Garuda - Garba Rujukan Digital

PHARMACOLOGICAL INVESTIGATION OF THE ORAL WOUND HEALING ACTIVITY OF Stachytarpheta jamaicensis ROOT EXTRACT GEL IN WISTAR RATS Utami, Juliyatin Putri; Wasiaturrahmah, Yusrinie; Carabelly, Amy Nindia; Aspriyanto, Didit; Nahzi, Yanuar Ichrom; Arifin, Rahmad; Ramadhaniyah, Nur; Jatmiko, Habibi Naufal
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 12 No. 1 (2025)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/jbbi.2025.9390

The Stachytarpheta jamaicensis (L) Vahl root contains bioactive compounds like saponins, alkaloids, flavonoids, tannins, phenols, and terpenoids, which have antibacterial and anti-inflammatory properties. This study investigates the wound healing effects of Stachytarpheta jamaicensis (L) Vahl root extract gel in oral mucosa. The experiment involved 28 male Wistar rats, divided into four groups: a positive control treated with povidone iodine 10%, a negative control treated with gel base, and two experimental groups treated with 6% and 10% S. jamaicensis root extract gels. The gel was applied twice daily, and wound healing was assessed by epithelial thickness, inflammation cell and hydroxyproline content. Both concentrations of S. jamaicensis root extract gel significantly enhanced wound healing, as shown by increased epithelial thickness, inflammation cell and hydroxyproline content levels compared to the negative control. These findings suggest that S. jamaicensis root extract gel effectively promotes wound healing in the excision wound model.

Antibacterial, Antifungal And Subchronic Toxicity Test Of Ficus Deltoidea Jack Leaves Extract Apriasari, Maharani Laillyza; Adhiya, Geyanina Melda; Wasiaturrahmah, Yusrinie; Utami, Juliyatin Putri; Firdaus, I Wayan Arya Krishnawan; Pramitha, Selviana Rizky
Odonto : Dental Journal Vol 12, No 1 (2025): April 2025
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.12.1.19-28

Background: Ficus deltoidea Jack is a plant that is often used as herbs medicine because of secondary metabolites such as alkaloids, phenolics, flavonoids, and steroids. This study aims to determine the activity of antibacterial, antifungal and toxicity effect of Ficus deltoidea Jack leaves (FDLE) extract. Method: Pure experimental study with a posttest-only design with a control group design. The in vitro test by dilution methods using Staphylococcus aureus and Candida albicans. The toxicity test used 16 male Rattus novergicus divided into four group consist a control group and three treatment group given FDLE doses with 1,250, 2,500, and 3,750 mg/kgBW. The treatment applied 2x1 ml FDLE every 24 hours orally for 28 days. Result: The MIC value and the MBC value of FDLE againts S. aureus were 8% and 10%, respectively. While, MIC and MBC value on C. albicans has similar value about 25%. The mean results of kidney toxicity test were still in the normal range. There was a significant difference in the results of the Kruskall Wallis test for urea (p<0.05), while there was no significant difference in the results of urea and creatinine level (p>0.05). Conclusion: There was antibacterial and antifungal efficacy of FDLE. Also, there was no toxic effect of giving FDLE at doses of 1,250, 2,500, and 3,750 mg/kgBW was showed on urea and creatinine normal level.

Antibacterial, Antifungal And Subchronic Toxicity Test Of Ficus Deltoidea Jack Leaves Extract Apriasari, Maharani Laillyza; Adhiya, Geyanina Melda; Wasiaturrahmah, Yusrinie; Utami, Juliyatin Putri; Firdaus, I Wayan Arya Krishnawan; Pramitha, Selviana Rizky
Odonto : Dental Journal Vol 12, No 1 (2025): April 2025
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.12.1.19-28

Background: Ficus deltoidea Jack is a plant that is often used as herbs medicine because of secondary metabolites such as alkaloids, phenolics, flavonoids, and steroids. This study aims to determine the activity of antibacterial, antifungal and toxicity effect of Ficus deltoidea Jack leaves (FDLE) extract. Method: Pure experimental study with a posttest-only design with a control group design. The in vitro test by dilution methods using Staphylococcus aureus and Candida albicans. The toxicity test used 16 male Rattus novergicus divided into four group consist a control group and three treatment group given FDLE doses with 1,250, 2,500, and 3,750 mg/kgBW. The treatment applied 2x1 ml FDLE every 24 hours orally for 28 days. Result: The MIC value and the MBC value of FDLE againts S. aureus were 8% and 10%, respectively. While, MIC and MBC value on C. albicans has similar value about 25%. The mean results of kidney toxicity test were still in the normal range. There was a significant difference in the results of the Kruskall Wallis test for urea (p<0.05), while there was no significant difference in the results of urea and creatinine level (p>0.05). Conclusion: There was antibacterial and antifungal efficacy of FDLE. Also, there was no toxic effect of giving FDLE at doses of 1,250, 2,500, and 3,750 mg/kgBW was showed on urea and creatinine normal level.

Correlation between the socio-demographic characteristics and clinical profile with oral manifestations of HIV/AIDS patients Apriasari, Maharani Laillyza; Aprilyani, Nur; Carabelly, Amy Nindia; Utami, Juliyatin Putri
Padjadjaran Journal of Dentistry Vol 33, No 1 (2021): March 2021
Publisher : Faculty of Dentistry Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjd.vol33no1.26025

Introduction: Human Immunodeficiency Virus (HIV) exhibits the capability to weaken human immune system. The infected subject will later be more susceptible to suffer from opportunistic diseases when the CD4 cell count is lesser than 200 cell/µL. Oral thrush, periodontal disease and xerostomia are common oral manifestations in AIDS patient which initially indicate the presence of HIV infection. This study was aimed to analyse the correlation between the socio-demographic characteristics and clinical profile with oral manifestations of HIV/AIDS patients. Methods: An analytic study with cross-sectional approach was conducted towards the clinical profile and oral manifestation data of HIV/AIDS patients, which obtained from secondary data in the form of medical record. The 55 samples were taken with total sampling technique. Results: The chi-square test found no significant correlation between HIV/AIDS patients socio-demographic and oral manifestations and several significant correlation of the HIV/AIDS patients' clinical profile with the oral manifestation as follows: the total number of CD4 and ARV therapy duration was significantly correlated with the HIV/AIDS patients with candidiasis and oral thrush (p=0.01); while in patients with periodontal disease was only significantly correlated with the total number of CD4 (p=0.02); and no significant correlation found in HIV/AIDS patients with xerostomia. Conclusion: There is no correlation between HIV/AIDS patients socio-demographic and oral manifestations. There is a correlation between several HIV/AIDS patients clinical profile with the oral manifestation. The number of CD4 cells and the ARV therapy duration was correlated with patients with candidiasis and oral thrush, while in patients with periodontal disease on correlated with the number and CD4 cells. HIV/AIDS patients with xerostomia have no correlation with any of their clinical profile.

PHARMACOLOGICAL INVESTIGATION OF THE ORAL WOUND HEALING ACTIVITY OF Stachytarpheta jamaicensis ROOT EXTRACT GEL IN WISTAR RATS Utami, Juliyatin Putri; Wasiaturrahmah, Yusrinie; Carabelly, Amy Nindia; Aspriyanto, Didit; Nahzi, Yanuar Ichrom; Arifin, Rahmad; Ramadhaniyah, Nur; Jatmiko, Habibi Naufal
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 12 No. 1 (2025)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/jbbi.2025.9390

The Stachytarpheta jamaicensis (L) Vahl root contains bioactive compounds like saponins, alkaloids, flavonoids, tannins, phenols, and terpenoids, which have antibacterial and anti-inflammatory properties. This study investigates the wound healing effects of Stachytarpheta jamaicensis (L) Vahl root extract gel in oral mucosa. The experiment involved 28 male Wistar rats, divided into four groups: a positive control treated with povidone iodine 10%, a negative control treated with gel base, and two experimental groups treated with 6% and 10% S. jamaicensis root extract gels. The gel was applied twice daily, and wound healing was assessed by epithelial thickness, inflammation cell and hydroxyproline content. Both concentrations of S. jamaicensis root extract gel significantly enhanced wound healing, as shown by increased epithelial thickness, inflammation cell and hydroxyproline content levels compared to the negative control. These findings suggest that S. jamaicensis root extract gel effectively promotes wound healing in the excision wound model.

UJI EFEKTIVITAS ANTIBAKTERI EKSTRAK DAUN KALANGKALA (Litsea angulata) TERHADAP PERTUMBUHAN BAKTERI Porphyromonas gingivalis (In vitro) Nor Rahman Sugiarto; Yusrinie Wasiaturrahmah; Tri Nurrahman; Muhammad Yanuar Ichrom Nahzi; Juliyatin Putri Utami; Bayu Indra Sukmana
Dentin Vol 9, No 2 (2025)
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentin.v9i2.17742

ABSTRACTBackground: Dental and oral health has not been a major focus due to the low level of public awareness regarding the importance of maintaining dental and oral health in Indonesia. Periodontitis is a disease with a prevalence of 74.1% in Indonesia. The main cause of chronic periodontitis is the bacterium Porphyromonas gingivalis. Chlorhexidin 0.2% is gold standard that preventing periodontitis. However Chlorhexidin 0.2% has long-term side effects such as tooth discolouration. Therefore, an alternative mouthwash that has antibacterial properties is needed. Kalangkala leaf (Litsea angulata) is known to have the potential to inhibit the growth of Porphyromonas gingivalis bacteria. Objective: To determine the antibacterial effectiveness of kalangkala (Litsea angulata) leaf extract against Porphyromonas gingivalis bacteria with concentrations of 6.25%, 12.5%, 25%, and 50% based on the minimum inhibitory Concentration (MIC) and minimum bactericidal Concentration(MBC). Methods: True experimental research with posttest-only with control group design. The sample consisted of 6 groups with Chlorhexidin 0.2% as positive control and distilled water as negative control with 4 samples each. Data were analysed using normality, homogeneity, Krusskall wallis, and Mann-whitney tests. Results: From the test results, there was no minimum inhibition 6.25%, 12.5%, 25%, and 50%. The testing was not pursued for MBC. Conclusion: There is no antibacterial effectiveness of kalangkala (Litsea angulata) leaf extract against Porphyromonas gingivalis.Keywords: antibacteria, leaf extract, litsea angulata, porphyromonas gingivalis ABSTRAK Latar Belakang: Kesehatan gigi dan mulut belum menjadi fokus utama karena tingkat kesadaran masyarakat yang rendah terkait pentingnya merawat kesehatan gigi dan mulut di Indonesia Periodontitis merupakan penyakit dengan prevalensi 74,1% di Indonesia. Penyebab utama periodontitis kronis yaitu bakteri Porphyromonas gingivalis. Chlorhexidin 0,2% merupakan gold standard dalam mencegah terjadinya periodontitis, tetapi Chlorhexidin 0,2% memiliki efek samping jangka panjang seperti perubahan warna pada gigi. Untuk mencegah terjadinya efek jangka panjang tersebut perlu obat kumur alternatif yang memiliki sifat antibakteri. Daun kalangkala (Litsea angulata) diketahui memiliki potensi untuk menghambat pertumbuhan bakteri Porphyromonas gingivalis. Tujuan: Mengetahui efektivitas antibakteri ekstrak daun kalangkala (Litsea angulata) terhadap bakteri Porphyromonas gingivalis dengan konsentrasi 6,25%, 12,5%, 25%, dan 50% berdasarkan Kadar hambat minimum (KHM) dan kadar bunuh minimum (KBM) Metode: Penelitian eksperimen murni (True Experimental) dengan rancangan percobaan menggunakan posttest-only with control group design. Sampel terdiri dari 6 kelompok dengan Chlorhexidin 0,2% sebagai kontrol positif dan akuades sebagai kontrol negatif dengan pengulangan masing-masing sebanyak 4 sampel. Data dianalisis dengan uji normalitas, homogenitas, Krusskall wallis, dan uji Mann-whitney. Hasil: Hasil uji tidak terdapat KHM pada semua konsentrasi ekstrak kalangkala yaitu konsentrasi 6,25%, 12,5%, 25%, dan 50%, sehingga tidak dilanjutkan untuk pengujian KBM. Kesimpulan: Tidak terdapat efektifitas antibakteri ekstrak daun kalangkala (Litsea angulata) konsentrasi 6,25%, 12,5%, 25%, dan 50% terhadap bakteri Porphyromonas gingivalis.Kata Kunci: antibakteri, ekstrak daun, litsea angulata porphyromonas gingivalis

STUDY ANALYSIS OF ORAL TUBERCULOSIS LESION IN SOUTH KALIMANTAN, INDONESIA Apriasari, Maharani Laillyza; Silalahi, Monita Valentine; Hatta, Isnur; Utami, Juliyatin Putri
Odonto : Dental Journal Vol 7, No 1 (2020): July 2020
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Background: Tuberculosis is an infectious disease which is the second-largest cause of death in the world after HIV / AIDS. Tuberculosis caused by Mycobacterium tuberculosis that usually attacks the lungs but can manifest in the oral mucosa. Clinical manifestations of oral Tuberculosis related to age, sex, duration of treatment, systemic disease, and Multi-Drug Resistant therapy. There is no research on descriptive studies of oral manifestations of tuberculosis patients in South Kalimantan, specifically in Banjarmasin. This study aims to analyze the clinical manifestations of oral Tuberculosis descriptively in South Kalimantan, Indonesia. Method: This was a descriptive analysis with cross-sectional study design, based on history and clinical oral examination. It was used 30 respondents by purposive sampling method. Data were analyzed by Chi-square (p<0.05). Results: During treatment, it showed the correlation between xerostomia and systemic disease (diabetes mellitus and HIV/AIDS) are (p=0.007) and a correlation between xerostomia and duration of treatment (p=0.024). The correlation between candidiasis and systemic disease (p=0.024). The correlation between angular cheilitis and age, sex, duration of treatment, systemic disease, and Multi-Drug Resistant therapy (p>0.05). The clinical manifestations of oral Tuberculosis are xerostomia, candidiasis, and angular cheilitis.Conclusion: The duration of treatment and the systemic diseases are associated with xerostomia and candidiasis in the oral cavity of TB patients.

Management of Herpangina Maharani Laillyza Apriasari; Juliyatin Putri Utami
Denta Journal Kedokteran Gigi Vol 14 No 2 (2020): Agustus
Publisher : Fakultas Kedokteran Gigi Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/denta.v14i2.4

Background: Herpangina is an acute infectious disease with self-limiting properties. While herpangina may heal without any treatment, it may be followed by various complications such as meningitis, encephalitis, cardiomyopathy, or even death. In 2018, there was a 10.07% prevalence rate of viral infection in Banjarmasin city, South Kalimantan. One of which was herpangina. Objective: To elucidate the management of herpangina. Case: Young female patient, 11 years old, complained of multiple ulcerations on the posterior side of her mouth with excruciating pain when swallowing. Ulceration had appeared for three days which was initially commenced by fever and cough. Case Management: The patient was prescribed methisoprinol syrup 250 mg four times a day, ibuprofen syrup 250 mg four times a day, mouthwash containing aloe vera extract to be applied thrice daily, and explicit instruction for bed rest. Conclusion: Dental practitioners must differentiate herpangina from other differential diagnoses thus enabling the acquirement of final diagnosis through clinical examination. This will significantly assist dental practitioners to provide precise clinical therapy for the patient with herpangina.

TOXICITY TEST OF Eusideroxylon zwageri BARK EXTRACT BASED ON KIDNEY HISTOPATHOLOGY OF BLEEDING AND NECROSIS Salsabila, Namira Fathya; Krishnawan Firdaus, I Wayan Arya; Wasiaturrahmah, Yusrinie; Putri Utami, Juliyatin; Setiawan, Bambang
Dentino: Jurnal Kedokteran Gigi Vol 10, No 1 (2025)
Publisher : FKG ULM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v10i1.22201

Background: Ironwood plant (Eusideroxylon zwageri) can potentially be an herbal medicine that accelerates wound healing because of the antioxidant compounds contained in it. The dominant compounds contained in ironwood bark are flavonoids 30.48 mgCE/g, phenolics 31.28 mgCE/g, and proanthocyanidins 183.3 mgCE/g. Before used as an herbal medicine, it is necessary to do an acute toxicity test on ironwood bark at doses of 1.250 mg/kgBW, 2.750 mg/kgBW, and 4.750 mg/kgBW to consider the right dose. Acute toxicity tests can be seen using histopathological appearance in the kidney based on bleeding and necrosis. Purpose: Determine the toxic effects of giving Eusideroxylon zwageri doses of 1.250 mg/kgBW, 2.750 mg/kgBW, and 4.750 mg/kgBW on the kidneys of Wistar rats (Rattus norvegicus) based on bleeding and necrosis in histopathological appearance. Method: Research is true experimental and posttest-only with control design. The study was divided into a control group given aquades and a treatment group given ironbark extract dose of 1.250 mg/kgBW, 2.750 mg/kgBW, and 4.750 mg/kgBW as much as 1 ml given 2 times a day orally for 14 days. Results: The percentage of histopathological appearances of bleeding and necrosis score is 1 or mild. Analysis of bleeding and necrosis did not show significant differences of ironwood bark extract doses of 1.250 mg/kgBW, 2.750 mg/kgBW, and 4.750 mg/kgBW. Conclusion: There were no toxic effects of ironwood bark extract doses of 1.250 mg/kgBW, 2.750 mg/kgBW, and 4.750 mg/kgBW on the kidney organs of wistar rats based on bleeding and necrosis in histopathological appearances.

EFFECT OF IRONWOOD BARK EXTRACT GEL ON LYMPHOCYTE COUNT IN BUCCAL MUCOSA WOUND HEALING RATS Muhlisin, Mahmud; Firdaus, I Wayan Arya Krishnawan; Apriasari, Maharani Lailyza; Utami, Juliyatin Putri; Wydiamala, Erida
Dentino: Jurnal Kedokteran Gigi Vol 10, No 2 (2025)
Publisher : FKG ULM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v10i2.24161

Background: Wounds are disruptions caused by chemical or physical trauma, resulting in tissue damage. During the healing process of oral mucosal wounds, the body initiates defensive and protective immune responses against injury. The acute inflammatory phase is the initial stage of wound healing, marked by the body’s response to injury within a few hours. Lymphocyte cells play a crucial role in the inflammatory phase as part of the adaptive immune system in wound healing. Secondary metabolites in the ironwood bark extract gel, such as proanthocyanidins, phenolics, and flavonoids, function as immunomodulators to enhance immune activity and act as anti-inflammatory and antioxidant agents to accelerate wound healing. Purpose: To prove the effect of ironwood bark extract gel at concentrations 5%, 12.5%, and 20% on lymphocyte cell number in the buccal mucosa incision wounds of male Wistar rats on days 3, 5, and 7. Methods: This study employed a pure experimental design with a post-test only with a control group design, using 36 male Wistar rats divided into treatment and negative control groups. Results: Two-way ANOVA tests revealed significant effects based on treatment and observation days (p < 0.05). Conclusion: Ironwood bark extract gel at concentrations of 5%, 12.5%, and 20% increased lymphocyte cell number on day 3, peaked on day 5 and decreased on day 7 compared to the control group (gel base). Keywords: eusideroxylon zwageri gel, lymphocyte cells, oral mucosal wound healing,

Title

Found 41 Documents
Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title Search

Found 41 Documents Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title

Found 41 Documents
Search