Article Per Year (5 Year)
p-Index From 2020 - 2025
3.662
P-Index
This Author published in this journals
All Journal HAYATI Journal of Biosciences METAMORFOSA Journal of Biological Sciences Jurnal Veteriner Jurnal Biologi Udayana Agrikultura Biotika: Jurnal Ilmiah Biologi Indonesian Journal of Applied Sciences Biota: Jurnal Ilmiah Ilmu-Ilmu Hayati Biotropika Quagga Bioeksperimen: Jurnal Penelitian Biologi Pro-Life Jurnal Biodjati Bioma : Jurnal Biologi Indonesia Biosaintifika: Journal of Biology & Biology Education Jurnal Riset Akuakultur Jurnal Kreativitas PKM Indonesian Journal of Limnology Manilkara: Journal of Bioscience Journal of Fisheries & Marine
Desak Made Malini
Departemen Biologi, Fakultas Matematika Dan Ilmu Pengetahuan, Universitas Padjadjaran
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Earth & Planetary Sciences Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

Published : 34 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search
Journal : Biotropika

 1 
Hematological Profile and Spleen Histology Improvement in Diabetic Rats Treated with PLGA Nanoparticles-Ethanol Extract of Jengkol (Archidendron pauciflorum) Fruit Peel Malini, Desak Made
Biotropika: Journal of Tropical Biology Vol. 10 No. 3 (2022)
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.biotropika.2022.010.03.01

Abstract

Jengkol (Archidendron pauciflorum) fruit peel-ethanol extract (JFP) contains several chemical compounds that act as antioxidant agents and are considered to have the potential to treat chronic disorders such as diabetes mellitus. Plant extract is generally applied in polylactic-co-glycolic acid (PLGA) nanoparticles due to its efficiency in entering the target organs. This study aims to investigate the effect of PLGA nanoparticles-ethanol extract of jengkol fruit peel (PLGA nanoparticle-JFP) on improving the hematological profile and the spleen histology of streptozotocin-induced diabetic rats. The treatment group was divided into six groups: (1) control group, (2) streptozotocin control (STZ); (3) 10 mg/kg BW of glibenclamide (GLB); (4) 770 mg/kg BW of jengkol fruit peel-ethanol extract (JFP1); (5) 110 mg/kg BW of JFP (JFP2); and (6) 770 mg/kg BW PLGA nanoparticle-JFP (PLGA-JFP). PLGA-JFP group showed a significant increase in erythrocytes and leukocytes counts (7.73x106 ± 0.02 cell/mm3 and 9.68x103 ± 3.0 cell/mm3 respectively), a decrease in lymphocytes and neutrophils percentage (66.5%±0.5% and 28±1.4% respectively) compared to the STZ group, and no significant difference in monocyte, eosinophils, and basophils percentage within groups. On the spleen histology, the white pulp diameter and the red pulp area showed significantly smaller (168.31±10.69μm and 8,01.28± 480.33 μm2 respectively) compared to the STZ group. Almost all parameters showed no significant difference compared to the GLB group but are significantly different from the control group. The administration of PLGA nanoparticle-JFP was proven to reverse hematological parameters and improve the spleen histology but has not yet reversed the diabetic rats’ condition back to normal.
Co-Authors . SUNARDI Adam Robisalmi, Adam Adnin Laila Amalia Shalihah Andi Perdana Anggraeni, Fajar ANNISA JOVIANI ASTARI Artati, Diah Asep Sopian Azalea Putri Bisri Mustofa Camellia Panatarani Damanhuri, Joni Haryadi Dea Rahman Khairunnisa Dita Aprila Khoirunnisa Dwi Rahmi Dzikrina Syahidah, Dzikrina Elsa Dwi Fauzany Emay Maulani Emilie Nuraida Erawan Fajar Anggraeni Fajar Anggraeni Firda Mohammad Firdous Hary Krettiawan Hikmat Kasmara I Made Joni Iin Supartinah Ikhsan Khasani Imron Imron Imron Imron, Imron Indriani Sasmita Johan Iskandar Joko Kusmoro Joko Kusmoro Kabul Fadilah Kamilawati, Fitri Kartiawati Alipin KEUKEU KANIAWATI Keukeu Kaniawati Rosada Khairul Syahputra, Khairul Kuntana, Yasmi Purnamasari Listiyowati, Nunuk Madihah Madihah Madihah Madihah Madihah Madihah Madihah Madihah Madihah Madihah Madihah Madihah, Madihah Melanie Melanie Melanie Melanie, Melanie Mia Miranti Rustama Miranti Ariyani Muliani, Reni Muliani, Reni Nadia Istiqomah Nana Media Nia Rossiana Nining Ratningsih Nining Ratningsih Nining Ratningsih Nining Ratningsih Nurullia Fitriani Octaviani, Regita Perdana, Andi Permana, Andre Dian Putri, Deviana Aulia Rani Maharani Reni Muliani Resty Agustin Ruly Budiono Sairandri Dyah Harjanti, Sairandri Dyah Sofia Dorothy SRI WULANDARI sunardi sunardi Supartinah, Iin Syifa Yolanda TEGUH HUSODO TEGUH HUSODO Tia Setiawati Tia Setiawati Tia Setiawati Tri Dewi K. P Tri Dewi Kusumaningrum Pribadi Tri Mayanti Virita Rossa Pratiwi Vita Novianti Wahyu Pamungkas Wawan Hermawan Wawan Hermawan Wawan Hermawan Wawan Hermawan Wawan Hermawan Wildanul Furqon Yasmi Purnamasari Kuntana