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All Journal Folia Medica Indonesiana Indonesian Journal of Tropical and Infectious Disease Jurnal Pengabdian Kepada Masyarakat (Indonesian Journal of Community Engagement) Majalah Kesehatan FKUB Jurnal Respirologi Indonesia Jurnal Respirasi (JR) Jurnal Ilmiah Akuntansi dan Bisnis JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Jurnal Abdi Insani JOURNAL OF COMMUNITY MEDICINE AND PUBLIC HEALTH RESEARCH Indian Journal of Forensic Medicine & Toxicology Narra J Jurnal Perak Malahayati : Pengabdian Kepada Masyarakat JUMANTIK (Jurnal Ilmiah Penelitian Kesehatan) Jurnal Keperawatan Ophthalmologica Indonesiana

Laksmi Wulandari

Departement Of Pulmonology, Faculty Of Medicine, Airlangga University

Author-ID : 3289685

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Other

Published : 39 Documents Claim Missing Document

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Prevalence of Lung Cancer with a History of Tuberculosis Nadira Putri Nastiti; Laksmi Wulandari; Sulistiawati Sulistiawati; Anna Febriani; Wiwin Is Effendi
Jurnal Respirasi Vol. 9 No. 2 (2023): May 2023
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v9-I.2.2023.87-92

Introduction: Lung cancer ranks as the second most common diagnosis of malignancy cases in the world with the highest mortality, while Indonesia is the country with the largest tuberculosis (TB) burden after India. Although these two diseases have a high incidence and mortality rate and are one of the main causes of health problems, coexistence between these two diseases is very rare. A similar clinical and radiological feature complicates the diagnosis and worsens the prognosis. This study aimed to determine the prevalence and distribution patterns of lung cancer incidence with a history of TB. Methods: This was a descriptive study. The data were obtained retrospectively from the electronic medical records of lung cancer patients from one roof oncology clinic, Dr. Soetomo General Hospital, Surabaya, in 2018–2020, meeting the inclusion and exclusion criteria. Results: Specifically, 76 out of 1,044 (7.3%) lung cancer patients had a history of TB, with the distribution being men (71.1%), in an age range of 50-59 years old (34.2%), who were active smokers (36.9%), had an adenocarcinoma type of cancer (90.8%), had a positive EGFR gene mutation (50%), and had a diagnosis of non–small cell lung cancer (NSCLC) during stage IV (79%) after a TB diagnosis (54%) with a time interval of 1 or >10 years. Conclusion: The prevalence of lung cancer with a history of TB was 7.3%. Lung cancer screening is important in TB patients after one or even >10 years of diagnosis to reduce the morbidity and mortality rates because of this risk of coexistence.

Profile of Pulmonary Tuberculosis Patients in Dr. Soetomo General Academic Hospital Muhammad Dany Ramadhan; Aryati Aryati; Laksmi Wulandari
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 29 No. 3 (2023)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v29i3.2040

Tuberculosis (TB) is a disease caused by Mycobacterium tuberculosis, which mainly attacks the lungs but can also infect other body organs. Tuberculosis is a global health problem that causes the highest death after Human Immunodeficiency Virus (HIV). Indonesia ranks third highest in the world, with 420,994 cases in 2017. This study aims to determine the profile of pulmonary tuberculosis patients at Dr. Soetomo General Academic Hospital, Surabaya from January 1st to December 31st, 2019. The research was conducted using a descriptive method by collecting secondary data, through medical records of pulmonary tuberculosis patients at the Inpatient Unit of Dr. Soetomo General Academic Hospital during January 1st - December 31st, 2019. The data obtained were processed according to gender, age, education, occupation, comorbidities, clinical symptoms, history of TB treatment, sputum examination results, and GeneXpert. This study uses total sampling presented in the form of pictures. The results showed that most of the patients were male (61.92%), aged 45-54 years old (25.13%), high school education level (56.48%), and private employees (34.45%). The most common comorbidities were diabetes mellitus (35.07%), the most clinical symptoms found were shortness of breath (29.56%), the complete history of TB treatment was first-line OAT (42.22%), as many as (77.97%) sputum examinations showed no data. Many (7.77%) GeneXpert results showed resistance to rifampicin after six months of therapy.

The Effect of Zinc Distribution for New TB Patients who Have Ethambutol Therapy Toward Visual Field Defect Neni Daniati; Kusdiantoro Kusdiantoro; Laksmi Wulandari; Nina Mauthia; Lukisiari Agustini
Majalah Oftalmologi Indonesia Vol 42 No 3 (2016): Ophthalmologica Indonesiana
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/journal.v42i3.96

Background: Tuberculosis is an infection disease that is caused by Mycobacterium tuberculosis. Ethambutol therapy for TB patients can cause side effect such as decreased visual acuity, visual field defect, decreased contrast sensitivity, and disturbance of colour detection. Zinc in TB patients has decreased that causes broken cell on retina ganglion and disturbance of mytochondria function. The aim of this study is the effect of zinc supplementation for new TB patients who have ethambutol therapy toward visual field defect.Methods: This study involved 40 new TB patients who have ethambutol therapy which is classified as 20 patients who have ethambutol therapy with zinc supplementation and 20 patients who have ethambutol therapy without zinc supplementation. Each patient underwent a routine examination including visual acuity using Snellen chart which is converted to LogMAR, anterior segment using slit lamp biomicroscope, non-contact tonometry for intraocular pressure examination, posterior segment using direct ophthalmoscope, and Humphrey perimetry for visual field examination which is performed three times on first time when initial patient came, first month, and second month duration.Results: This study showed no correlation between gender with visual field defect (p=0,554), there is no correlation between age with visual field defect (p=0,418), no correlation between smoking behaviour with visual field defect (p=1), no correlation between amount of meals consumption containing Zn with visual field defect (p=0,608), and also no correlation between systematic illness history with visual field defect (p=0,305). The effect of Zn treatment to visual field defect was significant with p=0,0085. Conclusion: Zinc treatment for new TB patients with ethambutol treatment may prevent visual field defect. Â Keywords: ethambutol, new TB patients, zinc, visual field defect

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/journal.v42i3.115

Background: Tuberculosis is an infection disease that is caused by Mycobacterium tuberculosis. Ethambutol therapy for TB patients can cause side effect such as decreased visual acuity, visual field defect, decreased contrast sensitivity, and disturbance of colour detection. Zinc in TB patients has decreased that causes broken cell on retina ganglion and disturbance of mytochondria function. The aim of this study is the effect of zinc supplementation for new TB patients who have ethambutol therapy toward visual field defect.Methods: This study involved 40 new TB patients who have ethambutol therapy which is classified as 20 patients who have ethambutol therapy with zinc supplementation and 20 patients who have ethambutol therapy without zinc supplementation. Each patient underwent a routine examination including visual acuity using Snellen chart which is converted to LogMAR, anterior segment using slit lamp biomicroscope, non-contact tonometry for intraocular pressure examination, posterior segment using direct ophthalmoscope, and Humphrey perimetry for visual field examination which is performed three times on first time when initial patient came, first month, and second month duration.Results: This study showed no correlation between gender with visual field defect (p=0,554), there is no correlation between age with visual field defect (p=0,418), no correlation between smoking behaviour with visual field defect (p=1), no correlation between amount of meals consumption containing Zn with visual field defect (p=0,608), and also no correlation between systematic illness history with visual field defect (p=0,305). The effect of Zn treatment to visual field defect was significant with p=0,0085.Conclusion: Zinc treatment for new TB patients with ethambutol treatment may prevent visual field defect.Keywords: ethambutol, new TB patients, zinc, visual field defect

IDENTIFICATION OF INFLUENZA VIRUSES IN HUMAN AND POULTRY IN THE AREA OF LARANGAN WET MARKET SIDOARJO-EAST JAVA, INDONESIA Frederika, Edith; Mareta, Aldise; Poetranto, Djoko; Wulandari, Laksmi; Setyoningrum, Retno Asih; Setyowati, Lucia Landia; Yudhawati, Resti; Soegiarto, Gatot; Yamaoka, Masaoki
Indonesian Journal of Tropical and Infectious Disease Vol. 4 No. 4 (2013)
Publisher : Institute of Topical Disease Universitas Airlangga

Background: Influenza is a viral infection that attacks the respiratory system (nose, throat, and lungs) that commonly known as "flu”. There are 3 types of influenza viruses, such as type A, type B, and type C. Influenza virus type A is the type of virus that can infect both human and animals, virus type B are normally found only in human, and Influenza virus type C can cause mild illness in human and not causing any epidemics or pandemics. Among these 3 types of influenza viruses, only influenza A viruses infect birds, particularly wild bird that are the natural host for all subtypes of influenza A virus. Generally, those wild birds do not get sick when they are infected with influenza virus, unlike chickens or ducks which may die from avian influenza. Aim: In this study, we are identifying the influenza viruses among poultry in Larangan wet market. Method: Around 500 kinds of poultry were examined from cloacal swab. Result: Those samples were restrained with symptoms of suspected H5. The people who worked as the poultry-traders intact with the animal everyday were also examined, by taking nasopharyngeal swab and blood serum. Conclusion: Identification of influenza viruses was obtained to define the type and subtype of influenza virus by PCR.

Disseminated Tuberculosis Mimicking Lung Cancer with Multiple Bone Metastasis: A Case Report Wulandari, Laksmi; Juwita, Putri Mega
Indonesian Journal of Tropical and Infectious Disease Vol. 8 No. 3 (2020)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v8i3.17961

Tuberculosis (TB) is a contagious infectious disease caused by Mycobacterium tuberculosis (Mtb) of which attacking various organs particularly the lungs. Tuberculosis can occur together with malignancy or manifest as malignancy. Lung tuberculosis may appear in a variety of clinical and radiological manifestations caused by other diseases including tumors. These tumors are called pseudo-tumors. TB pseudo-tumor is a rare manifestation that can occur in immunocompetent patients in both primary and post-primary TB. The clinical presentation of TB pseudo-tumor is nonspecific and the clinical suspicion must be increased to diagnose related diseases. Radiological features can also be challenging to be distinguished from actual tumors. The classic manifestations of pulmonary TB are generally easy to diagnose due to the distinctive clinical and radiological characteristics nonetheless some pulmonary TB symptoms are also often found in patients with lung cancer. Infection patients resemble malignancies most were asymptomatic (> 27%) and the remaining 27% showed symptoms that varied with the average symptoms experienced about 1 month earlier. Clinical presentations that require a lot of misdiagnosis result in delayed treatment and unnecessary procedures. Establishing a diagnosis in cases of tuberculosis that causes malignancy is very important since the management and outcomes of the infection and malignancy process are quite diï¬€erent. Consequently we report a 24-year-old man with tuberculosis possible lung cancer with multiple bone metastase. Extrapulmonary tuberculosis which attacks bones and joints constitutes 10% to 20% of all TB cases. The location of bone and joint TB generally develops in the lumbar or thoracic vertebrae

Different COVID-19 mRNA-based Vaccine Platforms as The Booster Dose and Their Impact on Omicron: A Literature-Based Overview Mahdi, Bagus Aulia; Soegiarto, Gatot; Wulandari, Laksmi; purnomosari, dewajani
Indonesian Journal of Tropical and Infectious Disease Vol. 11 No. 2 (2023)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v11i2.39597

Globally, the vaccine has been determined as one of the principal policies to tackle the COVID-19 pandemic. However, some vaccinated individuals with two complete doses of inactivated experienced SARS-CoV2 infection, including the healthcare workers (HCWs). This threat led to the emergent need for a vaccine booster with different types of platforms aiming to enhance immunity from the Omicron variant. We conducted a literature study on the concept of heterologous compared to homologous vaccines in COVID-19 vaccination. We obtained 22 studies about COVID-19 booster vaccines. Referring to seven of them, we compared and distinguished between heterologous and homologous vaccines. We then reported the literature review according to PRISMA guideline. The study demonstrated qualitatively that heterologous vaccinations boosted antibody receptor binding domain, neutralizing antibody, and spike-specific Th1 type T cell responses and had an impact on omicron infection when compared to homologous vaccines. In conclusion, heterologous, mRNA based vaccine, predominantly induces cellular and humoral responses better than the homologous vaccine. This increased immune response is expected to provide profound immunity against the Omicron.

Impact of Hypertension and Cardiovascular Diseases to Immune Response in COVID-19 Vaccination: A Systematic Review Fahmita, Karin Dhia; Soegiarto, Gatot; Wulandari, Laksmi; Purnomosari, Dewajani
Indonesian Journal of Tropical and Infectious Disease Vol. 11 No. 1 (2023)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v11i1.40266

To determine impact of hypertension and cardiovascular diseases towards effectivity and safety of COVID-19 vaccination. Systematic review based on PRISMA statement was done. Searching was conducted in PubMed, ScienceDirect, Scopus, and ProQuest and resulting in 6 studies involving 4,053 participants which deemed on good quality according to Joanna Briggs Institute tools for critical appraisal. After thorough analysis, we found that two out of four studies assessing mRNA-based vaccine found out that hypertension lower antibody response significantly. Two out of two studies assessing inactivated virus vaccine shown that hypertensive patients tend to have lower antibody titers compared to control. One of studies mentioned above found that antibody titer was not different between populations with cardiovascular diseases and control.Hypertension lessened response to COVID-19 vaccination regardless of vaccine type used. However, lack of studies on cardiovascular disease suggested that more studies should be conducted, along with hypertension, in-order to make meta-analysis possible to provide better evidence.

More severe comorbidities, advanced age, and incomplete vaccination increase the risk of COVID-19 mortality Pradhevi, Lukita; Soegiarto, Gatot; Wulandari, Laksmi; Lusida, Michael AP.; Saefudin, Rendra P.; Vincent, Agustinus
Narra J Vol. 4 No. 2 (2024): August 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i2.949

Numerous studies have stated that comorbidities are risk factors for coronavirus disease 2019 (COVID-19) mortality, but few have considered the severity or stage of these comorbidities. The aim of this study was to determine the association between the severity of comorbidity, age, and number of COVID-19 vaccinations with COVID-19 mortality. This case-control study was conducted from July 2021 until December 2022 at the Dr. Soetomo General Academic Hospital, Surabaya, Indonesia. The patients were divided into non-survived patients (case group) and survived patients (control group). The inclusion criteria for cases were adult patients hospitalized with confirmed COVID-19, based on reverse transcriptase-polymerase chain reaction (RT-PCR) testing of nasopharyngeal swabs. Using total sampling, 1,046 confirmed COVID-19 patients, which consisted of 450 (43%) non-survived patients and 596 (57%) survived patients, were included. The most common comorbidity was diabetes mellitus (DM) (82.7%), chronic kidney disease (CKD) (43%), hypertension (25.7%), and obesity (23.6%). Our multivariate analysis indicated that older age (aOR: 1.03; 95%CI: 1.02–1.04, p<0.001), male sex (aOR: 1.29; 95%CI: 1.11–2.00, p=0.007), severe COVID-19 at first admission (aOR: 3.13; 95%CI: 2.08–4.73, p<0.001), having pneumonia (aOR: 1.99; 95%CI: 1.21–3.33, p=0.005), poorly controlled DM with HbA1c≥9% (aOR: 2.90; 95%CI: 1.72–4.89, p<0.001), severe obesity with body mass index (BMI)≥30 (OR: 2.90; 95%CI: 1.72–4.89, p<0.001), hypertension stage 2 (aOR: 1.99; 95%CI: 1.12–3.53, p=0.019) or stage 3 (aOR: 6.59; 95%CI: 2.39–18.17, p<0.001), CKD stage 3 (aOR: 2.50; 95%CI: 1.36–4.59, p=0.003), stage 4 (aOR: 5.47; 95%CI: 2.18–13.69, p<0.001) or stage 5 (aOR: 1.71; 95%CI: 1.04–2.81, p=0.036), and having chronic lung disease (aOR: 3.08; 95%CI: 1.22–7.77, p=0.017) significantly increased the risk of COVID-19 mortality. In contrast, COVID-19 vaccination reduced the risk of COVID-19-associated death. This study highlights that more severe comorbidities, advanced age, and incomplete vaccination were associated with COVID-19 mortality.

Screening Lung Cancer in Sampang Regency, Madura Through Empowerment and Health Cadres Formation Yudhawati, Resti; Wulandari, Laksmi; Febriani, Anna; Wati, Farah Fatma; Thendeyas, Richar Tomy; Atik, Nurul; Hariputri, Wulan Rahmawati; Novananda, Donny Ardika; Riyanto, Shandy Billy
Jurnal Pengabdian kepada Masyarakat (Indonesian Journal of Community Engagement) Vol 10, No 2 (2024): June
Publisher : Direktorat Pengabdian kepada Masyarakat Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jpkm.92549

Treatment for lung cancer remains challenging since most of the patients seek medical advice at an advanced stage of disease. Sampang is one of the regencies that refers many lung cancer patients in late stages to Dr. Soetomo Hospital, Surabaya, due to lack of information of lung cancer and early detection. Limited number of health workers to deliver comprehensive education to all areas requires community volunteers to fill this gap. The objective of this study was to educate and promote lung cancer awareness to the health cadres in Sampang as well as training them to early detecting individuals in the community with high-risk factors, as an attempt to bridge between the health workers and community, therefore the number of lung cancer early detection may be improved. Early identification of cancer may result in reduced morbidity and mortality, and in some cases, if detected early enough, therapy may involve only surgery. The education was provided for the health cadres by providing information related to lung cancer and guidance to fill the questionnaire and scoring of lung cancer risk factors. The participants' understanding was measured using a pretest-posttest design. Thirty health cadres have been successfully formed, and they have gained knowledge of lung cancer and mastered capability to perform early-screening of lung cancer in the community as shown by the increase of post-test result compared to pre-test. The health cadres then implemented their knowledge of lung cancer early-screening by distributing questionnaires of lung cancer risk factor scoring to residents using door to door methods. The questionnaires’ evaluation collected by the health cadres showed that there were 93 residents with high-risk factors of lung cancer. In conclusion, the health cadres has been capable to detect high-risk factors individuals in the community which further be followed up by community health workers comprehensively.

Co-Authors Agustinus Rizki Aldise M Nastri Aldise Mareta Nastri Aldise Mareta, Aldise Ana Rima Ana Rima Setijadi Ananda, Fannie Rizki Andarini, Sita Andreas Infianto Anna Febriani Apriyanto, Yudi Arfiansyah, Mochammad Aris Arif Santoso Arif Santoso Ariobimo, Bonfilio Neltio Aris Widayati Arta Rahman Aryati Aryati Atik, Nurul Ayu Rahmanita Putri Soetrisno Cita Rosita Sigit Prakoeswa Dana Hendrawan Putra Delvac Oceandy Dewajani Purnomosari, Dewajani Dewajani Purnomosari3 Dewi, Gusti Agung Ayu Ira Kencana Djoko Poetranto, Djoko Duyen, Natalie Edith Frederika, Edith Elisna Syahruddin Emmanuel Djoko Poetranto Ermayanti, Sabrina Ermayanti, Sabrina Erwin Winaya Evelyn Asaleo Fahmita, Karin Dhia Farahannisaa, Kintan Adelia Febriani, Anna Ferry Dwi Kurniawan Gatot Soegiarto Gemilang Khusnurrokhman Gilang Muhammad Setyo Nugroho Grahana Ade Candra Wolayan Hamidah, Berliana Hanif, Muhammad Alfin Hariputri, Wulan Rahmawati Haryati Haryati Haryati Haryati Hendra Ikhwan Gautama Hidayat, Moulid Husniyah, Barizatul Ida Ayu Jasminarti Ida Ayu Jasminarti Dwi Kusumawardani Indana Eva Ajmala Infianto, Andreas Jasminarti, Ida Ayu Juwita, Putri Mega Kazufumi Shimizu Khansa Fahira Wisdana Kinanthi, Monica Tiara Arum Kurniawan, Ferry Dwi Kusdiantoro Kusdiantoro Kusdiantoro Kusdiantoro Landia Setiawati Lim, Darren Wan-Teck Linda Dewanti Lucia Landia Setyowati, Lucia Landia Luh Ade Wilan Krisna Lukisiari Agustini Lusida, Michael AP. Mahdi, Bagus Aulia Maqnun, Lu'lu'il Masaoki Yamaoka Masaoki Yamaoka, Masaoki Muhammad Amin Muhammad Dany Ramadhan Muhammad Fitra Ramadhan Nadira Putri Nastiti Nathaniel Aditya Neni Daniati Nikson Eduard Faot Nina Mauthia Noni Novisari Soeroso Novananda, Donny Ardika Novita Andayani, Novita Pakpahan, Cennikon Paladan, Triadi Putra Pradhevi, Lukita Pratama, Avissena Dutha Pratiwi, Suryanti Dwi Pudji Lestari Puteri, Rr. Astrid Aulia Artiono Putra, Andika Chandra Rebekah Setiabudi, Rebekah Resti Yudhawati Retno A Setyoningrum Retno Asih Retno Asih Setyoningrum Risnawati Risnawati Riyanto, Shandy Billy Saefudin, Rendra P. Sahrun Sahrun Santoso, Andintia Aisyah Setyawan, Ungky Agus Sita Andarini Sita Ro'yul Aini Sjahjenny Mustokoweni, Sjahjenny soedarto soedarto, soedarto Sri Melati Munir Sri Melati Munir Subagyo, Zaufy Verlieza Oktaviano Sulistiawati Sulistiawati Surya, Prima Ardiansah Susilowati Andajani, Susilowati Suwandi Syamsuri, Ibrahim Thendeyas, Richar Tomy Thirafi, Sacharissa Zerlina Tsarwah Tri Wibawa Utami Meilanie Putri Veda Septian Cahya Budi Vincent, Agustinus Wati, Farah Fatma Wibi Riawan Wiriansya, Edward Pandu Wiwin Is Effendi Yashinta, Yolanda Ayu Zahira Pelangi Rahmadilla Satriadi Zaini, Jamal Zaphiria Loka Pramesthi

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