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All Journal Jurnal Fitopatologi Indonesia VALENSI Jurnal Kimia (Journal of Chemistry) Agrikultura Biotika: Jurnal Ilmiah Biologi Journal of Marine Research Cropsaver : Journal of Plant Protection Jurnal Penelitian Hasil Hutan Padjadjaran Journal of Dentistry Chimica et Natura Acta ALCHEMY Jurnal Penelitian Kimia Indonesian Journal of Chemistry Molekul: Jurnal Ilmiah Kimia Jurnal Penelitian Hasil Hutan Jurnal Ilmiah Berkala Sains dan Terapan Kimia Makara Journal of Science Molekul: Jurnal Ilmiah Kimia Media Penelitian dan Pengembangan Kesehatan Jurnal Penelitian Hasil Hutan
Tri Mayanti
Jurusan Kimia, Fakultas Matematika Dan Ilmu Pengetahuan Alam, Universitas Padjadjaran
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Energy Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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Antioxidant Constituents from the Bark of Aglaia eximia (Meliaceae) Sianturi, Julinton; Farabi, Kindi; Mayanti, Tri; Harneti, Desi; Darwati,; Supratman, Unang; Awang, Khalijah; Hayashi, Hideo
Makara Journal of Science Vol. 20, No. 1
Publisher : UI Scholars Hub

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Abstract

The genus Aglaia is a a rich source of different compounds with interesting biological activities. A part of our continuing search for novel biologically active compounds from Indonesia Aglaia plants, the ethyl acetate extract of bark of Aglaia eximia showed significant antioxidant activity. Four antioxidant compounds, kaempferol (1), kaempferol-3-O-α-L-rhamnoside (2), kaempferol-3-O-β-D-glucoside (3) and kaempferol-3-O-β-D-glucosyl-(1→4)-α-L-rhamnoside (4) were isolated from the bark of Aglaia eximia (Meliaceae). The chemical structures of compounds 1-4 were identified on the basis of spectroscopic datas including UV, IR, NMR and MS along with by comparison with those spectra datas previously reported. All compounds showed DPPH radical-scavenging activity with IC50 values of 1.18, 6.34, 8.17, 10.63 mg/mL, respectively.
Flavonoid Compounds from the Bark of Aglaia eximia (Meliaceae) Sianturi, Julinton; Purnamasari, Mayshah; Mayanti, Tri; Harneti, Desi; Supratman, Unang; Awang, Khalijah; Hayashi, Hideo
Makara Journal of Science Vol. 19, No. 1
Publisher : UI Scholars Hub

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Abstract

Three flavonoid compounds, kaempferol (1), kaempferol-3-O-α-L-rhamnoside (2), and kaempferol-3-O-β-D-glucosyl-α-L-rhamnoside (3), were isolated from the bark of Aglaia eximia (Meliaceae). The chemical structures of compounds 1–3 were identified with spectroscopic data, including UV, IR, NMR (1H, 13C, DEPT 135°, HMQC, HMBC, 1H-1H-COSY NMR), and MS, as well as a compared with previously reported spectra data. All compounds were evaluated for their cytotoxic effects against P-388 murine leukemia cells. Compounds 1–3 showed cytotoxicity against P-388 murine leukemia cells with IC50 values of 1.22, 42.92, and >100 mg/mL, respectively
Cytotoxic Triterpenoid from the Stembark of Chisocheton celebicus (Meliaceae) Katja, Dewa Gede; Farabi, Kindi; Harneti, Desi; Mayanti, Tri; Supratman, Unang
Makara Journal of Science Vol. 21, No. 1
Publisher : UI Scholars Hub

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Abstract

Plants belonging to the Chisocheton genus are a rich source of tetracylic triterpenoids with diverse biological activities. Two triterpenoid compounds,dammar-20,24-dien-3-one (1) and 3β-hydroxy-tirucall-7-en (2) were isolated from the stembark of Chisocheton celebicus. The chemical structures of compounds 1 and 2 were identified by spectroscopic data, including IR, NMR (1H, 13C, DEPT 135°, HMQC, HMBC, 1H-1H COSY), and MS, and they were compared with previously reported spectral data. Compounds 1 and 2 were evaluated for their cytotoxic effects against P-388 murineleukemia cells. The compounds showed cytotoxicity against P-388 murine leukemia cells, with IC50 values of 30.2 and 4.3 μg/mL, respectively.
Nimonol from Chisocheton macrophyllus (Meliaceae) Seeds and Their Cytotoxic Activity against P-388 Leukaemia Cells Nurlelasari Nurlelasari; Desi Harneti P. Huspa; Rani Maharani; Darwati Darwati; Tri Mayanti; Kindi Farabi; Muhammad Hanafi; Unang Supratman
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 8, No. 2, November 2022
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v8i2.27782

Abstract

The Chisocheton genus belongs to the Meliaceae family which produces various structures and activities of compounds, such as antimalarial, antimicrobial, antitumor, anti-inflammatory, and cytotoxic. This plant has 53 species that are spread in tropical and sub-tropical forests, including Indonesia. Chisocheton plants have been known as plants that produce limonoids, namely triterpenoid compounds that have been modified to lose four terminal carbons (tetranortriterpenoids). One of the species whose phytochemical reports are still few and interesting for research on limonoid content is Chisocheton macrophyllus. Chisocheton macrophyllus is a tall plant that grows in the rainforest in the northern part of the island of Sulawesi, Indonesia, has the regional name ma aa, gula, pasak lingga, gending, ta suea, bekak, or pithraj tree. This paper will describe a limonoid compound, namely nimonol which has been isolated from Chisocheton macrophyllus. Nimonol is known to have the molecular formula C28H36O5 from a group of havanensin. The structure was determined by spectroscopic methods UV, IR, 1D-NMR (1H-NMR, 13C-NMR, and DEPT), 2D-NMR (1H-1H COSY, HMQC, and HMBC), and mass spectroscopy.
Isolation and Structure Determination of Stigmaterol from the Stem Bark of Lansium domesticum Corr. Cv. Kokossan Siska Elisahbet Sinaga; Fajar Fauzi Abdullah; Unang Supratman; Tri Mayanti; Rani Maharani
Chimica et Natura Acta Vol 10, No 3 (2022)
Publisher : Departemen Kimia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/cna.v10.n3.39240

Abstract

Indonesia is a tropical country with biodiversity and a source of natural compounds such as terpenoids, phenolic, flavonoids, and alkaloid groups. The steroid is one of the large groups of terpenoid compounds with various structures and bioactivities. The steroid was also commonly found in the Meliaceae family. One species of this family is Lansium domesticum Corr. which has been studied to have various activities from isolated compounds (limonoids, sesquiterpenoids, onoceranoids, cycloartanoids, and steroids) as well as from their extracts such as antidiarrheal, antimalarial, antimicrobial, antiinsecticide, antifeedant and were used as traditional medicine such as eye drops and scorpion stings. The n-hexane fraction from the bark of L. domesticum Cor. cv. Kokosan produced steroid compounds whose structure is determined by IR, 1H-NMR, 13C-NMR, and DEPT spectroscopy methods and compared with the literature. It was concluded that the steroid isolated was (22E)-stigmasta-5,22-dien-3ol and was first isolated from this genus. This compound was inactive against MCF-7 breast cancer cells with an IC50 value of 832.14 µM.
Aktivitas Antibakteri Ekstrak n-Heksana Daun Mangrove (Rhizospora stylosa Griff) Terhadap Bakteri Patogen Pada Ikan Nila (Oreochromis niloticus) Sri Rejeki Rahayuningsih; Siva Siti Patimah; Tri Mayanti; Mia Miranti Rustama
Journal of Marine Research Vol 12, No 1 (2023): Journal of Marine Research
Publisher : Departemen Ilmu Kelautan, Fakultas PerikanJurusan Ilmu Kelautan, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jmr.v12i1.35657

Abstract

Usaha bidang perikanan sering mendapat kendala karena terjadi penyakit infeksi yang berakibat kematian ikan dan penggunaan antibiotik untuk mengatasi infeksi bakteri pathogen pada bidang perikanan secara terus menerus yang tidak terukur telah menyebabkankan resistansi, dan berakibat menurunnya produktifitas. Diketahui bahwa Mangrove (Rhizophora stylosa) merupakan tumbuhan yang mengandung metabolit sekunder potensial sebagai antibakteri. Tujuan dari penelitian ini untuk mendapatkan konsentrasi ekstrak (n-heksana) daun mangrove R. stylosa yang dapat menghambat pertumbuhan bakteri Vibrio spp dan A.hydrophila. Penelitian menggunakan metode eksperimental dengan Rancangan Acak Lengkap (RAL), dengan dua faktor dan  3 ulangan. Faktor perlakuan pertama adalah jenis bakteri Vibrio spp dan A. hyrdophila dan faktor perlakuan kedua adalah konsentrasi ekstrak 5000ppm,10.000ppm, 15.000 ppm, 20.000 ppm, dan kontrol positif (amoxicillin). Parameter penelitian adalah Konsentrasi Hambat Minimum (KHM) dan diameter zona hambat . Data hasil dianalisis dengan ANAVA dan bila berbeda nyata dilanjutkan dengan Uji Jarak Berganda Duncan. Hasil penelitian menunjukkan bahwa terdapat Perbedaan nyata pengaruh Jenis bakteri dan konsentrasi ekstrak n-heksana daun mangrove terhadap kontrol positif amoxicillin. Ekstrak n-heksana daun R.stylosa lebih menghambat bakteri Vibrio sp.,pada  [5000] katagori kuat dan pada [20000] katagori sangat kuat daripada  A. hydrophila [5000-15000]katagori sedang tetapi pada [20000]katagori kuat dan KHM kedua bakteri vibrio sp dan A. hydrophila terjadi pada [5000]. Dapat disimpulkan bahwa ekstrak n-heksana daun R.stylosa berpotensi sebagai antibakteri Vibrio sp. dan A. hydrophila pada ikan nila (Oreochromis niloticus).   Businesses in the fishery sector often encounter problems due to infectious diseases which result in fish death. The continuous and unmeasured use of antibiotics to treat pathogenic bacterial infections in the fisheries sector has caused resistance, and resulted in decreased productivity. Mangrove (Rhizophora stylosa) is a plant that is known to contain potential secondary metabolites as antibacterial. The purpose of this study was to obtain a concentration of extract (n-hexane) of mangrove leaves R. stylosa which could inhibit the growth of Vibrio sp. and A. hydrophila bacteria. The study used an experimental method with a completely randomized design (CRD), with two factor treantments and 3 replications. The first treatment factor was the type of bacteria Vibrio sp and A. hyrdophila and the second treatment factor was the extract concentration of 5000ppm, 10,000ppm, 15,000 ppm, 20,000ppm, and a positive control (amoxicillin). The research parameters were MIC and the diameter of the inhibition zone The result data were analyzed by ANOVA and if they were significantly different, it was continued with Duncan's Multiple Distance Test. The results show there was a significant difference in the effect of the type of bacteria and the concentration of the n-hexane extract of mangrove leaves on the positive control of amoxicillin. The n-hexane extract of leaves inhibited more Vibrio sp. bacteria, at [5000] strong category and at [20000] very strong category than A. hydrophila [5000-15000] medium category, but in [20000] strong category and MIC of both Vibrio sp and A. hydrophila bacteria occurred in [5000].. It can be concluded that the n-hexane extract of  R. stylosa leaves has the potential as an antibacterial for   Vibrio sp. and A. hydrophila in nila fish(Oreochromis niloticus).
Steroids from Atactodea striata and Their Cytotoxic Activity against MCF-7 Breast Cancer Cell Lines Evan Hadrian; Aprilia Permata Sari; Tri Mayanti; Desi Harneti; Rani Maharani; Darwati Darwati; Kindi Farabi; Unang Supratman; Celcius Waranmaselembun; Supriatno Salam; Sofa Fajriah; Muhamad Nurul Azmi
Indonesian Journal of Chemistry Vol 23, No 1 (2023)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.76438

Abstract

Marine environment is known as a source of potential steroids with multiple biological activities, one of which is an anticancer agent. Atactodea striata are one of the seashells distributed in Indonesia located in the Kei Islands, Southeast Maluku. During the course of our continuing search for biologically active substances from Indonesia seashells, seven steroids have been isolated from the n-hexane fraction of A. striata and they were identified as 7β-hydroxy-sitosterol (1), campesterol (2), β-sitosterol (3), cholesterol (4), 5α,8α-epidioxycholest-6-en-3-β-ol (5), 7-keto-cholesterol (6), and 7α-hydroxy-cholesterol (7). The structure was identified by spectroscopic methods including 2D NMR techniques, FTIR, HRTOFMS, and chemical shift comparison with previously reported spectral data. Compounds 1-7 were evaluated for their cytotoxic effects against MCF-7 breast cancer cells and showed weak or no anticancer activity.
Terpenoids from the Stem bark of Aglaia elaeagnoidea and their cytotoxic activity against HeLa and DU145 Cancer Cell lines Dini Oktaviani; Winda Sukmawati; Kindi Farabi; Desi Harneti; Nurlelasari Nurlelasari; Darwati Darwati; Rani Maharani; Tri Mayanti; Agus Safari; Unang Supratman
Molekul Vol 17 No 1 (2022)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2022.17.1.5594

Abstract

Aglaia is the largest genus of the Meliaceae family which contains terpenoid compounds. This type of compounds showed a diverse structures and biological activities that can be found in natural resources. Aglaia elaeagnoidea is a species from Aglaia genus that only has a few previous research. This study was aimed to isolate and determine the chemical structure of terpenoid compounds from the ethyl acetate extract of A. elaeagnoidea stem bark. Ethyl acetate extracts were separated and purified by various chromatographic techniques to obtain compounds 1-5. Compounds 1-5 were identified their chemical structures by spectroscopic methods (IR, MS, and NMR) and comparison with previous reported spectral data. Compounds 1 and 2 were identified as eudesmane-type sesquiterpenoids, 5-epi-eudesm-4(15)-ene-1β,6β-diol (1) and 6α-Hydroxy-eudesm-4(15)-en-1-one (2). Compounds 3-5 were identified as dammarane-type triterpenoids, 20S,24S-epoxy-25-hydroxydammarane-3-one (3), 20S,24S-epoxydammarane-3α,25-diol (4), and 3α-epi-cabraleahydroxy lactone (5). These compounds are first time reported from this plant. Compounds 1-5 were tested for cytotoxicity against HeLa cervical cancer cell and DU145 prostate cancer cell and as a result, compound 4 (20S,24S-epoxydammarane-3α,25-diol) showed the stronger activity compared to other compounds.
Triterpenoids from the Stem Bark of Aglaia cucullata (Meliaceae) and Their Cytotoxic Activity against A549 Lung Cancer Cell Line Desi Harneti; Iqbal Wahyu Mustaqim; Darwati Darwati; Al Arofatus Naini; Purnama Purnama; Erina Hilmayanti; Tri Mayanti; Nurlelasari Nurlelasari; Shabarni Gaffar; Rani Maharani; Kindi Farabi; Unang Supratman; Sofa Fajriah; Mohamad Nurul Azmi; Yoshihito Shiono
Indonesian Journal of Chemistry Vol 23, No 4 (2023)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.78748

Abstract

The Aglaia species, which contains triterpenoids, is the most numerous in the Meliaceae family. The A. cucullata species, of which there are only a few known examples, has received scant research attention. This investigation aims to identify triterpenoids in an n-hexane preparation of A. cucullata stem bark and evaluate their effects against the A549 lung cancer cell line. Five dammarane-type triterpenoids were isolated from the A. cucullata trunk bark, which is (1) (20S)-20-hydroxydammar-24-en-3-one, (2) cabraleone, (3) cabralealactone, (4) eichlerianic acid, and (5) (+)-fouquierol. Their chemical structures were determined using infrared, high-resolution mass spectrometry, and nuclear magnetic resonance, as well as through data comparison of the reported compounds. Compound 1 was priorly separated from the Aglaia genus, compounds 2–4 were first isolated from the A. cucullata species, and compound 5 has been reportedly isolated from the Meliaceae family and the Aglaia genus. All substances were tested for their lethal potential against the A549 lung cancer cell type. A seco structure in the A ring of dammarane-type triterpenoid might play an important part in the lethal activity of component 4, which showed the greatest activity with an IC50 value of 32.17 µM against the A549 lung cancer cell line.
Steroid dari Kulit Batang Aglaia glabrata dan Aktivitas Sitotoksinya terhadap Sel Kanker Leukemia P-388 Risyandi Anwar; Desi Harneti; Vidia Afina Nuraini; Faizah Maira; Nurlelasari Nurlelasari; Tri Mayanti; Rani Maharani; Unang Supratman; Khalijah Awang
Chimica et Natura Acta Vol 11, No 2 (2023)
Publisher : Departemen Kimia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/cna.v11.n2.48980

Abstract

Steroid saponin baru, b-sitosterol-3-O-beta-D-galaktopiranosil-(1-4)-beta-D-glukopiranosida (1), bersama dengan empat steroid yang diketahui (2-5) diisolasi dari kulit batang dari Aglaia glabrata. Struktur kimia senyawa baru dijelaskan berdasarkan data-data spektroskopi. Semua senyawa diuji aktivitas sitotoksiknya terhadap sel kanker leukemia murine P-388. Diantara senyawa yang diisolasi tersebut, stigmasterol (4) menunjukkan aktivitas sitotoksik terkuat dengan nilai IC50 sebesar 12.2 mg/mL.
Co-Authors Abdillah, Lutfi Ace Tatang Hidayat Achmad Zainuddin Aditya Seiza Wibisono Agus Safari Agus Safari Agus Safari Agus Susanto Ahmad Darmawan Ajeng Diantini, Ajeng Al Arofatus Naini Alya Tsamrotul Andre A. Sonda Aneu Wahyuni Anindyta, Annisa Anjari, Intan Hawina Annisa Anindyta Aoliya, Salwa Rohmatul Aprilia Permata Sari Ari Hardianto Azmi, Mohamad Nurul Azzahra, Fathia Celcius Waranmaselembun Darwati Darwati Darwati Darwati Darwati Darwati Darwati Darwati Darwati Darwati Darwati Darwati Darwati Darwati Darwati Darwati Darwati Darwati, Darwati, Darwati Deden Indra Dinata Deden Indra Dinata, Deden Indra Desak Made Malini Desi Harneti Putri Huspa Dewa Gede Katja Dikdik Kurnia Dini Oktaviani DUDI RUNADI Elizabeth Fitriana Sari Endah Yulia Erina Hilmayanti Euis Julaeha Euis Julaeha Evan Hadrian Faizah Maira Fajar Fauzi Abdullah Farabi, Kindi Ferry Ferdiansyah Sofian, Ferry Ferdiansyah Fidela Histiya Gunawan Ghina Izdihar Gunawan, Latifah Harizon Harizon Hideo Hayashi Hideo Hayashi Hideo Hayashi Hikmat Kasmara Hilmayanti, Erina Indri Indriyani Indriyani, Indri Iqbal Wahyu Mustaqim Isramiharti Isramiharti Jamaluddin Al Anshori Jamaludin Al-Anshori Julinton Sianturi Julinton Sianturi Julita Nahar Kansy Haikal Kautsari, Arsi Khalijah Awang Khalijah Awang Khalijah Awang Khalijah Awang Khalijah Awang Khlaijah Awang Kindi Farabi Kindi Farabi Kindi Farabi Kindi Farabi Kindi Farabi Kindi Farabi Kindi Farabi Kindi Farabi Kindi Farabi Kusumiyati Lutfi Abdillah Madihah Madihah Maira, Faizah Mayshah Purnamasari Melanie Melanie Mia Miranti Rustama Mohamad Nurul Azmi Mohamad Nurul Azmi Mohamad Nurzaman Muchlis, Handi Nugraha Muhamad Nurul Azmi Muhammad Andry Muhammad Hanafi Muhammad Hanafi Mustaqim, Iqbal Wahyu Mustofa, Hidayat Nurul Nabila Maudi Nafiah, Mohamad Azlan Naini, Al Arofatus Noor Istifadah Nur Insani Amir Nurcahyanti, Ois Nurjihan, Khansa Nurlelasari Nurlelasari Nurlelasari Nurul Qomarilla Ois Nurcahyanti Purnama Purnama Purnama Purnama Qomarilla, Nurul Rani Maharani Rani Maharani Reina Yulianti Reina Yulianti Yulianti Rida Evalina Tarigan Rika Meliansyah Risyandi Anwar Riza Yulisar Romundza, Febbry Ronauli Fitriana Ronny Lesmana Rurini Retnowati Salam, Supriatno Sandra Amalia Riyadi Setiani, Cahya Shabarni Gaffar Shiono, Yoshihito Sianturi, Julinton Siska Elisahbet Sinaga Siva Siti Patimah Sofa Fajriah Sofa Fajriah Sofa Fajriah Sofa Fajriah Sri Hartati Sri Purwani Sri Rejeki Rahayuningsih Supriatno Salam Surbakti, Chemayanti Sylvia Rachmawati Meilanie Tati Herlina Tenny Putri Wikayani Tenny Putri Wikayani, Tenny Putri Unang Supratman Vidia Afina Nuraini Vita Novianti Wahyuni, Aneu Wawan Hermawan Wawan Hermawan Wibisono, Aditya Seiza Widyana, Almas Winda Sukmawati Yoshihito Shiono Yoshihito Shiono Yoshihito Shiono Yoshihito Shiono Yulisar, Riza Zahidah Nurulhaq Zulfikar Zulfikar