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Debie Rizqoh
Departemen Mikrobiologi Dan Imunologi, Fakultas Kedokteran Dan Ilmu Kesehatan, Universitas Bengkulu
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MANIFESTASI KLINIS DEMAM BERDARAH DENGUE (DBD) Enny Nugraheni; Debie Rizqoh; Mulya Sundari
JURNAL KEDOKTERAN DAN KESEHATAN Vol 10, No 3 (2023)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/JKK.V10I3.21425

Abstract

Abstrak Demam Berdarah Dengue ada penyakit infeksi yang disebabkan virus dengue. Manusia akan terinfeksi setelah diinfeksi oleh nyamuk Aedes Aegypti yang membawa virus DENV. Virus dengue terdiri dari 4 serotipe yaitu DENV-1, 2, 3 dan 4. Virus dengue dapat menyebabkan dua tipe infeksi yaitu infeksi primer dan infeksi sekunder. Infeksi primer dapat muncul sebagai demam akut atau disebut demam dengue yang akan dinetralisir dalam tujuh hari oleh respon imun. Sedangkan infeksi sekunder cenderung akan lebih berat dan akan mengakibatkan demam berdarah dengue (DBD) atau sindrom renjatan dengue (SRD).Manifestasi klinis DBD dapat diklasifikasikan berdasarkan kondisi klinis pasien dan hasil pemeriksaan penunjang. Kasus simptomatik dapat dibedakan menjadi beberapa klasifikasi diantaranya adalah undifferentiated febrile illness (UF), Demam Dengue (DD), Demam Berdarah Dengue (DBD), sindrom renjatan dengue (SRD) dan unusual dengue (UD). Manifestasi klinis dapat berdampak pada organ dan sistem yang ada di seluruh tubuh. Manifestasi klinis dengue bervariasi dari yang ringan sampai dengan berat. Manifestasi utama berupa adanya plasma leakage yang digambarkan pada fase awal adanya pendarahan ringan sampai berat. Tanda plasma leakage juga dapat ditemukan pada multiple organ Klasifikasi DBD dapat dilakukan berdasarkan WHO 1997 dan WHO 2009. Manifestasi klinis ini penting diketahui dan dipahami untuk menegakkan diagnosis yang cepat sehingga dapat melakukan penatalaksanaan DBD dengan baik sehingga mengurangi angka morbiditas dan mortalitas. Kata kunci: Syok, Infeksi, Gejala AbstractDengue Hemorrhagic Fever is an infectious disease caused by the dengue virus. Humans will become infected after being infected by the Aedes Aegypti mosquito that carries the DENV virus. Dengue virus consists of 4 serotypes namely DENV-1, 2, 3 and 4. Dengue virus can cause two types of infection, namely primary infection and secondary infection. Primary infection may appear as acute fever or called dengue fever which will be neutralized within seven days by the immune response. While secondary infections tend to be more severe and will result in dengue hemorrhagic fever (DHF) or dengue shock syndrome (SRD). The clinical manifestations of DHF can be classified based on the patient's clinical condition and the results of investigations. Symptomatic cases can be divided into several classifications including undifferentiated febrile illness (UF), Dengue Fever (DD), Dengue Hemorrhagic Fever (DHF), Dengue shock syndrome (SRD) and unusual dengue (UD). Clinical manifestations can impact organs and systems throughout the body. Dengue clinical manifestations vary from mild to severe. The main manifestation is the presence of plasma leakage which is described in the initial phase of light to heavy bleeding. Plasma leakage signs can also be found in multiple organs. Classification of DHF can be done based on WHO 1997 and WHO 2009. . It is important to know and understand these clinical manifestations in order to make a quick diagnosis so that DHF can be managed properly, thereby reducing morbidity and mortality.Keywords: Shock, infection, symptom
ANALISA BASIL TAHAN ASAM PADA DAHAK PENDERITA TUBERKULOSIS SEBELUM DAN SESUDAH MENDAPAT PENGOBATAN OBAT ANTI TUBERKULOSIS DI UPT. RUMAH SAKIT KHUSUS PARU MEDAN Ellen Maidia Djatmiko; Debie Rizqoh; Putri Maulida; Elvira Yunita
Jurnal Medika Malahayati Vol 7, No 3 (2023): Volume 7 Nomor 3
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jmm.v7i3.10845

Abstract

Abstrak: Analisa Basil Tahan Asam pada Dahak Penderita Tuberculosis Sebelum dan Sesudah Mendapat Pengobatan Obat Anti Tuberculosis di UPT. Rumah Sakit Khusus Paru Medan. Tuberkulosis (TB) adalah penyakit menular akut maupun kronis, terutama menyerang paru, yang disebabkan oleh Mycobacterium tuberculosis. Tuberkulosis merupakan penyakit yang menjadi perhatian global. Obat Anti Tuberkulosis (OAT) adalah komponen terpenting dalam pengobatan tuberkulosis untuk mencegah penyebaran lebih lanjut dari kuman tuberkulosis dan mempercepat proses penyembuhan pasien TB. Tujuan penelitian ini adalah untuk mengetahui BTA pada dahak penderita TB paru sebelum dan sesudah mendapat pengobatan OAT. Jenis penelitian ini bersifat deskriptif yang dilakukan di UPT. Rumah Sakit Khusus Paru Medan pada bulan Juli–Agustus 2017. Pemeriksaan ini dilakukan secara mikroskopis dengan menggunakan metode pewarnaan Ziehl Neelsen terhadap 17 sampel yang telah mendapat pengobatan OAT selama 6 bulan secara teratur. Dari hasil penelitian ini dapat menunjukkan adanya perubahan pada pasien TB Paru sebelum dan sesudah mendapat pengobatan OAT selama 6 bulan secara teratur. Data pemeriksaan awal sebelum mendapat pengobatan terdapat 100% dengan hasil pemeriksaan BTA (+3) dan sesudah mendapat pengobatan OAT selama 6 bulan secara teratur tidak ditemukan BTA (negatif) yaitu 0%. Hal ini menunjukkan bahwa efektifitas pengobatan di Labotratorium UPT. Rumah Sakit Khusus Paru Medan dapat dikatakan baik.
CONTAMINATION OF ESCHERICHIA COLI IN ES CAMPUR SOLD AT PETISAH MARKET IN MEDAN CITY Debie Rizqoh; Oktavia Silalahi
Proceeding B-ICON Vol. 2 No. 1 (2023): Proceeding of The 3rd Bengkulu International Conference on Health (B-ICON 2023)
Publisher : Poltekkes Kemenkes Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33088/bicon.v2i1.84

Abstract

Es Campur is a typical Indonesian drink that is made by mixing various types of drink ingredients in sweet syrup. Es Campur can be contaminated with Escherichia coli bacteria through unsterilized tools. This study aimed to determine the presence of E. coli in Es Campur being traded around the Petisah Market in Medan. Data analysis was carried out descriptively by looking at the percentage in the form of frequency and then analyzed by comparing the existing literature theory. The study used Lactose Broth, Endo Agar, IMVIC and TSI media. The population in this study were all Es Campur, traded around the Medan Petisah Market. Es Campur is contaminated with E. coli. The results of the Es Campur research conducted from 10 samples were two samples contaminated with E. coli bacteria. It is suggested to the public that when buying Es Campur, they need to pay attention to the cleanliness of the places where they are sold, whether it is the place used to wrap Es Campur drinks.
ANTIBODY IgG LEVELS AND ADVERSE EVENTS FOLLOWING IMMUNIZATION AFTER THIRD DOSE OF MODERNA VACCINE IN HEALTHWORKERS AFTER TWO DOSES OF SINOVAC VACCINE Ade Tiur Rumondang; Utari Hartati Suryani; Debie Rizqoh; Mardhatillah Sariyanti; Besly Sinuhaji
Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Vol. 10 No. 2 (2023): Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Univers
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/jkk.v10i2.345

Abstract

Health Care Workers (HCWs) are a top priority to receive the vaccination for Coronavirus Disease 2019 (Covid-19). After two doses of the Sinovac vaccine as the primary vaccine, protection against Covid-19 weakens over time, so a booster vaccination is considered to produce more antibodies. In addition, each vaccine is inseparable from Adverse Event Following Immunization (AEFI). This study compares antibody levels and AEFIs between two doses of the Sinovac vaccine with the Moderna booster. This research is an observational analytic study with a cross-sectional study design and the sampling method is random sampling with a total of 74 HCWs using a consecutive sampling method. Samples that had received two doses of the Sinovac vaccine or booster doses of the Moderna vaccine after two doses of the Sinovac vaccine were included. Samples that had been infected with Covid-19 before vaccination were excluded. IgG antibody levels were measured using Chemiluminescent Microparticle Immunoassay (CMIA), while vaccine type and AEFI were gathered via questionnaire. The severity of AEFIs is based on WHO classification. The data analysis used the Mann- Whitney and Chi-Square tests with a 95% Confidence Interval (CI) to determine the relationship between variables. Twenty-nine subjects received two doses of the Sinovac primary vaccine (38.2%), and forty-five received the Moderna booster vaccine (59.2%). In booster doses of the Moderna vaccine recipients, antibodies tended to be higher, and the most common AEFIs were systemic. There was a significant difference in IgG antibody levels between recipients of two doses of the Sinovac vaccine (median=2888.8 AU/mL) and booster Moderna vaccine recipients (median=18081.04 AU/mL) (p=0.000, p <0.05). There were significant differences in AEFI in the groups receiving two doses of the Sinovac vaccine and those receiving the booster vaccine (p=0.000, p<0.05). This study concludes that there is a significant correlation between administering the Covid-19 vaccine and post-vaccination IgG antibody levels and AEFI.
MANIFESTASI KLINIS DEMAM BERDARAH DENGUE (DBD) Enny Nugraheni; Debie Rizqoh; Mulya Sundari
Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Vol. 10 No. 3 (2023): Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Univers
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/jkk.v10i3.357

Abstract

Demam Berdarah Dengue ada penyakit infeksi yang disebabkan virus dengue. Manusia akan terinfeksi setelah diinfeksi oleh nyamuk Aedes Aegypti yang membawa virus DENV. Virus dengue terdiri dari 4 serotipe yaitu DENV-1, 2, 3 dan 4. Virus dengue dapat menyebabkan dua tipe infeksi yaitu infeksi primer dan infeksi sekunder. Infeksi primer dapat muncul sebagai demam akut atau disebut demam dengue yang akan dinetralisir dalam tujuh hari oleh respon imun. Sedangkan infeksi sekunder cenderung akan lebih berat dan akan mengakibatkan demam berdarah dengue (DBD) atau sindrom renjatan dengue (SRD).Manifestasi klinis DBD dapat diklasifikasikan berdasarkan kondisi klinis pasien dan hasil pemeriksaan penunjang. Kasus simptomatik dapat dibedakan menjadi beberapa klasifikasi diantaranya adalah undifferentiated febrile illness (UF), Demam Dengue (DD), Demam Berdarah Dengue (DBD), sindrom renjatan dengue (SRD) dan unusual dengue (UD). Manifestasi klinis dapat berdampak pada organ dan sistem yang ada di seluruh tubuh. Manifestasi klinis dengue bervariasi dari yang ringan sampai dengan berat. Manifestasi utama berupa adanya plasma leakage yang digambarkan pada fase awal adanya pendarahan ringan sampai berat. Tanda plasma leakage juga dapat ditemukan pada multiple organ Klasifikasi DBD dapat dilakukan berdasarkan WHO 1997 dan WHO 2009. Manifestasi klinis ini penting diketahui dan dipahami untuk menegakkan diagnosis yang cepat sehingga dapat melakukan penatalaksanaan DBD dengan baik sehingga mengurangi angka morbiditas dan mortalitas.
Edukasi Manfaat Vaksinasi Mengenai Dampak Infeksi Covid-19 di SMKS 9 Muhammadiyah Kota Bengkulu Dita, Diah Ayu Aguspa; Ocktaviani, Risti Dwi; Sariyanti, Mardhatillah; Rizqoh, Debie
DHARMA RAFLESIA Vol 20 No 2 (2022): DESEMBER (ACCREDITED SINTA 5)
Publisher : Universitas Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33369/dr.v20i2.21273

Abstract

The COVID-19 pandemic is a major challenge to Indonesia’s to improve public health. Vaccination has been increased in the fight against COVID-19. The education goal is to raise awareness about the advantages of COVID-19 vaccination. Ten teachers and education staff are taking part in this community service project. This activity began with completing a pre-test questionnaire about the advantages of the COVID-19 vaccination, followed by counseling from expertise and completing the post-test questionnaire. The results of the questionnaire evaluation after counseling improved by 95%, indicating a better understanding of the advantages of COVID-19 vaccination. Throughout the outreach activities, all participants were enthusiastic about the material presented while also discussing the hoaxes that were currently circulating in the community.
Akurasi Pemeriksaan Kato-Katz dan Mini-Flotac Dalam Diagnosis Kecacingan pada Feses Segar dan Feses Awetan Iqbal, Maulana; Triana, Dessy; Rizqoh, Debie; Gunasari, Lala Foresta Valentine; Umar, Liya Agustin
Jurnal Kedokteran dan Kesehatan Vol 19, No 1 (2023): JURNAL KEDOKTERAN DAN KESEHATAN
Publisher : Faculty of Public Health, Faculty of Medicine and Health, Universitas Muhammadiyah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24853/jkk.19.1.74-82

Abstract

Soil transmitted helminth (STH) penyebab infeksi kecacingan dengan insiden 24% pada populasi di dunia. Diagnosis infeksi STH dapat dilakukan dengan pemeriksaan feses secara mikroskopis dengan metode Kato-Katz sebagai baku emas dan metode Mini-Flotac. Tujuan penelitian menganalisis akurasi hasil pemeriksaan feses menggunakan metode Kato-Katz dan metode Mini-Flotac pada feses awetan formalin 10%. Rancangan penelitian menggunakan studi observasional dengan uji diagnostik. Subjek pada penelitian berjumlah 140 sampel feses awetan formalin 10% selama 13 bulan. Pemeriksaan spesimen feses awetan menggunakan metode Kato-Katz dan Mini-Flotac serta diamati dengan menggunakan mikroskop cahaya. Data analisis dilakukan dengan uji T. Hasil penelitian menunjukkan sebagian besar sampel feses awetan terinfeksi Ascaris lumbricoides dengan metode Kato-Katz (34,28%) dan Mini-Flotac (41,42%), dan infeksi Trichuris trichiura dengan metode Kato-Katz (15,71%) dan Mini-Flotac (22,85%). Tidak terdapat perbedaan yang signifikan antara metode Kato-Katz dan Mini-Flotac dalam mendeteksi infeksi Ascaris lumbricoides (p=0.96) dan Trichuris trichiura (p=0,76). Metode Mini-Flotac dapat menjadi alternatif dalam diagnosis infeksi STH.
HUBUNGAN ANTARA KETIDAKSEIMBANGAN KOMPOSISI MIKROBIOTA USUS TERHADAP GANGGUAN KESEHATAN : TELAAH LITERATUR Rizqoh, Debie; Laudy, Nabila Putri; Atiqah, Rissya Febiona; Fadlika, Rizki
Jurnal Medika Malahayati Vol 8, No 2 (2024): Volume 8 Nomor 2
Publisher : Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jmm.v8i2.14796

Abstract

Mikrobiota usus merupakan sekumpulan mikroorganisme yang berkolonisasi saluran pencernaan dan ditemukan dalam proporsi yang lebihtinggi dibandngkan sel sel utbuh lainnya. Mikrobiota usus  berperan sebagai penghalang masuknya patogen, sistem pencernaan, metabolisme, menjaga sistem imunitas, dan pengobatan gangguan sistem saraf pusat. Komposisi mikrobiota usus dipengaruhi oleh faktor internal dan eksternal. Ketidakseimbangan komposisi mikrobiota usus berdampak pada kesehatan tubuh manusia secara keseluruhan dikarenakan keterlibatannya dalam berbagai interaksi. Ketidakseimbangan komposisi mikrobiota usus disebut dysbiosis yang dapat menyebabkan berbagau masalah kesehatan seperti, radang usus, obesitas, gangguan hati, diabetes mellitus, gangguan kardiovaskuler, HIV, radang sendi, asma, asam urat, gangguan neurologis.
Novel Endophytic Bacteria Isolates from Andaliman (Zancthoxylum acanthopodium DC.) which Potentially Inhibit Escherichia coli and Staphylococcus aureus Rizqoh, Debie; Amelia, Aisyah; Kumala, Wulan Okta; Sipriyadi, Sipriyadi; Suryani, Utari Hartati; Sariyanti, Mardhatillah
Journal of Biomedicine and Translational Research Vol 10, No 1 (2024): April 2024
Publisher : Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jbtr.v10i1.21740

Abstract

Background: Irrational use of antibiotics has various side effects to resistance. Utilization of secondary metabolites of Andaliman plant endophytic bacteria (Z. acanthopodium DC) is an alternative known to act as an antibacterial to overcome this problem.Objective: This study aimed to determine the antimicrobial activity of the crude extract of Andaliman endophytic bacteria against Escherichia coli and Staphylococcus aureus.  Methods: This research is an experimental laboratory with qualitative data collection methods. The initial stages will be the isolation of endophytic bacteria from Andaliman, the antagonist test of Andaliman endophyte isolates against E. coli and S. aureus, and the extraction of endophytic bacterial isolates using ethyl acetate as solvent. An antagonistic test of bacterial isolate extract was performed using the disc diffusion method against pathogenic bacteria E. coli and S. aureus and observed by an inhibition zone. The final stage is the minimum inhibition test of endophytic isolates by dilution method on three potential endophytic isolates.Results: The results of the extraction of isolates EAA22, EAA28, EAB5, EAB6, and EAB7 Andaliman endophytic bacteria have inhibitory activity against S.aureus, and the results of the extraction of isolates EAB5, EAB6, EAA22 have inhibitory activity against E. coli.Conclusion: Endophyte bacteria isolates from Andaliman produce antibacterial compounds against E. coli and S. aureus. 
Kinetics IgM and IgG SARS-CoV-2 in Recovery patients with Negative Evaluation RT-PCR Endang, Jusup; Sariyanti, Mardhatillah; Triana, Dessy; Rizqoh, Debie; Enny, Nugraheni
Jurnal Ilmu Kesehatan dan Kesehatan Vol 7 No 02 (2023): AUGUST
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/mhsj.v7i02.4359

Abstract

Background: Coronavirus is the major pathogens at human respiratory system. The antibody is a response infected patients largely not clearly. We need to understanding of antibody responses to great diagnosis and treatment studies. Objective: In this article the objective is to describe that kinetics of IgM and IgG SARS-CoV-2 in recovery patients. Method: Cohort study used a total 19 subjects who had negative evaluation RT-PCR after confirmed. IgG and IgM of SARS-CoV-2 were detected by IFA (Immuno fluorosence assay) used serum. Serum were collected 3 times after 1 month, 2 month and 4 month negative evaluation RT-PCR We profiled the serological responses (IgM and IgG) to SARS-CoV-2. Result: Majority the IgM SARS-CoV-2 post evaluation RT-PCR were very low after 1,2,4 month negative evaluation. IgG SAR-CoV-2 patients post negative evaluation RT-PCR decreased after 4 months. The level IgM and IgG level increase at first week and decrease after 12 weeks. Conclusion: IgM level lower than IgG level overtime. Quantitative IgG and IgM detection could be point of diagnosis and manifestation.
Co-Authors Ade Tiur Rumondang Ade Tiur Rumondang Adiansyah Ahmad Fandi Alvi Jalilul Hakim Ambarsarie, Riry Amelia, Aisyah Annelin Kurniati Annelin Kurniati Arifani, Novita Ashan, Hesty Rhauda Athalia , Nabila Wine Atik Prihatiningrum, Atik Atiqah, Rissya Febiona Azella Chika Fauzia Besly Sinuhaji Besly Sinuhaji Besly Sinuhaji Dendrinson Purba Dendrinson Purba Dessy Triana Dessy Triana Dessy Triana Diah Ayu Aguspa Dita Dian Handayani Djatmiko, Ellen Maidia Ellen Maidia Djatmiko Ellen Maidia Djatmiko Elvira Yunita Elvira Yunita Endang, Jusup Enny Nugrahaeni Enny Nugrahaeni Enny Nugraheni Enny Nugraheni Enny Nugraheni Enny, Nugraheni Ety Febrianti Ety Febrianti Fadlika, Rizki Fahira, Dita Fandi, Ahmad Fauzia, Azella Chika Febrianti, Ety Febrina, Olivia Putri Grace Junita Bate'e Gunasari, Lala Foresta Valentine Hakim, Alvi Jalilul Hamka Ismuda Hestina Hestina Iqbal, Maulana Jusup Endang Kumala, Wulan Okta Kurniati, Annelin Laudy, Nabila Putri Mardhatillah Sariyanti Mardhatillah Sariyanti Mardhatillah Sariyanti Mardhatillah Sariyanti Meidiyanti, Prima Mulya Sundari Mulya Sundari Mulya Sundari Mulya Sundari Mulya Sundari Mulya Sundari Nabilah, Putri Syifa Nikki Aldi Massardi Noor Diah Erlinawati Novita Arifani Nugraheni, Enny Nur Fitri Ocktaviani, Risti Dwi Oktavia Salsadillah Putri Oktavia Silalahi Oktoviani Oktoviani, Oktoviani Pratiwi, Ulfa Hanum Putri Maulida Rachmawati, Indah Dwi Ramadhani, Abdah Zhafirah Rizkianti Anggraini Roina Sitanggang Roina Sitanggang Sariyanti, Mardhatillah Sipriyadi Suryani, Utari Hartati Umar, Liya Agustin Utari Hartati Suryani Utari Hartati Suryani Wulan Okta Kumala