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Molecular Docking of Citrus amblycarpa Active Compounds against FTO, Leptin, and Resistin Protein Roselina Panghiyangani; Juliyatin Putri Utami; Muhammad Akbar Baitullah; Novi Dwi Maulida
Molecular and Cellular Biomedical Sciences Vol 7, No 1 (2023)
Publisher : Cell and BioPharmaceutical Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21705/mcbs.v7i1.295

Abstract

Background: Citrus amblycarpa has been known to have various pharmacological activities, such as antioxidants, anticancer, antitumor, hepatoprotective, anti-inflammatory, antidiabetic, antiviral, antibacterial, and antifungal. Hesperidin, naringin, quercetin, rutin, gamma (γ)-aminobutyric acid (GABA), neoeriocitrin, and poncirin from C. amblycarpa were the major constituents that potentially act on some obesity proteins, such as fat mass and obesity-associated (FTO) protein, leptin, and resistin, the emerging targets in the treatment of obesity. This study aimed to investigate the interaction between major active compounds of C. amblycarpa with FTO, leptin and resistin.Materials and methods: The ligands of the docking study were seven major chemical compounds found in peel of C. amblycarpa, i.e., hesperidin, naringin, quercetin, rutin, GABA, neoeriocitrin, and poncirin. FTO, leptin and resistin structure were taken from Protein Data Bank, while the C. amblycarpa compounds were prepared using Open Babel integrated into PyRx 8.0. Molecular docking simulation was performed using Autodock Vina integrated into PyRx 8.0. Virtual prediction and visualization of protein–ligand complexes were analyzed and visualized using Discovery Studio.Results: All major compounds of C. amblycarpa peel used in this study did not have hepatotoxicity and AMES toxicity. Hesperidin had the lowest binding affinity score when interacted with FTO, leptin and resistin compared to other compounds. Moreover, GABA had the highest binding affinity score compared to other compounds.Conclusion: Hesperidin may be a candidate obesity protein antagonist and may have potential as a treatment for obesity.Keywords: Citrus amblycarpa, molecular docking, FTO, leptin, obesity, resistin
STUDY ANALYSIS OF ORAL TUBERCULOSIS LESION IN SOUTH KALIMANTAN, INDONESIA Maharani Laillyza Apriasari; Monita Valentine Silalahi; Isnur Hatta; Juliyatin Putri Utami
Odonto : Dental Journal Vol 7, No 1 (2020): July 2020
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (730.641 KB) | DOI: 10.30659/odj.7.1.1-8

Abstract

Background: Tuberculosis is an infectious disease which is the second-largest cause of death in the world after HIV / AIDS. Tuberculosis caused by Mycobacterium tuberculosis that usually attacks the lungs but can manifest in the oral mucosa. Clinical manifestations of oral Tuberculosis related to age, sex, duration of treatment, systemic disease, and Multi-Drug Resistant therapy. There is no research on descriptive studies of oral manifestations of tuberculosis patients in South Kalimantan, specifically in Banjarmasin. This study aims to analyze the clinical manifestations of oral Tuberculosis descriptively in South Kalimantan, Indonesia. Method: This was a descriptive analysis with cross-sectional study design, based on history and clinical oral examination. It was used 30 respondents by purposive sampling method. Data were analyzed by Chi-square (p<0.05). Results: During treatment, it showed the correlation between xerostomia and systemic disease (diabetes mellitus and HIV/AIDS) are (p=0.007) and a correlation between xerostomia and duration of treatment (p=0.024). The correlation between candidiasis and systemic disease (p=0.024). The correlation between angular cheilitis and age, sex, duration of treatment, systemic disease, and Multi-Drug Resistant therapy (p>0.05). The clinical manifestations of oral Tuberculosis are xerostomia, candidiasis, and angular cheilitis.Conclusion: The duration of treatment and the systemic diseases are associated with xerostomia and candidiasis in the oral cavity of TB patients.
FOURIER-TRANSFORM INFRARED SPECTROSCOPY ANALYSIS OF MAULI BANANA (MUSA ACUMINATA) EXTRACT AS A POTENTIAL PULP WOUND HEALING Dewi Puspitasari; Muhammad Yanuar Ichrom Nahzi; Yosi Kusuma Eriwati; Erni Marlina; Maharani Laillyza Apriasari; Maria Tanumihardja; Juliyatin Putri Utami; Amy Nindia Carabelly
Dentino : Jurnal Kedokteran Gigi Vol 8, No 2 (2023)
Publisher : FKG Unlam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v8i2.17536

Abstract

Background: Pulp wound healing is a critical aspect of endodontics, aiming to preserve the vitality and function of dental pulp tissues. Natural compounds have gained attention for their potential therapeutic applications in dentistry. Mauli banana (Musa acuminata) is a tropical fruit in South Kalimantan as one of the natural plants that have the ability as antibacterial, antifungal, anti-inflammatory, antioxidant, and immunomodulatory effects contains various bioactive molecules with potential pulp wound healing properties. Purpose: to identify and evaluate the functional groups present in mauli banana stem extracts. Methods: This study is true experimental research, the samples were mauli banana stem that were extracted with maceration technique and were subjected to Fourier-Transform Infrared Spectroscopy test. Results: Identification of functional groups of organic compounds from mauli banana are as follows: a) Peak 3638.95 cm-1  show O-H (nonbonded hydroxy group, OH stretch primary) component alcohol, b) Peak 3265.82 cm-1is C-H (alkane), c) Peak 2928.09 cm-1  refer to OH (carboxylic acid hydrogen bonds) and aldehydes groups, d) peak 1571.35 cm-1 refers to amide, C=O - asymetric stretching, e) peak 1400.82 cm-1, refers to CO2- symetric stretching and carboxylate (carboxylic acid salt) CH2 scissoring, f) peak 1030.17 cm-1 refers to C=C (alkanes), aliphatic phosphate, g)  Peak 520.53 cm-1 refers to inorganic phosphates. Conclusion: FTIR spectra analysis of mauli banana stem extract show the presence of O-H hydroxy groups, aldehydes groups, carbonyl groups, aliphatic groups, carbonyl groups, amides groups and C-O stretching vibrations suggests that the extract contains various bioactive molecules with potential pulp wound healing properties.
TOXICITY TEST OF CHANNA MICROPELTES EXTRACT BETWEEN NORMAL WISTAR RATS AND DIABETES MODEL BASED ON CARDIAC HISTOPATHOLOGY Annisa Noviany; Amy Nindia Carabelly; Juliyatin Putri Utami
Dentino : Jurnal Kedokteran Gigi Vol 8, No 2 (2023)
Publisher : FKG Unlam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v8i2.17525

Abstract

Background: DM is metabolic disease can prolong wound healing phase and cause oxidative stress that can affect cardiac damage such as degeneration, hypertrophy, and necrosis. They can be inhibited by the effect of 16 ml/kg BW CM containing palmitic acid (18.30%), albumin (3.6147g/dl), and amino acids are leucine (1.58%) and valine (0.97%). It's proven to accelerate wound healing in normal Wistar rats and DM. However, CM extract on the cardiac is unknown, so an acute toxicity test was carried out for 14 days. Purpose: To analyze the effect of oral administration of CM extract at an effective dose of 16 ml/kg BW on the histopathological exam of degeneration, hypertrophy, and cardiac necrosis of normal Wistar rats and diabetic models. Method: This study is true experimental study with a post-test only control group design which is divided into 4 groups are 2 groups of Wistar rats normal and diabetic models who were given CM extract at an effective dose of 16 ml/kg BW, 2 groups consisted of normal Wistar rats and diabetic models which were only given BR2 feed. Results: T-Independent test and the Mann-Whitney test showed that there was a significant difference between degeneration and hypertrophy (p<0.05) and necrosis. There was no significant difference (p>0.05). Conclusion: The effective dose of CM extract 16 ml/kg BW had an effect on the cardiac of normal Wistar rats and diabetic models in the form of a decrease in the level of damage to degeneration, hypertrophy, and cardiac necrosis. Keywords: Cardiac, Channa micropeltes, Degeneration, Hypertrophy, Necrosis.Background: DM is metabolic disease can prolong wound healing phase and cause oxidative stress that can affect cardiac damage such as degeneration, hypertrophy, and necrosis. They can be inhibited by the effect of 16 ml/kg BW CM containing palmitic acid (18.30%), albumin (3.6147g/dl), and amino acids are leucine (1.58%) and valine (0.97%). It's proven to accelerate wound healing in normal Wistar rats and DM. However, CM extract on the cardiac is unknown, so an acute toxicity test was carried out for 14 days. Purpose: To analyze the effect of oral administration of CM extract at an effective dose of 16 ml/kg BW on the histopathological exam of degeneration, hypertrophy, and cardiac necrosis of normal Wistar rats and diabetic models. Method: This study is true experimental study with a post-test only control group design which is divided into 4 groups are 2 groups of Wistar rats normal and diabetic models who were given CM extract at an effective dose of 16 ml/kg BW, 2 groups consisted of normal Wistar rats and diabetic models which were only given BR2 feed. Results: T-Independent test and the Mann-Whitney test showed that there was a significant difference between degeneration and hypertrophy (p<0.05) and necrosis. There was no significant difference (p>0.05). Conclusion: The effective dose of CM extract 16 ml/kg BW had an effect on the cardiac of normal Wistar rats and diabetic models in the form of a decrease in the level of damage to degeneration, hypertrophy, and cardiac necrosis. Keywords:       Cardiac, Channa micropeltes, Degeneration, Hypertrophy, Necrosis.
Molecular Docking of the Interaction between Citrus amblycarpa Extract Contents and Inflammatory Proteins of Hepatic Steatosis Rosida, Lena; Pratiwi, Dewi Indah Noviana; Panghiyangani, Roselina; Utami, Juliyatin Putri; Idhafi, Nasrul; Febriansyah, Muhammad; Budiarman, Andi Azizah Maulidia
Makara Journal of Science Vol. 28, No. 2
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Citrus amblycarpa possesses various pharmacological activities, such as antioxidant, anticancer, antitumor, hepatoprotective, anti-inflammatory, antidiabetic, antiviral, antibacterial, and antifungal. The main active compounds in C. amblycarpa (including gamma (γ)-aminobutyric acid [GABA], hesperidin, naringin, neoeriocitrin, poncirin, quercetin, and rutin) show potential to interact with the inflammatory proteins in hepatic steatosis (such as nuclear factor kappa beta [NF-kB], tumor necrosis alpha [TNF-alpha], interleukin-6 [IL-6], c-Jun NH2-terminal kinase [JNK], and adiponectin). Molecular docking simulations were performed using Swiss Dock (http://www.swissdock.ch/), and analysis and visualization were conducted using Discovery Studio 4.1. Rutin, poncirin, hesperidin, and neoeriocitrin exhibit high affinities to NF-κB, TNF-alpha, IL-6, and adiponectin proteins, respectively. Similar to curcumin–adiponectin complex interaction, neoeriocitrin–adiponectin interaction involves GLY 223, PRO41, and VAL93 residues. Thus, the most potent inhibitor of hepatic sterosis marker was neoeriocitrin.
ANTIBACTERIAL ACTIVITY OF PAPUYU FISH SCALE CHITOSAN (Anabas testudineus) AGAINST Staphylococcus aureus At-Thoyyar, Aila; Ichrom Nahzi, Muhammad Yanuar; Puspitasari, Dewi; Aspriyanto, Didit; Utami, Juliyatin Putri
Dentino: Jurnal Kedokteran Gigi Vol 9, No 2 (2024)
Publisher : FKG ULM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v9i2.20399

Abstract

Backgrounds: Pulp disease due to caries can be treated through endodontic treatment, which aims to eliminate bacteria in the root canal so microorganisms cannot multiply. Staphylococcus aureus is a resistant microorganism causing root canal treatment failure. Chlorhexidine as a gold standard cannot remove biofilm and other organic debris. Utilization of nature, chitosan of papuyu fish scales (Anabas testudineus) has antibacterial properties that can be an alternative root canal irrigation material. Purpose: Analyze the antibacterial activity of chitosan of papuyu fish scales against Staphylococcus aureus based on the Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC). Methods: This research is a true experimental design with posttest only with control group design. The research groups were chitosan of Papuyu fish scales with concentrations of 25%, 50%, 75%, 100%, chlorhexidine gluconate 2% (positive control), and aquadest (negative control) with 6 repetitions. Results: The MIC value in the One-Way ANOVA test showed a significant difference (p<0.05). Data analysis followed by Post Hoc Games-Howell test showed all treatment groups had significant differences between each other (p<0.05). The MBC value in the Kruskal Wallis test shows that there is a significant difference (p<0.05). Data analysis followed by MannWhitney test showed significant differences between each other (p<0.05) except for the group of papuyu fish scale chitosan 25% concentration against papuyu fish scale chitosan 50% concentration, papuyu fish scale chitosan 100% concentration against chlorhexidine gluconate 2% (p>0.05). Conclusion: There is a difference in the antibacterial activity of chitosan of Papuyu fish scales concentrations of 25%, 50%, 75%, 100%, chlorhexidine gluconate 2% (positive control) and aquadest (negative control) against Staphylococcus aureus bacteria.
TOXICITY TEST OF Eusideroxylon zwageri BARK EXTRACT BASED ON LIVER HISTOPATHOLOGY HYDROPIC DEGENERATION AND NECROSIS Azminida, Dhiya Salma; Firdaus, I Wayan Arya Krishnawan; Utami, Juliyatin Putri; Oktiani, Beta Widya; Wydiamala, Erida
Dentino: Jurnal Kedokteran Gigi Vol 9, No 2 (2024)
Publisher : FKG ULM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v9i2.20400

Abstract

Background: Ironwood bark extract contains antioxidant properties such as flavonoids, phenolics, and proanthocyanidins, which can stabilize ROS in the body and help accelerate wound healing. The liver plays a role in nutrient metabolism, detoxification, and ROS production. The lack of antioxidants to neutralize excess ROS makes the liver vulnerable to damage. Purpose: This study aimed to determine that there was no toxic effect of giving ironwood bark extract (Eusideroxylon zwageri) doses of 1.250 mg/kg, 2.750 mg/kg, and 4.750 mg/kg on the liver of Wistar rats based on histopathological features of hydropic degeneration and necrosis. Methods: Pure laboratory experimental quantitative (true experimental) with a post-test-only research design with control group design and One Way Anova statistical test. Treatment was given to 4 groups, namely group (K) was given aquadest control, group (T1) was given ironwood bark extract at a dose of 1.250 mg/kgBW, group (T2) was given ironwood bark extract at a dose of 2.750 mg/kgBW, and group (T3) given ironwood bark extract at a dose of 4.750 mg/kgBW. Results: The results showed no significant difference between the four treatment groups based on the average percentage of hydropic degeneration and necrosis. Conclusion: There was no toxic effect of giving ironwood bark extract doses of 1.250 mg/kgBW, 2.750 mg/kgBW, and 4.750 mg/kgBW on the liver of Wistar rats based on histopathological appearance of hydropic degeneration and necrosis for 14 days.
THE CORRELATION OF OROMOTOR DYSFUNCTION TO ORAL HEALTH-RELATED QUALITY OF LIFE IN CHILDREN WITH DOWN SYNDROME Dewi, Nurdiana; Kelana, Adhytya Suryo; Utami, Juliyatin Putri
Dentino: Jurnal Kedokteran Gigi Vol 9, No 1 (2024)
Publisher : FKG ULM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v9i1.18867

Abstract

Background: The genetic condition known as Down syndrome (DS) is brought on by chromosome 21 trisomy. Children with DS frequently have oromotor dysfunctiont. Oromotor dysfunction in children with Down syndrome can lead to oral health issues and lower the oral health-related quality of life. Studies on the relationship between oromotor dysfunction and quality of life related to dental health in children with Down syndrome are still lacking, nevertheless. Objective: To analyze the correlation between oromotor dysfunction and oral health-related quality of life in children with DS. Methods: Total respondents used in this research was 30 children with DS and the parents in Banjarmasin Special Schools. Oromotor dysfunction was determined using the Oral Motor Assessment Scale (OMAS) and oral health-related quality of life was determined using the Modified Parent-Caregiver Perception Questionnaire (P-CPQ). The Spearman correlation test was used to analyze the correlation between oromotor dysfunction and oral health related quality of life in Down syndrome children.  Results: The Spearman correlation test showed that there was a significant correlation between oromotor dysfunction and oral health-related quality of life in children with DS with a significance value of 0.000 (p <0.05) with the correlation coefficient of 0.637. Conclusion: There was a positive and strong correlation between oromotor dysfunction and oral health-related quality of life in children with DS. The weaker the oromotor function in children with Down syndrome is, the worse the oral health-related quality of life will be.Keywords: Down syndrome, oral health-related quality of life, oromotor dysfunction. 
TOXICITY TEST OF Eusideroxylon zwageri BARK EXTRACT ON KIDNEY HISTOPATHOLOGY GLOMERULAR HYPERTROPHY AND HYDROPIC DEGENERATION Nur Tsaniya, Gusti Erysa; Firdaus, I Wayan Arya Krishnawan; Dewi, Nurdiana; Utami, Juliyatin Putri; Setiawan, Bambang
Dentino: Jurnal Kedokteran Gigi Vol 9, No 2 (2024)
Publisher : FKG ULM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v9i2.20403

Abstract

Background: Ironwood bark extract (Eusideroxylon zwageri) has antioxidant properties such as tannins, phenolics, flavonoids, saponins and alkonoids. Most compounds in the ironwood bark extract were phenolics (31.28 mg GAE/g), flavonoids (30.48 mg CE/g), and proanthocyanidins (183.30 mg PE/g). These can be used as alternative herbal medicines, but also has toxic effects, so a toxicity test is necessary. Toxicity tests can be seen through histopathological parameters based on glomerular hypertrophy and hydropic degeneration. Purpose: To determine the toxic effect of ironwood bark extract administration at doses of 1,250 mg/kg, 2,750 mg/kg, and 4,750 mg/kg orally on the kidneys of Wistar rats based on histopathological appearance of glomerular hypertrophy and hydropic degeneration. Methods: Pure experimental study with a posttest-only with control design, consisting of 4 groups with 3 treatment groups given ironwood bark extract at doses of 1,250 mg/kg, 2,750 mg/kg, and 4,750 mg/kg, and 1 control group was given distilled water 2x1 ml every 24 hours orally for 14 days. Results: In administration of ironwood bark extract at doses of 2,750 mg/kgBW and 4,750 mg/kgBW, glomerular diameter was found increased. The histopathological hydropic degeneration showed a score of 1 in all dose groups. The research data were analyzed using the One Way Anova and Kruskal Wallis tests. Both tests showed no significant differences between groups. Conclusion: There was no toxic effect of ironwood bark extract at doses of 1,250 mg/kg, 2,750 mg/kg, and 4,750 mg/kg on the kidneys of Wistar rats based on histopathological appearance of glomerular hypertrophy and hydropic degeneration.
PELATIHAN PEMBUATAN OBAT KUMUR AKAR PECUT KUDA (STACHYTARPHETA JAMAICENSIS) DI SUNGAI ABIT, BANJARBARU Utami, Juliyatin Putri; Carabelly, Amy Nindia; Sari, Galuh Dwinta; Baitullah, Muhammad Akbar; Maulida, Novi Dwi
Jurnal Pengabdian Sumber Daya Manusia Vol. 3 No. 2 (2023): EDISI Oktober 2023
Publisher : Scholar Center

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Bahan dasar obat kumur bisa berasal dari bahan alam yang berpotensi sebagai antibakteri seperti akar pecut kuda (Stacytharpetha jamaicensis). Akar pecut kuda banyak dijumpai di lokasi mitra pengabdian yaitu, Sungai Abit, Kelurahan Cempaka, Banjarbaru. Pelaksanaan kegiatan diawali dengan pretest, dilanjutkan pelaksanaan pelatihan pembuatan obat kumur dari akar pecut kuda dan melakukan konsultasi gigi gratis pada ibu-ibu RT 27 Sungai Abit, kelurahan Cempaka, Banjarbaru. Di akhir kegiatan, melakukan post test hasil dari pelatihan. Kegiatan pengabdian kepada masyarakat menghasilkan luaran berupa peningkatan pengetahuan warga terhadap penggunaan obat kumur dengan nilai delta (?) sebesar 35,26 didukung oleh hasil uji Wilcoxon dengan nilai sig. p<0,05 (p=0,000). Warga Sungai Abit dapat membuat obat kumur alami secara mandiri memanfaatkan bahan dasar akar S. jamaicensis menggunakan peralatan sederhana. Hasil kegiatan ini dapat meningkatkan kesadaran masyarakat akan pentingnya penggunaan obat kumur dan pemanfaatannya menggunakan herbal alami sehingga dapat mendukung kesehatan gigi dan mulut.
Co-Authors Adhiya, Geyanina Melda Agung Satria Wardhana Ainna Dewi Iriani Amalia, Aysca Fakhira Amy Nindia Carabelly Anisa Novia Farrasti Annisa Noviany Aprilyani, Nur Arifin, Rahmad Aspriyanto, Didit At-Thoyyar, Aila Azminida, Dhiya Salma Baitullah, Muhammad Akbar Bambang Setiawan Beta Widya Oktiani Budiarman, Andi Azizah Maulidia Dewi Indah Noviana Pratiwi, Dewi Indah Noviana Dewi Nurdiana Dewi Purboningsih Dewi Puspitasari Dewi Puspitasari Diana Lyrawati Diana Wibowo Erika Norfitriyah Eriwati, Yosi Kusuma Erni Marlina Febriansyah, Muhammad Firda Damayanti Firdaus, I Wayan Arya Krishnawan Fransiska Uli Arta Panjaitan Gita Puspa Ningrum Hadi Waskito Haluanry Doane Santoso Hatta, Isnur Ichrom Nahzi, Muhammad Yanuar Idhafi, Nasrul Ika Kusuma Wardani Jatmiko, Habibi Naufal Kelana, Adhytya Suryo Krishnawan Firdaus, I Wayan Arya Kurnianingsih, Nia Lena Rosida Maghfirah, Yolanda Sajjida Maharani Laillyza Apriasari Maharani Laillyza Apriasari Maria Tanumihardja, Maria Maulida, Novi Dwi Melisa Budipramana, Melisa Milka Widya Sari Mira Hadistiana Monita Valentine Silalahi Muhammad Adeya Herdira Putra Muhammad Akbar Baitullah Muhammad Hasanu Reksi Muhammad Reza Faisal, Muhammad Reza Muhammad Rizal Bima Saputra Nahzi, Yanuar Ichrom Nanda Putri Arini Nia Kurnianingsih Nida, Raihatun Nisa Fachrizha Munier Norfitriyah, Erika Novi Dwi Maulida Novia Damayanti Nur Tsaniya, Gusti Erysa Nurdiana Nurdiana Oktiani, Beta Widya Panghiyangani, Roselina Pramitha, Selviana Rizky Priyawan Rachmadi Rahmad Arifin Ramadhaniyah, Nur Roselina Panghiyangani Safa Muzdalifah Salsabila, Namira Fathya Sandra Bhakti Mafriana Sari, Galuh Dwinta Sari, Milka Widya Sarifah, Norlaila Sherli Diana Tri Putri, Deby Kania Wydiamala, Erida Yunike Christanti Yusrinie Wasiaturrahmah