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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Medical Journal of Indonesia Majalah Obstetri dan Ginekologi Majalah Kesehatan FKUB Medical Laboratory Technology Journal Health Notions Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) Indonesian Journal of Medicine JKM (Jurnal Kebidanan Malahayati) MMJ (Mahakam Midwifery Journal) Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia JOURNAL LA MEDIHEALTICO Devotion: Journal of Research and Community Service Asian Journal of Health Research
Tatit Nurseta
Department Of Obstetric And Gynecology, Faculty Of Medicine, Universitas Brawijaya, Malang
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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The Relationship Between Physical Activity 7 Days Before Delivery And The Duration Of Active Phase Of First Stage Labor In Primipara Mothers Jundyah, Nazhifa Zalfa; Indahwati, Lilik; Rahayu, Indriati Dwi; Nurseta, Tatit
JKM (Jurnal Kebidanan Malahayati) Vol 11, No 4 (2025): Volume 11 No 4, April 2025
Publisher : Program Studi Kebidanan Fakultas Ilmu Kesehatan Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jkm.v11i4.19867

Abstract

Latar belakang: Persalinan yang berlangsung terlalu lama dapat meningkatkan risiko komplikasi bagi ibu dan janin, namun risiko tersebut dapat diminimalkan melalui aktivitas fisik yang dapat mempengaruhi kemampuan aerobik dan kardiorespirasi tubuh, yang mengakibatkan peningkatan maksimal asupan oksigen maksimum yang selanjutnya dapat meningkatkan pasokan energi. Pasokan energi ini penting untuk mendukung kontraksi otot miometrium selama persalinan, terutama pada tahap awal. Tujuan: Penelitian ini bertujuan untuk mengetahui hubungan aktivitas fisik dengan durasi persalinan kala I fase aktif pada ibu primipara. Metode: Penelitian menggunakan jenis penelitian observasional dengan pendekatan cross-sectional pada 30 ibu primipara di fasilitas kesehatan Malang. Hasil: Pengambilan data dilakukan dengan pengisian kuesioner PPAQ (Pregnancy Physical Activity Questionnaire) dan dianalisis menggunakan uji rank spearman. Hasil uji analisis diperoleh p = 0,049 (p < 0,05) yang berarti ada hubungan aktivitas fisik 7 hari sebelum persalinan terhadap durasi persalinan kala I fase aktif pada ibu primipara di Fasilitas Kesehatan Malang. Kesimpulan: Kesimpulan yang didapat yaitu semakin tinggi kategori aktivitas fisik 7 hari sebelum persalinan, maka durasi kecepatan persalinan kala I fase aktif semakin meningkat. Kata kunci: Aktifitas fisik, durasi persalinan kala I fase aktif, primipara. ABSTRACT Background: Prolonged labor can increase the risk of complications for the mother and fetus, but these risks can be minimized through physical activity that can affect the body's aerobic and cardiorespiratory capabilities, resulting in an increase in maximum maximum oxygen intake which can further increase energy supply. This energy supply is important to support myometrial muscle contractions during labor, especially in the early stages. Objective: This study aims to determine the relationship between physical activity and the duration of labor in active phase I in primiparous mothers. Methods: The study used observational research with a cross-sectional approach on 30 primiparous mothers in Malang health facilities. Results: Data were collected by filling out the PPAQ (Pregnancy Physical Activity Questionnaire) questionnaire and analyzed using the spearman rank test. The results of the analysis test obtained p = 0.049 (p < 0.05) which means that there is a relationship between physical activity 7 days before delivery on the duration of labor in active phase I in primiparous mothers in Malang Health Facility. Conclusion: The conclusion obtained is that the higher the category of physical activity 7 days before labor, the duration of the active phase I labor speed increases. Keywords: Physical activity, duration of active phase I labor, primipara.  
Vitamin D and its Role in Cell Cycle Dynamics: A Review of the Molecular and Clinical Studies Sastradinata, Irawan; Murti, Krisna; Saleh, Irsan; Nurseta, Tatit
Journal La Medihealtico Vol. 6 No. 3 (2025): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v6i3.2096

Abstract

Vitamin D is an essential nutrient that not only plays a role in calcium homeostasis and bone health, but also has broad functions in the regulation of various biological processes, including cell cycle dynamics. This study aims to examine in depth the role of vitamin D in cell cycle dynamics based on evidence from molecular and clinical studies. The method used was qualitative research with a literature study approach, where data was collected from relevant articles such as PubMed, EuropePMC, and Google Scholar. Analysis was carried out through the process of filtering, presenting data, and drawing conclusions. The results showed that vitamin D in its active form, 1,25-dihydroxyvitamin D3, interacts with the vitamin D receptor (VDR) in cells and modulates the expression of genes involved in cell proliferation. This mechanism involves an increase in the expression of cell cycle inhibitory genes, such as p21 and p27, and a decrease in the expression of cell cycle promoting genes, such as cyclin D1, which contributes to the arrest effect on the cell cycle. Thus, in addition to being important for bone health, vitamin D has a significant role in cell cycle regulation, and its deficiency can increase the risk of various diseases, including cancer. Therefore, maintaining optimal vitamin D levels through sun exposure, consumption of foods rich in vitamin D, or supplementation is essential. Further research is needed to understand the role of vitamin D in genetic regulation, particularly in relation to cancer.
Correlation of Leucine Intake with Serum Prolactin and Breast Milk Protein Levels in Breastfeeding Women Lestari, Ni Putu Yunita Sri; Wardani, Widya Kusuma; Ratnawati, Linda; Nurseta, Tatit; Rahardjo, Bambang
Devotion : Journal of Research and Community Service Vol. 3 No. 10 (2022): Devotion: Journal of Research and Community Service
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36418/dev.v3i10.199

Abstract

Breast milk is the best choice food for a baby’s growth and development of infants at some point of the primary 6 months of life. Fulfillment of nutrition during breastfeeding is an important requirement, one of which is the intake of the amino acid leucine which is said to affect prolactin as a regulator of breast milk production and protein synthesis in breast milk. This can support the quality and quantity of breast milk to meet the nutritional needs of infants support infant growth and development and reduce the incidence of stunting at the age of toddlers. This research aims to determine the relationship between leucine intake and levels of prolactin and protein in breast milk in breastfeeding mothers. This research is an analytic observational study with a cross-sectional method. This study carried out normality using the Kolmogorov-Smirnov test and using the Pearson correlation test to determine the relationship between variables. Based on the test results of the relationship between leucine intake and serum prolactin levels, a significance value of 0.005 (p<0.05) was obtained with a correlation coefficient value of 0.183 and the relationship between leucine intake and breast milk protein levels obtained a significance value of 0.033 (p<0.05) with a correlation coefficient of 0.147. The results of this test showed a significant relationship between these variables. There is a weak correlation between leucine intake and levels of prolactin and protein in breast milk
Effect of Bengkoang (Pachyrhizus erosus) Extract on Estrogen Receptor-?, Progesterone Receptor Expression, and Follicle-Stimulating Hormone Levels Suryanti; Putri Ardela, Mayasari; Frenty Hadiningsih, Eka; Winarsih, Sri; Noorhamdani; Nurseta, Tatit; Norahmawati, Eviana
Indonesian Journal of Obstetrics and Gynecology Volume 13. No. 3 July 2025
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v13i3.2180

Abstract

Abstract Objective: Progesterone functions by inhibiting the release of Gonadotropin-Releasing Hormone (GnRH), which decreases Follicle-Stimulating Hormone (FSH) levels and converts them into hypoestrogens. This condition affects the expression of steroid, estrogen, and progesterone receptors, contributing to endometrial proliferation and secretion during the menstrual cycle. Methods: This study aims to demonstrate that Bengkoang extract administration increases the expression of Estrogen Receptor (ER), Progesterone Receptor (PR), and Follicle-Stimulating Hormone (FSH) in Wistar model rats. This study divided 25 female Wistar rats into five groups: one control group without progesterone and Bengkoang extract and four treatment groups injected with progesterone. After exposure, Bengkoang extract was administered to three treatment groups at doses of 70 mg/200 g BW/day (treatment 1), 140 mg/200 g BW/day (treatment 2), and 280 mg/200 g BW/day (treatment 3). Results: The results showed an increase in the expression of Estrogen Receptor- ? (Er?), Progesterone Receptor (PR), and Follicle-Stimulating Hormone (FSH) levels in treatment 1, treatment 2, and treatment 3 groups compared to the KP with p <0.05 Conclusion: The study investigating the effect of Bengkoang (Pachyrhizus erosus) extract on estrogen receptor-? (ER?), progesterone receptor (PR) expression, and follicle-stimulating hormone (FSH) levels has demonstrated significant findings. Keywords: Estrogen, Estrogen receptor-?, Follicle-stimulating hormone, Pachyrhizus erosus, Progesterone, Progesterone receptor
Co-Authors A.A. Ketut Agung Cahyawan W AA Sudharmawan, AA Adys Werestandina, Adys Agustina Tri Endharti Ambar Dwi Retnoningrum Anandasari , Noni Fidya Ayu Anandasari, Noni Fidya Ayu Angelica, Aina Anisak, Siti Asih, Sari Wulan Bambang Rahardjo Cholid Rohman Riskianto Diana Lyrawati Dwi Yuni Nur Hidayati Elisa Danik Kurniawati Endah Wijayanti Eviana Norahmawati Fajar Ari Nugroho Frenty Hadiningsih, Eka Hidayat Sujuti Indahwati, Lilik Indriati Dwi Rahayu jundyah, nazhifa zalfa Juniartha, Putu Karyono Mintaroem Kaspirayanthi, Ni Ketut Devy Kenty Wantri Anita, Kenty Wantri Kridayanti, Novalia Krisna Murti Kusworini Handono Leksono, Setio Lestari, Ni Putu Yunita Sri Mudinillah, Adam Muhammad Irsan Saleh Muhammad Rasjad Indra Muhammad Rivai Mukhamad Nooryanto Natalina, Riny Ni Putu Sri Haryati Noorhamdani Novida Ariani Permata, Dear Ayu Prawiro, Sumarno Reto Putri Ardela, Mayasari Rahajeng Rahajeng Rahmi Utami Ratnawati, Linda Ratnawati, Putu A.R. Sastradinata, Irawan Selvi Marcellia Sitompul, Barlian Sri Winarsih Subandi Subandi SURYANTI Syah Sembung Wasiso Tanti Tri Lestary Tri Yudani MR Wardani, Widya Kusuma Widowati, Ayu Rizky Wijasa, Arsana Wisnu, Gusti Ayu Made Pratishita Wiyasa, I W.A. Wiyasa, I Wayan Arsana Yahya Irwanto Yudhanto, Hendy Setyo Yudistira Yunus