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Diana Tri Lestari
Universitas Muhammadiyah Kudus
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Journal : Pharmascience

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Lumbricus Rubellus Earthworm Extract Hydrogel for Treatment of Diabetic Ulcer Wounds Diana Tri Lestari; Muhamad Jauhar; Eko Retnowati
Journal of Pharmascience Vol 13, No 1 (2026): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v13i1.22880

Abstract

A diabetic ulcer is a complication that requires serious treatment because it is the highest cause of amputation. This condition has an impact on the morbidity, mortality, and socioeconomics of people with diabetes. Therefore, accuracy is needed in managing diabetic ulcers, one of which is natural ingredients that have potential as topical ulcer medicines, namely the Lumbricus rubellus earthworm. This study aims to find out the most effective formula for the treatment of diabetic ulcer wounds. The formula for this drug candidate is made using the hydrogel preparation formulation using an HPMC 940 base with variations in the active ingredient of lumbricus worm extract of 20%, 50%, and 80% to obtain the desired hydrogel preparation. The candidate drug will be tested, namely physical tests including organoleptic tests, homogeneity tests, pH tests, viscosity tests, spreadability tests, and adhesive tests. After that in vivo trial using Wistar rat experiments. The results of the organoleptic test showed that the three formulas were in gel form with a distinctive extract odor, but the three preparations showed different colors, namely brownish yellow, dark brown, and blackish brown. The three formulations appear homogeneous, having a pH between 4.36 and 4.44 and a viscosity between 5,376 cp and 5,894 cp. The spreading power in formulas 2 and 3 is good, and formula 2 has good adhesion. The results of this study demonstrate that the group treated with 50% Lumbricus rubellus topical extract experienced the most significant and rapid wound healing among all intervention groups. Lumbricus extract can be used as a topical gel preparation for wound care, with the best formulation at a concentration of 50%.
Co-Authors Achmad Ridwan Ajeng, Putri Allena Ade Aman, Syahrial Anggara Dwi Sulistiyanto Anis Lailatul Qudriyah Anjrah Harmoko Arya Dwi Cahyono Ashri Maulida Rahmawati Biyanti Dwi Winarsih Dewi Hartinah Diah Fatmawati, Diah Diah Putri Nugraheni Edi Wibowo Edi Wibowo Suwandi Edita Pusparatri Efendi Efendi Eko Retnowati Eko Retnowati, Eko Endang Setyowati Erni Suprapti Faridha Alfiatur Rohmaniah Faridha Alfiatur Rohmaniah Fery Nanik Handayani Fitriana Kartikasari Fitriana, Ida Hasriyani Hasriyani, Hasriyani Hindriyastuti, Sri Ika Puji Eviyanti Indanah Istyanti, Gabriella Sekar Iswatun Qasanah Iswatun Qasanah Jeki Pornomo Jeki Purnomo Lintang Ayu Diana Linsqy Lismawati, Dini Marniati Kadir Mohamad Khafidh Rio Irwansyah Muhamad Jauhar Muhammad Jauhar, Muhammad Mukaromah, Isna Aulia Muslimah, Aulya Choirul Nadya Asyh Selvya Nana Umi Farida Nila Friscandani Ninda Titian Asta Gini Nisdayanti, Dela Amanda Noor Cholifah Noor Faidah Noor Hidayah Putri, Sheryl Nisrina Aulia Rabiatul Adawiyah Rahmasari, Lutfir Fitri Rahmawati, Ashri Mualida Rika Barotut Taqiyah Risnawati, Heni Rusnoto Rusnoto rusnoto rusnoto Sari, Sri Wulan Sholahudin, Mohammad Sinta Novia Dewi Sri Hartini Sri Karyati Sukamto Sukamto Sukamto SUKARMIN Sukarmin, S Sukesih Sukesih Sukma Wijayanti Sunarya, Dian Fitriani Surastuti, Putri Syahrial Aman Tiara, Novi Tukiyo Tuti Anggarawati Vera Fahreza Wahyu Yusianto Widiastari, Yunita Widya Cholid Wahyudin Widyastuti, Anik Wulandari, Fifi Faryanti Yanti, Vivin Amei Yayuk Mundriyastutik Yulisetyaningrum Yunita Rusidah Yusuf Ilham Romadhoni