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All Journal Indonesian Journal of Applied Sciences Media Kesehatan Masyarakat Indonesia Jurnal Kedokteran Brawijaya International Journal of Integrated Health Sciences Majalah Kedokteran Bandung Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Althea Medical Journal Jurnal Keolahragaan Global Medical and Health Communication JURNAL PENDIDIKAN KEPERAWATAN INDONESIA The Indonesian Journal of Public Health JURNAL PENDIDIKAN JASMANI DAN OLAHRAGA NurseLine Journal Jurnal Gizi Klinik Indonesia Jurnal Ergonomi dan K3 Jurnal Biomedika dan Kesehatan Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Bali Anatomy Journal Jurnal Ilmu Faal Olahraga Indonesia Jurnal Sains dan Kesehatan Folia Medica Indonesiana
Leonardo Lubis
Anatomy Division, Department Of Biomedical Sciences, Faculty Of Medicine, Universitas Padjadjaran
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Education Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Medicine & Pharmacology Neuroscience Nursing Public Health

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PHYSICAL ACTIVITY PROFILE BASED ON GLOBAL PHYSICAL ACTIVITY QUESTIONNAIRE (GPAQ) FOR MINING WORKERS Leonardo Lubis; Talia Rahmaniar; Nandina Oktavia
The Indonesian Journal of Public Health Vol. 18 No. 3 (2023): THE INDONESIAN JOURNAL OF PUBLIC HEALTH
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijph.v18i3.2023.481-492

Abstract

Introduction: Physical activity has several related factors, which are age, gender, educational level, and type of occupation. It is known that 1 in 4 adults in the world do not meet the minimum physical activity. Physical inactivity is one of the main factors causing non-communicable disease (NCD) as well as obesity, heart disease, and cancer. In Indonesia, 26.1% of the population is included in the category of less physical activity. Aims: to find out the physical activity profile of mining workers based on age, gender, educational level, and type of occupation. Methods: This study uses a descriptive design study with a cross-sectional approach that included 124 workers at PT. Borneo Indobara 2020. The measure was used in this research is the Global Physical Activity Questionnaire (GPAQ). The total level of physical activity is divided into three categories in MET-minutes/week, which are high (≥ 3.000 MET), moderate (≥ 600 or < 3.000 MET), and low (< 600 MET). Result: The workers who have a higher percentage of low physical activity are workers of middle age, female, highly educated, and have a position as leader/officer which is 75% compared to each category. Conclusion: The majority of mining workers at PT. Borneo Indobara has low physical activity. This research can be used as feedback or consideration for evaluating and motivating mining workers at PT. Borneo Indobara and the wider community to increase physical activity.
Impact of Propolis Administration on Osteocrin Expression and Osteoblast-to-Osteoclast Ratio in the Femurs of Rats Fed a High-fat Diet Widiyanti, Alvira; Tarawan, Vita Murniati; Lubis, Leonardo
Global Medical & Health Communication (GMHC) Vol 12, No 2 (2024)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v12i2.13833

Abstract

A high-fat diet (HFD) is associated with bone inflammatory processes that can affect bone remodeling balance. Osteocrin produced by periosteal osteoblasts correlates with osteoblast activity, is expressed on osteoblast-derived cells, and is localized in osteoblasts and young osteocytes. Propolis is an antioxidant and anti-inflammatory in bone remodeling by inhibiting proinflammatory factors NF-κB and COX-2, reducing inflammatory suppression of cytokines responsible for osteoclast differentiation and osteoblast apoptosis. The flavonoid content increases the production of nitric oxide and osteoprotegerin, which enhances osteoblastogenesis. This study determined the effect of propolis administration on bone formation and resorption in bone previously damaged by an HFD. This research was conducted in the Animal Laboratory of Postgraduate Building Dipati Ukur and Genetics and Molecular Laboratory Eycman Building, Faculty of Medicine, Universitas Padjadjaran. The research time was from January 2023–May 2024. Male Wistar rats were divided into four groups: normal chow diet (NCD), NCD with propolis administration, HFD, and HFD with propolis administration. The 12-week-old rats were given an HFD for 12 weeks and then treated with propolis at a 300 mg/kgBW dose for nine weeks. The administration of propolis increased the ratio of osteoblasts-osteoclast cells in the femur of the HFD rats but did not affect periosteal osteocrin expression.
Pengaruh Zat Besi dan Seng terhadap Perkembangan Balita serta Implementasinya Dwi Monik Purnamasari; Leonardo Lubis; Dida A. Gurnida
Jurnal Sains dan Kesehatan Vol. 2 No. 4 (2020): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v2i4.194

Abstract

Angka kejadian gangguan perkembangan balita di Indonesia cukup tinggi. Gangguan perkembangan pada balita, terutama pada 1000 hari pertama kehidupan dapat menurunkan produktivitas anak tersebut sampai dewasa. Akibatnya, kemampuan belajar tahap pendidikan selanjutnya tidak tercapai secara optimal dan berkaitan dengan penghasilan di masa depan. Beberapa faktor dapat memengaruhi perkembangan balita, diantaranya adalah defisiensi seng dan zat besi. Defisiensi zat besi dapat menyebabkan hipomyelinasi, gangguan pertumbuhan, diferensiasi, dan elektrofisiologi neuron, serta perubahan regulasi neurotransmiter di otak. Seng berperan dalam neurotransmiter di area neuron presinaptik dan postsinaptik serta berperan dalam neurogenesis, maturasi dan migrasi neuron dan pembentukan sinapsis otak. Defisiensi kedua mineral ini akan menyebabkan perkembangan balita terganggu atau tidak optimal. Guna mencegah anemia, WHO merekomendasikan pemberian suplementasi zat besi setiap hari selama 3 bulan berturut-turut setiap tahun untuk anak 6 bulan hingga 5 tahun. Pemberian seng rutin untuk balita sampai saat ini belum menjadi rekomendasi dari WHO. Rekomendasi yang telah dikeluarkan terkait seng masih terbatas pada pemberian seng sebagai terapi tambahan pada anak dengan diare.
Correlation of Various Levels of Body Mass Index to Vascular Endothelial Growth Factor-A Permana, Noah Jefferson; Lesmana, Ronny; Setiawan, Setiawan; Lubis, Leonardo; Rosdianto, Aziiz Mardanarian; Rejeki, Purwo Sri
Althea Medical Journal Vol 12, No 3 (2025)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v12n3.4296

Abstract

Background: Obesity, reflected by high body mass index (BMI) value, has become a global health concern. Both obesity and vascular endothelial growth factor-A (VEGF-A) are major risk factors for cardiometabolic diseases. Although many studies have shown that obesity induces angiogenesis through increased VEGF-A, there remains a  gap regarding the correlation between BMI categories and VEGF-A levels. This study aimed to analyze the correlation between various level of BMI and VEGF-A concentrations.Methods: This cross-sectional in vivo study analyzed blood samples from 90 adults enrolled in the Universitas Padjadjaran Wellness Program ( December 2022–June 2023) selected using simple random sampling.VEGF-A concentrations were measured using multiplex ELISA assays. Data normality was assessed using the Kolmogorov-Smirnov test. Differences between BMI groups were analyze with ANOVA, and correlations were evaluated using Pearson’s test. Results: Of the 90 samples, 62 were included, and were grouped as normal weight (29%), overweight (32.2%), obesity class I (30.6%), obesity class II (6.4%), and obesity class III (1.6%). Mean VEGF-A concentrations showed an increasing trend with higher BMI, though differences between groups were not statistically significant (p=0.482). A weak positive correlation was observed between BMI and VEGF-A levels (r=0.267; p=0.036).Conclusion: Higher BMI is associated with higher VEGF-A, indicating obesity-induced inflammation and angiogenic activity. These findings highlight the importance of weight control through balanced diet and physical activity to mitigate long-term risks of cardiometabolic and chronic diseases.
Peran Intensitas Latihan dalam Hipertrofi Otot Skeletal Irawati, Nur Ayu Virginia; Sylviana, Nova; Lubis, Leonardo
Jurnal Biomedika dan Kesehatan Vol 7 No 1 (2024)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2024.v7.124-132

Abstract

Endurance training, a form of physical activity that relies on continuous aerobic exercise and repetitive muscle contractions, is widely acknowledged for its positive effects on overall physical fitness. Aerobic exercise, an essential component of endurance training, has numerous benefits including improved cardiovascular and respiratory health, increased muscle endurance, and enhanced resistance against fatigue. It has also been found to contribute to skeletal muscles, potentially by stimulating the synthesis of proteins involved in muscle fiber formation. Although resistance exercise has been favored for promoting muscle growth, some suggests that aerobic exercise can also produce skeletal muscle hypertrophy comparable to that of resistance exercise if performed correctly. The duration, intensity, and specific type of aerobic exercise play important roles in determining skeletal muscle mass. The mammalian target of rapamycin (mTOR) known as a key regulator of muscle protein synthesis that associated with exercise activity. Several signaling pathways, such as Akt/mTOR and MAPK, are involved in controlling muscle protein synthesis during exercise. This review aimed to understand the impact of aerobic exercise intensity and other training parameters on skeletal muscle, to provide valuable insights for optimizing exercise programs and fostering muscle hypertrophy. In this review, we had systematically searched PubMed and Google Scholar from January 2013 to May 2023. Our result indicated that aerobic exercise can be expected to promote skeletal muscle hypertrophy and improve muscle mass and function. The regulation of skeletal muscle mass is complex, involving various signaling pathways such as mTOR, as well as the influence of hormones and growth factors.
Plant-based diet dan sindrom metabolik: uji pendahuluan pada komunitas plant-based diet Bandung Lubis, Leonardo; Luftimas, Dimas Erlangga; Faiza, Tiara; Fatimah, Siti Nur; Fitria, Nita; Purba, Ambrosius
Jurnal Gizi Klinik Indonesia Vol 21, No 2 (2024): Oktober
Publisher : Minat S2 Gizi dan Kesehatan, Prodi S2 IKM, FK-KMK UGM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijcn.84198

Abstract

Association between plant-based diet and metabolic syndrome: a pilot study on Bandung plant-based diet communityBackground: Metabolic syndrome is a cluster of disorders related to cardiometabolic abnormalities that are experienced by two out of five people in Indonesia. Miscellaneous factors increase the risk of metabolic syndrome, including improper diet. Plant-based diets are expected to lower the risk of metabolic syndrome.Objective: The study investigated the association between a plant-based diet and metabolic syndrome.Methods: A cross-sectional study design was conducted on 60 subjects, consisting of 20 subjects who applied the plant-based diet and 40 subjects who did not apply the plant-based diet. Visceral fat rating, body mass index, blood pressure, fasting blood glucose, triglyceride, and HDL were also measured to identify the amount of metabolic syndrome indicators that occurred in each subject. Data was analyzed using a parametric independent sample t-test, non-parametric Mann-Whitney U, and Chi-Square tests.Results: Non-parametric test analysis in fasting blood glucose showed a significant result (p=0.022), but not in other metabolic syndrome indicators, as well as the Chi-Square test (p=1.000).Conclusions: This study found no association between a plant-based diet and metabolic syndrome. 
Pengaruh Akut Musik Klasik terhadap Kemampuan Spasial Lubis, Leonardo; Fitria, Nita
Majalah Kedokteran Indonesia Vol 69 No 4 (2019): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, Vo
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.69.4-2019-68

Abstract

Introduction: Classical music is a complex melody composition that couldactivate the Brodmann’s area 22, 9, 46, 17, 18, and 19, which are associated inspatial ability as well. Spatial ability is a cognitive function in devising, por-traying, and visualizing an object in space accurately. In the medical field,spatial ability greatly required in learning anatomy, radiograph interpretingand doing the surgical procedure. The aim of this study is to prevail the effectof classical music on spatial ability. Method: An experimental study conducted on the 182 subjects consists of 117female and 65 male medical students. Subjects were divided into two groups,classical music(treatment) group, and silence (control) group. The treatment group listened to Mozart sonata K448 for 10 minutes, while at the very sametime but in a different place, the control group just sat tight for10 minutes aswell. Soon after the 10 minutes, both groups performed the spatial ability test. The spatial test result then analyzed by independent t-test. Result: The spatial score in the treatment group is significantly higher (p less than 0,05)than the control group, both female (33,6379 vs. 31,6949) and male (36,8387vs. 33,9198). Conclusion: Listening to the Mozart sonata K448 could acutely improve thespatial ability
Response of Long-Term Memory to Molecular Changes of BDNF in Hippocampus in Various Intensities of Physical Activity Lubis, Leonardo; Setiawan, Setiawan
International Journal of Integrated Health Sciences Vol 4, No 2 (2016)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (92.072 KB)

Abstract

Objective: To analyze the physiological response of long-term memory (LTM) to the molecular changes of brain-derived neurotrophic factor (BDNF) in the hippocampus by the treatment of various intensities of physical activity. Methods: Subjects were 7–8 week old male Wistar rats weighed between 201–250 grams. This study was an experimental study with pre-(day-1) and post-(day-14) design. Molecular changes reflected by the changes in the expression of mRNA and protein of BDNF in the hippocampus. Treatment of physical activity on the subjects was running on the Animal Treadmill by grouping of the physical activity: light intensity at a speed of 10 m/min, moderate intensity at a speed of 20 m/min and heavy intensity at a speed of 30 m/min. The treatment’s duration was 30 minutes.Then, analysis of data on pre (day-1) and post (day-14) which were: LTM response based on travel time swimming test, the expression of mRNA (Ct) and protein (%) of BDNF in hippocampus based on RT-PCR and immunohistochemistry. Results: The results showed that moderate intensity group caused the better physiological and molecular responses than the other groups, as follows: travel time (0.6260 vs 0.7270 vs 0.9400 vs. 1.4000 seconds (p<0.05)), mRNA BDNF expression (17.2320 vs 18.8800 vs 19.7540 vs 20.7750 Ct (p<0.05)), and hippocampal BDNF protein expression. Conclusions: The study conclude that the moderate intensity is the best physical activity to improve LTM as showed by the BDNF mRNA expression as well as BDNF protein in hippocampus. Keywords: Intensity, long-term memory, brain-derived neurotrophic factor, hippocampus DOI: 10.15850/ijihs.v4n2.839
Physical activity profile of the professors of padjadjaran university based on global physical activity questionnaire Maulida, Mutia Nur; Lubis, Leonardo; Sari, Dian Marta
Folia Medica Indonesiana Vol. 53, No. 4
Publisher : Folia Medica Indonesiana

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Physical activity is one of the factors which determines one's health and fitness, including the professors of Padjadjaran University, as it might support their academic performances. Global Physical Activity Questionnaire (GPAQ) may describe physical activity. The purpose of this study was to describe physical activity profile of the professors of Padjadjaran University based on GPAQ. Physical activity profile which was classified as gender, age group, recommendation fulfillment, and intensity variables by present-ing quantity (n) and percentage (%) was obtained from 141 professors who fulfilled the inclusion criteria. The result of this des-criptive-quantitative study showed that 109 of the respondents were male, and 32 were female. According to WHO age group cate-gories, 35 respondents were middle aged, 78 were elderly, and 28 were late elderly. Fifty-eight respondents (41.1%) did not fulfill minimal recommendation for physical activity, 114 respondents (80.8%) underwent moderate activity and 29 respondents (20.6%) underwent vigorous activity. Therefore, it can be concluded that professors of Padjadjaran University, which were mostly middle-aged men, did not fulfill minimal recommendation for physical activities, although many of them underwent moderate activities in their daily routines.
Correlation between ldl, hdl, and triglyceride conditions with body fat percentage of universitas padjadjaran professors Saputra, Yosi Wailan; Miftahurachman, Miftahurachman; Lubis, Leonardo
Folia Medica Indonesiana Vol. 53, No. 3
Publisher : Folia Medica Indonesiana

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Elderly is a problem that may disrupt the balance of various molecules in the body, especially fat molecules, which may result in the emergence of various diseases so that blood fat and adipose level examinations need to be done regularly and periodically as an effort of early detection. This study aimed to find correlation between Low Density Lipoprotein (LDL), High Density Lipoprotein (HDL), and triglyceride with body fat percentage among professors in Universitas Padjadjaran (Unpad) who were mostly in elderly age. This study was a linear regression analytical study conducted on 52 Unpad professors (♂ 75%, ♀ 25%) based on data of LDL, HDL, and triglyceride levels obtained through laboratory examination, as well as body fat percentage data by using Bio Impedance Analysis (BIA). The correlation between low density lipoprotein (LDL), High Density Lipoprotein (HDL), and triglyceride with body fat percentage in male professors group was R2=0.072; P>0.05 and in female was R2=0.028; P>0.05. As a conclusion, there was no correlation between Low Density Lipoprotein (LDL), High Density Lipoprotein (HDL), and triglyceride with body fat percentage in Unpad professors.
Co-Authors Adilla Zulfana Hermawan Ajeng Fitria Ajeng Fitria Ambrosius Purba Ambrosius Purba Ambrosius Purba Ambrosius Purba Ambrosius Purba Amira Addiniya Arviana Adamantina Putri Arviana Adamantina Putri Azkane Adila Putri Cynthia, Jessica Daniel Womsiwor Della Aprilliana Suherlim* Della Suherlim Dian Marta Sari Dida A. Gurnida Dimas Erlangga Luftimas Dimas Erlangga Luftimas Dimas Erlangga Luftimas Dwi Monik Purnamasari Faiza, Tiara Fani, Regina Chintya Faysal Kastella Febi Dwirahmadi Fidella Fidella Filiani Natalia Salim Fitria, Nita Gita Tiara Dewi Nasution Gita Tiara Dewi Nasution Hanna Goenawan Hikmat Permana Hikmat Permana Ida Ayu Putu Sri Widnyani Irawati, Nur Ayu Virginia Irma Suwandi Sadikin Jessica Cynthia Julistio T. B. Djais Julistio T. B. Djais, Julistio T. B. Lucky Saputra Lucky Saputra, Lucky Lydyana, Lynna Lynna Lidyana Lynna Lidyana Marietta Shanti Prananta Maulida, Mutia Nur Miftahurachman Miftahurachman, Miftahurachman Muhammad, Afan Maulana Mulya Nurmansyah Ardisasmita Mustari, Ryandika Elvereza Mutia Nur Maulida Nadhifah Salsabila Nandina Oktavia Nandina Oktavia Nani Kurniani Nani Kurniani Nicole Ngo Zhe Yiin Nicole Ngo Zhe Yiin Nisrina Tache Nita Fitria Nova Sylviana Novi Vicahyani Utami NUGRAHA SUTADIPURA Nurain Yahya Ong, Paulus Anam Paulus Anam Ong Permana, Noah Jefferson Primadhi, Raden Andri Putri, Azkane Adila Putri, Jesslyn Christianningrum Rahmat Budi Kuswiyanto Rahmat Budi Kuswiyanto, Rahmat Budi Rajamany, Thyviyaa Ramadhan, Wahyu Syahrul Rejeki, Purwo Sri Rizki Perdana Ronny Lesmana Ronny Lesmana Rosdianto, Aziiz Mardanarian Rossanti, Rini Ryandika Elvereza Mustari Sadikin, Irma Suwandi Saputra, Yosi Wailan Setiawan . Setiawan Setiawan Shelly Iskandar Siska Wiramihardja, Siska Sitepu, Gabriel Armando Siti Akbari Siti Aminah Sobana Siti Nur Fatimah Tache, Nisrina Talia Rahmaniar Tarigan, Beltasar Tatang Muchtar Sutaryan Tatang Muchtar Sutaryan Tetty Yuniati Tetty Yuniati Thyviyaa Rajamany Tiara Kusumawiyanti Vita Murniati Tarawan Vitriana Vitriana Vitriana Vitriana Widiyanti, Alvira Yahya, Nurain