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All Journal INDONESIAN JOURNAL OF PHARMACY UNEJ e-Proceeding JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Science and Technology Indonesia Panrita Abdi - Jurnal Pengabdian pada Masyarakat Health Notions Abdimas Talenta : Jurnal Pengabdian Kepada Masyarakat Indonesian Journal of Chemistry JSFK (Jurnal Sains Farmasi & Klinis) PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Abdimas: Jurnal Pengabdian Masyarakat Universitas Merdeka Malang Jurnal Layanan Masyarakat (Journal of Public Service) Archives Pharmacia Pharmaceutical Sciences and Research (PSR) Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Sains dan Kesehatan Folia Medica Indonesiana
Noorma Rosita
Departemen Ilmu Kefarmasian, Fakultas Farmasi, Universitas Airlangga, Surabaya
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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Journal : Health Notions

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Preparation and Characteristics of NLC Coenzym Q10 with A Combination of Hyaluronic Acid Nurhidayah Sarifuddin; Widji Soerarti; Noorma Rosita
Health Notions Vol 3, No 1 (2019): January
Publisher : Humanistic Network for Science and Technology (HNST)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (234.118 KB) | DOI: 10.33846/hn.v3i1.250

Abstract

Coenzyme Q10, often also known as ubiquinone, coenzyme Q10 or Q10, is soluble in lipids and is naturally present in plants, animals and in mitochondria. Coenzyme Q10 functions as an antioxidant that can protect the body from damage caused by free radicals. Hyaluronic acid is known as a hydrophilic polymer derived from polysaccharides which has the ability to increase percutaneous penetration by changing the composition of tightly arranged stratum corneum cells to increase the permeability of the skin. Nanostructured Lipid Carrier is a modification of the SLN system, consisting of a mixture of solid and liquid lipids (oil), stabilized by aqueous surfactant solution, is one method to increase drug penetration through the stratum corneum because it has several advantages. The purpose of this study was to see the effect of adding hyaluronic acid to the characteristics of the Nanostructure Lipid Carrier (NLC) as anti aging. Examination of characteristics including organoletis, pH, particle size and polidispersity index was carried out. The results of organoleptic NLC coenzym Q10-HA examination obtained dark orange color, liquid consistency, lipid efficacy odor and soft texture. The pH measurement results of the preparation ranged from 5.05-5.23. The results of the particle size examination ranged from 267-128 nm and the particle size distribution ranged between 0.308-0.200 Keywords: Coenzym Q10, Hyaluronic acid , NLC
Co-Authors Abhimata Paramanandana Afandi, Ryan Agustin Agustin Agustin Agustin Alya Nur Amilia Amilia, Alya Nur Andang Miatmoko Ardhani Dwi Lestari1 Athiyyah, Wafa'ul Bambang Tri Purwanto Cahyono, Definta Anisa Tamara Dewi Isadiartuti Dewi Melani Hariyadi Dicky Pratama Dini Retnowati Dini Retnowati Djoko Agus Purwanto Dwi Setiawan Dwi Setyawan Dyah Rahmasari Esti Hendradi Etik Wahyuningsih Farida Ifadotunnikmah Febrianti, Winanda Rizki Firdausiah Fania Dwi Putri Putri Fransisca Dita Mayangsari Frida Magdalena Hadi Poerwono Hamdan, Siti Hartini Hanafi Tanojo Herra Studiawan Hidayah, Rohmawati I Gusti Ayu Adhi Aryapatni I NYOMAN WIJAYA Juni Ekowati Kholis Amalia Nofianti Mahardian Rahmadi Marcellino Rudyanto Maria Lucia Ardhani Dwi Lestari Melanny Ika Sulistyowaty Mochammad Yuwono Mohammad Agus Sjamsur Rijal Muhammad Agus Syamsur Rijal Muhammad Faris Adrianto, Muhammad Faris Nugroho, Nadia Paramitha Nurhidayah Sarifuddin Paramita, Diajeng Putri Pradita Fiqlyanur Isna Primadana Prayoga, Adistiar Purwitasari, Neny Qurrotu A'yunin Rahmadhanniar, Erwinda Rahman, Fakhrinnisa Wildani Retno Sari Retno Widyowati Rianti, Dian Ratna Rohmawati Hidayah Rufaidah Azzahrah Sairiyah, Siti Nasikatus Sarifuddin, Nurhidayah Sayyidati Aqilah Setiawan, Albertus Aditya Siti Hartini Hamdan Soerarti, Widji Sugiyartono1 Suko Hardjono SUZANA, SUZANA Tekla Kalalo Tiara Jeni Rosadi Tristiana Erawati Tristiana Erawati Tutiek Purwanti Tutiek Purwati Ulvan, Angkasa Megistra Virnanda Syafira Hartatiningrum Widji Soerarti Widji Soeratri Wiwik Handayani Yusuf, Helmy Yusuf, Helmy Zhihrotulwida, Dzakiya