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All Journal Jurnal Fitopatologi Indonesia Jurnal Kimia (Journal of Chemistry) Agrikultura Biotika: Jurnal Ilmiah Biologi Journal of Marine Research Cropsaver : Journal of Plant Protection Padjadjaran Journal of Dentistry Chimica et Natura Acta Indonesian Journal of Chemistry Molekul: Jurnal Ilmiah Kimia Makara Journal of Science Molekul: Jurnal Ilmiah Kimia Media Penelitian dan Pengembangan Kesehatan
Tri Mayanti
Jurusan Kimia, Fakultas Matematika Dan Ilmu Pengetahuan Alam, Universitas Padjadjaran
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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Antioxidant Constituents from the Bark of Aglaia eximia (Meliaceae) Sianturi, Julinton; Farabi, Kindi; Mayanti, Tri; Harneti, Desi; Darwati,; Supratman, Unang; Awang, Khalijah; Hayashi, Hideo
Makara Journal of Science Vol. 20, No. 1
Publisher : UI Scholars Hub

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Abstract

The genus Aglaia is a a rich source of different compounds with interesting biological activities. A part of our continuing search for novel biologically active compounds from Indonesia Aglaia plants, the ethyl acetate extract of bark of Aglaia eximia showed significant antioxidant activity. Four antioxidant compounds, kaempferol (1), kaempferol-3-O-α-L-rhamnoside (2), kaempferol-3-O-β-D-glucoside (3) and kaempferol-3-O-β-D-glucosyl-(1→4)-α-L-rhamnoside (4) were isolated from the bark of Aglaia eximia (Meliaceae). The chemical structures of compounds 1-4 were identified on the basis of spectroscopic datas including UV, IR, NMR and MS along with by comparison with those spectra datas previously reported. All compounds showed DPPH radical-scavenging activity with IC50 values of 1.18, 6.34, 8.17, 10.63 mg/mL, respectively.
Flavonoid Compounds from the Bark of Aglaia eximia (Meliaceae) Sianturi, Julinton; Purnamasari, Mayshah; Mayanti, Tri; Harneti, Desi; Supratman, Unang; Awang, Khalijah; Hayashi, Hideo
Makara Journal of Science Vol. 19, No. 1
Publisher : UI Scholars Hub

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Abstract

Three flavonoid compounds, kaempferol (1), kaempferol-3-O-α-L-rhamnoside (2), and kaempferol-3-O-β-D-glucosyl-α-L-rhamnoside (3), were isolated from the bark of Aglaia eximia (Meliaceae). The chemical structures of compounds 1–3 were identified with spectroscopic data, including UV, IR, NMR (1H, 13C, DEPT 135°, HMQC, HMBC, 1H-1H-COSY NMR), and MS, as well as a compared with previously reported spectra data. All compounds were evaluated for their cytotoxic effects against P-388 murine leukemia cells. Compounds 1–3 showed cytotoxicity against P-388 murine leukemia cells with IC50 values of 1.22, 42.92, and >100 mg/mL, respectively
Cytotoxic Triterpenoid from the Stembark of Chisocheton celebicus (Meliaceae) Katja, Dewa Gede; Farabi, Kindi; Harneti, Desi; Mayanti, Tri; Supratman, Unang
Makara Journal of Science Vol. 21, No. 1
Publisher : UI Scholars Hub

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Abstract

Plants belonging to the Chisocheton genus are a rich source of tetracylic triterpenoids with diverse biological activities. Two triterpenoid compounds,dammar-20,24-dien-3-one (1) and 3β-hydroxy-tirucall-7-en (2) were isolated from the stembark of Chisocheton celebicus. The chemical structures of compounds 1 and 2 were identified by spectroscopic data, including IR, NMR (1H, 13C, DEPT 135°, HMQC, HMBC, 1H-1H COSY), and MS, and they were compared with previously reported spectral data. Compounds 1 and 2 were evaluated for their cytotoxic effects against P-388 murineleukemia cells. The compounds showed cytotoxicity against P-388 murine leukemia cells, with IC50 values of 30.2 and 4.3 μg/mL, respectively.
Isolation and Structure Determination of Stigmaterol from the Stem Bark of Lansium domesticum Corr. Cv. Kokossan Siska Elisahbet Sinaga; Fajar Fauzi Abdullah; Unang Supratman; Tri Mayanti; Rani Maharani
Chimica et Natura Acta Vol 10, No 3 (2022)
Publisher : Departemen Kimia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/cna.v10.n3.39240

Abstract

Indonesia is a tropical country with biodiversity and a source of natural compounds such as terpenoids, phenolic, flavonoids, and alkaloid groups. The steroid is one of the large groups of terpenoid compounds with various structures and bioactivities. The steroid was also commonly found in the Meliaceae family. One species of this family is Lansium domesticum Corr. which has been studied to have various activities from isolated compounds (limonoids, sesquiterpenoids, onoceranoids, cycloartanoids, and steroids) as well as from their extracts such as antidiarrheal, antimalarial, antimicrobial, antiinsecticide, antifeedant and were used as traditional medicine such as eye drops and scorpion stings. The n-hexane fraction from the bark of L. domesticum Cor. cv. Kokosan produced steroid compounds whose structure is determined by IR, 1H-NMR, 13C-NMR, and DEPT spectroscopy methods and compared with the literature. It was concluded that the steroid isolated was (22E)-stigmasta-5,22-dien-3ol and was first isolated from this genus. This compound was inactive against MCF-7 breast cancer cells with an IC50 value of 832.14 µM.
Limonoids Isolated from Chisocheton pentandrus (Meliaceae) Stembarks and its Cytotoxicity Towards MCF-7 Breast Cancer Cell Line Runadi, Dudi; Anjari, Intan Hawina; Purnama, Purnama; Nurlelasari, Nurlelasari; Harneti, Desi; Mayanti, Tri; Harizon, Harizon; Hidayat, Ace Tatang; Salam, Supriatno; Azmi, Mohamad Nurul; Supratman, Unang
Makara Journal of Science
Publisher : UI Scholars Hub

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Abstract

Chisocheton is a large source of limonoids with various pharmacological effects, such as antiviral, antibacterial, antimalarial, antifungal, and cytotoxic activities. This study aimed to isolate, elucidate, and evaluate the cytotoxicity of limonoids from C. pentandrus stembarks. Isolation was carried out using various separation methods including extraction and column chromatography. Spectral data were analyzed by FT-IR, UV, DEPT 135°, 1H, 13C-NMR, and HRTOF-MS and compared with those previously reported to determine the chemical structure.The obtained limonoids were lasiocarpine (1), lasiocarpine B (2), pentandricine (3), and 16β-hydroxydysobinin (4); all of which were successfully isolated from C. pentandrus for the first time. The cytotoxic activity of these limonoids were also evaluated against Michigan Cancer Foundation-7 (MCF-7) breast cancer cells using PrestoBlue method. Lasiocarpine A revealed the strongest cytotoxicity with an IC50 of 42.62 µM in moderate level.
Potency of Yeast’s Volatile Compounds to Control Cercospora coffeicola: Potency of Yeast’s Volatile Compounds to Control Cercospora coffeicola Hartati, Sri; Meliansyah, Rika; Mayanti, Tri
Jurnal Fitopatologi Indonesia Vol. 20 No. 1 (2024): Januari 2024
Publisher : The Indonesian Phytopathological Society (Perhimpunan Fitopatologi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14692/jfi.20.1.1-14

Abstract

Penyakit bercak daun cercospora yang disebabkan oleh Cercospora coffeicola merupakan salah satu penyakit utama pada tanaman kopi. Di antara metode alternatif untuk mengendalikan penyakit tanaman ialah dengan memanfaatkan senyawa volatil anticendawan yang dihasilkan oleh agens antagonis. Khamir merupakan salah satu agens yang berperan dan berpotensi menghasilkan senyawa volatil anticendawan. Penelitian ini bertujuan menentukan karakter morfologi khamir dan kemampuannya menghasilkan senyawa volatil yang bersifat anticendawan terhadap C. coffeicola. Isolasi khamir dilakukan dari tanaman kopi di beberapa lokasi di Kecamatan Cilengkrang, Kabupaten Bandung dan Kecamatan Jatinangor, Kabupaten Sumedang. Tahapan penelitian yang dilakukan terdiri atas isolasi khamir dari daun dan buah kopi, karakterisasi koloni dan sel khamir secara morfologi, dan uji kemampuan anticendawan senyawa volatil khamir secara in vitro dengan metode double dish system. Hasil penelitian didapatkan sebanyak 52 isolat khamir. Karakteristik koloni isolat khamir yang didapatkan didominasi oleh warna putih, krem, dan oranye, memiliki tepian yang rata, bergerigi hingga berfilamen serta memiliki bentuk koloni bulat hingga tidak beraturan. Karakteristik mikroskopis dari isolat khamir yang didapatkan menunjukkan bentuk yang bervariasi, yaitu bulat, bundar telur, jorong, bulat telur, serta memanjang dengan ukuran berkisar 2.59-18.13 × 1.23-7.77 µm. Seluruh isolat khamir yang didapatkan mampu menghambat pertumbuhan C. coffeicola melalui aktivitas senyawa volatil anticendawan dengan tingkat penghambatan berkisar antara 11.85% dan 79.26%.
Efek Sitotoksisitas Dan Genotoksisitas Dari Fraksi-Fraksi Ekstrak Etanol Daun Rhizopora stylosa Griff. Terhadap Pembelahan Sel Dan Kromosom Pada Akar Allium cepa L. Rahayuningsih, Sri Rejeki; Mayanti, Tri; Azzahra, Fathia
Journal of Marine Research Vol 12, No 4 (2023): Journal of Marine Research
Publisher : Departemen Ilmu Kelautan, Fakultas PerikanJurusan Ilmu Kelautan, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jmr.v12i4.41360

Abstract

Rhizopora stylosa, yang dikenal sebagai bakau merah, merupakan salah satu jenis tanaman bakau yang dapat ditemukan melimpah di Indonesia. Masyarakat secara tradisional memanfaatkan tanaman ini sebagai sumber pewarna dan obat tradisional. R. stylosa juga terbukti mengandung zat bioaktif dan metabolit sekunder yang memiliki nilai penting bagi manusia dan organisme lain. Tujuan dari penelitian ini adalah untuk menguji tingkat sitotoksisitas dan genotoksisitas senyawa metabolit sekunder dalam fraksi-fraksi ekstrak etanol R. stylosa terhadap akar dan kromosom tanaman bawang Allium cepa. Penelitian ini menggunakan metode eksperimental dengan Rancangan Acak Lengkap (RAL), melibatkan sebelas fraksi dengan konsentrasi seragam (125 ppm), serta kontrol negatif berupa larutan akuades dan kontrol positif berupa larutan EMS, dengan dilakukan sebanyak 3 kali pengulangan. Parameter yang diobservasi meliputi indeks mitosis, pertumbuhan akar bawang, dan aberasi kromosom. Hasil pengamatan dianalisis menggunakan ANOVA Ft(α.05) dan uji lanjutan Duncan Ft (α.05). Hasil pengujian sebelas fraksi dengan konsentrasi 125 ppm menunjukkan penurunan nilai indeks mitosis yang bervariasi, serta terdeteksi adanya aberasi kromosom dengan frekuensi yang beragam. Meskipun demikian, sebelas fraksi tidak menunjukkan sifat subletal maupun letal terhadap indeks mitosis. Jenis aberasi kromosom yang teramati meliputi anaphase spindle break, ball metaphase, break, bridge, c-mitosis, delayed anaphase, diagonal anaphase, disorder of chromosome kinetic, double bridge, double lesion, fragment, giant cell showing polyploidy, laggard, micronucleus, nuclear erosion, nuclear extrusion, ring, star, stickiness, dan vagrant. Rhizopora stylosa (red mangrove) is one species of mangrove that is easily found in large quantities in Indonesia. This plant is widely used traditionally by the community as dyes and herbal medicine. R. stylosa is also known to contain valuable bioactive substances and secondary metabolites for humans and other organisms. This study aims to examine the cytotoxicity and genotoxicity of secondary metabolite compounds from fractions of R. stylosa ethanolic leaf extract on the roots and chromosomes of A. cepa onions. The study was conducted using an experimental method with a Completely Randomized Design (CRD), the treatment of eleven fractions with one 125 ppm for all fractions, and negative control of distilled water solution and positive control of EMS solution, with 3 repetitions for each treatment. The parameters observed were mitotic index, onion root growth and chromosomal aberration. The observations were analyzed with ANAVA Ft (α.05) and followed by Duncan Ft test (α.05). The results of eleven fractions with a concentration of 125 ppm showed a decrease in the value of various mitotic indices and the discovery of chromosome aberrations with varying frequencies. However, eleven fractions did not show a sub-lethal or lethal effect onf the mitotic index. Among the types of chromosomal aberrations observed were anaphase spindle break, ball metaphase, break, bridge, c-mitosis, delayed anaphase, diagonal anaphase, disorder of chromosome kinetic, double bridge, double lesion, fragment, giant cell showing polyploidy, laggard, micronucleus, nuclear erosion, nuclear extrusion, ring, star, stickiness, and vagrant. 
Morelloflavone and Molecular Docking from Stembark of Chisocheton lasiocarpus and Its Cytotoxic Activity Against Breast Cancer Mcf-7 Cell Lines Nurlelasari, Nurlelasari; Harneti, Desi; Maharani, Rani; Darwati, Darwati; Mayanti, Tri; Farabi, Kindi; Hanafi, Muhammad; Supratman, Unang
Molekul Vol 18 No 2 (2023)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2023.18.2.6845

Abstract

Chisocheton is a plant of the Meliaceae family which has been known as a source of limonoids, triterpenoids, steroids, alkaloids and phenolics. This plant is the second largest in the Meliaceae, with 53 species widely distributed in tropical and subtropical regions including Indonesia. From this genus, compounds that have interesting activities have been found, including anti-inflammatory, antimalarial, cytotoxic, antitumor and anticancer. One of the species that has the potential to find new compounds is Chisocheton lasiocarpus because there are still few phytochemical studies. This study aims to inform the structural elucidation of one of the compounds from the stem bark of C. lasiocarpus, namely morelloflavone and its cytotoxic potential against breast cancer cells using the in silico method against ER-α receptors (PDB code: 3ERD), ER-β (PDB code: 1QKM). ) and HER-2 (GDP code: 3PP0).
The Sesquiterpenoids from the Stem Bark of Dysoxylum excelsum and Their Cytotoxic Activities against HeLa Cancer Cell Lines Supratman, Unang; Kautsari, Arsi; Naini, Al Arofatus; Riyadi, Sandra Amalia; Mayanti, Tri; Harizon, Harizon; Fajriah, Sofa
Molekul Vol 19 No 1 (2024)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2024.19.1.9406

Abstract

Sesquiterpenoids belong to a group of terpenoid compounds with interesting structures that are abundant in natural products especially in higher plants. Sesquiterpenoids have a wide variety of bioactivities with great potential cytotoxic activity. The species Dysoxylum excelsum belongs to the Meliaceae family known as higher plant, but only a few sesquiterpenoids have been reported particularly for their cytotoxic activity. Therefore, this research aims to isolate and elucidate the sesquiterpenoids structure from D. excelsum stem bark and examines their cytotoxicity against HeLa cervical cancer cells. Through various column chromatography separations, four known sesquiterpenes namely β-caryophyllene oxide (1), caryophyllenol II (2), humulene dioxide A (3), and guai-6-en-10β-ol (4) were acquired from the n-hexane extract. Compounds 1-4 were isolated for the first time from D. excelsum species. The sesquiterpenoid structures were elucidated according to Nuclear Magnetic Resonance, Infrared, and HR-TOF-MS analysis. The cytotoxicity compounds 1-4 was determined against HeLa cervical cancer cells by examination with the PrestoBlue method and compound 3 exhibited the most potent cytotoxicity with an IC50 value of 160.74 µM. Keywords: cytotoxic activity, Dysoxylum excelsum, HeLa, Meliaceae, sesquiterpenoid.
Sesquiterpenoids from The Stem Bark of Aglaia cucullata (Meliaceae) and Their Cytotoxic Activity Against A549 Lung Cancer Cell Lines Mustaqim, Iqbal Wahyu; Harneti, Desi; Naini, Al Arofatus; Hilmayanti, Erina; Darwati, Darwati; Nurlelasari, Nurlelasari; Mayanti, Tri; Maharani, Rani; Farabi, Kindi; Hidayat, Ace Tatang; Supratman, Unang; Fajriah, Sofa; Azmi, Mohamad Nurul; Shiono, Yoshihito
Molekul Vol 19 No 2 (2024)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2024.19.2.9823

Abstract

ABSTRACT. Sesquiterpenoids are a class of terpenoid compounds with a remarkable diversity of structures and biological activities. Sesquiterpenoids are primarily found in higher plants, such as the Meliaceae family's Aglaia genus. Aglaia cucullata is a species of Aglaia that is still rarely explored and can potentially contain sesquiterpenoid compounds with cytotoxic activity. Hence, the research intended to isolate sesquiterpenoids from the n-hexane extract of A. cucullata stem bark and evaluate their cytotoxic effect against A549 lung cancer cells. Compounds 1 and 2 were isolated and purified from n-hexane extracts utilizing various chromatographic techniques. The structure of compounds 1 and 2 was determined by analyzing various spectroscopic methods (IR, MS, and NMR) and comparing them to previously reported spectral data. Compound 1 was identified as an isodaucane-type sesquiterpenoid, 10-hydroxy-6,10-epoxy-7(14)-isodaucane, and was first reported in Meliaceae family. Compound 2 was confirmed as an eudesmane-type sesquiterpenoid, eudesm-4(15)-ene-1β,6α-dihydroxy, and was first reported in Aglaia cucullata. Cytotoxic activity of 1 and 2 were investigated in vitro against A549 lung cancer cells using the PrestoBlue assay and resulted in inactive and low cytotoxicity with IC50 values of 292.77 and 90.55 μM, respectively. Key words: Aglaia cucullata, , A549 cell lines, cytotoxic activity, Meliaceae, sesquiterpenoids.
Co-Authors Abdillah, Lutfi Ace Tatang Hidayat Agus Susanto Ajeng Diantini, Ajeng Andre A. Sonda Anindyta, Annisa Anjari, Intan Hawina Aoliya, Salwa Rohmatul Azmi, Mohamad Nurul Azzahra, Fathia Darwati Darwati Darwati, Deden Indra Dinata, Deden Indra Desi Harneti Putri Huspa Dewa Gede Katja Dikdik Kurnia DUDI RUNADI Elizabeth Fitriana Sari Endah Yulia Euis Julaeha Fajar Fauzi Abdullah Farabi, Kindi Ferry Ferdiansyah Sofian, Ferry Ferdiansyah Gunawan, Latifah Harizon Harizon Hideo Hayashi Hilmayanti, Erina Indriyani, Indri Isramiharti Isramiharti Jamaludin Al-Anshori Kautsari, Arsi Khalijah Awang Kindi Farabi Kindi Farabi Kindi Farabi Kusumiyati Madihah Madihah Maira, Faizah Mayshah Purnamasari Mohamad Nurzaman Muchlis, Handi Nugraha Muhammad Andry Muhammad Hanafi Mustaqim, Iqbal Wahyu Mustofa, Hidayat Nurul Nafiah, Mohamad Azlan Naini, Al Arofatus Noor Istifadah Nurcahyanti, Ois Nurjihan, Khansa Nurlelasari Nurlelasari Purnama Purnama Qomarilla, Nurul Rani Maharani Reina Yulianti Reina Yulianti Yulianti Rida Evalina Tarigan RIKA MELIANSYAH Romundza, Febbry Ronny Lesmana Salam, Supriatno Sandra Amalia Riyadi Setiani, Cahya Shiono, Yoshihito Sianturi, Julinton Siska Elisahbet Sinaga Sofa Fajriah Sri Hartati Sri Rejeki Rahayuningsih Surbakti, Chemayanti Tati Herlina Tenny Putri Wikayani, Tenny Putri Unang Supratman Wahyuni, Aneu Wawan Hermawan Wibisono, Aditya Seiza Yoshihito Shiono Yulisar, Riza Zahidah Nurulhaq