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All Journal Folia Medica Indonesiana Indonesian Journal of Tropical and Infectious Disease Jurnal Pengabdian Kepada Masyarakat (Indonesian Journal of Community Engagement) Majalah Kesehatan FKUB Jurnal Respirologi Indonesia Jurnal Respirasi (JR) Jurnal Ilmiah Akuntansi dan Bisnis JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Jurnal Abdi Insani JOURNAL OF COMMUNITY MEDICINE AND PUBLIC HEALTH RESEARCH Indian Journal of Forensic Medicine & Toxicology Narra J Jurnal Perak Malahayati : Pengabdian Kepada Masyarakat JUMANTIK (Jurnal Ilmiah Penelitian Kesehatan) Jurnal Keperawatan Ophthalmologica Indonesiana
Laksmi Wulandari
Departement Of Pulmonology, Faculty Of Medicine, Airlangga University
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Other

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TELEMEDICINE AS AN EFFORT TO IMPROVE PUBLIC KNOWLEDGE TO FIGHT COVID-19 PANDEMIC Thirafi, Sacharissa Zerlina Tsarwah; Paladan, Triadi Putra; Ariobimo, Bonfilio Neltio; Husniyah, Barizatul; Kinanthi, Monica Tiara Arum; Dewi, Gusti Agung Ayu Ira Kencana; Surya, Prima Ardiansah; Yashinta, Yolanda Ayu; Subagyo, Zaufy Verlieza Oktaviano; Wulandari, Laksmi; Dewanti, Linda
Journal of Community Medicine and Public Health Research Vol. 2 No. 1 (2021): Journal of Community Medicine and Public Health Research
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (321.018 KB) | DOI: 10.20473/jcmphr.v2i1.21883

Abstract

The role of the community is an essential part to cut down the COVID-19 chain transmission, a current world pandemic. Knowledge determines a person's healthy behavior that can prevent transmission of COVID-19. This research's goal is to analyze the effect of health promotion via telemedicine on increasing knowledge about COVID-19 prevention in the productive-age population in Indonesia. This study used one group pretest-posttest design and accidental sampling method involving 146 respondents based on the inclusion criteria. The data collection method was carried out by using a questionnaire containing simple and general questions related to COVID-19 that tested subjects before and after telemedicine health promotion. Based on the assessment of the questionnaire through pretest and posttest, there was an increase in the average knowledge after being given health education with telemedicine with p<0.001 (CI 95%). This study shows that telemedicine could significantly increase average knowledge about COVID-19 prevention in the productive-age population in Indonesia.
THE CORRELATION BETWEEN KNOWLEDGE AND PERCEPTION OF YOUTH USERS OF VAPE TOWARDS VAPING BEHAVIOR IN BANGIL DISTRICT Maqnun, Lu'lu'il; Lestari, Pudji; Wulandari, Laksmi
Journal of Community Medicine and Public Health Research Vol. 2 No. 1 (2021): Journal of Community Medicine and Public Health Research
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (372.821 KB) | DOI: 10.20473/jcmphr.v2i1.22685

Abstract

The use of e-cigarettes year by year increases among adolescents. The increase correlates with their lack of knowledge about e-cigarettes and the perception that e-cigarettes are safer than conventional cigarettes. This research aims to analyze the relationship between the level of knowledge and perception of e-cigarettes to vaping behavior in adolescents in Bangil, Pasuruan. This study was analytic observational with a cross-sectional approach conducted from September until October 2019. The subjects in this study were 76 respondents selected by the purposive sampling method. The respondents were recruited from 3 cafes in Bangil by distributing questionnaires to those who met the inclusion criteria. The independent variables are the respondent's knowledge level and perception about e-cigarettes, while the dependent variable is vaping behavior. The data has been analyzed with Spearman's rho. From the analysis, there was a correlation between level of knowledge and vaping behavior with p=0.019 (p<0.05) and 0.269 correlation coefficient. Also, a correlation between perception and vaping behavior with p=0.000 (p<0.05) and 0.420 correlation coefficient. There was a correlation between knowledge level and perception of e-cigarettes to vaping behavior among adolescent users.
Indonesian Society of Respirology Position Paper on Lung Cancer Control in Indonesia Andarini, Sita; Santoso, Andintia Aisyah; Arfiansyah, Mochammad Aris; Syahruddin, Elisna; Zaini, Jamal; Putra, Andika Chandra; Kurniawan, Ferry Dwi; Ermayanti, Sabrina; Soeroso, Noni Novisari; Munir, Sri Melati; Infianto, Andreas; Setijadi, Ana Rima; Setyawan, Ungky Agus; Wulandari, Laksmi; Haryati, Haryati; Jasminarti, Ida Ayu; Hidayat, Moulid; Santoso, Arif
Jurnal Respirologi Indonesia Vol 44, No 4 (2024)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v44i4.884

Abstract

Lung cancer is a major health concern in Indonesia due to its increasing prevalence, late-stage diagnosis, younger population, and high mortality. Addressing this issue requires nationwide implementation of comprehensive lung cancer control, which includes risk reduction and prevention strategies, focusing on tobacco control and air pollution mitigation. Screening with low-dose computed tomography (LDCT) and early detection in symptomatic patients, along with TB screening programs and all non-communicable diseases, is strongly recommended to enhance early case findings, treatment effectiveness, and overall patient outcomes. A multidisciplinary team (MDT) approach is important to ensure accurate diagnosis and comprehensive care. Moreover, the integration of palliative care at the early stages of advanced lung cancer is vital, focusing on symptom management and enhancing the quality of life for patients. While national guidelines are available for the diagnosis and treatment of lung cancer, significant disparities in healthcare access remain across Indonesia. Thus, it is essential to improve universal health coverage and referral systems to guarantee equal access to lung cancer care for patients at all levels through advocacy and ease of access.
LYMPHOCYTE-T TYPE TH1 AND TH2 ACTIVITY DIFFERENCE OF LUNG TISSUE ON Heligmosomoides polygyrus NEMATODE AND Mycobacterium tuberculosis SEQUENTIAL CO-INFECTION Wulandari, Laksmi; Amin, Muhammad; Soedarto, Soedarto; Soegiarto, Gatot
Folia Medica Indonesiana Vol. 53 No. 2 (2017): JUNE 2017
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (371.852 KB) | DOI: 10.20473/fmi.v53i2.6356

Abstract

Tuberculosis (TB) is a chronic infectious disease caused by Mycobacterium tuberculosis that are often associated with uneffectiveness of the BCG vaccine and the high worm infection. The objective of this study was to determine the differences in the activity of Limfosit T type Th1 (IFN-g) and Th2 (IL-4) in lung tissue on Heligmosomoides polygyrus nematode and Mycobacterium tuberculosis sequential co-infection. This research using 49 mice were divide into 7 groups treated with infection by Mycobacterium tuberculose inhaled and Heligmosomoides polygyrus orally within 8 and 16 weeks. The levels of IFN-g in peripheral blood serum (89.929 + 3.533 pg/mL) resembles the pattern of the percentage of lymphocytes T CD4+ Th1 in lung tissue (3.246 + 0.519%) and peripheral blood (4.950 + 0.237%), while the levels IL-4 in the peripheral blood serum (20.782 + 4.043%) resembles the pattern of the percentage of lymphocytes T CD4+ Th2 in intestinal tissue (1.048 + 0.359%) and peripheral blood (1.196 + 0.557%). In conclusion, there is difference in the activity of lymphocytes T type Th1 and Th2 but it does not affect the immune response to Mycobacterium tuberculosis infection.
Monitoring and Evaluation of Therapy Response in Advanced-Stage Lung Cancer Treated with Systemic Therapy Syamsuri, Ibrahim; Febriani, Anna; Wulandari, Laksmi; Wati, Farah Fatma
Jurnal Respirasi Vol. 11 No. 2 (2025): May 2025
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v11-I.2.2025.183-190

Abstract

Lung cancer is the second most commonly diagnosed malignancy, with the highest mortality rate in the world. In Indonesia, lung cancer ranks third with 34,783 cases, contributing to the highest number of deaths due to cancer. Most patients are diagnosed at an advanced stage, requiring systemic therapy. Therapeutic modalities for lung cancer patients can include surgery, radiotherapy, and systemic therapy, with the choice of therapy determined by the histological type, disease stage, laboratory results, performance status (PS), and comorbidities. This situation requires regular monitoring and evaluation to reduce the symptoms and improve the patient’s quality of life (QoL). Therapy response in systemic therapy patients can be evaluated through subjective, semi-subjective, and objective evaluations. Subjective evaluation involves monitoring QoL, focusing on cancer outcomes, and patients’ well-being. Semi-subjective evaluation consists of monitoring the patient’s weight and PS. Objective evaluation uses imaging equipment, such as computed tomography (CT) scans, fluoroscopy, magnetic resonance imaging (MRI), and positron emission tomography (PET) scans to monitor tumor progression.
PEMANFAATAN MEDIA DARING AUDIOVISUAL SEBAGAI SARANA EDUKASI PERAN GENETIKA MANUSIA PADA PENYAKIT INFEKSI Hamidah, Berliana; Pakpahan, Cennikon; Puteri, Rr. Astrid Aulia Artiono; Farahannisaa, Kintan Adelia; Wulandari, Laksmi; Wibawa, Tri; Prakoeswa, Cita Rosita Sigit
Jurnal Abdi Insani Vol 12 No 3 (2025): Jurnal Abdi Insani
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/abdiinsani.v12i3.2386

Abstract

Penyakit infeksi merupakan penyakit dengan insidensi tinggi di Indonesia sebagai negara tropis. Dewasa ini, berbagai penelitian tidak hanya seputar agen penyebab (bakteri, virus, parasit) ataupun faktor lingkungan saja, namun juga banyak melibatkan inang, termasuk genetika manusia. Pengabdian masyarakat ini bertujuan mengedukasi sasaran terbatas yaitu akademisi, mahasiswa, peneliti, dan klinisi di bidang kedokteran dan kesehatan di Indonesia tentang peran genetika manusia dalam penyakit infeksi. Pengabdian masyarakat dilakukan dengan membuat media daring audiovisual berupa tanya jawab bersama pakar dengan evaluasi setelah satu bulan dari pengunggahan video. Hasil pengabdian masyarakat menunjukkan bahwa penggunaan media daring audiovisual efektif dalam meningkatkan pemahaman akademisi, mahasiswa, peneliti, dan klinisi mengenai peran genetika manusia dalam penyakit infeksi. Diskusi dengan responden menghasilkan daftar pertanyaan yang relevan, yang kemudian dijawab oleh pakar melalui video edukatif. Video ini diunggah dan dibagikan kepada sasaran terbatas, memperoleh 48 penayangan serta respon positif dalam satu bulan. Evaluasi menunjukkan perlunya distribusi lebih luas untuk meningkatkan dampak edukasi. Model serupa dapat dikembangkan untuk memperluas jangkauan edukasi kedokteran berbasis daring. Pemanfaatan media daring audiovisual dalam pengabdian masyarakat bagi akademisi, mahasiswa, peneliti, dan klinisi di bidang kedokteran dan kesehatan meningkatkan pemahaman tentang peran genetika manusia pada penyakit infeksi. Untuk memperluas dampaknya, distribusi konten perlu diperluas. Model edukasi serupa dapat dikembangkan lebih lanjut untuk menjangkau masyarakat luas, seiring dengan kemajuan teknologi dan kebutuhan informasi kesehatan yang terus berkembang.
The Time to Progression in Lung Adenocarcinoma Patients Receiving First- and Second-Generation EGFR-TKI in Indonesia Syahruddin, Elisna; Soeroso, Noni Novisari; Ananda, Fannie Rizki; Wulandari, Laksmi; Setijadi, Ana Rima; Ermayanti, Sabrina; Pratiwi, Suryanti Dwi; Infianto, Andreas; Andayani, Novita; Munir, Sri Melati; Pratama, Avissena Dutha; Kusumawardani, Ida Ayu Jasminarti Dwi; Haryati, Haryati; Duyen, Natalie; Hanif, Muhammad Alfin; Lim, Darren Wan-Teck
Jurnal Respirasi Vol. 11 No. 1 (2025): January 2025
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v11-I.1.2025.22-30

Abstract

Introduction: Targeted therapy, particularly epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI), is the first-line treatment for non-small cell lung cancer (NSCLC). However, drug resistance has grown in the last few decades. This study compared the progression time of lung cancer patients treated with first- and second-generation EGFR-TKI. Methods: Based on cytology and histological results, this cross-sectional study included 1,008 participants diagnosed with lung adenocarcinoma (LUAD) from 11 Indonesian Respiratory Centers. Every three months, the response to treatment was assessed using the Response Evaluation Criteria in Solid Tumours (RECIST) criteria in 1.1. Significant differences in the clinical features of the three TKI treatment groups were identified using logistic regression analysis, the median time to disease progression was estimated using the Kaplan-Meier technique, and independent prognostic factors related to the time to progression (TTP) were assessed using Cox proportional hazards regression. Results: This study examined 505 patients, the majority of whom were females (50.9%), never smoked (59.8%), diagnosed at an advanced stage (99.2%), and had an Eastern Cooperative Oncology Group (ECOG) scale of 0-1 (83.2%). Approximately 98.1% of patients were treated with afatinib (14.8%), erlotinib (18.6%), and gefitinib (66.1%) due to common mutations. The groups did not differ significantly (p>0.05). The median overall survival (OS) rate was 9 months. The time to LUAD progression in lung cancer was significantly impacted by poor performance (p=0.001). Conclusion: Epidermal growth factor receptor-tyrosine kinase inhibitor treatment can only prolong the TTP of LUAD by up to 9 months, and the performance scale when receiving the EGFR-TKI significantly affects the prognosis.
Primary Pulmonary Myxoid Sarcoma: A Rare and Challenging Diagnosis in Thoracic Oncology Apriyanto, Yudi; Febriani, Anna; Wulandari, Laksmi; Wati, Farah Fatma
Jurnal Respirasi Vol. 11 No. 1 (2025): January 2025
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v11-I.1.2025.69-74

Abstract

Introduction: Primary pulmonary myxoid sarcoma (PPMS) is a rare malignant mesenchymal lung tumor, with fewer than 40 cases reported worldwide. This care report presented a case of PPMS with surgical difficulties. Case: A 53-year-old man presented with a six-month history of exertional dyspnea, coughing up blood, right chest pain, anorexia, and weight loss. Thoracic computed tomography (CT) imaging revealed an enhancing solid mass in the middle-posterior mediastinum. Histopathological examination of a core biopsy identified anaplastic lipoblast cells indicative of liposarcoma. Based on the multidisciplinary team (MDT) discussion, the patient was diagnosed with mediastinal liposarcoma, and tumor excision was planned. However, during the surgery, a lung tumor with adhesions to the middle and lower lobes of the right lung was discovered, precluding the complete tumor. An open biopsy was performed instead, revealing a proliferation of anaplastic cells with round to oval spindle nuclei arranged reticularly within a myxoid stroma, along with positive Alcian blue staining. Immunohistochemical analysis demonstrated focal desmin positivity in the cytoplasm of the tumor cells. The diagnosis of PPMS was confirmed based on the criteria by the World Health Organization (WHO) in 2021, including primary lung tumor, spindle-shaped and round tumor cells in a reticular pattern within a myxoid stroma, and immunohistochemical findings that exclude other histologically similar tumors. Conclusion: Although rare, PPMS should be considered in the differential diagnosis of thoracic tumors. Most PPMS patients were treated surgically and had a good prognosis. However, tumor excision could not be performed in this patient due to the adhesion of the tumor mass to the middle and lower lobes of the right lung.
Indonesian Society of Respirology Position Paper on Lung Cancer Control in Indonesia Andarini, Sita; Santoso, Andintia Aisyah; Arfiansyah, Mochammad Aris; Syahruddin, Elisna; Zaini, Jamal; Putra, Andika Chandra; Kurniawan, Ferry Dwi; Ermayanti, Sabrina; Soeroso, Noni Novisari; Munir, Sri Melati; Infianto, Andreas; Setijadi, Ana Rima; Setyawan, Ungky Agus; Wulandari, Laksmi; Haryati, Haryati; Jasminarti, Ida Ayu; Hidayat, Moulid; Santoso, Arif
Jurnal Respirologi Indonesia Vol 44 No 4 (2024)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v44i4.884

Abstract

Lung cancer is a major health concern in Indonesia due to its increasing prevalence, late-stage diagnosis, younger population, and high mortality. Addressing this issue requires nationwide implementation of comprehensive lung cancer control, which includes risk reduction and prevention strategies, focusing on tobacco control and air pollution mitigation. Screening with low-dose computed tomography (LDCT) and early detection in symptomatic patients, along with TB screening programs and all non-communicable diseases, is strongly recommended to enhance early case findings, treatment effectiveness, and overall patient outcomes. A multidisciplinary team (MDT) approach is important to ensure accurate diagnosis and comprehensive care. Moreover, the integration of palliative care at the early stages of advanced lung cancer is vital, focusing on symptom management and enhancing the quality of life for patients. While national guidelines are available for the diagnosis and treatment of lung cancer, significant disparities in healthcare access remain across Indonesia. Thus, it is essential to improve universal health coverage and referral systems to guarantee equal access to lung cancer care for patients at all levels through advocacy and ease of access.
Co-Authors Agustinus Rizki Aldise M Nastri Aldise Mareta Nastri Aldise Mareta, Aldise Ana Rima Ana Rima Setijadi Ananda, Fannie Rizki Andarini, Sita Andreas Infianto Anna Febriani Apriyanto, Yudi Arfiansyah, Mochammad Aris Arif Santoso Arif Santoso Ariobimo, Bonfilio Neltio Aris Widayati Arta Rahman Aryati Aryati Atik, Nurul Ayu Rahmanita Putri Soetrisno Cita Rosita Sigit Prakoeswa Dana Hendrawan Putra Delvac Oceandy Dewajani Purnomosari, Dewajani Dewajani Purnomosari3 Dewi, Gusti Agung Ayu Ira Kencana Djoko Poetranto, Djoko Duyen, Natalie Edith Frederika, Edith Elisna Syahruddin Emmanuel Djoko Poetranto Ermayanti, Sabrina Ermayanti, Sabrina Erwin Winaya Evelyn Asaleo Fahmita, Karin Dhia Farahannisaa, Kintan Adelia Febriani, Anna Ferry Dwi Kurniawan Gatot Soegiarto Gemilang Khusnurrokhman Gilang Muhammad Setyo Nugroho Grahana Ade Candra Wolayan Hamidah, Berliana Hanif, Muhammad Alfin Hariputri, Wulan Rahmawati Haryati Haryati Haryati Haryati Hendra Ikhwan Gautama Hidayat, Moulid Husniyah, Barizatul Ida Ayu Jasminarti Ida Ayu Jasminarti Dwi Kusumawardani Indana Eva Ajmala Infianto, Andreas Jasminarti, Ida Ayu Juwita, Putri Mega Kazufumi Shimizu Khansa Fahira Wisdana Kinanthi, Monica Tiara Arum Kurniawan, Ferry Dwi Kusdiantoro Kusdiantoro Kusdiantoro Kusdiantoro Landia Setiawati Lim, Darren Wan-Teck Linda Dewanti Lucia Landia Setyowati, Lucia Landia Luh Ade Wilan Krisna Lukisiari Agustini Lusida, Michael AP. Mahdi, Bagus Aulia Maqnun, Lu'lu'il Masaoki Yamaoka Masaoki Yamaoka, Masaoki Muhammad Amin Muhammad Dany Ramadhan Muhammad Fitra Ramadhan Nadira Putri Nastiti Nathaniel Aditya Neni Daniati Nikson Eduard Faot Nina Mauthia Noni Novisari Soeroso Novananda, Donny Ardika Novita Andayani, Novita Pakpahan, Cennikon Paladan, Triadi Putra Pradhevi, Lukita Pratama, Avissena Dutha Pratiwi, Suryanti Dwi Pudji Lestari Puteri, Rr. Astrid Aulia Artiono Putra, Andika Chandra Rebekah Setiabudi, Rebekah Resti Yudhawati Retno A Setyoningrum Retno Asih Retno Asih Setyoningrum Risnawati Risnawati Riyanto, Shandy Billy Saefudin, Rendra P. Sahrun Sahrun Santoso, Andintia Aisyah Setyawan, Ungky Agus Sita Andarini Sita Ro'yul Aini Sjahjenny Mustokoweni, Sjahjenny soedarto soedarto, soedarto Sri Melati Munir Sri Melati Munir Subagyo, Zaufy Verlieza Oktaviano Sulistiawati Sulistiawati Surya, Prima Ardiansah Susilowati Andajani, Susilowati Suwandi Syamsuri, Ibrahim Thendeyas, Richar Tomy Thirafi, Sacharissa Zerlina Tsarwah Tri Wibawa Utami Meilanie Putri Veda Septian Cahya Budi Vincent, Agustinus Wati, Farah Fatma Wibi Riawan Wiriansya, Edward Pandu Wiwin Is Effendi Yashinta, Yolanda Ayu Zahira Pelangi Rahmadilla Satriadi Zaini, Jamal Zaphiria Loka Pramesthi