Claim Missing Document
Check
Articles

Found 40 Documents
Search

In Silico Study of Phytochemical Compounds from Mekai (Albertisia papuana Becc.) Leaves as Anti-Breast Cancer Agents Miningsih Miningsih; Dora Dayu Rahma Turista; Masitah Masitah; Rusni Ernopita Ulan; Risty Geofani; Dorce Bani; Sintya Sintya; Vera Damayanti
Jurnal Mandala Pharmacon Indonesia Vol. 12 No. 1 (2026): Jurnal Mandala Pharmacon Indonesia 
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v12i1.1217

Abstract

Breast cancer is a disease that is most commonly suffered by women, with the highest number of cases and mortality rates in the world. Current breast cancer treatment still has limitations and causes serious side effects, thus encouraging the exploration of alternative therapies based on natural sources or phytochemicals. The purpose of this study is to investigate the potential anti-breast cancer properties of the traditional herbal plant Mekai (Albertisia papuana Becc.) using an in silico approach. Molecular docking analysis of JNK and EGFR targets showed that several compounds had relatively high binding affinities (-10.1 to -9.3 kcal/mol) comparable to the positive control doxorubicin, while NUDT5 had relatively moderate binding affinities to each compound. Among these compounds, 7H-dibenzo-c,g-carbazole showed the strongest binding affinity to JNK (-10.1 kcal/mol), making it potentially the most promising candidate compound. Evaluation based on Lipinski's rules shows that selected compounds from Mekai (Albertisia papuana Becc.) leaves meet the basic parameters for drug candidates and ADME-Tox predictions, including moderate toxicity (class IV), thus supporting their suitability for further development as anticancer agent candidates, while also providing a scientific basis for the use of traditional Dayak medicinal plants in the development of natural breast cancer therapies. Further research is recommended in vitro and in vivo to confirm its efficacy, safety, and clinical relevance.
Organoleptic Evaluation and Consumer Preferences for Singkil Tea and Kombucha Products (Premna corymbose Rottl. Et Willd) Teguh Pribadi; Zulfa Zakiyyah; Nurul Anisa; Imam Wijayadi; Masitah Masitah; Eadvin Rosrinda Awang Sari; Ingghrid Ranesti Clarita Hadi; Ayu Indah Rahmawati
JURNAL PEMBELAJARAN DAN BIOLOGI NUKLEUS Vol 11, No 2: Jurnal Pembelajaran Dan Biologi Nukleus June 2025
Publisher : Universitas Labuhanbatu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36987/jpbn.v11i2.7120

Abstract

Background: Changes in tea consumption trends present opportunities for the tea industry, especially as alternative raw materials have been tested in recent years to develop tea and kombucha with distinct organoleptic and functional properties. This study evaluates the organoleptic characteristics and consumer preferences for Singkil tea and Singkil kombucha. Methodology: A sensory evaluation was conducted with 30 untrained panelists to assess color, aroma, taste, texture, and overall acceptability using a hedonic scale. Additionally, the alcohol content was measured. Findings: The results of the hedonic test indicated that all treatments fell into category 3 "slightly liked", suggesting an acceptable level of consumer preference. On average, both Singkil tea and Singkil kombucha received an acceptance score of 3, indicating that they were "slightly liked." This suggests their potential as alternative beverages suitable for commercialization. Furthermore, the safety of the product was confirmed, as it contains 0% alcohol, meets halal standards. Contribution: This study concludes that Singkil kombucha has the potential to be a viable alternative beverage for the market, and that it is safe for consumption due to its 0% alcohol content, which complies with halal standards
EVALUATION OF WATER QUALITY IN PANCA JAYA VILLAGE BLUE LAKE AS A BASIS FOR SAFE TOURISM MANAGEMENT Nabila Asa Dinina; Andi ’Afifatul Fathonah; Yenni Kusrini Abelia; Masitah Masitah
BIOLINK (Jurnal Biologi Lingkungan Industri Kesehatan) Vol. 13 No. 1 (2026): Biolink August
Publisher : Universitas Medan Area

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31289/biolink.v13i1.18544

Abstract

The high recreational potential of Danau Biru in Panca Jaya Village a former mining site poses a risk of health hazards to visitors due to chemical contamination of the water. This study aims to evaluate the physical and chemical quality of Danau Biru’s water as a basis for recommendations on sustainable safety management of the tourist destination. This mixed-methods study employed purposive sampling in two zones (shore and center) with three replicates. Parameters were analyzed using descriptive and comparative methods in accordance with Ministry of Health Regulation No. 2 of 2023. Laboratory test results indicated extremely hyperacidic conditions with pH values ranging from 2.39–2.52 (shore) and 2.29–3.88 (center), far below the quality standard (6.0–9.0). Biochemical Oxygen Demand (BOD) values ranged from 3.68–4.96 mg/L (periphery) and 3.20–4.80 mg/L (center), exceeding the maximum limit of 3 mg/L. Meanwhile, Dissolved Oxygen (DO) was recorded at 4.1–4.6 mg/L, still meeting the minimum criterion (≥ 4 mg/L). It is concluded that the water in Danau Biru does not yet meet recreational water quality standards; therefore, swimming is strongly discouraged to prevent the risk of skin irritation and chronic toxicity to visitors.
ANALYSIS OF THE WATER QUALITY OF POST-MINING LAKE BUKIT SEMPAJA INDAH BASED ON BOD, COD, AND DO PARAMETERS Nabila Putri Shakila; Gadis Nindi Aprilia; Masitah Masitah; Dimas Adhitya Wardiman Setyawan
BIOLINK (Jurnal Biologi Lingkungan Industri Kesehatan) Vol. 13 No. 1 (2026): Biolink August
Publisher : Universitas Medan Area

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31289/biolink.v13i1.18551

Abstract

Lake Bukit Sempaja Indah is a post-mining water body utilized by the surrounding community for various activities, making water quality monitoring necessary to assess its condition against applicable quality standards. This study aimed to evaluate the water quality of Lake Bukit Sempaja Indah based on Biochemical Oxygen Demand (BOD), Chemical Oxygen Demand (COD), and Dissolved Oxygen (DO). A descriptive quantitative approach was employed using purposive sampling at one sampling point representing an area with intensive community activities. Water samples were collected in January 2026 and analyzed in the laboratory according to Indonesian National Standards (SNI). The results showed that BOD, COD, and DO values were 1.84 mg/L, 11.10 mg/L, and 4.44 mg/L, respectively. All parameters met the Class II water quality standards stipulated in Government Regulation of the Republic of Indonesia No. 22 of 2021. The BOD and COD values indicated a relatively low organic pollution load, while the DO concentration indicated sufficient dissolved oxygen to support aquatic organisms. Based on measurements at the sampling point and during the sampling period, the water quality of Lake Bukit Sempaja Indah met Class II water quality standards based on BOD, COD, and DO parameters. Further monitoring at multiple locations and sampling periods, along with additional water quality parameters, is recommended to provide a more comprehensive assessment of the lake's condition.
Pengaruh Model Pembelajaran CTL (Contextual Teaching and Learning) terhadap Kemampuan Kolaborasi dan Hasil Belajar Siswa SMA pada Pembelajaran Biologi Nur Anita Syafitri; Jailani; Ruqoyyah Nasution; Suparno Putera Makkadafi; Masitah
PendIPA Journal of Science Education Vol 9 No 2 (2025): June
Publisher : UNIB Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33369/pendipa.9.2.283-289

Abstract

Grade X students of SMA Negeri 2 Bontang experienced problems of low biology learning outcomes and lack of collaboration skills due to conventional teacher-centered learning. This study aimed to determine the effect of implementing the CTL (Contextual Teaching and Learning) model on students' collaboration skills and learning outcomes. The CTL model emphasizes active student involvement in the learning process, connecting material with real-life contexts, and encouraging collaboration and group discussion. This study used a quantitative approach with a quasi-experimental method and a non-equivalent control group design. Sampling was carried out by purposive sampling, with class X5 as the experimental class implementing the CTL model and class X6 as the control class using conventional methods. Data analysis was carried out using the N-Gain test and the Independent Sample t Test. The results showed that the experimental class had an N-Gain value of 0.72 (high category) while the control class had 0.59 (moderate category). The t test showed a significance value of 0.000 <0.05 for collaboration skills and learning outcomes. These results indicate a significant difference between the experimental class and the control class after the CTL model was implemented. Based on these results, it can be concluded that the application of the CTL model has a positive and significant effect on improving the collaboration skills and learning outcomes of class X students of SMA Negeri 2 Bontang in biology subjects.
Pengaruh Model Pembelajaran TPS (Think Pair Share) Terhadap Kemampuan Literasi Lingkungan Siswa Kelas X MAN 1 Samarinda: Pengaruh Model Pembelajaran TPS (Think Pair Share) Terhadap Kemampuan Literasi Lingkungan Siswa Kelas X Wafi Sayyidaturrofi'ah; Ruqoyyah Nasution; Masitah Masitah; Sri Purwati
PendIPA Journal of Science Education Vol 9 No 2 (2025): June
Publisher : UNIB Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33369/pendipa.9.2.480-487

Abstract

This study aimed to determine the effect of the Think Pair Share (TPS) learning model on students’ environmental literacy skills in Grade X at MAN 1 Samarinda. The research employed a quantitative approach using a quasi-experimental method with a Pretest-Posttest Control Group Design. The sample consisted of class XF and XG, each comprising 30 students. Sampling was conducted using the Simple Random Sampling technique, resulting in class XF as the experimental group and class XG as the control group. To measure students’ environmental literacy covering knowledge, cognitive skills, attitudes, and environmental behavior the N-Gain test was applied. The results of the N-Gain analysis showed that the control group experienced an increase in the low to moderate category, while the experimental group demonstrated more significant improvement, particularly in the behavioral domain, which obtained an N-Gain score of 0.86 categorized as high. This indicates the effectiveness of the TPS model in encouraging changes in students’ environmental behavior. Furthermore, hypothesis testing was conducted using the Mann-Whitney U test with a 5% significance level. The results showed a p-value of 0.001 < 0.05, indicating that H0 was rejected and H1 was accepted, meaning there was a statistically significant difference. Thus, it can be concluded that the Think Pair Share learning model has a significant effect on students’ environmental literacy in Grade X at MAN 1 Samarinda.
Pengaruh Kecerdasan Emosional Terhadap Prestasi Belajar Siswa Kelas VIII Pada Mata Pelajaran IPA di SMP IT Cordova Samarinda Sheryna Nur Khotimah; Akhmad Akhmad; Sri Purwati; Masitah Masitah
PendIPA Journal of Science Education Vol 10 No 1 (2026): January - March
Publisher : UNIB Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33369/pendipa.10.1.184-191

Abstract

Emotional intelligence is one of the crucial elements that contribute to students' academic achievement. However, based on initial observations at SMP IT Cordova Samarinda, it was identified that the emotional regulation ability of some eighth-grade students has not reached an optimal level, although their academic achievement in science subjects is considered satisfactory. This study aims to examine the impact of emotional intelligence on student learning achievement in Natural Sciences at SMP IT Cordova Samarinda. This study applies a quantitative approach with an ex-postfacto correlational design, where the sample was selected through a purposive sampling technique and the data analysis used was simple linear regression with a significance level of 0.05. The findings from the simple linear regression test stated that the significance value (Sig.) reached 0.20, which exceeds 0.05. Therefore, it can be concluded that there is no influence of emotional intelligence on the learning achievement of eighth-grade students in Natural Sciences at SMP IT Cordova Samarinda, with an R Square value of 0.031, which concludes that emotional intelligence only contributes 3.1% to student learning achievement in that field.
Implementasi Model Pembelajaran Problem Based Learning Berbantuan Media Zep Quiz terhadap Hasil Belajar Siswa pada Mata Pelajaran IPA Kelas VII SMP Aldila Dewi Ratna Supriadi; Masitah; Sonja Verra Tinneke Lumowa; Nelda Anasthasia Serena; Sri Purwati
PendIPA Journal of Science Education Vol 10 No 3 (2026): July - September
Publisher : UNIB Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33369/pendipa.10.3.685-693

Abstract

The student achievement in science is characterized by low levels of student engagement, students’ lack of mastery of basic material, and the lack of implementation of media-assisted Problem-Based Learning (PBL) in the learning process. These conditions prompted this study, which aims to examine the implementation of media-assisted PBL using the Zep Quiz on student achievement in science for seventh-grade students at SMP Negeri 4 Samarinda. This study employed a quantitative approach using a quasi-experimental design with a pretest-posttest nonequivalent control group design. Sampling was conducted using purposive sampling, with a total sample of 54 students comprising Class VII-6 as the control group and Class VII-7 as the experimental group. In the experimental class, the Problem-Based Learning model supported by the Zep Quiz media was implemented during the introductory activities as well as during the stages of analyzing and evaluating the problem-solving process. Data analysis was conducted using the N-Gain test and the independent samples t-test. The analysis results showed that the average N-Gain scores in the control and experimental classes were in the moderate category, with values of 0,45 and 0,60, respectively. The results of the independent samples t-test yielded a significance value of 0,000 < 0,05, so H0 was rejected and Ha was accepted. Based on the research results, it can be concluded that the implementation of the Problem-Based Learning model supported by the Zep Quiz media has an effect on student learning outcomes in 7th-grade science at SMP Negeri 4 Samarinda.
Pengaruh Pendekatan Deep Learning Berbasis PJBL Materi Fungi Berbantuan Media Kahoot Terhadap Hasil Belajar dan Keaktifan Siswa Pada Pembelajaran Biologi SMA Kelas X Novia Nabila Ramadhana Novia; Jailani; Masitah; Ruqoyyah Nasution; Suparno Putera Makkadafi; Arifai
PendIPA Journal of Science Education Vol 10 No 3 (2026): July - September
Publisher : UNIB Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33369/pendipa.10.3.797-805

Abstract

Penelitian ini bertujuan untuk mengetahui pengaruh pendekatan Deep Learning berbasis PjBL berbantuan media Kahoot terhadap hasil belajar dan keaktifan siswa pada materi Fungi di kelas X SMA Negeri 13 Samarinda. Penelitian ini menggunakan pendekatan kuantitatif dengan metode quasi-experimental dalam bentuk pretest-posttest control group design. Populasi penelitian berjumlah 267 siswa dengan sampel 60 siswa, kelas X-1 sebagai kelas eksperimen dan X-6 sebagai kelas kontrol yang dipilih melalui teknik purposive sampling. Data dikumpulkan melalui tes hasil belajar dan lembar observasi keaktifan siswa, kemudian dianalisis menggunakan uji normalitas, uji homogenitas, uji independent sample t-test, dan uji N-Gain. Hasil penelitian menunjukkan rata-rata pre-test dan post-test kelas kontrol sebesar 34,00 dan 66,67 sedangkan kelas eksperimen sebesar 41,83 dan 82,83. Uji independent sample t-test menunjukkan pengaruh signifikan terhadap hasil dengan nilai signifikansi 0,000 (<0,05) dan terhadap keaktifan siswa sebesar 0,030 (<0,05). Nilai N-Gain kelas eksperimen sebesar 0,7099 termasuk kategori tinggi, sedangkan kelas kontrol sebesar 0,4998 termasuk kategori sedang. Dengan demikian, pendekatan Deep Learning berbasis PjBL berbantuan media Kahoot lebih efektif dalam meningkatkan hasil belajar dan keaktifan siswa pada pembelajaran Biologi kelas X di SMA Negeri 13 Samarinda.  
Pengaruh Model Discovery Learning Berbantuan Media Kahoot terhadap Hasil Belajar dan Motivasi Belajar Materi Ekosistem dan Interaksinya Dwita Rosalinda Sinabariba; Herliani; Masitah; Elsje Theodora Maasawet; Sri Purwati; Arifai
PendIPA Journal of Science Education Vol 10 No 3 (2026): July - September
Publisher : UNIB Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33369/pendipa.10.3.875-884

Abstract

Penelitian ini dilatarbelakangi oleh kesulitan peserta didik dalam memahami materi ekosistem, rendahnya motivasi belajar siswa, pembelajaran biologi yang monoton, serta terbatasnya penggunaan media pembelajaran di SMA Negeri 13 Samarinda. Penelitian ini bertujuan untuk mengetahui pengaruh model pembelajaran discovery learning berbantuan Kahoot terhadap hasil belajar dan motivasi belajar siswa pada materi ekosistem. Penelitian ini menggunakan metode kuasi eksperimen dengan desain Non-equivalent Control Group Pretest and Posttest. Melalui teknik purposive sampling, dipilih 72 siswa kelas X SMA Negeri 13 Samarinda yang dibagi menjadi kelas eksperimen dan kelas kontrol. Data dikumpulkan melalui tes kognitif pilihan ganda, angket motivasi, observasi, dan wawancara. Pengujian hipotesis dilakukan menggunakan independent sample t test. Hasil penelitian menunjukkan adanya peningkatan signifikan pada hasil belajar kognitif di kelas eksperimen dibandingkan kelas kontrol, yang dibuktikan dengan nilai signifikansi 0,000 (p < 0,05). Selain itu, penerapan model pembelajaran ini secara signifikan meningkatkan motivasi belajar siswa, dengan nilai signifikansi 0,038 (p < 0,05). Sebagai kesimpulan, model discovery learning berbantuan Kahoot memberikan pengaruh positif dan signifikan terhadap peningkatan hasil belajar maupun motivasi belajar pada materi ekosistem. Oleh karena itu, disarankan bagi tenaga pendidik untuk mengimplementasikan kombinasi model dan media ini sebagai alternatif guna menciptakan lingkungan belajar yang interaktif dan efektif.
Co-Authors Abdul Hakim AKHMAD Akhmad Akhmad Akhmad Akhmad Akhmad Alamsyah, Syauqi Maulani Aldila Dewi Ratna Supriadi Aloysius Hardoko Andi ’Afifatul Fathonah Andini Nor Rahman Ardila, Vila Wahyu Arifai Arifai Ayu Indah Rahmawati Bonita, Tias Chipsy, Anggi Putri Yulia Cyndirela Daniel Tarigan Dimas Adhitya Wardiman Setyawan Dinaisa Eriyanti Dora Dayu Rahma Turista Dorce Bani Dwita Rosalinda Sinabariba Eadvin Rosrinda Awang Sari Elsje Theodora Maasawet Elsje Theodora Maasawet Elsje Theodore Massawet Farras Abida Lestari Gadis Nindi Aprilia Haang Adelita Hariyani Hariyani, Hariyani Harrits, Reynaldi Ferdhani Herliani Herliani Herliani Herliani Herliani Herliani Imam Wijayadi Indriani, Yeni Ingghrid Ranesti Clarita Hadi Jailani Jailani Jailani Jailani Jailani Jusma Kartika, Tyas Bella Krishna Purnawan Candra Laelasari, Iseu Lambang Subagiyo Lambang Subagiyo Latifah, Mirda Lumowa, Sonja Lumowa, Sonja V.T Mabrurah, Muthmainah Qulub Makrina Tindangen Miningsih Miningsih Muhammad Amir Masruhim Muhammad Ridho Nabila Asa Dinina Nabila Putri Shakila Nelda Anasthasia Serena Noer Dhevie Sopian Novia Nabila Ramadhana Novia Nur Anita Syafitri Nurkhasanah, Benti Nurlaila Nurul Anisa Nurul Qolby, Isnania Ayunda Pradana, Nirza Purwati, Sri Putri Nulissa Putriyanni Putriyanni Rambitan, Vandalita Rambitan, Vandalita M. M. Rambitan, Vandalita M.M. Rasuna Yasmin, Wifa Resi Mandalia Richart Singal Riska Rahmawati Utami Risty Geofani Ruqoyyah Nasution Rusni Ernopita Ulan Serena, Nelda A. Setiawan, Volta Kellik Sheryna Nur Khotimah Sintya Sintya Sonja V.T. Lumowa Sonja Verra Tinneke Lumowa Sonja Verra Tinneke Lumowa Sonja VT Lumowa Sri Purwati Sri Purwati, Sri Sri Roma Yuliarta Sugeng Santoso Sukartiningsih Suparno Putera Makkadafi Taufan Purwokusumaning Daru, Taufan Purwokusumaning Teguh Pribadi Teguh Pribadi Vandalita M.M. Rambitan Vandalita Maria Magdalena Rambitan Vandalita Maria Magdalena Rambitan Vera Damayanti Visyam, Vila Wahyu Ardila Wafi Sayyidaturrofi'ah Yeni Oktavia Yenni Kusrini Abelia Yusak Hudiyono Yusak Hudiyono, Yusak Zenia Lutfi Kurniawati Zulfa Zakiyyah