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All Journal HAYATI Journal of Biosciences METAMORFOSA Journal of Biological Sciences Jurnal Veteriner Jurnal Biologi Udayana Agrikultura Biotika: Jurnal Ilmiah Biologi Indonesian Journal of Applied Sciences Biota: Jurnal Ilmiah Ilmu-Ilmu Hayati Biotropika Quagga Bioeksperimen: Jurnal Penelitian Biologi Pro-Life Jurnal Biodjati Bioma : Jurnal Biologi Indonesia Biosaintifika: Journal of Biology & Biology Education Jurnal Riset Akuakultur Jurnal Kreativitas PKM Indonesian Journal of Limnology Manilkara: Journal of Bioscience Journal of Fisheries & Marine

Desak Made Malini

Departemen Biologi, Fakultas Matematika Dan Ilmu Pengetahuan, Universitas Padjadjaran

Author-ID : 313249

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Earth & Planetary Sciences Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Malformasi Rangka Fetus Tikus Wistar Akibat Efek Teratogenik Insektisida Endosulfan (SKELETAL MALFORMATION OF WISTAR RAT FETUSES DUE TO THE TERATOGENIC EFFECT OF ENDOSULFAN INSECTICIDE) Desak Made Malini; Madihah Madihah; Amalia Shalihah
Jurnal Veteriner Vol 18 No 3 (2017)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

Endosulfan an organochlorine insecticide that is commonly used even though it has been banned due to its toxic and teratogenic effect. This study aims to determine the effect of orally endosulfan exposure to pregnant rat (Rattus norvegicus) at day 6-15th of gestation period to the foetus skeletal malformation. A Completely Randomized Design (CRD) by endosulfan dosages: 0 (control); 0.083; 0.190; 0.440; 1.000 mg/kg BW/day with 5 replicates was applied. At 20th of the gestational period, the rats were sacrificed, their reproductive organs and the fetal skeletal malformation were observed using Alizarin red S method. The results of one-way ANOVA test showed that endosulfan exposure did not significantly affect the pregnancy outcomes ie. female rats weight gain, the numbers of implanted foetus, foetal body weight and length, respectively. Malformation of foetus implantation, foetus size and foetus skeletal occured in the endosulfan exposure groups. Fisher’s exact test results showed a significant difference between the control group and the endosulfan exposure group on the number of foetuses that have abnormalities in the number of skeletons of the sternum, fore and hind paws. The exposure of endosulfan at 0.083-1.000 mg / kg BW / day in pregnant rats caused skeletal malformations of the foetus ie. decreased in the number on sternum, fore- and hind paw bones. ABSTRAK Endosulfan merupakan insektisida golongan organoklorin yang masih digunakan hingga kini meski telah dilarang karena bersifat toksik dan teratogenik. Penelitian ini bertujuan untuk mengetahui efek pemajanan endosulfan secara oral terhadap malformasi rangka fetus tikus (Rattus norvegicus Berkenhout, 1769) selama umur kebuntingan 6-15 hari. Penelitian dilakukan secara eksperimental di laboratorium menggunakan Rancangan Acak Lengkap (RAL) dengan pemajanan endosulfan dosis: 0 (kontrol); 0,083; 0,19; 0,44; dan 1 mg/kg BB/hari dan masing-masing diulang sebanyak lima kali. Induk betina dengan umur kebuntingan 20 hari, dikorbankan nyawanya lalu dibedah dan diamati tampilan reproduksi induk serta malformasi rangka pada fetus dengan metode pewarnaan Alizarin red S. Hasil uji sidik ragam satu arah menunjukkan pemajanan endosulfan tidak berpengaruh secara signifikan terhadap rataan pertambahan bobot badan induk, jumlah fetus terimplantasi, bobot badan dan panjang fetus. Malformasi implantasi fetus, ukuran fetus dan rangka fetus terjadi pada kelompok pemajanan endosulfan. Hasil uji eksak Fisher menunjukkan adanya perbedaan yang signifikan antara kelompok kontrol dengan kelompok pemajanan endosulfan terhadap jumlah fetus yang mengalami kelainan jumlah rangka penyusun sternum, cakar depan dan cakar belakang. Simpulan dari penelitian ini adalah pemajanan endosulfan dosis 0,083- 1,000 mg/kg BB/hari pada tikus bunting menimbulkan malformasi rangka pada fetus yaitu berkurangnya jumlah tulang penyusun sternum, cakar depan, dan cakar belakang.

Ekstrak Etanol Kulit Buah Jengkol Menurunkan Kadar Glukosa dan Meningkatkan Hormon Insulin Tikus Diabetes Yang Diinduksi Streptozotocin Desak Made Malini; Madihah Madihah; Dita Aprila Khoirunnisa; Indriani Sasmita; Nining Ratningsih; Kartiawati Alipin; Wawan Hermawan
Jurnal Veteriner Vol 20 No 1 (2019)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

Diabetes Mellitus (DM) is a disease with metabolism disorder signed by increasing of glucose blood (hyperglicemia), caused by disorder of insulin secretion and or increasing of insulin resistance. Therapy of jengkol’s fruit peel is an alternative treatment for DM. This study aims to determine the effect of ethanol extract of jengkol’s fruit peel to decrease glucose and increase insulin level of Wistar female rats which induced by streptozotocin (STZ). This research used the experimental method of Completely Randomized Design (RAL). Rat were first induced by single intravenous injection of STZ except Negative Control. Furthermore, rats were divided into six groups, namely Negative Control (NC), Positive Control (PC), Reference Group (RG) glibenclamide 10 mg/kg BW, and ethanol extract of jengkol’s fruit peel (EEOJFP) treatment at dose of 385 (P1), 770 (P2), and 1540 (P3) mg/kg BW with four replications each. Treatment was administered orally for 14 days. Data were analyzed by analysis of variance (ANAVA) with 95% confidence level and Duncan Multiple Range Test. The result showed that treatment of EEOJFP with dose of 385, 770 and 1540 mg/ kgBW decreased blood glucose 28.6%;65.4% and 59.1% successively, increased insulin as 54%; 230% and 206%. There was a protective effect of EEOJEF to level of blood glucose and insulin secretion of rat-STZ induced. The conclusion from this research is Ethanol extract of Jengkol’s fruit peel at dose 770 mg/kg BW is an effective dose in decreasing the level of glucose and increasing the level of insulin hormone in STZinduced diabetic rats.

Noni simplistic effect with Chicken Shank Gelatin Film on White Rat Spleen Exposed to Dexamethasone Virita Rossa Pratiwi; Yasmi Purnamasari Kuntana; Ruly Budiono; Desak Made Malini; Joko Kusmoro
Jurnal Veteriner Vol 24 No 1 (2023)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19087/jveteriner.2023.24.1.122

Dexamethasone is a corticosteroid drug belong to glucocorticoid group. Dexamethasone is immunosuppressant and anti-inflammatory in various inflammatory conditions. Side effects of its use can cause cell apoptosis in various organs such as the spleen. The immunosuppressant effect of dexamethasone can reduce and inhibit peripheral lymphocytes and macrophages until the death of lymphoid cells in the white pulps of the spleen. The simultaneous effect of administering chicken shank gelatin and noni has the potential to improve the structure of the spleen. This study was aimed to prove and obtain effective and safe dose of chicken shank gelatin and noni on the spleens of rats exposed to dexamethasone. The research was carried out experimentally in the laboratory with a completely randomized design (CRD). A total of 25 heads male rats were grouped into five treatments and each treatment consist of five repetitions. There was a treatment group P1 as a negative control, P2 as a positive control (dexamethasone 5 mg/kg BW), P3-P5 (dexamethasone 5 mg/kg + gelatin 1.585 mg/kg + noni simplicia 50; 112; 250 mg/kg BW). The results of the study showed an increase in the area of white pulps and a decrease in the percentage of necrotic cells in the spleen, however, it did not increase the relative weight of the spleen and serum albumin levels (P>0.05). In conclusion, the effective and safe dose for the spleen organs of rats exposed to dexamethasone is 250 mg/kg BW.

Perbaikan Profil Kolesterol dan Histologis Jantung Tikus Model Diabetes dengan Nanopartikel Poly(Lactic-Co-Glycolic Acid) -Ekstrak Etanol Kulit Buah Jengkol desak made Malini; Firda Mohammad Firdous; Madihah Madihah; Wawan Hermawan
Jurnal Veteriner Vol 24 No 2 (2023)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19087/jveteriner.2023.24.2.238

Diabetes mellitus merupakan penyakit kelainan metabolisme glukosa akibat defisiensi atau penurunan efektivitas insulin. Kondisi ini memicu terjadinya hiperlipidemia yang ditandai dengan kadar low density lipoprotein (LDL) yang tinggi dan high density lipoprotein (HDL) rendah serta meningkatkan risiko terkena penyakit jantung. Penelitian ini bertujuan untuk menguji efektivitas nanopartikel poly(lactic-co-glycolic acid) atau PLGA-ekstrak etanol kulit buah jengkol (EEKBJ) dalam memperbaiki profil kolesterol dan kerusakan struktur histologis jantung tikus (Rattus Norvegicus) Wistar model diabetes. Tikus yang digunakan sebanyak 30 ekor yang dibagi menjadi enam kelompok yaitu satu kelompok normal dan lima kelompok diabetes. Induksi model tikus diabetes dilakukan dengan injeksi intravena streptozotocin (STZ) dosis 65 mg/kg BB. Perlakuan yang diberikan adalah KN (Carboxy Methyl Cellulose (CMC) 0,5%), kontrol positif (KP) (STZ+CMC 0,5%), pembanding (Pb) (STZ+Glibenklamid dosis 10 mg/kg BB), P1 (STZ+EEKBJ 770 mg/kg BB), P2 (STZ+EEKBJ 110 mg/kg BB), dan P3 (STZ+nanopartikel PLGA-EEKBJ 110 mg/kg BB) selama 14 hari berturut-turut. Parameter yang diamati adalah kadar kolesterol HDL dan LDL, jumlah sel nekrosis, dan derajat kerusakan pada sel miokardium (degenerasi hidropik, degenerasi lemak, dan infiltrasi sel radang). Uji analisis statistika menggunakan sidik ragam, dilanjutkan dengan uji Kruskal Wallis dan uji jarak berganda Duncan. Hasil penelitian menunjukkan bahwa pemberian nanopartikel PLGA-EEKBJ menurunkan kadar LDL, jumlah sel nekrosis, derajat kerusakan histologis dan meningkatkan kadar kolesterol HDL secara signifikan (p>0,05), Simpulan dari penelitian ini adalah nanopartikel PLGA-EEKBJ dosis 110 mg/kg BB efektif memperbaiki profil kolesterol dan struktur histologis jantung tikus model diabetes.

Co-Authors . SUNARDI Adam Robisalmi, Adam Adnin Laila Amalia Shalihah Andi Perdana Anggraeni, Fajar ANNISA JOVIANI ASTARI Artati, Diah Asep Sopian Azalea Putri Bisri Mustofa Camellia Panatarani Damanhuri, Joni Haryadi Dea Rahman Khairunnisa Dita Aprila Khoirunnisa Dwi Rahmi Dzikrina Syahidah, Dzikrina Elsa Dwi Fauzany Emay Maulani Emilie Nuraida Erawan Fajar Anggraeni Fajar Anggraeni Firda Mohammad Firdous Furqon, Wildanul Hary Krettiawan Hikmat Kasmara I Made Joni Iin Supartinah Ikhsan Khasani Imron Imron Imron Imron, Imron Indriani Sasmita Johan Iskandar Joko Kusmoro Joko Kusmoro Kabul Fadilah Kamilawati, Fitri Kartiawati Alipin KEUKEU KANIAWATI Keukeu Kaniawati Rosada Khairul Syahputra, Khairul Kuntana, Yasmi Purnamasari Listiyowati, Nunuk Madihah Madihah Madihah Madihah Madihah Madihah Madihah Madihah Madihah Madihah Madihah Madihah, Madihah Melanie Melanie Melanie Melanie, Melanie Mia Miranti Rustama Miranti Ariyani Muliani, Reni Muliani, Reni Nadia Istiqomah Nana Media Nia Rossiana Nining Ratningsih Nining Ratningsih Nining Ratningsih Nining Ratningsih Nurullia Fitriani Octaviani, Regita Perdana, Andi Permana, Andre Dian Putri, Deviana Aulia Rani Maharani Reni Muliani Resty Agustin Ruly Budiono Sairandri Dyah Harjanti, Sairandri Dyah Sofia Dorothy SRI WULANDARI sunardi sunardi Supartinah, Iin Syifa Yolanda TEGUH HUSODO TEGUH HUSODO Tia Setiawati Tia Setiawati Tia Setiawati Tri Dewi K. P Tri Dewi Kusumaningrum Pribadi Tri Mayanti Virita Rossa Pratiwi Vita Novianti Wahyu Pamungkas Wawan Hermawan Wawan Hermawan Wawan Hermawan Wawan Hermawan Wawan Hermawan Wildanul Furqon Yasmi Purnamasari Kuntana

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