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Journal : INDONESIAN JOURNAL OF PHARMACY

MONOSODIUM GLUTAMATE EXPOSURE AT EARLY DEVELOPMENTAL STAGE INCREASES APOPTOSIS AND STEREOTYPIC BEHAVIOR RISKS ON ZEBRAFISH (DANIO RERIO) LARVAE Nia Kurnianingsih; Juliyatin Putri Utami; Nurdiana Nurdiana; Diana Lyrawati
Indonesian Journal of Pharmacy Vol 27 No 3, 2016
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1107.374 KB) | DOI: 10.14499/indonesianjpharm27iss3pp128

Abstract

Excessive glutamate may give neurotoxic effects and contribute to Autism spectrum disorder(ASD). In this study, we investigated prolonged exposure effects of 10 µg/mL Monosodium Glutamate (MSG) on intracellular calcium level, bax, bcl-2, ratio of bax/bcl-2 genes expression, caspase-3, apoptosis of brain cells and stereotypic behavior of Zebrafish (Danio rerio) larvae at early developmental stages. Genes expression were determined by real time PCR, caspase-3 using ELISA, intracellular Ca2+ and apoptotic cells of brain using confocal microscopy, locomotor activity by using crossing lines assay whereas stereotypic behavior by circle swimming. The results indicated that MSG exposure increased brain bax and bcl-2; and caspase-3; intracellular Ca2+; and apoptosis; stereotypic behavior; and decreased locomotor activity. Termination of MSG treatments resulted in recovery of bax, bcl-2, caspase-3 basal levels and stereotypic behavior. In conclusion, MSG exposure at early embryonic stage increased brain cell damage and risk of behavior changes.
Co-Authors Adhiya, Geyanina Melda Agung Satria Wardhana Ainna Dewi Iriani Amalia, Aysca Fakhira Amy Nindia Carabelly Anisa Novia Farrasti Annisa Noviany Aprilyani, Nur Arifin, Rahmad Aspriyanto, Didit At-Thoyyar, Aila Azminida, Dhiya Salma Baitullah, Muhammad Akbar Bambang Setiawan Beta Widya Oktiani Budiarman, Andi Azizah Maulidia Dewi Indah Noviana Pratiwi, Dewi Indah Noviana Dewi Nurdiana Dewi Purboningsih Dewi Puspitasari Dewi Puspitasari Diana Lyrawati Diana Wibowo Erika Norfitriyah Eriwati, Yosi Kusuma Erni Marlina Febriansyah, Muhammad Firda Damayanti Firdaus, I Wayan Arya Krishnawan Fransiska Uli Arta Panjaitan Gita Puspa Ningrum Hadi Waskito Haluanry Doane Santoso Hatta, Isnur Ichrom Nahzi, Muhammad Yanuar Idhafi, Nasrul Ika Kusuma Wardani Jatmiko, Habibi Naufal Kelana, Adhytya Suryo Krishnawan Firdaus, I Wayan Arya Kurnianingsih, Nia Lena Rosida Maghfirah, Yolanda Sajjida Maharani Laillyza Apriasari Maharani Laillyza Apriasari Maria Tanumihardja, Maria Maulida, Novi Dwi Melisa Budipramana, Melisa Milka Widya Sari Mira Hadistiana Monita Valentine Silalahi Muhammad Adeya Herdira Putra Muhammad Akbar Baitullah Muhammad Hasanu Reksi Muhammad Reza Faisal, Muhammad Reza Muhammad Rizal Bima Saputra Nahzi, Yanuar Ichrom Nanda Putri Arini Nia Kurnianingsih Nida, Raihatun Nisa Fachrizha Munier Norfitriyah, Erika Novi Dwi Maulida Novia Damayanti Nur Tsaniya, Gusti Erysa Nurdiana Nurdiana Oktiani, Beta Widya Panghiyangani, Roselina Pramitha, Selviana Rizky Priyawan Rachmadi Rahmad Arifin Ramadhaniyah, Nur Roselina Panghiyangani Safa Muzdalifah Salsabila, Namira Fathya Sandra Bhakti Mafriana Sari, Galuh Dwinta Sari, Milka Widya Sarifah, Norlaila Sherli Diana Tri Putri, Deby Kania Wydiamala, Erida Yunike Christanti Yusrinie Wasiaturrahmah