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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Jurnal Kedokteran Brawijaya Indonesian Journal of Human Nutrition Majalah Kesehatan FKUB Jurnal Respirasi (JR) Jurnal Ners CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL CRJIM (Clinical and Research Journal in Internal Medicine) Narra J Caring : Jurnal Pengabdian Masyarakat Cermin Dunia Kedokteran COMSERVA: Jurnal Penelitian dan Pengabdian Masyarakat Asian Journal of Health Research Jurnal Kedokteran Komunitas (Journal of Community Medicine) The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Jurnal Penyakit Dalam Indonesia Journal of Law, Education and Business Indonesian Journal of Biomedicine and Clinical Sciences Deka in Medicine
Syifa Mustika
Brawijaya University
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Liver Injury Associated with Antituberculosis Medications Mustika, Syifa; Susanti, Lia
Current Internal Medicine Research and Practice Surabaya Journal Vol. 6 No. 2 (2025): CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cimrj.v6i2.66980

Abstract

Tuberculosis remains a major global health concern, with a sharp increase in new cases in 2022, exceeding the prevalence before the coronavirus disease 2019 (COVID-19) pandemic. Conventional antituberculosis therapy, comprising a combination of first-line medications, is essential for controlling tuberculosis. However, more than 7% of patients undergoing treatment may develop drug-induced liver injury (DILI), mainly from isoniazid and rifampicin. This literature review aimed to evaluate DILI in tuberculosis, focusing on its causes, diagnosis, and management. Several factors, including age, sex, genetic predisposition, and pre-existing liver conditions, affect the occurrence of antituberculosis DILI. Advanced age and being female are significant risk factors for severe liver injury. Diagnosing DILI requires careful differentiation from other hepatic disorders, as its clinical presentation may include symptoms such as jaundice, abdominal pain, and elevated liver enzyme levels. Early detection relies heavily on liver function tests and clinical assessments. Managing DILI involves promptly discontinuing the offending drug, closely monitoring the patient, and gradually reintroducing medications, prioritizing less hepatotoxic options, such as rifampicin. Hepatoprotective agents and alternative drug regimens, particularly those excluding pyrazinamide, may be used to mitigate the risk of liver injury. The rise in tuberculosis cases in 2022 underscores the ongoing global burden of this disease and the critical need for effective treatment strategies. Tailored therapeutic approaches, comprehensive liver function monitoring, and early identification of DILI are vital for minimizing hepatotoxicity while ensuring successful tuberculosis management. Although hepatoprotective drugs and alternative regimens show promise, further research is necessary to optimize their application across diverse patient populations.   Highlights: 1. This article presents a thorough evaluation of antituberculosis drug-induced liver injury, particularly concerning its causes, diagnosis, and management, highlighting the importance of a meticulous differentiation from other liver disorders through a comprehensive assessment of clinical indicators. 2. The literature review included studies utilizing advanced diagnostic tools for precise causality determination as well as innovative approaches, such as the selective omission of pyrazinamide or the integration of non-standard treatment protocols, which offer promising avenues to mitigate hepatotoxicity risk. 3. This literature review suggests that hepatoprotective agents, such as N-acetylcysteine, may have advantages due to their notable efficacy in preserving liver function, offering a proactive strategy for patient safety.
COMPARING LECTURE AND INTERACTIVE DISCUSSION METHODS TO ENHANCE HEPATITIS B KNOWLEDGE IN PREGNANT WOMEN AND COUPLES IN GONDANGLEGI Supriono, Supriono; Wibowo, Bogi Pratomo; Mustika, Syifa; Fachrureza, Mochamad; Imroatussholihah, Al; Prayitno, Tia Rahmi; Amalia, Dinda; Nugroho, Rama Tiar
Caring: Jurnal Pengabdian Masyarakat Vol 5, No 2 (2025): CARING Jurnal Pengabdian Masyarakat (Agustus 2025)
Publisher : Caring: Jurnal Pengabdian Masyarakat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.caringjpm.2025.005.02.1

Abstract

Hepatitis B is a global health issue that has a significant impact on society, especially in terms of the risk of transmission from mother to child during childbirth. Health education is an important effort to prevent the spread of infection, particularly among pregnant women. This community service activity aims to increase knowledge about hepatitis B among pregnant women and reproductive-age couples in Gondanglegi, Malang, through two educational methods: lectures and interactive discussions. The lecture was conducted using a conventional approach, where information about hepatitis B was delivered directly to participants with the aid of visual PowerPoint materials to clarify the content. Meanwhile, the interactive discussion involved several speakers discussing the topic of hepatitis B, allowing participants to engage in discussions, share experiences, and ask questions to the speakers. Both methods were effective in increasing participants' knowledge, with the lecture method providing a more significant improvement. This activity is expected to strengthen public understanding of hepatitis B, while also supporting efforts to prevent the transmission from pregnant women to their babies.
Tantangan Diagnostik Seorang Laki-laki 19 Tahun dengan Kista Koledokus Tipe IC Ratnaningtyas, Yosefin; Mustika, Syifa; Supriono, Supriono; Pratomo , Bogi
COMSERVA : Jurnal Penelitian dan Pengabdian Masyarakat Vol. 4 No. 9 (2025): COMSERVA: Jurnal Penelitian dan Pengabdian Masyarakat
Publisher : Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/comserva.v4i9.2838

Abstract

Kista koledokus merupakan dilatasi kistik dari saluran empedu, baik intra maupun ekstrahepatik, yang dapat menyebabkan obstruksi biliaris dan sirosis biliaris progresif. Kondisi ini sering dikaitkan dengan trias klasik berupa nyeri perut kanan atas, massa intraabdomen, dan ikterus obstruktif. Modalitas pencitraan seperti MRCP dan ERCP dianggap sebagai standar emas untuk mendiagnosis kista koledokus dan anomali terkait. Artikel ini bertujuan untuk memahami tantangan diagnostik kista koledokus melalui analisis kasus seorang pasien dewasa muda dengan gejala klinis dan pencitraan yang tidak khas. Seorang laki- laki, 19 tahun, datang dengan nyeri perut kanan atas, mual, muntah, urine berwarna seperti teh, tinja berwarna dempul, dan gatal-gatal. Pemeriksaan laboratorium menunjukkan obstruksi saluran empedu. Pemeriksaan USG abdomen mencurigai adanya kista koledokus, namun MRCP menyimpulkan batu pada duktus biliaris komunis dengan dilatasi duktus hepatikus kanan kiri, duktus hepatikus komunis, duktus sistikus, dan duktus biliaris komunis. Pasien direncanakan prosedur ERCP untuk evakuasi batu namun evakuasi gagal dilakukan diduga akibat obstruksi pada duktus koledokus dengan kemungkinan kista koledokus. Pasien kemudian menjalani operasi. Diagnosis tegak dengan ditemukan kista koledokus tipe 1C. Pasien mengalami perbaikan klinis dan laboratorium setelah operasi. Kista koledokus pada orang dewasa lebih sering muncul dengan gejala mirip batu empedu seperti nyeri perut kanan atas dan tanda-tanda obstruksi bilier, dibandingkan massa intraabdomen. Kegagalan interpretasi MRCP pada kasus ini menunjukkan pentingnya pemahaman yang mendalam mengenai kista koledokus, dan perlunya kehati-hatian dalam evaluasi diagnostik dan penggunaan modalitas pencitraan
Pengaruh Edukasi Gizi terhadap Asupan dan Status Gizi Pasien Sirosis Hati Mustika, Syifa; Nurmalita, Shafira; Samichah, Samichah; Putri, Fildzah Karunia; Sembiring, Frinny; Ruliana, Ruliana; Handayani, Dian
Indonesian Journal of Human Nutrition Vol. 7 No. 2 (2020)
Publisher : Department of Nutrition, Faculty of Health Sciences, Universitas Brawijaya Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.ijhn.2020.007.02.5

Abstract

ABSTRAK Malnutrisi adalah masalah yang umum terjadi pada pasien sirosis hati. Kurangnya pengetahuan tentang gizi sehingga menyebabkan adanya pembatasan diet yang tidak perlu dan kemudian berkontribusi pada kejadian malnutrisi. Penelitian ini bertujuan untuk mengetahui adanya pengaruh pemberian edukasi gizi terhadap status gizi dan asupan pasien sirosis hati di Poli Gastroenterohepatologi Rumah Sakit dr. Saiful Anwar Malang. Jenis penelitian yang dilakukan termasuk dalam penelitian experimental dengan desain penelitian pre-post test control group design. Kelompok intervensi adalah kelompok yang diberi edukasi gizi pada awal pengambilan data, sedangkan kelompok kontrol adalah kelompok yang tidak diberi edukasi gizi. Data yang diambil pada penelitian ini adalah data antropometri, data asupan saat pengambilan data awal dan akhir serta data asupan makan partisipan yang dimonitoring selama 1 bulan menggunakan food diary. Hasil penelitian ini menunjukkan tidak terdapatnya penurunan yang signifikan (p=0.48) pada Indeks Massa Tubuh partisipan di kelompok intervensi dan kontrol. Sedangkan asupan energi dan karbohidrat pada kelompok intervensi mengalami peningkatan yang signifikan (p<0.05). Pemberian edukasi akan memberikan efek positif dan efektif jika dilakukan bersama dengan peningkatan aktivitas fisik. Efek dari pemberian edukasi gizi akan nampak bila durasi monitoring dan evaluasi diperpanjang. Kata kunci: edukasi gizi, sirosis hati, status gizi, asupan zat gizi, antropometri giziABSTRACT Malnutrition is a common problem among liver cirrhosis patients. Lack of knowledge about nutrition causes unnecessary dietary restrictions and leads to the incidence of malnutrition. This study aimed to determine the effect of nutrition education on intake and nutritional status of patients with liver cirrhosis at the Gastroenterohepatology Department, dr. Saiful Anwar General Hospital, Malang. The design used was an experimental study with a pre-post test control group. The intervention group is the group given nutrition education, while the control group is the group without nutrition education. The data taken in this study were anthropometric, intake data when taking initial and final data, and participants' daily food intake monitored for a month using a food diary. The study results showed no significant decrease (p = 0.48) in the body mass index of participants in the intervention and control groups. However, the energy and carbohydrate intake in the intervention group experienced a significant increase (p <0.05). Providing nutrition education will have a positive and effective effect if done together with increased physical activity. The duration of monitoring and evaluation should be extended to see the effectiveness of the nutrition educationKeywords: nutritional education, liver cirrhosis, nutritional status, nutrient intake, nutritional anthropometry
Co-Authors A.A. Ketut Agung Cahyawan W Achmad Rudijanto Adam Adam Ade Rahmawati Affa Kiysa Waafi Amalia, Dinda Amanda C Wowor Anton Komala Arifah, Nina Nur Bayu Eka Nugraha Bogi Pratomo Bogi Pratomo Bogi Pratomo Bogi Pratomo Bogi Pratomo Bogi Pratomo Brahmantyo, Herwindo Pudjo Budi Herlianto Budi Herlianto Budiarto, Andika Agus Caesar Ahmad Tidel Camoya Gersom Charisma Dian Simatupang Daryadijaya, Daya Daya Daryadijaya Dewi Santosaningsih Dewi Santosaningsih Dian Handayani Dian Handayani Dian Hasanah Diana Jeni H Diana Jeni H, Diana Jeni edy susanto Endang S. Rahayu Erlina B Fachrureza, Mochamad Fachrurrezza, Mochammad Faridah, Amirah Fathoni, Alfan Fiqih Faruz Gatya, Mifta Harijono Achmad Harijono Achmad Harijono Achmad Harijono Ahmad Hartaya, Arsy Hanandya Imroatussholihah, Al Indriyaningrum, Nurria Betty Indriyaningrum, Nurria Betty Jonny K. Fajar Kenty Wantri Anita, Kenty Wantri Komala, Anton Kongkam, Pradermchai Larasati, Putu Anissa Lia Sasmithae Lutfiyanto Nurhidayat M. Farid Rakhman Mariyatun Mariyatun, Mariyatun Marzuki, Mochammad Jalalul Michaela, Cleine Muli Yaman Muthiah, Mark Nabila Ramadhani Nabila, Salsala Sifa Nanik Triana Nasution, Muhammad Imanuddin Nina Nur Arifah Novita Apramadha Kartika Sari Nugraha, Bayu Eka Nugroho, Rama Tiar Nurlaili, Retti Nurmalita, Shafira Nurria Betty Indriyaningrum Pandu Tridana Sakti, Pandu Tridana Pramesi, Putrika C. Pratista Adi Krisna Pratomo , Bogi Prayitno, Tia Rahmi Priyanto, Tia Rahmi Putri, Dinda Amalia Eka Putri, Fildzah Karunia Rakhmadhan, Iraky Ramadi Satryo Wicaksono Ratnaningtyas, Yosefin RC Tarigan Renny Tandya Retti Nurlaili Reyhan , Muhammad Rosita, Firdha Ruliana Ruliana, Ruliana Rulli Rosandi Safira, Zahra Sagala, Ida Samichah Samichah Sasmithae, Lia Satiti, Ika Sembiring, Frinny Sholihah, Al Imroatus Sigit Triyus Priyantoro Sigit Triyus Priyantoro, Sigit Triyus Sopacua , Andre Supriono Supriono ., Supriono Supriono Supriono Supriono Supriono Supriono Supriono Susanti, Lia Susanto, Jefri P. Suyoso Suyoso Tarigan, RC Tiar Oktavian Effendi Triana, Nanik Vianty , Liku Wibowo, Bogi Pratomo Wijayanti Saputri, Nur Estu Yuni Rahmawati