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All Journal Jurnal Farmasi Klinik Indonesia INDONESIAN JOURNAL OF PHARMACY JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Science and Technology Indonesia Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) JFIOnline Jurnal Layanan Masyarakat (Journal of Public Service) Jurnal Insan Farmasi Indonesia Prisma Sains: Jurnal Pengkajian Ilmu dan Pembelajaran Matematika dan IPA IKIP Mataram Folia Medica Indonesiana
Mahardian Rahmadi
Department Of Clinical Pharmacy, Faculty Of Pharmacy, Airlangga University
Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Earth & Planetary Sciences Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Physics Social Sciences Other

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Journal : Science and Technology Indonesia

 1 
Quercetin Solid Lipid Microparticle Stability and Deposition in Rat Lungs: A Study of Surfactant Effect Hariyadi, Dewi Melani; Sairiyah, Siti Nasikatus; Rahman, Fakhrinnisa Wildani; Rijal, Muhammad Agus Syamsur; Rosita, Noorma; Rahmadi, Mahardian
Science and Technology Indonesia Vol. 9 No. 3 (2024): July
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2024.9.3.682-696

Abstract

This study aims to determine the effect of surfactant concentration on Quercetin SLM as a potential carrier of respiratory diseases, especially ones resulting from oxidative stress injury. Quercetin is a natural antioxidant with high activity. SLM was formed with 5% compritol 888 ATO as a lipid and different concentrations of poloxamer 188 as a surfactant. SLM was produced by a combination of emulsification and sonication involving freeze drying. SLM is characterized by organolepsis, morphology, yield, particle size, drug loading, and entrapment efficiency. The antioxidant activity of quercetin SLMs was tested using the ABTS method. SLMs are characterized as having round and smooth morphology, high yield (F1 88.53%; F2 91.44%; F3 92.87%); particle size (F1 1.81 um; F2 1.90 um; F3 1.94 um); high drug loading (F1 15.96%; F2 13.74%; F3 13.19%); and high entrapment efficiency (F1 96.53%; F2 87.94%; F3 87.48%). Increasing surfactant concentration did not produce a significant difference between formulas. Quercetin SLM showed high antioxidant activity (Quercetin 94.43%; F1 94.35%; F2 94.36%; F3 94.37%). SLM was stable at storage temperatures between 25°C and 40°C. The effect of surfactant can be seen on particle size, drug loading, and entrapment efficiency at 40°C. Results of in vivo deposition study indicated that all SLM formulas were able to deliver quercetin to the lungs. Increasing the concentration of surfactant in Quercetin SLMs made no difference to the lung deposition as confirmed by observations conducted at 1 hour and 4 hours. Quercetin SLM has the potential for lung delivery by inhalation.
Effect of Sodium Alginate-Carrageenan Concentration in Rifampicin Pulmospheres on Physical Characteristics, Release, and Anti-Tuberculosis Activity Liempepas, Angelika; Rahmadi, Mahardian; Ifadotunnikmah, Farida; Hariyadi, Dewi Melani
Science and Technology Indonesia Vol. 10 No. 3 (2025): July
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2025.10.3.817-825

Abstract

Pulmonary tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis, which mostly attacks the lungs, but can also affect other organs. Tuberculosis is one of the biggest health problems worldwide. Conventional oral rifampicin preparations have several limitations, such as poor bioavailability, low solubility, and drug instability in the gastrointestinal fluid. Only a small portion of the tuberculosis drug can reach the alveoli, the main target of the tuberculosis drug. Drug delivery Systems are one of the solutions to this problem. They are a formulation or system that can mediate the delivery of therapeutic substances in the body to increase therapeutic effects, reduce drug side effects, increase bioavailability, and improve patient compliance. Pulmonary drug delivery requires a small dose and particle size, so microspheres are selected for lung delivery. This research aims to study the effect of sodium alginate concentration and carrageenan (0.75%, 1%, 1.25%) with a ratio of 1:1 on physical characteristics, in vitro release, and anti-tuberculosis activity. Preparation of Rifampicin Sodium Alginate-Carageenan Pulmospheres with Ionotropic Gelation-Aerosolization. Pulmospheres were evaluated for entrapment efficiency, morphology, yield, particle size, drug loading, in vitro release, and Mycobacterium smegmatis activity. Increasing concentrations of sodium alginate and carrageenan produce rifampicin pulmospheres with good physical characteristics, increase rifampicin release, and result in inhibitory activity against Mycobacterium smegmatis
Characteristics, Release, and Stability (Kinetics and Shelf-life) of Ciprofloxacin HCl-Alginate-Carrageenan Microspheres: Effects of Drug Concentration and Type of Lyoprotectant Amiruddin; Rahmadi, Mahardian; Hariyadi, Dewi Melani
Science and Technology Indonesia Vol. 11 No. 1 (2026): January
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2026.11.1.148-160

Abstract

Tuberculosis, an infectious disease caused by the Mycobacterium tuberculosis bacteria, is one of the main causes of death worldwide. Alternative treatments are necessary due to the rising prevalence of medication resistance in Mycobacterium tuberculosis. Fluoroquinolones, such as ciprofloxacin HCl, are among these alternatives and are generally administered orally, but they have limitations. Therefore, pulmonary targeted inhalation delivery systems have been developed. Inhalation of microspheres enables deposition in the lungs at appropriate particle sizes. This study formulates ciprofloxacin HCl microspheres with an optimal ratio and concentration of polymer combination and crosslinker, aiming to determine the effect of drug concentration and lyoprotectant type on characteristics, release, and stability, including degradation kinetics and shelf life. The results showed that the ciprofloxacin HCl-alginate-carrageenan microsphere powder was yellowish-white, with smooth morphology, a yield percentage of 96.08% ± 0.84 – 97.00% ± 0.19, particle sizes below 5 µm, drug loading between 4.57% ± 0.13 – 6.76% ± 0.06, and entrapment efficiency ranging from 79.45% ± 2.53 – 90.80% ± 0.77. The powder had moisture content below 5% and excellent flow properties. Ciprofloxacin HCl release from microspheres at pH 7.4 for 30 hours was 84.55% ± 0.89 – 90.74% ± 0.22, following Korsmeyer-Peppas kinetics based on the Fickian diffusion mechanism. Ciprofloxacin HCl-alginate-carrageenan microspheres were stable and exhibited good shelf life. This study concluded that particle size, drug loading, entrapment efficiency, and drug release are all influenced by drug concentration, while moisture content and flow properties, with adequate shelf life, are influenced by the type of lyoprotectant.
Co-Authors Abdul Rahem, Abdul Alma Nuril Aliyah Amiruddin Ana Yuda Anak Agung Sagung Dyah Pramesti Andarsari, Mareta R. Aniek S. Budiatin Anita Purnamayanti Aprilia, Pingkan Aqsha, Aulia Charis Arie Sulistyarini Arina Dery Puspitasari Bambang Sidharta Budi Suprapti Budiatin, Aniek S. Budiatin, Aniek Setiya Budiatin, Aniek Setiya Budiatin, Aniek Setya Budiatin, Aniek Setya Cahyo Wibisono Chris Alderman Chrismawan Ardianto Chrismawan Ardianto Dewi Melani Hariyadi Dewi W. Shinta Dewi Wara Shinta Didik Hasmono Eddy Rahardjo Farida Ifadotunnikmah Fathia Ramadiani Galuh Laksatrisna Pide Gesnita Nugraheni Gusti Noorrizka Veronika Ahmad Hapsari, Pharmasinta P. Hermansyah, Andi Heru Purwanto I Nengah Budi Sumartha I NYOMAN WIJAYA Ika Ayu Mentari Imam Susilo Indira D. Kharismawati Irvina Harini Junaidi Khotib Liempepas, Angelika Lina, Rifda Naufa Luke Wongso Mareta R. Andarsari Mareta Rindang Andarsari Megawati, Selvi Muhammad Agus Syamsur Rijal Muhammad Taher Muhammad Zaki Bin Ramli Naufalina, Rifda Nia Widyasari Noorma Rosita Pharmasinta P. Hapsari Pingkan Aprilia Priyandani, Yuni Rahman, Fakhrinnisa Wildani Ramadiani, Fathia Rifda Naufa Lina Rifda Naufalina Sairiyah, Siti Nasikatus Samirah Samirah Sarah Puspita Atmaja Shinta, Dewi W. Sjamsiah, Siti Sjamsiah, Siti Suharjono Suharjono, Suharjono Sukorini, Anila Impian Sumarno . Sumarno Sumarno Sumartha, I Nengah Budi Tarisya Dinda Saraya Toetik Aryani Tuhfatul Ulya Umi Athiyah, Umi Winda Fatma Sari Wirasasmita, Yuyun Yulistiani Yulistiani Yulistiani, . Yusuf Alif Pratama Zainul Amiruddin Zakaria Zamrotul Izzah Zulkarnain, Bambang Subakti