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All Journal journal of internal medicine Microbiology Indonesia Jurnal NERS Indonesian Journal of Tropical and Infectious Disease Indonesian Journal of Chemistry Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) ANIMA Indonesian Psychological Journal Indian Journal of Forensic Medicine & Toxicology Narra J Jurnal Natural Folia Medica Indonesiana
Nasronudin Nasronudin
Faculty Of Medicine, Universitas Airlangga, Surabaya. Indonesian-Japan Collaborative Research Center For Emerging And Re-emerging Infectious Diseases, Institute Of Tropical Disease, Universitas Airlangga, Surabaya.
Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Earth & Planetary Sciences Energy Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences

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Prevalence of major INSTI and HIV-1 drug resistance mutations in pre- and antiretroviral-treated patients in Indonesia Djojosugito, Fauzia A.; Arfianti, Arfianti; Wisaksana, Rudi; Siregar, Fajri M.; Nasronudin, Nasronudin; Rachman, Brian E.; Khairunisa, Siti Q.; Indrati, Agnes R.
Narra J Vol. 4 No. 3 (2024): December 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i3.1022

Abstract

Indonesia has one of the highest HIV infection rates in Southeast Asia. The use of dolutegravir, an integrase strand transfer inhibitor (INSTI), as a first-line treatment underscores the need for detailed data on INSTI drug resistance mutations (DRMs). Currently, there is a lack of comprehensive data on DRMs INSTI and other HIV drug resistance in Indonesian patients, both pre- and post-treatment. The aim of this study was to identify the subtypes and drug resistance mutations of the protease, reverse transcriptase, and integrase genes in both treatment-naive and ARV-treated patients in Bandung, West Java, Indonesia. A cross-sectional study was conducted involving HIV-positive patients at Hasan Sadikin Hospital, Bandung, Indonesia, from September 2022 to January 2023. The patients were categorized into two groups: ARV-treated and pre-treatment patients. Peripheral blood mononuclear cells (PBMCs) were processed for DNA extraction, followed by amplification and sequencing of the pol gene to detect mutations and subtypes. The study found that the predominant subtype was CRF01_AE, accounting for 85.4% and 69% of pre-treatment and treated patients, respectively, followed by recombinant forms such as A1/CRF01_AE, CRF01_AE/CRF02_AG, subtype B, and other subtypes. Among ARV-treated/INSTI-naive patients, major INSTI DRMs R263K and Y143H were identified, while pre-treatment patients exhibited accessory integrase DRMs. The most common DRMs detected were non-nucleoside reverse transcriptase inhibitor (NNRTI) DRMs, with prevalences of 14.6% and 7% in pre-treatment and ARV-treated patients, respectively. In conclusion, CRF01_AE emerged as the predominant subtype in both pre-treatment and ARV-treated patients in Bandung, underscoring the necessity for ongoing surveillance of integrase DRMs, particularly given the presence of major INSTI DRMs in patients undergoing INSTI treatment.
Co-Authors . PURWATI Achmad Ardianto, Achmad Adiana Mutamsari Witaningrum Adiana Mutamsari, Adiana Agung Prasetiyo Aksono HP., Eduardus Bimo Aldise Mareta Nastri, Aldise Mareta Arfianti Arfianti Arfianto V Arief Suseno, Arief Artaria Tjempakasari, Artaria Asmarawati, Tri Pudy Atika Atika Badi'ah, Hanim Istatik Bambang Prajogo Bimo Aksono Bimo Dwi Lukito, Bimo Dwi Bramanton Bramantono Bramantono, Bramantono Budi Utomo Danny Irawan Djojosugito, Fauzia A. Dwi Wahyu Indriati, Dwi Wahyu Eddy Bagus Wasito Eddy Wasito, Eddy Edith Frederika, Edith Endah Dewati, Endah Endang Retnowati ENDANG RETNOWATI KUSUMOWIDAGDO Endra Gunawan Fedik Abdul Rantam Ferdiansyah Ferdiansyah Ferry Effendi Ganden Supriyanto Hadi U Hamidah - Hening Laswati Putra Indrati, Agnes R. Irine Normalina, Irine Irma Yuliawati, Irma Johana E. Prawitasari Juniastuti Juniastuti Khairunisa, Siti Khairunisa, Siti Q. Lilis Mundri Jannah, Lilis Mundri M. Qushay, M. Maria Inge Lusida Masanori Kameoka, Masanori Maskoep, Wiwiek Indriyani Mei Wulan, Sri Mardjiati Meilani Meilani, Meilani Muhammad Qushai Y. Matondang, Muhammad Qushai Y. Muhammad Qushai Yunifiar M, Muhammad Qushai Muhammad Vitanata Arfijanto, Muhammad Vitanata Musofa Rusli Ni Kadek Mulyantari Ni Nyoman Tri Puspaningsih Nur Syamsiatul Fajar, Nur Syamsiatul Nurlaila Effendy Nuzul Qur'aniati Prihartini Widiyanti Purwaningsih - Purwati - Purwati Purwati Rachman, Brian E. Rachman, Brian Eka Rahayu Anggraini Rahmat Zainuddin, Rahmat Retno Indrawati Roestamadji Retno Pudji Rahayu Ririek Parwitasari, Ririek Rudi Wisaksana Rury Mega, Rury Shuhei Ueda, Shuhei Siregar, Fajri M. Siti Qamariyah Khairunisa, Siti Qamariyah Siti Qomariyah Khairunisa, Siti Qomariyah SOETJIPTO . Soewandojo E Suharto - Suryono Suryono Thomas Dicky Hastjarjo, Thomas Dicky Tigor Yeheskiel, Tigor Tjahjono, Ganis Tomohiro Kotaki, Tomohiro Triyono EA Ulfa Kholili Usman Hadi Yayuk Susilawati, Yayuk Yulia Ismail Yulia Sari Ismail