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All Journal Jurnal Kesehatan Masyarakat Indonesia Jurnal Kedokteran Diponegoro Althea Medical Journal Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Journal of Biomedicine and Translational Research Jurnal Kesehatan Andalas Biomedical Journal of Indonesia Jurnal Kedokteran dan Kesehatan Jurnal Medika Malahayati Medical and Health Science Journal JURNAL ANALIS LABORATORIUM MEDIK Dharma Raflesia : Jurnal Ilmiah Pengembangan dan Penerapan IPTEKS AgriHealth: Journal of Agri-food, Nutrition and Public Health Jurnal Kedokteran Universitas Palangka Raya Jurnal Kesehatan Tambusai Jurnal Kedokteran Raflesia Jurnal PADAMU NEGERI (Pengabdian pada Masyarakat Bidang Eksakta) JUMANTIK (Jurnal Ilmiah Penelitian Kesehatan) Jurnal Pengabdian Masyarakat As-salam Dikdimas : Jurnal Pengabdian Kepada Masyarakat Proceeding of Bengkulu International Conference on Health Proceeding International Conference Of Innovation Science, Technology, Education, Children And Health Proceeding International Conference Of Innovation Science, Technology, Education, Children And Health
Debie Rizqoh
Departemen Mikrobiologi Dan Imunologi, Fakultas Kedokteran Dan Ilmu Kesehatan, Universitas Bengkulu
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Pelatihan pembuatan hand sanitizer sebagai antiseptik berstandar WHO Oktoviani, Oktoviani; Rizqoh, Debie; Handayani, Dian; Rachmawati, Indah Dwi; Kumala, Wulan Okta
Jurnal PADAMU NEGERI (Pengabdian pada Masyarakat Bidang Eksakta) Vol. 2 No. 2 (2021)
Publisher : Perkumpulan Dosen Muda (PDM) Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (394.844 KB) | DOI: 10.37638/padamunegeri.v2i2.437

Abstract

The incessant socialization of the government regarding health protocols to a new life order has resulted in most Indonesians becoming introspective in maintaining cleanliness. However, some of the community also experienced panic, so that they acted unnaturally by buying up more goods than they needed, including hand sanitizers. This is one of the reason the price of hand sanitizers has increased. That’s why people need to know how to make hand sanitizers so that they are no longer worry about the scarcity of hand sanitizers and can make their own hand sanitizers. The purpose of this activity is to meet the needs of residents for hand sanitizer as an antiseptic with WHO standards. The method used in training in making hand sanitizers in a direct demonstration. Demonstrations are also supported by a PowerPoint and video that is displayed repeatedly with the help of an LCD projector. This was done to repeat the key points of the demonstration sp that a good level of understanding was achieved by the citizens. Then the Citizen representativeswere asked to repeat the demonstration so that the activities of seeingm listening and practicing the knowledge  of making hand sanitizers were completed. Then at the end of the event, an evaluation was carried out using the discussion or question and answer method. The results of the training in making hand sanitizers have helped meet the needs of residents for hand sanitizers, helped residents to be more independent in meeting their needs for hand sanitizers, and increased knowledge and skills of residents regarding making hand sanitizers as WHO standard antiseptics
DEVELOPMENT OF HIGHLY PATHOGENIC AVIAN INFLUENZA VACCINE FOR PANDEMIC INFLUENZA PREPAREDNESS: A REVIEW S,Si, M.Biomed, Debie Rizqoh
JURNAL KEDOKTERAN RAFLESIA Vol 10 No 1 (2024)
Publisher : UNIVERSITAS BENGKULU

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33369/juke.v10i1.35776

Abstract

The Highly Pathogenic Avian Influenza (HPAI) H5N1 virus caused extraordinary incidents in several countries, especially Asia, Africa, and Europe. The disease's fatality rate caused by the H5N1 virus reaches 60%. This incident raised concerns about a wider HPAI H5N1 virus pandemic if effective human-to-human transmission occurred. Therefore, the World Health Organization (WHO) calls on all countries to prepare themselves for a pandemic that may occur. One of the strategies in preparation for this pandemic is to develop a vaccine. So far, vaccines are effective in disease prevention efforts because they can work to trigger a natural immune response and induce a memory response against the pathogen in question. Several strategies are needed to develop an effective influenza vaccine in carrying out vaccine development research and in-depth understanding of (i) virology, (ii) virus life cycle, (iii) host immune response to infection, (iv) pathology, and (v) HPAI H5N1 vaccine development strategy. Until now, many HPAI H5N1 vaccines have been developed, from vaccines developed using conventional methods to alternative vaccines using more modern methods. The results of the development of the vaccine are expected to provide provisions for a possible pandemic caused by the HPAI H5N1 virus. Keywords : Influenza, virus, vaccine
Edukasi Perilaku Hidup Bersih dan Sehat untuk Pencegahan Penyakit Infeksi Kulit Rizqoh, Debie; Nugraheni, Enny; Prihatiningrum, Atik; Meidiyanti, Prima
DHARMA RAFLESIA Vol 22 No 2 (2024): DESEMBER (ACCREDITED SINTA 5)
Publisher : Universitas Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33369/dr.v22i2.37797

Abstract

Penyakit kulit sering ditemukan pada masyarakat yang kurang memperhatikan personal hygiene dan sanitasi lingkungan. Beberapa jenis penyakit yang sering dialami masyarakat yaitu psoriasis, kusta atau hansen, dermatitis, scabies, panu, cacar, dan lain-lain. Kebersihan kulit, tangan, kuku dan kebersihan handuk paling banyak masuk dalam kategori buruk. Kebersihan kulit, tangan, kuku, pakaian, handuk, tempat tidur, sprei, dan sanitasi lingkungan memiliki korelasi yang signifikan dengan keluhan penyakit kulit. Perilaku hidup bersih dan sehat (PHBS) merupakan salah satu strategi untuk menanggulangi masalah penyakit infeksi kulit. Kegiatan pengabdian kepada masyarakat ini telah dilaksanakan di Desa Sri Kuncoro, Kecamatan Pondok Kelapa, Kabupaten Bengkulu Tengah. Kegiatan dilaksanakan pada tanggal 28 Agustus 2024. Sebelum kegiatan tersebut, tim pengabdian menyusun buku edukasi dan poster edukasi yang dibagikan pada saat kegiatan penyuluhan. Pada saat kegiatan pengabdian, ada dua materi yang disampaikan yaitu materi “Penyakit Infeksi pada Kulit” dan “Pencegahan Penyakit Infeksi Kulit”. Selain itu, dilakukan pre-test dan post-test untuk mengevaluasi pengetahuan peserta. Terjadi peningkatan pengetahuan peserta setelah mengikuti kegiatan pengabdian.
Perbandingan Tingkat Keparahan Infeksi Sekunder Virus Dengue pada Keempat Serotipe di Indonesia: Systematic Review Kurniati, Annelin; Fandi, Ahmad; Sariyanti, Mardhatillah; Febrianti, Ety; Rizqoh, Debie
Jurnal Kesehatan Andalas Vol. 10 No. 1 (2021): Online March 2021
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v10i1.1615

Abstract

Secondary infection with the dengue virus causes mild to severe manifestations. The distribution of dengue virus serotypes varies in various areas and can change over time. There are four dengue serotypes, namely DENV-1, DENV-2, DENV-3 and DENV-4. Objectives: To knew the distribution of virus serotypes in an area and determined the pathogenesis of the disease, which can cause severe manifestations in patients with secondary infections. Methods: The data taken is the severity of secondary infections and dengue serotypes. The literature search was performed on PMC and Cochrane. Search criteria were performed using keywords (secondary infection * OR secondary dengue infection *) AND (Dengue Virus * OR Dengue Infection * OR Dengue * OR DENV) AND (Serotype * OR Serogroup) AND (severe dengue * OR severity * OR severity of illness indexs * OR dengue fever * OR dengue haemorrhage fever * OR dengue shock syndrome * OR DF * OR DHF * OR DSS *) AND (Indonesia *). Results: Literature study search found 387 literature with five studies conducted the analysis. From the results of the analysis, it was found that secondary infections were more common in patients with recurrent dengue infection with serotype 2 (DENV-2), serotype 3 (DENV-3) and serotype 4 (DENV-4). Conclusion: Secondary infection of dengue virus serotype 2 (DENV-2) and serotype 3 (DENV-3) can cause severe dengue infection.Keywords:  Dengue Virus, Indonesia, Secondary Infection, Serotype, Severity
Relationship between Viral Load Levels and Malnutrition Screening and Nutritional Status in HIV Patients at RSUD Dr. M Yunus Bengkulu Oktavia Salsadillah Putri; Enny Nugraheni; Noor Diah Erlinawati; Mulya Sundari; Debie Rizqoh
Proceeding International Conference Of Innovation Science, Technology, Education, Children And Health Vol. 4 No. 1 (2024): Proceeding of The International Conference of Inovation, Science, Technology, E
Publisher : Program Studi DIII Rekam Medis dan Informasi Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62951/icistech.v4i1.81

Abstract

Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome (HIV/AIDS) cases continue to increase and are becoming a top global public health problem. When weight loss is more than 10% below the previous body weight, the relative risk of death is going to increase almost 6-fold. A viral load checkup is a test to measure the amount of HIV in the blood. The increase in nutritional needs and tissue catabolism is caused by the increase in viral load in the body. Malnutrition screening is necessary to evaluate nutritional status so that this treatment can be recommended if the patient is malnourished. This research is an analytical observational study with a cross-sectional design. Analysis was carried out on 109 people living with HIV who received treatment at RSUD Dr. M Yunus Bengkulu. The independent variable in this study is the viral load level, while the dependent variable is screening for malnutrition and the nutritional status of people living with HIV/AIDS—data analysis using the Spearman Rank test. The study results showed no correlation between viral load levels and nutritional status with a value of p=0.243 (p>0.05), and there was a correlation between viral load levels and malnutrition screening with p≤001. The viral load of HIV patients at Dr. M Yunus Bengkulu does not correlate with nutritional status, but it correlates with malnutrition screening.
Relationship between Viral Load Levels and Malnutrition Screening and Nutritional Status in HIV Patients at RSUD Dr. M Yunus Bengkulu Oktavia Salsadillah Putri; Enny Nugraheni; Noor Diah Erlinawati; Mulya Sundari; Debie Rizqoh
Proceeding International Conference Of Innovation Science, Technology, Education, Children And Health Vol. 4 No. 1 (2024): Proceeding of The International Conference of Inovation, Science, Technology, E
Publisher : Program Studi DIII Rekam Medis dan Informasi Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62951/icistech.v4i1.81

Abstract

Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome (HIV/AIDS) cases continue to increase and are becoming a top global public health problem. When weight loss is more than 10% below the previous body weight, the relative risk of death is going to increase almost 6-fold. A viral load checkup is a test to measure the amount of HIV in the blood. The increase in nutritional needs and tissue catabolism is caused by the increase in viral load in the body. Malnutrition screening is necessary to evaluate nutritional status so that this treatment can be recommended if the patient is malnourished. This research is an analytical observational study with a cross-sectional design. Analysis was carried out on 109 people living with HIV who received treatment at RSUD Dr. M Yunus Bengkulu. The independent variable in this study is the viral load level, while the dependent variable is screening for malnutrition and the nutritional status of people living with HIV/AIDS—data analysis using the Spearman Rank test. The study results showed no correlation between viral load levels and nutritional status with a value of p=0.243 (p>0.05), and there was a correlation between viral load levels and malnutrition screening with p≤001. The viral load of HIV patients at Dr. M Yunus Bengkulu does not correlate with nutritional status, but it correlates with malnutrition screening.
PENGARUH USIA DAN JENIS KELAMIN TERHADAP KADAR IGG DAN KEJADIAN COVID-19 PASCAVAKSINASI PADA TENAGAESEHATAN KOTA BENGKULU Nabilah, Putri Syifa; Suryani, Utari Hartati; Massardi, Nikki Aldi; Rizqoh, Debie; Ambarsarie, Riry
Jurnal Kesehatan Tambusai Vol. 5 No. 1 (2024): MARET 2024
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v5i1.24902

Abstract

Variabilitas respons antibodi terhadap vaksinasi COVID-19 dipengaruhi oleh faktor-faktor seperti usia dan jenis kelamin. Penelitian ini bertujuan untuk mengkaji dampak usia dan jenis kelamin terhadap kadar IgG serta kejadian COVID-19 pascavaksinasi. Dengan memperoleh pemahaman mendalam tentang hubungan ini, diharapkan dapat ditingkatkan strategi vaksinasi yang lebih efektif dan efisien bagi berbagai kelompok populasi. Penelitian ini adalah penelitian cross-sectional yang dilakukan selama periode Juli hingga Desember 2021, melibatkan partisipasi 60 tenaga kesehatan dari Rumah Sakit Harapan dan Doa (RSHD) di Kota Bengkulu. Data primer dikumpulkan dari responden ini dalam rangka mengidentifikasi hubungan antara usia, jenis kelamin, dan respons antibodi terhadap vaksinasi COVID-19. Pengambilan data kadar antibodi IgG dilakukan dengan teknik CMIA, sementara data usia, jenis kelamin, dan kejadian COVID-19 pascavaksinasi melalui kuesioner. Metode statistik yang diterapkan dalam penelitian ini mencakup serangkaian uji, seperti uji Kruskal-Wallis, uji Mann-Whitney, dan uji Chi-Square. Temuan penelitian menegaskan bahwa kelompok usia 40-55 tahun dan perempuan memiliki kadar IgG yang lebih tinggi, sedangkan proporsi kejadian COVID-19 pascavaksinasi lebih tinggi pada kelompok usia 20-29 tahun dan laki-laki. Hal ini menunjukkan pengaruh signifikan dari usia dan jenis kelamin terhadap respons antibodi dan kejadian COVID-19 pascavaksinasi. Kesimpulan ini memberikan wawasan penting bagi strategi vaksinasi yang lebih efektif dan cermat bagi berbagai kelompok populasi.
Health Education About Clean and Healthy Lifestyle Behavior (PHBS) in the Transition Period of the Covid-19 Pandemic for Students Rizqoh, Debie; Djatmiko, Ellen Maidia; Massardi, Nikki Aldi; Hakim, Alvi Jalilul; Arifani, Novita; Fauzia, Azella Chika
DIKDIMAS : Jurnal Pengabdian Kepada Masyarakat Vol. 2 No. 1 (2023): DIKDIMAS : JURNAL PENGABDIAN KEPADA MASYARAKAT  VOL 2 NO 1 APRIL 2023
Publisher : Asosiasi Profesi Multimedia Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58723/dikdimas.v2i1.93

Abstract

After the COVID-19 pandemic is ongoing up to 3 years, finally Indonesia started experience transition from pandemic going to endemic, following decreasing of case positive for COVID-19. During the transition, a number of rule start relaxed, however government recommend public for still carry out health protocol. Besides, in field education, all school carry out 100 % offline learning. The students have to stay alert from COVID-19 infection or another infection. So that, clean and healthy lifestyle (PHBS) is necessary carried out at school. There are several indicators of PHBS in schools that are necessary known by students. This health education aims to give education to 97 students in schools especially at SMK Negeri 2 Bengkulu City about importance implementing PHBS in the transition period of COVID-19 pandemic. This activity took place on Thursday , 22 September 2022. The method used form give education and discussion regarding PHBS in schools. We evaluated student’s understanding by pre-test and post-test about PHBS. Participant generally already have own knowledge regarding PHBS and more understand PHBS after participated in this activity.
Immunotherapy and Immune Checkpoints: Unlocking The Immune System’s Potential to Treat Cancer Rizqoh, Debie; Febrina, Olivia Putri; Pratiwi, Ulfa Hanum; Ramadhani, Abdah Zhafirah; Athalia , Nabila Wine
Jurnal Kedokteran Universitas Palangka Raya Vol 13 No 2 (2025): Jurnal Kedokteran Universitas Palangka Raya
Publisher : Fakultas Kedokteran, Universitas Palangka Raya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37304/jkupr.v13i2.21738

Abstract

Conventional cancer therapies, such as surgery, chemotherapy, and radiation therapy, often produce limited results and negatively affect patients' quality of life. In recent years, immunotherapy based on immune checkpoint inhibitors (ICIs) has emerged as a promising new approach. Immune checkpoint molecules, such as PD-1, PD-L1, and CTLA-4, play a crucial role in suppressing the immune response to tumors, making them primary targets in ICI therapy. This study examines the mechanisms of immune checkpoints, the efficacy of ICI therapy, and the remaining challenges in clinical practice. The review was conducted through a literature review of scientific publications and the latest clinical trial results. The results demonstrate the efficacy of ICIs, such as ipilimumab and pembrolizumab, in improving overall and progression-free survival rates across various types of cancer, particularly melanoma and non-small cell lung cancer. Combining two ICIs has been shown to have higher synergistic effects than monotherapy, as demonstrated in the CheckMate 067 and KEYNOTE-024 clinical trials. Despite its promise, this therapy is not fully effective in all patients due to immune resistance, autoimmune side effects, and the complexity of tumor heterogeneity and the immune microenvironment. Therefore, combination therapy strategies, dose adjustments, schedule modifications, and personalized approaches based on biomarkers are needed to optimize clinical benefits and expand the scope of therapy. In conclusion, ICIs hold great potential for future cancer therapies and are being developed to be more effective and personalized.  
PPAR-γ, but not KCNJ11, Is Associated with Type 2 Diabetes Mellitus Progression among First-Generation Offspring of Lembak Ethnicity in Bengkulu, Indonesia Dita, Diah Ayu Aguspa; Yunita, Elvira; Rizqoh, Debie; Ashan, Hesty Rhauda; Fahira, Dita
Althea Medical Journal Vol 12, No 4 (2025)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v12n4.4448

Abstract

Background: Genetic and environmental factors influence the onset and progression of type 2 diabetes mellitus (T2DM). Variants affecting peroxisome proliferator activated-receptor gamma (PPAR-γ) and potassium, inwardly rectifying channel subfamily J member 11 (KCNJ11) may alter insulin secretion and sensitivity. This study investigated the association between PPAR-γ and KCNJ11 gene expression and the risk of T2DM among first-generation (F1) offspring of T2DM patients of Lembak ethnicity in Bengkulu, Indonesia.Methods: A cross-sectional observational study was conducted from July to September 2024, recruiting 60 unrelated participants aged 18–40 years, all of whom were exposed to the neron tradition (high-sugar consumption). Gene expression of PPAR-γ and KCNJ11 was determined using real-time quantitative PCR (qRT-PCR).Results: F1 offspring of T2DM patients (n=30) had significantly (p<0.05) higher body weight (66.89±15.62 kg; p=0.008), body mass index (BMI) (23.55±3.46 kg/m2), HbA1C (6.55±1.25), random blood glucose levels (median 131 [75–371] mg/dl), and duration of neron consumption (median 3 [1–12] years) compared with controls (n=30). PPAR-γ expression differed significantly between group (1.60±2.91 vs 4.23±8.54; p=0.009), whereas KCNJ11 expression did not (0.79±0.76 vs 1.37±0.89; p=0.124). Multivariate analysis revealed no correlation between gene expression and the patients characteristic (p>0.05). Linear regression showed 30.4% of PPAR-γ and 45.8% of KCNJ11 variability.Conclusions: PPAR-γ expression is associated with T2DM onset among Lembak F1 offspring, whilst KCNJ11 expression is not. Multiple genetic and environmental factors likely contribute to disease progression. Screening for PPAR-γ expression may support interventions targeting insulin sensitivity and lipid metabolism.
Co-Authors Ade Tiur Rumondang Ade Tiur Rumondang Adiansyah Ahmad Fandi Alvi Jalilul Hakim Ambarsarie, Riry Amelia, Aisyah Annelin Kurniati Annelin Kurniati Arifani, Novita Ashan, Hesty Rhauda Athalia , Nabila Wine Atik Prihatiningrum, Atik Atiqah, Rissya Febiona Azella Chika Fauzia Besly Sinuhaji Besly Sinuhaji Besly Sinuhaji Dendrinson Purba Dendrinson Purba Dessy Triana Dessy Triana Dessy Triana Diah Ayu Aguspa Dita Dian Handayani Djatmiko, Ellen Maidia Ellen Maidia Djatmiko Ellen Maidia Djatmiko Elvira Yunita Elvira Yunita Endang, Jusup Enny Nugrahaeni Enny Nugrahaeni Enny Nugraheni Enny Nugraheni Enny Nugraheni Enny, Nugraheni Ety Febrianti Ety Febrianti Fadlika, Rizki Fahira, Dita Fandi, Ahmad Fauzia, Azella Chika Febrianti, Ety Febrina, Olivia Putri Grace Junita Bate'e Gunasari, Lala Foresta Valentine Hakim, Alvi Jalilul Hamka Ismuda Hestina Hestina Iqbal, Maulana Jusup Endang Kumala, Wulan Okta Kurniati, Annelin Laudy, Nabila Putri Mardhatillah Sariyanti Mardhatillah Sariyanti Mardhatillah Sariyanti Mardhatillah Sariyanti Meidiyanti, Prima Mulya Sundari Mulya Sundari Mulya Sundari Mulya Sundari Mulya Sundari Mulya Sundari Nabilah, Putri Syifa Nikki Aldi Massardi Noor Diah Erlinawati Novita Arifani Nugraheni, Enny Nur Fitri Ocktaviani, Risti Dwi Oktavia Salsadillah Putri Oktavia Silalahi Oktoviani Oktoviani, Oktoviani Pratiwi, Ulfa Hanum Putri Maulida Rachmawati, Indah Dwi Ramadhani, Abdah Zhafirah Rizkianti Anggraini Roina Sitanggang Roina Sitanggang Sariyanti, Mardhatillah Sipriyadi Suryani, Utari Hartati Umar, Liya Agustin Utari Hartati Suryani Utari Hartati Suryani Wulan Okta Kumala