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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Jurnal Kedokteran Brawijaya Indonesian Journal of Human Nutrition Majalah Kesehatan FKUB Jurnal Respirasi (JR) Jurnal Ners CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL CRJIM (Clinical and Research Journal in Internal Medicine) Narra J Caring : Jurnal Pengabdian Masyarakat Cermin Dunia Kedokteran Asian Journal of Health Research Jurnal Kedokteran Komunitas (Journal of Community Medicine) The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Jurnal Penyakit Dalam Indonesia Journal of Law, Education and Business Indonesian Journal of Biomedicine and Clinical Sciences Deka in Medicine
Syifa Mustika
Brawijaya University
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Comparative study of SCFA and butyrate levels in chronic hepatitis versus cirrhosis patients Mustika, Syifa; Fachrurrezza, Mochammad; Rakhmadhan, Iraky; Adam, Adam; Reyhan , Muhammad
Deka in Medicine Vol. 2 No. 2 (2025): August 2025
Publisher : PT. DEKA RESEARCH INSTITUTE

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69863/dim.2025.e688

Abstract

BACKGROUND: Cirrhosis is a common complication of chronic liver disease and exerts a profound influence on gut microbiota and metabolic function. Short-chain fatty acids (SCFAs), particularly butyrate, are crucial to intestinal integrity and immunomodulation. The relationship between SCFA levels and the progression of liver disease is not well understood. OBJECTIVES: The current study aimed to study the level of SCFAs and butyrate in fecal samples of patients with chronic hepatitis B, chronic hepatitis C, and compensated cirrhosis. METHODS: The research was conducted at Dr. Saiful Anwar General Hospital, Malang, Indonesia, from January to June 2023. Fecal samples were collected and measured for SCFA and butyrate concentrations by gas chromatography. The comparison was made statistically by the Mann-Whitney U test between groups. RESULTS: A total of 26 patients with chronic hepatitis B, chronic hepatitis C, or compensated cirrhosis were enrolled in the study. The overall mean SCFA level in the participants was 9.85 ± 4.78 mg/mL. The findings revealed no difference in the level of SCFA in chronic hepatitis patients and cirrhosis patients (p = 0.72). Likewise, there was no difference in butyrate levels between the two groups (p = 0.37). CONCLUSION: During the present study, SCFA and butyrate levels were not significantly different in chronic hepatitis patients compared to cirrhosis patients. SCFA synthesis and use may be affected by various factors such as dietary patterns, microbiota diversity, and metabolic differences among individuals. Further studies with larger populations and dietary control are necessary to delineate the role of SCFAs in the pathogenesis of liver disease and therapeutic applications.
Liver Injury Associated with Antituberculosis Medications Mustika, Syifa; Susanti, Lia
Current Internal Medicine Research and Practice Surabaya Journal Vol. 6 No. 2 (2025): CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cimrj.v6i2.66980

Abstract

Tuberculosis remains a major global health concern, with a sharp increase in new cases in 2022, exceeding the prevalence before the coronavirus disease 2019 (COVID-19) pandemic. Conventional antituberculosis therapy, comprising a combination of first-line medications, is essential for controlling tuberculosis. However, more than 7% of patients undergoing treatment may develop drug-induced liver injury (DILI), mainly from isoniazid and rifampicin. This literature review aimed to evaluate DILI in tuberculosis, focusing on its causes, diagnosis, and management. Several factors, including age, sex, genetic predisposition, and pre-existing liver conditions, affect the occurrence of antituberculosis DILI. Advanced age and being female are significant risk factors for severe liver injury. Diagnosing DILI requires careful differentiation from other hepatic disorders, as its clinical presentation may include symptoms such as jaundice, abdominal pain, and elevated liver enzyme levels. Early detection relies heavily on liver function tests and clinical assessments. Managing DILI involves promptly discontinuing the offending drug, closely monitoring the patient, and gradually reintroducing medications, prioritizing less hepatotoxic options, such as rifampicin. Hepatoprotective agents and alternative drug regimens, particularly those excluding pyrazinamide, may be used to mitigate the risk of liver injury. The rise in tuberculosis cases in 2022 underscores the ongoing global burden of this disease and the critical need for effective treatment strategies. Tailored therapeutic approaches, comprehensive liver function monitoring, and early identification of DILI are vital for minimizing hepatotoxicity while ensuring successful tuberculosis management. Although hepatoprotective drugs and alternative regimens show promise, further research is necessary to optimize their application across diverse patient populations.   Highlights: 1. This article presents a thorough evaluation of antituberculosis drug-induced liver injury, particularly concerning its causes, diagnosis, and management, highlighting the importance of a meticulous differentiation from other liver disorders through a comprehensive assessment of clinical indicators. 2. The literature review included studies utilizing advanced diagnostic tools for precise causality determination as well as innovative approaches, such as the selective omission of pyrazinamide or the integration of non-standard treatment protocols, which offer promising avenues to mitigate hepatotoxicity risk. 3. This literature review suggests that hepatoprotective agents, such as N-acetylcysteine, may have advantages due to their notable efficacy in preserving liver function, offering a proactive strategy for patient safety.
COMPARING LECTURE AND INTERACTIVE DISCUSSION METHODS TO ENHANCE HEPATITIS B KNOWLEDGE IN PREGNANT WOMEN AND COUPLES IN GONDANGLEGI Supriono, Supriono; Wibowo, Bogi Pratomo; Mustika, Syifa; Fachrureza, Mochamad; Imroatussholihah, Al; Prayitno, Tia Rahmi; Amalia, Dinda; Nugroho, Rama Tiar
Caring: Jurnal Pengabdian Masyarakat Vol 5, No 2 (2025): CARING Jurnal Pengabdian Masyarakat (Agustus 2025)
Publisher : Caring: Jurnal Pengabdian Masyarakat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.caringjpm.2025.005.02.1

Abstract

Hepatitis B is a global health issue that has a significant impact on society, especially in terms of the risk of transmission from mother to child during childbirth. Health education is an important effort to prevent the spread of infection, particularly among pregnant women. This community service activity aims to increase knowledge about hepatitis B among pregnant women and reproductive-age couples in Gondanglegi, Malang, through two educational methods: lectures and interactive discussions. The lecture was conducted using a conventional approach, where information about hepatitis B was delivered directly to participants with the aid of visual PowerPoint materials to clarify the content. Meanwhile, the interactive discussion involved several speakers discussing the topic of hepatitis B, allowing participants to engage in discussions, share experiences, and ask questions to the speakers. Both methods were effective in increasing participants' knowledge, with the lecture method providing a more significant improvement. This activity is expected to strengthen public understanding of hepatitis B, while also supporting efforts to prevent the transmission from pregnant women to their babies.
Co-Authors A.A. Ketut Agung Cahyawan W Achmad Rudijanto Adam Adam Ade Rahmawati Affa Kiysa Waafi Amalia, Dinda Amanda C Wowor Anton Komala Arifah, Nina Nur Bayu Eka Nugraha Bogi Pratomo Bogi Pratomo Bogi Pratomo Bogi Pratomo Bogi Pratomo Bogi Pratomo Brahmantyo, Herwindo Pudjo Budi Herlianto Budi Herlianto Budiarto, Andika Agus Caesar Ahmad Tidel Camoya Gersom Charisma Dian Simatupang Daryadijaya, Daya Daya Daryadijaya Dewi Santosaningsih Dewi Santosaningsih Dian Handayani Dian Handayani Dian Handayani Dian Hasanah Diana Jeni H Diana Jeni H, Diana Jeni edy susanto Endang S. Rahayu Erlina B Fachrureza, Mochamad Fachrurrezza, Mochammad Faridah, Amirah Fathoni, Alfan Fildzah Karunia Putri Fiqih Faruz Frinny Sembiring Gatya, Mifta Harijono Achmad Harijono Achmad Harijono Achmad Harijono Ahmad Hartaya, Arsy Hanandya Imroatussholihah, Al Indriyaningrum, Nurria Betty Indriyaningrum, Nurria Betty Jonny K. Fajar Kenty Wantri Anita, Kenty Wantri Komala, Anton Kongkam, Pradermchai Larasati, Putu Anissa Lia Sasmithae Lutfiyanto Nurhidayat M. Farid Rakhman Mariyatun Mariyatun, Mariyatun Marzuki, Mochammad Jalalul Michaela, Cleine Muli Yaman Muthiah, Mark Nabila Ramadhani Nabila, Salsala Sifa Nanik Triana Nasution, Muhammad Imanuddin Nina Nur Arifah Novita Apramadha Kartika Sari Nugraha, Bayu Eka Nugroho, Rama Tiar Nurlaili, Retti Nurria Betty Indriyaningrum Pandu Tridana Sakti, Pandu Tridana Pramesi, Putrika C. Pratista Adi Krisna Prayitno, Tia Rahmi Priyanto, Tia Rahmi Putri, Dinda Amalia Eka Rakhmadhan, Iraky Ramadi Satryo Wicaksono RC Tarigan Renny Tandya Retti Nurlaili Reyhan , Muhammad Rosita, Firdha Ruliana Ruliana Rulli Rosandi Safira, Zahra Sagala, Ida Samichah Samichah Sasmithae, Lia Satiti, Ika Shafira Nurmalita Sholihah, Al Imroatus Sigit Triyus Priyantoro Sigit Triyus Priyantoro, Sigit Triyus Sopacua , Andre Supriono Supriono ., Supriono Supriono Supriono Supriono Supriono Supriono Supriono Susanti, Lia Susanto, Jefri P. Suyoso Suyoso Tarigan, RC Tiar Oktavian Effendi Triana, Nanik Vianty , Liku Wibowo, Bogi Pratomo Wijayanti Saputri, Nur Estu Yuni Rahmawati