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All Journal Indonesian Journal of Tropical and Infectious Disease Jurnal Pengabdian Kepada Masyarakat (Indonesian Journal of Community Engagement) Majalah Kesehatan FKUB Jurnal Respirologi Indonesia Jurnal Respirasi (JR) Jurnal Ilmiah Akuntansi dan Bisnis JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Jurnal Abdi Insani JOURNAL OF COMMUNITY MEDICINE AND PUBLIC HEALTH RESEARCH Indian Journal of Forensic Medicine & Toxicology Narra J Jurnal Perak Malahayati : Pengabdian Kepada Masyarakat JUMANTIK (Jurnal Ilmiah Penelitian Kesehatan) Indonesian Journal of Cancer Jurnal Keperawatan Ophthalmologica Indonesiana Folia Medica Indonesiana

Laksmi Wulandari

Departement Of Pulmonology, Faculty Of Medicine, Airlangga University

Author-ID : 3289685

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health

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IDENTIFICATION OF INFLUENZA VIRUSES IN HUMAN AND POULTRY IN THE AREA OF LARANGAN WET MARKET SIDOARJO-EAST JAVA, INDONESIA Frederika, Edith; Mareta, Aldise; Poetranto, Djoko; Wulandari, Laksmi; Setyoningrum, Retno Asih; Setyowati, Lucia Landia; Yudhawati, Resti; Soegiarto, Gatot; Yamaoka, Masaoki
Indonesian Journal of Tropical and Infectious Disease Vol. 4 No. 4 (2013)
Publisher : Institute of Topical Disease Universitas Airlangga

Background: Influenza is a viral infection that attacks the respiratory system (nose, throat, and lungs) that commonly known as "flu”. There are 3 types of influenza viruses, such as type A, type B, and type C. Influenza virus type A is the type of virus that can infect both human and animals, virus type B are normally found only in human, and Influenza virus type C can cause mild illness in human and not causing any epidemics or pandemics. Among these 3 types of influenza viruses, only influenza A viruses infect birds, particularly wild bird that are the natural host for all subtypes of influenza A virus. Generally, those wild birds do not get sick when they are infected with influenza virus, unlike chickens or ducks which may die from avian influenza. Aim: In this study, we are identifying the influenza viruses among poultry in Larangan wet market. Method: Around 500 kinds of poultry were examined from cloacal swab. Result: Those samples were restrained with symptoms of suspected H5. The people who worked as the poultry-traders intact with the animal everyday were also examined, by taking nasopharyngeal swab and blood serum. Conclusion: Identification of influenza viruses was obtained to define the type and subtype of influenza virus by PCR.

Disseminated Tuberculosis Mimicking Lung Cancer with Multiple Bone Metastasis: A Case Report Wulandari, Laksmi; Juwita, Putri Mega
Indonesian Journal of Tropical and Infectious Disease Vol. 8 No. 3 (2020)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v8i3.17961

Tuberculosis (TB) is a contagious infectious disease caused by Mycobacterium tuberculosis (Mtb) of which attacking various organs particularly the lungs. Tuberculosis can occur together with malignancy or manifest as malignancy. Lung tuberculosis may appear in a variety of clinical and radiological manifestations caused by other diseases including tumors. These tumors are called pseudo-tumors. TB pseudo-tumor is a rare manifestation that can occur in immunocompetent patients in both primary and post-primary TB. The clinical presentation of TB pseudo-tumor is nonspecific and the clinical suspicion must be increased to diagnose related diseases. Radiological features can also be challenging to be distinguished from actual tumors. The classic manifestations of pulmonary TB are generally easy to diagnose due to the distinctive clinical and radiological characteristics nonetheless some pulmonary TB symptoms are also often found in patients with lung cancer. Infection patients resemble malignancies most were asymptomatic (> 27%) and the remaining 27% showed symptoms that varied with the average symptoms experienced about 1 month earlier. Clinical presentations that require a lot of misdiagnosis result in delayed treatment and unnecessary procedures. Establishing a diagnosis in cases of tuberculosis that causes malignancy is very important since the management and outcomes of the infection and malignancy process are quite diï¬€erent. Consequently we report a 24-year-old man with tuberculosis possible lung cancer with multiple bone metastase. Extrapulmonary tuberculosis which attacks bones and joints constitutes 10% to 20% of all TB cases. The location of bone and joint TB generally develops in the lumbar or thoracic vertebrae

Different COVID-19 mRNA-based Vaccine Platforms as The Booster Dose and Their Impact on Omicron: A Literature-Based Overview Mahdi, Bagus Aulia; Soegiarto, Gatot; Wulandari, Laksmi; purnomosari, dewajani
Indonesian Journal of Tropical and Infectious Disease Vol. 11 No. 2 (2023)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v11i2.39597

Globally, the vaccine has been determined as one of the principal policies to tackle the COVID-19 pandemic. However, some vaccinated individuals with two complete doses of inactivated experienced SARS-CoV2 infection, including the healthcare workers (HCWs). This threat led to the emergent need for a vaccine booster with different types of platforms aiming to enhance immunity from the Omicron variant. We conducted a literature study on the concept of heterologous compared to homologous vaccines in COVID-19 vaccination. We obtained 22 studies about COVID-19 booster vaccines. Referring to seven of them, we compared and distinguished between heterologous and homologous vaccines. We then reported the literature review according to PRISMA guideline. The study demonstrated qualitatively that heterologous vaccinations boosted antibody receptor binding domain, neutralizing antibody, and spike-specific Th1 type T cell responses and had an impact on omicron infection when compared to homologous vaccines. In conclusion, heterologous, mRNA based vaccine, predominantly induces cellular and humoral responses better than the homologous vaccine. This increased immune response is expected to provide profound immunity against the Omicron.

Impact of Hypertension and Cardiovascular Diseases to Immune Response in COVID-19 Vaccination: A Systematic Review Fahmita, Karin Dhia; Soegiarto, Gatot; Wulandari, Laksmi; Purnomosari, Dewajani
Indonesian Journal of Tropical and Infectious Disease Vol. 11 No. 1 (2023)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v11i1.40266

To determine impact of hypertension and cardiovascular diseases towards effectivity and safety of COVID-19 vaccination. Systematic review based on PRISMA statement was done. Searching was conducted in PubMed, ScienceDirect, Scopus, and ProQuest and resulting in 6 studies involving 4,053 participants which deemed on good quality according to Joanna Briggs Institute tools for critical appraisal. After thorough analysis, we found that two out of four studies assessing mRNA-based vaccine found out that hypertension lower antibody response significantly. Two out of two studies assessing inactivated virus vaccine shown that hypertensive patients tend to have lower antibody titers compared to control. One of studies mentioned above found that antibody titer was not different between populations with cardiovascular diseases and control.Hypertension lessened response to COVID-19 vaccination regardless of vaccine type used. However, lack of studies on cardiovascular disease suggested that more studies should be conducted, along with hypertension, in-order to make meta-analysis possible to provide better evidence.

More severe comorbidities, advanced age, and incomplete vaccination increase the risk of COVID-19 mortality Pradhevi, Lukita; Soegiarto, Gatot; Wulandari, Laksmi; Lusida, Michael AP.; Saefudin, Rendra P.; Vincent, Agustinus
Narra J Vol. 4 No. 2 (2024): August 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i2.949

Numerous studies have stated that comorbidities are risk factors for coronavirus disease 2019 (COVID-19) mortality, but few have considered the severity or stage of these comorbidities. The aim of this study was to determine the association between the severity of comorbidity, age, and number of COVID-19 vaccinations with COVID-19 mortality. This case-control study was conducted from July 2021 until December 2022 at the Dr. Soetomo General Academic Hospital, Surabaya, Indonesia. The patients were divided into non-survived patients (case group) and survived patients (control group). The inclusion criteria for cases were adult patients hospitalized with confirmed COVID-19, based on reverse transcriptase-polymerase chain reaction (RT-PCR) testing of nasopharyngeal swabs. Using total sampling, 1,046 confirmed COVID-19 patients, which consisted of 450 (43%) non-survived patients and 596 (57%) survived patients, were included. The most common comorbidity was diabetes mellitus (DM) (82.7%), chronic kidney disease (CKD) (43%), hypertension (25.7%), and obesity (23.6%). Our multivariate analysis indicated that older age (aOR: 1.03; 95%CI: 1.02–1.04, p<0.001), male sex (aOR: 1.29; 95%CI: 1.11–2.00, p=0.007), severe COVID-19 at first admission (aOR: 3.13; 95%CI: 2.08–4.73, p<0.001), having pneumonia (aOR: 1.99; 95%CI: 1.21–3.33, p=0.005), poorly controlled DM with HbA1c≥9% (aOR: 2.90; 95%CI: 1.72–4.89, p<0.001), severe obesity with body mass index (BMI)≥30 (OR: 2.90; 95%CI: 1.72–4.89, p<0.001), hypertension stage 2 (aOR: 1.99; 95%CI: 1.12–3.53, p=0.019) or stage 3 (aOR: 6.59; 95%CI: 2.39–18.17, p<0.001), CKD stage 3 (aOR: 2.50; 95%CI: 1.36–4.59, p=0.003), stage 4 (aOR: 5.47; 95%CI: 2.18–13.69, p<0.001) or stage 5 (aOR: 1.71; 95%CI: 1.04–2.81, p=0.036), and having chronic lung disease (aOR: 3.08; 95%CI: 1.22–7.77, p=0.017) significantly increased the risk of COVID-19 mortality. In contrast, COVID-19 vaccination reduced the risk of COVID-19-associated death. This study highlights that more severe comorbidities, advanced age, and incomplete vaccination were associated with COVID-19 mortality.

Screening Lung Cancer in Sampang Regency, Madura Through Empowerment and Health Cadres Formation Yudhawati, Resti; Wulandari, Laksmi; Febriani, Anna; Wati, Farah Fatma; Thendeyas, Richar Tomy; Atik, Nurul; Hariputri, Wulan Rahmawati; Novananda, Donny Ardika; Riyanto, Shandy Billy
Jurnal Pengabdian kepada Masyarakat (Indonesian Journal of Community Engagement) Vol 10, No 2 (2024): June
Publisher : Direktorat Pengabdian kepada Masyarakat Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jpkm.92549

Treatment for lung cancer remains challenging since most of the patients seek medical advice at an advanced stage of disease. Sampang is one of the regencies that refers many lung cancer patients in late stages to Dr. Soetomo Hospital, Surabaya, due to lack of information of lung cancer and early detection. Limited number of health workers to deliver comprehensive education to all areas requires community volunteers to fill this gap. The objective of this study was to educate and promote lung cancer awareness to the health cadres in Sampang as well as training them to early detecting individuals in the community with high-risk factors, as an attempt to bridge between the health workers and community, therefore the number of lung cancer early detection may be improved. Early identification of cancer may result in reduced morbidity and mortality, and in some cases, if detected early enough, therapy may involve only surgery. The education was provided for the health cadres by providing information related to lung cancer and guidance to fill the questionnaire and scoring of lung cancer risk factors. The participants' understanding was measured using a pretest-posttest design. Thirty health cadres have been successfully formed, and they have gained knowledge of lung cancer and mastered capability to perform early-screening of lung cancer in the community as shown by the increase of post-test result compared to pre-test. The health cadres then implemented their knowledge of lung cancer early-screening by distributing questionnaires of lung cancer risk factor scoring to residents using door to door methods. The questionnaires’ evaluation collected by the health cadres showed that there were 93 residents with high-risk factors of lung cancer. In conclusion, the health cadres has been capable to detect high-risk factors individuals in the community which further be followed up by community health workers comprehensively.

TELEMEDICINE AS AN EFFORT TO IMPROVE PUBLIC KNOWLEDGE TO FIGHT COVID-19 PANDEMIC Thirafi, Sacharissa Zerlina Tsarwah; Paladan, Triadi Putra; Ariobimo, Bonfilio Neltio; Husniyah, Barizatul; Kinanthi, Monica Tiara Arum; Dewi, Gusti Agung Ayu Ira Kencana; Surya, Prima Ardiansah; Yashinta, Yolanda Ayu; Subagyo, Zaufy Verlieza Oktaviano; Wulandari, Laksmi; Dewanti, Linda
Journal of Community Medicine and Public Health Research Vol. 2 No. 1 (2021): Journal of Community Medicine and Public Health Research
Publisher : Universitas Airlangga

The role of the community is an essential part to cut down the COVID-19 chain transmission, a current world pandemic. Knowledge determines a person's healthy behavior that can prevent transmission of COVID-19. This research's goal is to analyze the effect of health promotion via telemedicine on increasing knowledge about COVID-19 prevention in the productive-age population in Indonesia. This study used one group pretest-posttest design and accidental sampling method involving 146 respondents based on the inclusion criteria. The data collection method was carried out by using a questionnaire containing simple and general questions related to COVID-19 that tested subjects before and after telemedicine health promotion. Based on the assessment of the questionnaire through pretest and posttest, there was an increase in the average knowledge after being given health education with telemedicine with p<0.001 (CI 95%). This study shows that telemedicine could significantly increase average knowledge about COVID-19 prevention in the productive-age population in Indonesia.

THE CORRELATION BETWEEN KNOWLEDGE AND PERCEPTION OF YOUTH USERS OF VAPE TOWARDS VAPING BEHAVIOR IN BANGIL DISTRICT Maqnun, Lu'lu'il; Lestari, Pudji; Wulandari, Laksmi
Journal of Community Medicine and Public Health Research Vol. 2 No. 1 (2021): Journal of Community Medicine and Public Health Research
Publisher : Universitas Airlangga

The use of e-cigarettes year by year increases among adolescents. The increase correlates with their lack of knowledge about e-cigarettes and the perception that e-cigarettes are safer than conventional cigarettes. This research aims to analyze the relationship between the level of knowledge and perception of e-cigarettes to vaping behavior in adolescents in Bangil, Pasuruan. This study was analytic observational with a cross-sectional approach conducted from September until October 2019. The subjects in this study were 76 respondents selected by the purposive sampling method. The respondents were recruited from 3 cafes in Bangil by distributing questionnaires to those who met the inclusion criteria. The independent variables are the respondent's knowledge level and perception about e-cigarettes, while the dependent variable is vaping behavior. The data has been analyzed with Spearman's rho. From the analysis, there was a correlation between level of knowledge and vaping behavior with p=0.019 (p<0.05) and 0.269 correlation coefficient. Also, a correlation between perception and vaping behavior with p=0.000 (p<0.05) and 0.420 correlation coefficient. There was a correlation between knowledge level and perception of e-cigarettes to vaping behavior among adolescent users.

Indonesian Society of Respirology Position Paper on Lung Cancer Control in Indonesia Andarini, Sita; Santoso, Andintia Aisyah; Arfiansyah, Mochammad Aris; Syahruddin, Elisna; Zaini, Jamal; Putra, Andika Chandra; Kurniawan, Ferry Dwi; Ermayanti, Sabrina; Soeroso, Noni Novisari; Munir, Sri Melati; Infianto, Andreas; Setijadi, Ana Rima; Setyawan, Ungky Agus; Wulandari, Laksmi; Haryati, Haryati; Jasminarti, Ida Ayu; Hidayat, Moulid; Santoso, Arif
Jurnal Respirologi Indonesia Vol 44, No 4 (2024)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v44i4.884

Lung cancer is a major health concern in Indonesia due to its increasing prevalence, late-stage diagnosis, younger population, and high mortality. Addressing this issue requires nationwide implementation of comprehensive lung cancer control, which includes risk reduction and prevention strategies, focusing on tobacco control and air pollution mitigation. Screening with low-dose computed tomography (LDCT) and early detection in symptomatic patients, along with TB screening programs and all non-communicable diseases, is strongly recommended to enhance early case findings, treatment effectiveness, and overall patient outcomes. A multidisciplinary team (MDT) approach is important to ensure accurate diagnosis and comprehensive care. Moreover, the integration of palliative care at the early stages of advanced lung cancer is vital, focusing on symptom management and enhancing the quality of life for patients. While national guidelines are available for the diagnosis and treatment of lung cancer, significant disparities in healthcare access remain across Indonesia. Thus, it is essential to improve universal health coverage and referral systems to guarantee equal access to lung cancer care for patients at all levels through advocacy and ease of access.

Monitoring and Evaluation of Therapy Response in Advanced-Stage Lung Cancer Treated with Systemic Therapy Syamsuri, Ibrahim; Febriani, Anna; Wulandari, Laksmi; Wati, Farah Fatma
Jurnal Respirasi Vol. 11 No. 2 (2025): May 2025
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v11-I.2.2025.183-190

Lung cancer is the second most commonly diagnosed malignancy, with the highest mortality rate in the world. In Indonesia, lung cancer ranks third with 34,783 cases, contributing to the highest number of deaths due to cancer. Most patients are diagnosed at an advanced stage, requiring systemic therapy. Therapeutic modalities for lung cancer patients can include surgery, radiotherapy, and systemic therapy, with the choice of therapy determined by the histological type, disease stage, laboratory results, performance status (PS), and comorbidities. This situation requires regular monitoring and evaluation to reduce the symptoms and improve the patient’s quality of life (QoL). Therapy response in systemic therapy patients can be evaluated through subjective, semi-subjective, and objective evaluations. Subjective evaluation involves monitoring QoL, focusing on cancer outcomes, and patients’ well-being. Semi-subjective evaluation consists of monitoring the patient’s weight and PS. Objective evaluation uses imaging equipment, such as computed tomography (CT) scans, fluoroscopy, magnetic resonance imaging (MRI), and positron emission tomography (PET) scans to monitor tumor progression.

Co-Authors Agustinus Rizki Aldise M Nastri Aldise Mareta Nastri Aldise Mareta, Aldise Ana Rima Ana Rima Setijadi Ananda, Fannie Rizki Andarini, Sita Andreas Infianto Anna Febriani Apriyanto, Yudi Arfiansyah, Mochammad Aris Arif Santoso Arif Santoso Ariobimo, Bonfilio Neltio Aris Widayati Arta Rahman Aryati Aryati Atik, Nurul Ayu Rahmanita Putri Soetrisno Cita Rosita Sigit Prakoeswa Dana Hendrawan Putra Delvac Oceandy Dewajani Purnomosari, Dewajani Dewajani Purnomosari3 Dewi, Gusti Agung Ayu Ira Kencana Djoko Poetranto, Djoko Dominicus Husada Duyen, Natalie Edith Frederika, Edith Elisna Syahruddin Emmanuel Djoko Poetranto Ermayanti, Sabrina Ermayanti, Sabrina Erwin Winaya Evelyn Asaleo Fahmita, Karin Dhia Farahannisaa, Kintan Adelia Febriani, Anna Ferry Dwi Kurniawan Gatot Soegiarto Gemilang Khusnurrokhman Gilang Muhammad Setyo Nugroho Grahana Ade Candra Wolayan Hamidah, Berliana Hanif, Muhammad Alfin Hariputri, Wulan Rahmawati Haryati Haryati Haryati Haryati Hayati, Fierly Hendra Ikhwan Gautama Hidayat, Moulid Husniyah, Barizatul Ida Ayu Jasminarti Ida Ayu Jasminarti Dwi Kusumawardani Indana Eva Ajmala Infianto, Andreas Jasminarti, Ida Ayu Juwita, Putri Mega Kazufumi Shimizu Khansa Fahira Wisdana Khusnurrokhman, Gemilang Kinanthi, Monica Tiara Arum Kurniawan, Ferry Dwi Kusdiantoro Kusdiantoro Kusdiantoro Kusdiantoro Landia Setiawati Lim, Darren Wan-Teck Linda Dewanti Lucia Landia Setyowati, Lucia Landia Luh Ade Wilan Krisna Lukisiari Agustini Lusida, Michael AP. Mahdi, Bagus Aulia Maqnun, Lu'lu'il Masaoki Yamaoka Masaoki Yamaoka, Masaoki Muhammad Amin Muhammad Dany Ramadhan Muhammad Fitra Ramadhan Nadira Putri Nastiti Nathaniel Aditya Neni Daniati Nikson Eduard Faot Nina Mauthia Noni Novisari Soeroso Novananda, Donny Ardika Novita Andayani, Novita Pakpahan, Cennikon Paladan, Triadi Putra Pradhevi, Lukita Pratama, Avissena Dutha Pratiwi, Suryanti Dwi Prodjosoewojo, Susantina Pudji Lestari Puteri, Rr. Astrid Aulia Artiono Putra, Andika Chandra Rebekah Setiabudi, Rebekah Resti Yudhawati Retno A Setyoningrum Retno Asih Retno Asih Setyoningrum Risnawati Risnawati Riyanto, Shandy Billy Rizki, Agustinus Rusli, Musofa Saefudin, Rendra P. Sahrun Sahrun Sahrun, Sahrun Santoso, Andintia Aisyah Setyawan, Ungky Agus Shivabasappa, Santhosh Sita Andarini Sita Ro'yul Aini Sjahjenny Mustokoweni, Sjahjenny soedarto soedarto, soedarto Sopha, May Ira Sri Melati Munir Sri Melati Munir Subagyo, Zaufy Verlieza Oktaviano Sulistiawati Sulistiawati Surya, Prima Ardiansah Susilowati Andajani, Susilowati Suwandi Syamsuri, Ibrahim Thendeyas, Richar Tomy Thirafi, Sacharissa Zerlina Tsarwah Tri Wibawa Utami Meilanie Putri Veda Septian Cahya Budi Vincent, Agustinus Wati, Farah Fatma Wibi Riawan Wiriansya, Edward Pandu Wiwin Is Effendi Yashinta, Yolanda Ayu Zahira Pelangi Rahmadilla Satriadi Zaini, Jamal Zaphiria Loka Pramesthi

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