Article Per Year (5 Year)
p-Index From 2020 - 2025
2.715
P-Index
This Author published in this journals
All Journal Folia Medica Indonesiana INDONESIAN JOURNAL OF PHARMACY UNEJ e-Proceeding JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Science and Technology Indonesia Panrita Abdi - Jurnal Pengabdian pada Masyarakat Health Notions Abdimas Talenta : Jurnal Pengabdian Kepada Masyarakat Indonesian Journal of Chemistry JSFK (Jurnal Sains Farmasi & Klinis) PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Abdimas: Jurnal Pengabdian Masyarakat Universitas Merdeka Malang Jurnal Layanan Masyarakat (Journal of Public Service) Archives Pharmacia Pharmaceutical Sciences and Research (PSR) Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Sains dan Kesehatan
Noorma Rosita
Departemen Ilmu Kefarmasian, Fakultas Farmasi, Universitas Airlangga, Surabaya
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

Published : 26 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search
Journal : INDONESIAN JOURNAL OF PHARMACY

 1 
Effect of Lipid Ratio of Stearic Acid and Oleic Acid on Characteristics of Nanostructure Lipid Carrier (NLC) System of Diethylammonium Diclofenac Hendradi, Esti; Rosita, Noorma; Rahmadhanniar, Erwinda
Indonesian Journal of Pharmacy Vol 28 No 4, 2017
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1059.064 KB) | DOI: 10.14499/indonesianjpharm28iss4pp198

Abstract

The aim of this study was to determine the effect of lipid ratio of stearic acid and oleic acid on the physical characteristics as well as the entrapment efficiency of diethylammonium diclofenac with Nanostructure Lipid Carrier (NLC) system. Diethylammonium diclofenac (DETA) is Non-Steroid Anti-Inflamatory Drugs (NSAIDs) that has been widely used in the treatment of osteoarthritis and rheumatoid arthritis. In the formulation of NLC-DETA, three different lipid ratios were used, which the ratio of  stearic acid:oleic acid were 60:40, 70:30, and 80:20, respectively. In this NLC system, DETA served as the active drug, stearic acid as solid lipid, oleic acid as liquid lipid, and Tween 80 as surfactant components. NLC were characterized for organoleptic characteristics, pH, viscosity, particle morphology, particle size and polydispersity index (PI), profiles of Fourier Transform Infra-Red (FTIR) and Differential Thermal Analysis (DTA), and drug entrapment efficiency. The particle shape and morphology were determined by Transmission Electron Microscopy (TEM). The results  showed that the different ratios of oleic acid lipids and stearic acid had no significant effects on the viscosity and entrapment efficiency of NLC-DETA. On the other hand, it affected the pH of all formulas, which were significantly different. Increasing the amount of liquid lipid in the formulations reduced the size of NLC-DETA particles. 
Co-Authors Abhimata Paramanandana Agustin Agustin Agustin Agustin Albertus Aditya Setiawan Alya Nur Amilia Andang Miatmoko Angkasa Megistra Ulvan Ardhani Dwi Lestari1 Athiyyah, Wafa'ul Bambang Tri Purwanto Cahyono, Definta Anisa Tamara Dewi Isadiartuti Dewi Isadiartuti Dewi Melani Hariyadi Dian Ratna Rianti Dicky Pratama Dini Retnowati Djoko Agus Purwanto Dwi Setiawan Dwi Setyawan Dyah Rahmasari Esti Hendradi Etik Wahyuningsih Farida Ifadotunnikmah Firdausiah Fania Dwi Putri Putri Fransisca Dita Mayangsari Frida Magdalena Hadi Poerwono Hamdan, Siti Hartini Hanafi Tanojo Herra Studiawan I Gusti Ayu Adhi Aryapatni I Nyoman Wijaya Juni Ekowati Kholis Amalia Nofianti Mahardian Rahmadi Marcellino Rudyanto Maria Lucia Ardhani Dwi Lestari Melanny Ika Sulistyowaty Mochammad Yuwono Mohammad Agus Sjamsur Rijal Muhammad Agus Syamsur Rijal Muhammad Faris Adrianto Nurhidayah Sarifuddin Paramita, Diajeng Putri Pradita Fiqlyanur Isna Primadana Prayoga, Adistiar Purwitasari, Neny Qurrotu A'yunin Rahmadhanniar, Erwinda Rahman, Fakhrinnisa Wildani Retno Sari Retno Widyowati Rohmawati Hidayah Rufaidah Azzahrah Ryan Afandi Sairiyah, Siti Nasikatus Sarifuddin, Nurhidayah Sayyidati Aqilah Siti Hartini Hamdan Soerarti, Widji Sugiyartono1 Suko Hardjono Suzana Tekla Kalalo Tiara Jeni Rosadi Tristiana Erawati Tristiana Erawati Tutiek Purwanti Tutiek Purwati Virnanda Syafira Hartatiningrum Widji Soerarti Widji Soeratri Widji Soeratri Winanda Rizki Febrianti Wiwik Handayani Yusuf, Helmy Zhihrotulwida, Dzakiya