peels, which are able to increase immune system of human body.Materials and method: In vitro assay was applied to examine the active compounds, identified as lupeol, obtained from isolated extract of red dragon fruit for their lymphocyte proliferation and nitric oxide (NO)-producing activities. Lymphocyte proliferation assay was performed with 3-4.5-dimethylthiazol-2-yl)-2.5-diphenyltetrazolium bromide (MTT) method. The cell control was lymphocyte cell suspension in RPMI medium added with phytohaemaglutinine (PHA). The NO measurement was conducted with nitric solvent and Greiss reagent.Results: The ANOVA analysis of the average optical density (OD) of lymphocyte proliferation showed that the addition of isolated lupeol at the concentrations of 6.25, 12.5, 25, 50 and 100 µg/mL were able to improve lymphocyte proliferation and activate the NO production in the rats with treatment of positive control. Conclusion: Isolated lupeol at concentrations of 6.25, 12.5, 25, 50 and 100 µg/mL revealed significant difference with medium control and cell control. It was able to increase effects on lymphocyte proliferation and NO production. Therefore, the lupeol which was isolated might have high potential to be an immunostimulant.Keywords: Hylocereus polyrhizus, lupeol, lymphocyte proliferation, nitric oxide production
Profil Hematologi pada Tikus Putih (Rattus norvegicus L.) Galur Wistar Setelah Pemberian Ekstrak Etanol Daun Bawang Dayak (Eleutherine americana (Aubl.) Merr. ex K.Heyne.) Sri Wahdaningsih; Eka Kartika Untari; Robiyanto Robiyanto
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 17 No. 02 Desember 2020
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pharmacy.v17i2.7499

Abstract

Tanaman bawang dayak (Eleutherine americana (Aubl.) Merr. ex K.Heyne.) secara empirik telah digunakan sebagai obat tradisional. Golongan flavonoid yang terdapat dalam tanaman bawang dayak mungkin dapat mempengaruhi pembentukan sel darah, namun belum tersedia  informasi  mengenai  keamanan  terhadap  profil  hematologi  untuk penggunaan secara  oral  terutama ekstrak  etanol  daun  bawang dayak  dalam  jangka  waktu panjang.  Penelitian  ini bertujuan untuk  mengamati  profil  hematologi  ekstrak etanol  daun  bawang dayak  yang  diberikan  pada  tikus  putih  galur  Wistar  jantan  dan betina  menggunakan  metode  uji  prakilinik  toksisitas  subkronik  28  hari.  Daun bawang dayak diekstrak secara maserasi dengan pelarut etanol 70%.  Profil  hematologi  terdiri  dari  parameter  hemoglobin,  leukosit,  eritrosit, hematokrit, trombosit,  MCV,  MCH,  dan  MCHC.  Hewan  dibagi  menjadi  6  kelompok  yaitu kelompok  kontrol  diberikan  CMC-Na  1%,  ekstrak etanol daun bawang dayak  dosis  100  mg/kgBB, dosis  400  mg/kgBB,  dosis  1000  mg/kgBB,  kelompok  satelit  kontrol diberikan  CMC-Na  1%,  dan   satelit  dosis  1000  mg/kgBB.  Induksi  dan pengamatan  dilakukan  selama  28  hari,  dan  dilanjutkan  14  hari  untuk  kelompok satelit.  Hasil  pengamatan  profil  hematologi  menunjukkan bahwa tidak terdapat perbedaan antara kelompok perlakuan dengan kontrol satelit dalam jumlah maupun kadar hemoglobin, eritrosit, leukosit, hematokrit, trombosit,  MCV,  MCH,  dan  MCHC. Dapat disimpulkan  secara  umum  penggunaan  ekstrak etanol daun bawang dayak tidak  mempengaruhi  profil hematologi hewan uji.
Efek Fraksi n-Heksana Kulit Hylocereus polyhizus Terhadap Kadar Malondialdehida Tikus Stres Oksidatif Sari, Wirna Maya; Wahdaningsih, Sri; Untari, Eka Kartika
Pharmaceutical Sciences and Research Vol. 1, No. 3
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Excessive free radical production will lead to oxidative stress. One of the indicators used to determine stress oxidative is malondialdehyde (MDA). Hylocereus polyhizus peel is potential used natural exogenous antioxidant. The aim of this research was to study the effect of n-hexane fraction of H.polyhizus peel on MDA level and to determine the dose that could reduce the MDA level. H.polyhizus peel was macerated with chloroform, fractionated with n-Hexane. Rats were divided into 7 groups : normal, negative, positive control vitamin E (18 mg/ kgbw), positive control quercetin (4 mg/200gbw), H.polyhizus peel extract group treated with dose I (10mg/ 200gbw), dose II (20 mg/200gbw) and dose III (40 mg/200gbw). Each group consist of 4 rats and induced to oxidative stress by 10 minute swimming each day and food restriction for 5 days. Measurement of MDA level are using Spectrophotometer UV-Vis in 532 nm. MDA levels were analyzed using One way Anova and LSD test. The data shown that MDA level at normal, negative, positive vitamin E, positive kuersetin, dose I, II, III group is 0.042; 0.051; 0.034; 0.042; 0.038; 0.039; 0.042 µg/ml. The n-Hexane fraction of red dragon fruit peel was a potent antioxidant because posessing the ability to lowering the MDA level on stress oxidative rats.
Efek Fraksi n-Heksana Kulit Hylocereus polyrhizus TerhadapAktivitas Katalase Tikus Stres Oksidatif Untari, Eka Kartika; Wahdaningsih, Sri; Damayanti, Agustia
Pharmaceutical Sciences and Research Vol. 1, No. 3
Publisher : UI Scholars Hub

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Abstract

Production of excess free radicals cause oxidative damage and degenerative diseases. Catalase enzyme is one of the endogenous intracellular antioxidant that can be reduced by oxidative stress conditions. The peel of red dragon fruit (Hylocereus polyrhizus) as a potent exogenous antioxidants could support the internal enzyme activity to prevent free radicals. The aim of this research was to determine the effect of n-hexane fraction of H.polyrhizus’s peel and the dose that could increase activity of catalase. The peel was maserated with chloroform, then fractionated by n-hexane. Stress condition was achieved by five days fasting and swimming for 10 mins/day to test animals. UV-Vis spectrophotometer was used to measure the activity of catalase. The rats were divided into 6 groups: normal control, negative control, dose I (10 mg/200 gBB), dose II (40 mg/200 gBB), positive control quercetin as (4 mg/200 gBB) and vitamin E (17.64 mg/kg). The activity of catalase enzyme in the normal control is 29.4 units/ml; negative control is 7.08 units/ml; dose I is 14.42 units/ml; dose II is 14.79 units/ml’quercetin is 28.18 units/ml; and vitamin E is 71.29 units/ml. Our conclusion is the activity of the catalase enzyme rat under oxidative stress can be increased by the n-hexane fraction of H. polyrhizus.
Co-Authors A.A. Ketut Agung Cahyawan W Agustia Damayanti Agustia Damayanti Agustia Damayanti Agustia Damayanti, Agustia Agustriangga, Muhammad Rafly Alifa Rapaella Fadia Tito Putri Andres Andres Anggie Cahyadi Anis Marselia Annafiatuzakiah Annafiatuzakiah Ardini, Citra Asri Adyttia Asri Adyttia Asri Adyttia Asri Adyttia, Asri Ayu Aulia Uly Fahmi Chang, Samuel Crishanzen Dian Novita Sari Diana Natalia Dina Pratiwi, Dina Eka Kartika Untari Eka Kartika Untari Erna Prawita Setyowati Erna Prawita Setyowati Erna Prawita Setyowati Ernawati Ernawati F. Nour Aulia Mustari F. Nour Aulia Mustari, F. Nour Aulia Fahmi, Ayu Aulia Uly Fajar Nugraha Faujiah, Nurul Goneril, Aldo Hadi Kurniawan Hafidzah Ramadhaniyah Al Idrus Hainun A Hestiva, Hestiva Imania, Imania Indriyani, Risa Isnindar Isnindar Iswahyudi Iswahyudi Iswahyudi Iswahyudi Kamil, Insan Kristina Lusty Tohomi Liberti, Oktaviona Winda Liza Pratiwi M Rafly Agustriangga Melda Mery Andiriyani Meri Ropica Muhammad Rafly Agustriangga Nadhiirah Nadhiirah Nadilla Nadilla Nadilla, Nadilla Najini, Robby Nera Umilia Purwanti Nera Umilia Purwanti, Nera Umilia Norwahidah Norwahidah Novi Riyani Nurmainah Nurmainah Nurul Hanifah Rafika Sari Rafika Sari Retno Murwanti Risa Indriyani Robby Najini Robby Najini Robiyanto, Robiyanto Ropiqa, Meri Rupiani, Aprias Samudra, Nizam Elang Samuel Crishanzen Chang Setio Jatmiko Shoma Rizkifani Siti Nani Nurbaeti Sri Amalia Sri Amalia Sri Amalia, Sri Subagus Wahyuono Subagus Wahyuono Subagus Wahyuono Subagus Wahyuono Sugeng Riyanto Syaazaratul Qamelia Innas Uray Cindy Hafinur Utari, Eka Kartika Vanny Ade Rahmasari Wijaya, Anisa William Rinaldi Wintari Taurina Wirna Maya Sari Wirna Maya Sari Wirna Maya Sari Wirna Maya Sari, Wirna Maya Yunita Fauziah Yunita Fauziah, Yunita