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All Journal Journal of Dentistry Indonesia ODONTO Dental Journal Majalah Obat Tradisional INDONESIAN JOURNAL OF PHARMACY Dentino: Jurnal Kedokteran Gigi Padjadjaran Journal of Dentistry Molecular and Cellular Biomedical Sciences (MCBS) Dentin An-Nadaa: Jurnal Kesehatan Masyarakat Bubungan Tinggi: Jurnal Pengabdian Masyarakat Jurnal Pengabdian Ilung (Inovasi Lahan Basah Unggul) Jurnal Pengabdian Sumber Daya Manusia Denta: Jurnal Kedokteran Gigi Makara Journal of Science Odonto dental journal Jurnal Bioteknologi & Biosains Indonesia (JBBI) Jurnal Bioteknologi & Biosains Indonesia Global Medical and Health Communication

Utami, Juliyatin Putri

Departemen Biomedik, Fakultas Kedokteran Gigi, Universitas Lambung Mangkurat

Author-ID : 3130752

Agriculture, Biological Sciences & Forestry Arts Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Dentistry Economics, Econometrics & Finance Education Energy Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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FOURIER-TRANSFORM INFRARED SPECTROSCOPY ANALYSIS OF MAULI BANANA (MUSA ACUMINATA) EXTRACT AS A POTENTIAL PULP WOUND HEALING Dewi Puspitasari; Muhammad Yanuar Ichrom Nahzi; Yosi Kusuma Eriwati; Erni Marlina; Maharani Laillyza Apriasari; Maria Tanumihardja; Juliyatin Putri Utami; Amy Nindia Carabelly
Dentino : Jurnal Kedokteran Gigi Vol 8, No 2 (2023)
Publisher : FKG Unlam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v8i2.17536

Background: Pulp wound healing is a critical aspect of endodontics, aiming to preserve the vitality and function of dental pulp tissues. Natural compounds have gained attention for their potential therapeutic applications in dentistry. Mauli banana (Musa acuminata) is a tropical fruit in South Kalimantan as one of the natural plants that have the ability as antibacterial, antifungal, anti-inflammatory, antioxidant, and immunomodulatory effects contains various bioactive molecules with potential pulp wound healing properties. Purpose: to identify and evaluate the functional groups present in mauli banana stem extracts. Methods: This study is true experimental research, the samples were mauli banana stem that were extracted with maceration technique and were subjected to Fourier-Transform Infrared Spectroscopy test. Results: Identification of functional groups of organic compounds from mauli banana are as follows: a) Peak 3638.95 cm-1 show O-H (nonbonded hydroxy group, OH stretch primary) component alcohol, b) Peak 3265.82 cm-1is C-H (alkane), c) Peak 2928.09 cm-1 refer to OH (carboxylic acid hydrogen bonds) and aldehydes groups, d) peak 1571.35 cm-1 refers to amide, C=O - asymetric stretching, e) peak 1400.82 cm-1, refers to CO2- symetric stretching and carboxylate (carboxylic acid salt) CH2 scissoring, f) peak 1030.17 cm-1 refers to C=C (alkanes), aliphatic phosphate, g) Peak 520.53 cm-1 refers to inorganic phosphates. Conclusion: FTIR spectra analysis of mauli banana stem extract show the presence of O-H hydroxy groups, aldehydes groups, carbonyl groups, aliphatic groups, carbonyl groups, amides groups and C-O stretching vibrations suggests that the extract contains various bioactive molecules with potential pulp wound healing properties.

TOXICITY TEST OF CHANNA MICROPELTES EXTRACT BETWEEN NORMAL WISTAR RATS AND DIABETES MODEL BASED ON CARDIAC HISTOPATHOLOGY Annisa Noviany; Amy Nindia Carabelly; Juliyatin Putri Utami
Dentino : Jurnal Kedokteran Gigi Vol 8, No 2 (2023)
Publisher : FKG Unlam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v8i2.17525

Background: DM is metabolic disease can prolong wound healing phase and cause oxidative stress that can affect cardiac damage such as degeneration, hypertrophy, and necrosis. They can be inhibited by the effect of 16 ml/kg BW CM containing palmitic acid (18.30%), albumin (3.6147g/dl), and amino acids are leucine (1.58%) and valine (0.97%). It's proven to accelerate wound healing in normal Wistar rats and DM. However, CM extract on the cardiac is unknown, so an acute toxicity test was carried out for 14 days. Purpose: To analyze the effect of oral administration of CM extract at an effective dose of 16 ml/kg BW on the histopathological exam of degeneration, hypertrophy, and cardiac necrosis of normal Wistar rats and diabetic models. Method: This study is true experimental study with a post-test only control group design which is divided into 4 groups are 2 groups of Wistar rats normal and diabetic models who were given CM extract at an effective dose of 16 ml/kg BW, 2 groups consisted of normal Wistar rats and diabetic models which were only given BR2 feed. Results: T-Independent test and the Mann-Whitney test showed that there was a significant difference between degeneration and hypertrophy (p<0.05) and necrosis. There was no significant difference (p>0.05). Conclusion: The effective dose of CM extract 16 ml/kg BW had an effect on the cardiac of normal Wistar rats and diabetic models in the form of a decrease in the level of damage to degeneration, hypertrophy, and cardiac necrosis. Keywords: Cardiac, Channa micropeltes, Degeneration, Hypertrophy, Necrosis.Background: DM is metabolic disease can prolong wound healing phase and cause oxidative stress that can affect cardiac damage such as degeneration, hypertrophy, and necrosis. They can be inhibited by the effect of 16 ml/kg BW CM containing palmitic acid (18.30%), albumin (3.6147g/dl), and amino acids are leucine (1.58%) and valine (0.97%). It's proven to accelerate wound healing in normal Wistar rats and DM. However, CM extract on the cardiac is unknown, so an acute toxicity test was carried out for 14 days. Purpose: To analyze the effect of oral administration of CM extract at an effective dose of 16 ml/kg BW on the histopathological exam of degeneration, hypertrophy, and cardiac necrosis of normal Wistar rats and diabetic models. Method: This study is true experimental study with a post-test only control group design which is divided into 4 groups are 2 groups of Wistar rats normal and diabetic models who were given CM extract at an effective dose of 16 ml/kg BW, 2 groups consisted of normal Wistar rats and diabetic models which were only given BR2 feed. Results: T-Independent test and the Mann-Whitney test showed that there was a significant difference between degeneration and hypertrophy (p<0.05) and necrosis. There was no significant difference (p>0.05). Conclusion: The effective dose of CM extract 16 ml/kg BW had an effect on the cardiac of normal Wistar rats and diabetic models in the form of a decrease in the level of damage to degeneration, hypertrophy, and cardiac necrosis. Keywords: Cardiac, Channa micropeltes, Degeneration, Hypertrophy, Necrosis.

Molecular Docking of the Interaction between Citrus amblycarpa Extract Contents and Inflammatory Proteins of Hepatic Steatosis Rosida, Lena; Pratiwi, Dewi Indah Noviana; Panghiyangani, Roselina; Utami, Juliyatin Putri; Idhafi, Nasrul; Febriansyah, Muhammad; Budiarman, Andi Azizah Maulidia
Makara Journal of Science Vol. 28, No. 2
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Citrus amblycarpa possesses various pharmacological activities, such as antioxidant, anticancer, antitumor, hepatoprotective, anti-inflammatory, antidiabetic, antiviral, antibacterial, and antifungal. The main active compounds in C. amblycarpa (including gamma (γ)-aminobutyric acid [GABA], hesperidin, naringin, neoeriocitrin, poncirin, quercetin, and rutin) show potential to interact with the inflammatory proteins in hepatic steatosis (such as nuclear factor kappa beta [NF-kB], tumor necrosis alpha [TNF-alpha], interleukin-6 [IL-6], c-Jun NH2-terminal kinase [JNK], and adiponectin). Molecular docking simulations were performed using Swiss Dock (http://www.swissdock.ch/), and analysis and visualization were conducted using Discovery Studio 4.1. Rutin, poncirin, hesperidin, and neoeriocitrin exhibit high affinities to NF-κB, TNF-alpha, IL-6, and adiponectin proteins, respectively. Similar to curcumin–adiponectin complex interaction, neoeriocitrin–adiponectin interaction involves GLY 223, PRO41, and VAL93 residues. Thus, the most potent inhibitor of hepatic sterosis marker was neoeriocitrin.

PELATIHAN PEMBUATAN OBAT KUMUR AKAR PECUT KUDA (STACHYTARPHETA JAMAICENSIS) DI SUNGAI ABIT, BANJARBARU Utami, Juliyatin Putri; Carabelly, Amy Nindia; Sari, Galuh Dwinta; Baitullah, Muhammad Akbar; Maulida, Novi Dwi
Jurnal Pengabdian Sumber Daya Manusia Vol. 3 No. 2 (2023): EDISI Oktober 2023
Publisher : Scholar Center

Show Abstract | Download Original | Original Source | Check in Google Scholar

Bahan dasar obat kumur bisa berasal dari bahan alam yang berpotensi sebagai antibakteri seperti akar pecut kuda (Stacytharpetha jamaicensis). Akar pecut kuda banyak dijumpai di lokasi mitra pengabdian yaitu, Sungai Abit, Kelurahan Cempaka, Banjarbaru. Pelaksanaan kegiatan diawali dengan pretest, dilanjutkan pelaksanaan pelatihan pembuatan obat kumur dari akar pecut kuda dan melakukan konsultasi gigi gratis pada ibu-ibu RT 27 Sungai Abit, kelurahan Cempaka, Banjarbaru. Di akhir kegiatan, melakukan post test hasil dari pelatihan. Kegiatan pengabdian kepada masyarakat menghasilkan luaran berupa peningkatan pengetahuan warga terhadap penggunaan obat kumur dengan nilai delta (?) sebesar 35,26 didukung oleh hasil uji Wilcoxon dengan nilai sig. p<0,05 (p=0,000). Warga Sungai Abit dapat membuat obat kumur alami secara mandiri memanfaatkan bahan dasar akar S. jamaicensis menggunakan peralatan sederhana. Hasil kegiatan ini dapat meningkatkan kesadaran masyarakat akan pentingnya penggunaan obat kumur dan pemanfaatannya menggunakan herbal alami sehingga dapat mendukung kesehatan gigi dan mulut.

Anti-inflammatory Effects of Channa micropeltes Extract through NF-κB and TNF-α in Diabetic Rat Carabelly, Amy Nindia; Aspriyanto, Didit; Sari, Milka Widya; Norfitriyah, Erika; Utami, Juliyatin Putri
Majalah Obat Tradisional Vol 29, No 1 (2024)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.87104

Diabetes mellitus (DM) is a disorder of carbohydrate, fat, and protein metabolism caused by impaired insulin secretion, insulin action, or both characterized by hyperglycemia. Hyperglycemic condition is associated with inflammation process leading to complications. Food supplements play an important role in controlling protein metabolism and have anti-inflammatory properties such as Channa micropeltes (CM). This study aimed to analyze the effect of CM extract on the levels of molecular markers Nuclear factor kappa beta (NF-κB) and Tumor Necrosis Factor alfa (TNF-α) in normal and diabetic rats. The experimental design of this investigation was a post-test-only control group design and the samples were the diabetic model group given CM extract at 16 mL/kgBB dose, and negative control group for 14 days, respectively. Serum concentrations of NF-κB and TNF-α were measured by ELISA. DM-CM group showed decreasing levels of NF-κB. TNF- α was detected with the lowest level in the N-CM group. The levels of TNF- α declined close to normal levels in the DM-CM group. Hence, the conclusion was the CM at a dose of 16 mL/kg BW for 14 days in Wistar rats can reduce Nf-κB and TNF-α in groups of normal and diabetic rats.

Pengaruh Ekstrak Kulit Limau Kuit (Citrus Amblycarpa Hassk) Terhadap Perlemakan Hepar Tikus (Rattus Norvegicus) Yang Diberi Diet Tinggi Lemak Rosida, Lena; Pratiwi, Dewi Indah Noviana; Panghiyangani, Roselina; Utami, Juliyatin Putri; Maghfirah, Yolanda Sajjida; Amalia, Aysca Fakhira
An-Nadaa: Jurnal Kesehatan Masyarakat (e-Journal) Vol 10, No 2 (2023): AN-NADAA JURNAL KESEHATAN MASYARAKAT (DESEMBER)
Publisher : Universitas Islam Kalimantan Muhammad Arsyad Al Banjari Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31602/ann.v10i2.11053

Akumulasi trigliserida di hepar dapat terjadi akibat diet tinggi lemak yang berlebihan, sehingga dapat menginduksi terjadi inflamasi dan stres oksidatif di hepar. Perlemakan hepar secara histopatologis ditandai oleh adanya steatosis. Tanaman Limau Kuit (Citrus amblycarpa Hassk) sebagai tanaman lokal Kalimantan Selatan memiliki manfaat dalam menghambat pembentukan akumulasi lemak berlebihan karena kulit jeruk Limau Kuit mengandung alkaloid, saponin, triterpenoid, tanin, dan flavonoid. Penelitian ini bertujuan untuk menganalisis pengaruh pemberian ekstrak kulit Limau Kuit (Citrus amblycarpa Hassk) terhadap perlemakan hepar tikus (Rattus norvegicus) yang diberi diet tinggi lemak. Metode penelitian adalah true experimental design dengan posttest with control group design dengan 6 kelompok, yaitu KI (diet standar + akuades, KII (diet tinggi lemak + akuades), KIII (diet tinggi lemak + orlistat), KIV (diet tinggi lemak + ekstrak kulit Limau Kuit 200 mg/KgBB), KV (diet tinggi lemak + ekstrak kulit Limau Kuit 300 mg/KgBB), dan KVI (diet tinggi lemak + ekstrak kulit Limau Kuit 400 mg/KgBB). Perlakuan diberikan selama 6 minggu. Perlemakan hepar dinilai dari jumlah sel hepar yang mengalami perlemakan pada 5 lapangan pandang dari sediaan histologis hepar yang diwarnai HE dan perbesaran 400 x. Uji statistik menggunakan Kruskal-Wallis test. Hasil penelitian menunjukkan rerata perlemakan hepar KI 38,83 + 35,63, KII 24,00 + 21,46, KIII 20,40 + 13,90, KIV 42,40 + 11,93, KV 19,60 + 12,50, KVI 30,50 + 14,80, dengan p = 0,447. Kesimpulan penelitian ini adalah tidak ada perbedaan yang bermakna dari pemberian ekstrak kulit Limau Kuit terhadap perlemakan tikus (Rattus norvegicus) yang diberi pakan tinggi lemak (p > 0,05).Keywords: Diet tinggi lemak; Kulit jeruk Limau Kuit; Perlemakan hepar; Rattus norvegicus; Steatosis.

PHARMACOLOGICAL INVESTIGATION OF THE ORAL WOUND HEALING ACTIVITY OF Stachytarpheta jamaicensis ROOT EXTRACT GEL IN WISTAR RATS Utami, Juliyatin Putri; Wasiaturrahmah, Yusrinie; Carabelly, Amy Nindia; Aspriyanto, Didit; Nahzi, Yanuar Ichrom; Arifin, Rahmad; Ramadhaniyah, Nur; Jatmiko, Habibi Naufal
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 12 No. 1 (2025)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/jbbi.2025.9390

The Stachytarpheta jamaicensis (L) Vahl root contains bioactive compounds like saponins, alkaloids, flavonoids, tannins, phenols, and terpenoids, which have antibacterial and anti-inflammatory properties. This study investigates the wound healing effects of Stachytarpheta jamaicensis (L) Vahl root extract gel in oral mucosa. The experiment involved 28 male Wistar rats, divided into four groups: a positive control treated with povidone iodine 10%, a negative control treated with gel base, and two experimental groups treated with 6% and 10% S. jamaicensis root extract gels. The gel was applied twice daily, and wound healing was assessed by epithelial thickness, inflammation cell and hydroxyproline content. Both concentrations of S. jamaicensis root extract gel significantly enhanced wound healing, as shown by increased epithelial thickness, inflammation cell and hydroxyproline content levels compared to the negative control. These findings suggest that S. jamaicensis root extract gel effectively promotes wound healing in the excision wound model.

Antibacterial, Antifungal And Subchronic Toxicity Test Of Ficus Deltoidea Jack Leaves Extract Apriasari, Maharani Laillyza; Adhiya, Geyanina Melda; Wasiaturrahmah, Yusrinie; Utami, Juliyatin Putri; Firdaus, I Wayan Arya Krishnawan; Pramitha, Selviana Rizky
Odonto : Dental Journal Vol 12, No 1 (2025): April 2025
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.12.1.19-28

Background: Ficus deltoidea Jack is a plant that is often used as herbs medicine because of secondary metabolites such as alkaloids, phenolics, flavonoids, and steroids. This study aims to determine the activity of antibacterial, antifungal and toxicity effect of Ficus deltoidea Jack leaves (FDLE) extract. Method: Pure experimental study with a posttest-only design with a control group design. The in vitro test by dilution methods using Staphylococcus aureus and Candida albicans. The toxicity test used 16 male Rattus novergicus divided into four group consist a control group and three treatment group given FDLE doses with 1,250, 2,500, and 3,750 mg/kgBW. The treatment applied 2x1 ml FDLE every 24 hours orally for 28 days. Result: The MIC value and the MBC value of FDLE againts S. aureus were 8% and 10%, respectively. While, MIC and MBC value on C. albicans has similar value about 25%. The mean results of kidney toxicity test were still in the normal range. There was a significant difference in the results of the Kruskall Wallis test for urea (p<0.05), while there was no significant difference in the results of urea and creatinine level (p>0.05). Conclusion: There was antibacterial and antifungal efficacy of FDLE. Also, there was no toxic effect of giving FDLE at doses of 1,250, 2,500, and 3,750 mg/kgBW was showed on urea and creatinine normal level.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.12.1.19-28

Correlation between the socio-demographic characteristics and clinical profile with oral manifestations of HIV/AIDS patients Apriasari, Maharani Laillyza; Aprilyani, Nur; Carabelly, Amy Nindia; Utami, Juliyatin Putri
Padjadjaran Journal of Dentistry Vol 33, No 1 (2021): March 2021
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjd.vol33no1.26025

Introduction: Human Immunodeficiency Virus (HIV) exhibits the capability to weaken human immune system. The infected subject will later be more susceptible to suffer from opportunistic diseases when the CD4 cell count is lesser than 200 cell/µL. Oral thrush, periodontal disease and xerostomia are common oral manifestations in AIDS patient which initially indicate the presence of HIV infection. This study was aimed to analyse the correlation between the socio-demographic characteristics and clinical profile with oral manifestations of HIV/AIDS patients. Methods: An analytic study with cross-sectional approach was conducted towards the clinical profile and oral manifestation data of HIV/AIDS patients, which obtained from secondary data in the form of medical record. The 55 samples were taken with total sampling technique. Results: The chi-square test found no significant correlation between HIV/AIDS patients socio-demographic and oral manifestations and several significant correlation of the HIV/AIDS patients' clinical profile with the oral manifestation as follows: the total number of CD4 and ARV therapy duration was significantly correlated with the HIV/AIDS patients with candidiasis and oral thrush (p=0.01); while in patients with periodontal disease was only significantly correlated with the total number of CD4 (p=0.02); and no significant correlation found in HIV/AIDS patients with xerostomia. Conclusion: There is no correlation between HIV/AIDS patients socio-demographic and oral manifestations. There is a correlation between several HIV/AIDS patients clinical profile with the oral manifestation. The number of CD4 cells and the ARV therapy duration was correlated with patients with candidiasis and oral thrush, while in patients with periodontal disease on correlated with the number and CD4 cells. HIV/AIDS patients with xerostomia have no correlation with any of their clinical profile.

Co-Authors Adhiya, Geyanina Melda Adhytya Suryo Kelana Agung Satria Wardhana Aila At-Thoyyar Ainna Dewi Iriani Amalia, Aysca Fakhira Amy Nindia Carabelly Andi Muthia Azizah Tenri Bali Anisa Novia Farrasti Annisa Noviany Aprilyani, Nur Arifin, Rahmad Aspriyanto, Didit Baitullah, Muhammad Akbar Bambang Setiawan Bayu Indra Sukmana Beta Widya Oktiani Budiarman, Andi Azizah Maulidia Dewi Indah Noviana Pratiwi Dewi Indah Noviana Pratiwi, Dewi Indah Noviana Dewi Nurdiana Dewi Purboningsih Dewi Puspitasari Dewi, Renie Kumala Dhiya Salma Azminida Diana Lyrawati Diana Wibowo Erida Wydiamala Erika Norfitriyah Eriwati, Yosi Kusuma Erni Marlina Febriansyah, Muhammad Firda Damayanti Firdaus, I Wayan Arya Krishnawan Fransiska Uli Arta Panjaitan Gita Puspa Ningrum Gusti Erysa Nur Tsaniya Hadi Waskito Haluanry Doane Santoso Hamdani, Riky Hatta, Isnur I Wayan Arya Krishnawan Firdaus Ichrom Nahzi, Muhammad Yanuar Idhafi, Nasrul Ika Kustiyah Oktaviyanti Ika Kusuma Wardani Jatmiko, Habibi Naufal Kurnianingsih, Nia Lena Rosida Lena Rosida Maghfirah, Yolanda Sajjida Maharani Laillyza Apriasari Maharani Lailyza Apriasari Mahmud Muhlisin Maria Tanumihardja, Maria Maria Ulfah Maulida, Novi Dwi Melisa Budipramana, Melisa Milka Widya Sari Mira Hadistiana Monita Valentine Silalahi Muhammad Adeya Herdira Putra Muhammad Akbar Baitullah Muhammad Hasanu Reksi Muhammad Reza Faisal, Muhammad Reza Muhammad Rizal Bima Saputra Nahzi, Yanuar Ichrom Namira Fathya Salsabila Nanda Putri Arini Nia Kurnianingsih Nisa Fachrizha Munier Nor Rahman Sugiarto Norfitriyah, Erika Novi Dwi Maulida Novia Damayanti Nurdiana Nurdiana Nurrahman, Tri Panghiyangani, Roselina Pramitha, Selviana Rizky Priyawan Rachmadi Rachmayani, Nevrila Dewi Rahmad Arifin Raihatun Nida Ramadhaniyah, Nur Rizki Aprian Roselina Panghiyangani Roselina Panghiyangani Ruzhanah, Huda Safa Muzdalifah Sandra Bhakti Mafriana Sari, Galuh Dwinta Sari, Milka Widya Sarifah, Norlaila Sherli Diana Silalahi, Monita Valentine Siti Wasilah Tri Putri, Deby Kania Wardhana, Agung Satria Yunike Christanti Yusrinie Wasiaturrahmah

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