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All Journal Folia Medica Indonesiana INDONESIAN JOURNAL OF PHARMACY UNEJ e-Proceeding JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Science and Technology Indonesia Panrita Abdi - Jurnal Pengabdian pada Masyarakat Health Notions Abdimas Talenta : Jurnal Pengabdian Kepada Masyarakat Indonesian Journal of Chemistry JSFK (Jurnal Sains Farmasi & Klinis) PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Abdimas: Jurnal Pengabdian Masyarakat Universitas Merdeka Malang Jurnal Layanan Masyarakat (Journal of Public Service) Archives Pharmacia Pharmaceutical Sciences and Research (PSR) Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Sains dan Kesehatan
Noorma Rosita
Departemen Ilmu Kefarmasian, Fakultas Farmasi, Universitas Airlangga, Surabaya
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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Journal : UNEJ e-Proceeding

 1 
EFFECT OF SOLID LIPID NANOPARTICLE (SLN) AND NANO STRUCTURE LIPID CARRIER (NLC) SYSTEM ON ANTIOXIDANT STABILITY OF TOMATO EXTRACT (LIPID: CETYL ALCOHOL AND ISOPROPYL MYRISTATE) Sayyidati Aqilah; Esti Hendradi; Noorma Rosita
UNEJ e-Proceeding Proceeding of 1st International Conference on Medicine and Health Sciences (ICMHS)
Publisher : UPT Penerbitan Universitas Jember

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Abstract

Tomato extract was known contains manyantioxidants (Chauhan et al., 2010), such aslycopene, that are easily degraded by UV-B rays. Themechanism lycopene as an antiaging is to reduceskin regeneration and increase the thickness of theepidermis (Sahasrabuddhe, 2011). As anantioxidant, lycopene easily degraded when exposedto light, heat, and oxygen (Chauhan et al., 2011).Drug delivery system based on nanolipid carriersystem, such as: Solid Lipid Nanoparticles (SLN) wasappropriate to stabilize lycopene, as lipophilicsubstance (Wissing and Muller, 2003; Helgason etal., 2009; and Okonogi dan Riangjanapatee, 2014).One of the limitations of SLN is the drug moleculethat has been trapped expulsed easily duringstorage. It is caused of the orderdness of lattice lipidcrystal. Replacement part of solid lipid using liquidlipid (called as nanostructure lipid carriers or NLC)can reduce the orderdness of lattice lipid crystall andit will repaired it (Kaur et al, 2015).In this research have been tried to be compared theability of SLN and NLC to improve the stability ofantioxidant tomato extract. Using 20% total amountof lipid, extract tomato-SLN made from cetyl alcoholas solid lipid and extract tomato-NLC made fromdifference ratio between cetyl alcohol and isopropylmyristate (IPM) such as: 9:1 and 7:3. Tween 80 andKollipor were used as surfactant and co-surfactant.IPM was choose because of its enhancer andemollient effect so easily to apply to the skin(Vadgama et al, 2015).
Co-Authors Abhimata Paramanandana Afandi, Ryan Agustin Agustin Agustin Agustin Alya Nur Amilia Amilia, Alya Nur Andang Miatmoko Ardhani Dwi Lestari1 Athiyyah, Wafa'ul Bambang Tri Purwanto Cahyono, Definta Anisa Tamara Dewi Isadiartuti Dewi Melani Hariyadi Dicky Pratama Dini Retnowati Dini Retnowati Djoko Agus Purwanto Dwi Setiawan Dwi Setyawan Dyah Rahmasari Esti Hendradi Etik Wahyuningsih Farida Ifadotunnikmah Febrianti, Winanda Rizki Firdausiah Fania Dwi Putri Putri Fransisca Dita Mayangsari Frida Magdalena Hadi Poerwono Hamdan, Siti Hartini Hanafi Tanojo Herra Studiawan I Gusti Ayu Adhi Aryapatni I Nyoman Wijaya Juni Ekowati Kholis Amalia Nofianti Mahardian Rahmadi Marcellino Rudyanto Maria Lucia Ardhani Dwi Lestari Melanny Ika Sulistyowaty Mochammad Yuwono Mohammad Agus Sjamsur Rijal Muhammad Agus Syamsur Rijal Muhammad Faris Adrianto, Muhammad Faris Nurhidayah Sarifuddin Paramita, Diajeng Putri Pradita Fiqlyanur Isna Primadana Prayoga, Adistiar Purwitasari, Neny Qurrotu A'yunin Rahmadhanniar, Erwinda Rahman, Fakhrinnisa Wildani Retno Sari Retno Widyowati Rianti, Dian Ratna Rohmawati Hidayah Rufaidah Azzahrah Sairiyah, Siti Nasikatus Sarifuddin, Nurhidayah Sayyidati Aqilah Setiawan, Albertus Aditya Siti Hartini Hamdan Soerarti, Widji Sugiyartono1 Suko Hardjono SUZANA, SUZANA Tekla Kalalo Tiara Jeni Rosadi Tristiana Erawati Tristiana Erawati Tutiek Purwanti Tutiek Purwati Ulvan, Angkasa Megistra Virnanda Syafira Hartatiningrum Widji Soerarti Widji Soeratri Widji Soeratri Wiwik Handayani Yusuf, Helmy Yusuf, Helmy Zhihrotulwida, Dzakiya