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All Journal Sari Pediatri Paediatrica Indonesiana Eksakta : Berkala Ilmiah Bidang MIPA Majalah Patologi Indonesia Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia The New Ropanasuri Journal of Surgery Archives of Pediatric Gastroenterology, Hepatology, and Nutrition Indonesian Journal of Biomedicine and Clinical Sciences
Hanifah Oswari
Departemen Ilmu Kesehatan Anak FKUI/RSCM
Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Neuroscience Public Health

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The Effect of Probiotic Supplementation in Cholestasis Liver Disease: A Systematic Review of Animal Studies Azizah, Nur; Oswari, Hanifah; Sjatha, Fithriyah
EKSAKTA: Berkala Ilmiah Bidang MIPA Vol. 25 No. 03 (2024): Eksakta : Berkala Ilmiah Bidang MIPA (E-ISSN : 2549-7464)
Publisher : Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Negeri Padang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/eksakta/vol25-iss03/533

Abstract

Gut microbiome is essential in maintaining metabolism, gut barrier homeostasis, inflammation, and hematopoiesis. Several factors affect gut microbiome composition, including genetics, lifestyle, external factors, and disease. Cholestasis liver disease promotes gut dysbiosis via abnormal bile production or flow to the intestine and disrupts the gut microbiome. This condition leads to intestinal leakage, which enables bacterial and endotoxin translocation to the liver through the portal vein. Bacterial translocation promotes inflammatory responses, which worsen liver damage in cholestasis. Moreover, probiotic supplementation in other diseases has been shown to preserve gut microbiome composition. While such studies have documented probiotics' beneficial effects, no adequate clinical trials support probiotics' potency as a cholestasis treatment. Hence, this systematic review aims to provide an in-depth analysis of probiotic supplementation as a therapy for cholestasis liver disease in animal models. The search strategies were conducted based on PRISMA methodologies based on various academic literature. The selected studies have shown improvements in bile acid metabolism, microbiota-gut-liver axis, gut epithelium integrity, liver damage and inflammation response, and liver fibrosis progression, which need to be confirmed in human clinical trials.
Jadwal Imunisasi Anak Usia 0-18 Tahun Rekomendasi Ikatan Dokter Anak Indonesia Tahun 2024 Kaswandani, Nastiti; Gunardi, Hartono; Prayitno, Ari; Kartasasmita, Cissy B.; Prasetyo, Dwi; Husada, Dominicus; Sarosa, Gatot Irawan; Oswari, Hanifah; Ismoedijanto, Ismoedijanto; Rusmil, Kusnandi; Maddepunggeng, Martira; Sitaresmi, Mei Neni; Raihan, Raihan; Handryastuti, Setyo; Soedjatmiko, Soedjatmiko; Hadinegoro, Sri Rezeki S.; Munasir, Zakiudin
Sari Pediatri Vol 26, No 5 (2025)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/sp26.5.2025.328-36

Abstract

Satuan Tugas Imunisasi Ikatan Dokter Anak Indonesia secara periodik melakukan kaji ulang jadwal imunisasi dengan menyelaraskan dengan buku pedoman imunisasi di Indonesia edisi ke 7 tahun 2024, dan sumber-sumber lainnya. Jadwal imunisasi selalu dievaluasi ulang karena beredarnya vaksin baru yang telah disetujui oleh BPOM dan vaksin yang tidak tersedia lagi di Indonesia. Terdapat beberapa perubahan dalam jadwal imunisasi rekomendasi IDAI tahun 2024 yaitu ketersediaan jenis vaksin, seperti pada pneumococcal conjugate vaccine (PCV), vaksin rotavirus, vaksin varisela, vaksin dengue, dan vaksin human papillomavirus (HPV). Agar dalam pelaksanaan lebih mudah, disertakan juga tabel jadwal imunisasi tahun 2024 di akhir.
Efektivitas Pemberian Makan Dini pada Anak dengan Pankreatitis Akut Oswari, Hanifah; Rachmajati, Arinurtia
Sari Pediatri Vol 26, No 2 (2024)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/sp26.2.2024.116-24

Abstract

Latar belakang. Pankreatitis akut pada anak dapat menyebabkan morbiditas hingga mortalitas yang signifikan. Tata laksana saat ini meliputi terapi simtomatis, pasien dipuasakan, dan pemberian nutrisi parenteral. Pada dewasa, pemberian makan dini dapat menurunkan komplikasi, durasi perawatan dan mortalitas. Belum ada cukup data mengenai keefektivan pemberian makan dini pada anak.Tujuan. Mengetahui efektivitas pemberian makan dini pada anak dengan pankreatitis akut terhadap perbaikan klinis dan durasi rawat. Metode. Penelusuran pustaka database elektronik, yaitu Pubmed, Cochrane, ScienceDirect, Scopus dan Embase dengan kata kunci “child*”, ‘OR” “pediatric* “OR” paediatric” “AND” “acute pancreatitis”, “AND” “early feeding”, “OR” “early nutrition. Hasil. Penelusuran literatur diperoleh 4 artikel yang terpilih kemudian dilakukan telaah kritis. Studi oleh Ledder, dkk, dengan level of evidence 1b, diperoleh tidak terdapat perbedaan lama rawat anak yang diberi makan tanpa restriksi lemak dalam 24 jam pertama perawatan dibandingkan dengan yang dipuasakan dengan median 2,6 (IK95%: 2,5-3,1, p=0,56). Hal ini serupa dengan penelitian oleh Abu El-Hajja, dkk. Namun, studi oleh Szabo dkk dan Rivera dkk menunjukkan lama rawat yang lebih singkat pada anak yang diberi makan dalam 48 jam dan 72 jam pertama perawatan.Kesimpulan. Pemberian makan dini dalam 24 jam pertama perawatan masih mungkin mempersingkat lama rawat.
Perbedaan Profil Histomorfologik Jaringan Hati Resipien dan Donor Pascatransplantasi Hati Anak antara Kelompok Pasien Rejeksi dan Tidak Rejeksi di Departemen Patologi Anatomik FKUI/RSCM Periode 2010-2019 Perkasa, Alif Gilang; Stephanie, Marini; Rahadiani, Nur; Handjari, Diah Rini; Krisnuhoni, Ening; Oswari, Hanifah
Majalah Patologi Indonesia Vol. 31 No. 1, Januari 2022
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v31i1.487

Abstract

BackgroundLiver rejection is an immune system response of recipient in which attacking the antigen originating from a donor that can causedamage to the transplanted organ. Although the prevalence of liver rejection has decreased due to the use of immunosuppressivedrugs, it is estimated that 20-40% of recipients still experience rejection and are at risk of re-transplantation and even death. Thisstudy aims to investigating histomorphological characteristics that can play a role as risk factors for rejection by assessing thedifferences in histomorphological characteristics before transplantation between recipient groups with rejection and non-rejection inpediatric liver transplant recipients in the Department of Anatomical Pathology, Faculty of Medicine, University of Indonesia, Dr.Cipto Mangunkusumo (PA-FKUI/RSCM)MethodsThis study was an analytical study with a cross sectional design, using secondary data from the archives of the Department ofAnatomical Pathology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo 2010-2019. The clinical andhistopathologic data obtained were analyzed using comparative statistical tests.ResultsRejection were found in 25% of recipients. Rejection were more common in the group of recipients aged >1 (75%), male (58%),cirrhosis 4C (92%) and mild portal inflammation (56%). Rejection were more common in the group of donor with male (66%) andsteatosis ≤10% (92%). There were no significant differences in the histomorphological profiles of recipients and donors with orwithout rejection.ConclusionThe histomorphologic profiles of both recipients and donors were known to be descriptively associated with complications of posttransplant liver rejection. However, in terms of analysis, there was not any significant differences
Tandem therapeutic plasma exchange and continuous kidney replacement therapy in a pediatric post-liver transplant patient: a case report Fahlevi, Reza; Puspitasari, Henny Adriani; Hidayati, Eka Laksmi; Pardede, Sudung Oloan; Trihono, Partini Pudjiastuti; Puspaningtyas, Niken Wahyu; Oswari, Hanifah; Sanstiono, Sastiono
Paediatrica Indonesiana Vol. 65 No. 6 (2025): November 2025
Publisher : Indonesian Pediatric Society

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Abstract

In critical condition, sometimes continuous kidney replacement therapy (CKRT) treatment should not be held while therapeutic plasma exchange (TPE) is needed. Simultaneous use of both modalities is defined as tandem therapy, available as an option.  
Therapeutic reassessment of first-line antiepileptic drugs in pediatric patients unresponsive to second-line agents: a randomized trial in Jakarta Perdani, Roro Rukmi Windi; Arozal, Wawaimuli; Mangunatmadja, Irawan; Kaswandani, Nastiti; Handryastuti, Setyo; Medise, Bernie Endyarni; Wardani, Amanda Saphira; Thandavarayan, Rajarajan Amirthalingam; Oswari, Hanifah; Lee, Hee Jae
Paediatrica Indonesiana Vol. 65 No. 6 (2025): November 2025
Publisher : Indonesian Pediatric Society

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Abstract

Background Epilepsy has a significant incidence in children, with 20-25% resistance to standard antiepileptic drugs (AEDs). Drug-resistant epilepsy (DRE) refers as the failure of two or more AEDs, either as monotherapies or in combination, to achieve seizure freedom, which includes the absence of all seizure types, even auras. Treatment algorithms for children with epilepsy range from starting with the lowest effective dose to using add-on or substitution therapy of AEDs. It usually started from using first-line AEDs (valproic acid, phenytoin, phenobarbital, carbamazepine) with titrated dose based on the patient condition, if seizure persist, another first-line AEDs may be added or substituted. Second-line AEDs (topiramate, levetiracetam, oxcarbazepine) are introduced when seizure persist despite optimal doses of first-line drugs with good compliance. Epilepsy treatment response is a dynamic process, not a fixed state. In some cases, repeating the medication cycle remains an option, as patient may initially appear drug-resistant but later respond to treatment. Thus, first-line AEDs may also serve as substitution therapy in children unresponsive to second-line agents as studies show comparable effectiveness between the two regimens. Objective To evaluate the efficacy and safety of first-line AEDs as substitution therapy (intentional replacement of patient’s current medication) in children resistant to second-line AEDs. Methods This 12-week, open-label, multicenter, randomized controlled trial was conducted in 91 epileptic children. Children aged 1 – 18 years with DRE, were randomized into the intervention (patients who received substitution therapy:  one AEDs was changed to first-line of AEDs) and control (patients who got standard therapy: one AEDs was changed to second-line of AEDs) groups. The primary outcome was the difference in the proportion of responders between the two groups. Secondary outcomes were analyzing the different improvements in quality of life (QoL), EEG feature, and time to achieve seizure reduction in both groups. The QoL was assessed by Quality of Life in Childhood Epilepsy Questionnaire 55 (QOLCE-55) to assess cognitive, emotional, social, and physical functions. Results There were no significant differences in the proportion of responders between the substitution therapy group (62.5%) and the standard therapy group (68.4%). Both groups experienced substantial reductions in seizure frequency, ranging from 78% to 80%. For further analysis, the average difference of seizure frequency before and after intervention was statistically significant in each group, it was P=0.000 in substitution group and P=0.00 in standard group. The analysis of quality of life showed the mean of total score in both groups was low even though the score was higher in the substitution group. For spesific function of quality of life, the cognitive and social function, was improved significantly in the group p<0.05). However, there were no significant differences of EEG improvement, seizure duration, time to achieve seizure frequency reduction, or adverse effects between the two groups. Conclusions First-line AEDs have comparable efficacy as second-line AEDs with mild to moderate adverse effects in DRE children. Thus, the repeated use of first-line AEDs as substitution therapy might be an option for children who resistant to second line AEDS.
Co-Authors Abdul Latief Afina Syarah Lidvihurin Ali K Alhadar Alif Gilang Perkasa Arfianti Chandra Dewi Ari Prayitno, Ari Arwin AP Akib Ashadi, Dhiya Athaullah Nurfateen Badriul Hegar Badriul Hegar Badriul Hegar Badriul Hegar Sjarif Bambang Supriyatno Bernie Endyarni Medise Bina Akura Catrawardhana, Prajnadiyan Cissy B. Kartasasmita Cissy B. Kartasasmita Clara Riski Amanda Darmawan B Setyanto Darmawan B. Setyanto Diah Rini Handjari Diah Rini Handjari Djajadiman Gatot Dominicus Husada Dwi Prasetyo Eka Laksmi Hidayati, Eka Laksmi Elina Waiman Elina Waiman Elizabeth Yohmi Elizabeth Yohmi Elizabeth Yohmi Ellen Gandaputra Endang Windiastuti Endang Windiastuti Ening Krisnuhoni Eveline Nainggolan Eveline Nainggolan Eveline Panjaitan Fadilah Fadilah, Fadilah Ferry Damardjati Ferry Damardjati S.P. Gatot Irawan Sarosa, Gatot Irawan Grace N.A. Simatupang Hardiono D Poesponegoro Hardiono D Pusponegoro Harijadi Harijadi Hartono Gunardi Hartono Gunardi Hartono Gunardi Hendri Tanu Jaya Henny Adriani Puspitasari, Henny Adriani Hindra Irawan Satari I Gusti Ayu Nyoman Partiwi I Gusti Ayu Nyoman Partiwi I Gusti Ayu Nyoman Partiwi Idham Amir Idham Amir Imral Chair Irawan Mangunatmadja Ismoedijanto Jason, Jason Jose RL Batubara Julfina Bisanto Julfina Bisanto Julfina Bisanto, Kadim S. Bachtiar Kemas Firman Kristo B. P. Siahaan Kusnandi Rusmil Laila Laila Lee, Hee Jae Maddepunggeng, Martira Maheranny, Marethania Marini Stephanie Marini Stephanie Mei Neni Sitaresmi Meutia Ayuputeri Kumaheri Muhamad Rizqy Fadhillah Mulya Rahma Karyanti, Mulya Rahma Najib Advani Nanis S. Marzuki Nanis Sacharina Marzuki Nanis Sacharina Marzuki Nastiti Kaswandani Nina Dwi Putri Nur Azizah Nur Azizah Nur Rahadiani Nurul Gusti Khatimah Pamela Kartoyo Pardede, Sudung Oloan Partini Pudjiastuti Trihono, Partini Pudjiastuti Partini Trihono Perkasa, Alif Gilang Piprim B Yanuarso Purnama, Asep Aziz Purnamawati S P Purnamawati S Pujiarto Purnamawati SP Puspaningtyas, Niken Wahyu Pustika Amalia Rachmajati, Arinurtia Rahadiani, Nur Raihan Raihan, Raihan REZA FAHLEVI Rhea Putri Ulima Rinawati Rohsiswatmo Rismala Dewi Rita Mey Rina Rizky Clarinta Putri Roro Rukmi Windi Perdani, Roro Rukmi Sanstiono, Sastiono Sastiono, Sastiono Setyo Handryastuti SJATHA, FITHRIYAH Soedjatmiko Soedjatmiko Soedjatmiko Sri Rezeki Hadinegoro Sri Rezeki S. Hadinegoro, Sri Rezeki S. Suraiyah Suraiyah Teny Tjitra Thandavarayan, Rajarajan Amirthalingam Theola, Jason Toto Wisnu Hendrarto Tri H. Rahayatri Tuty Rahayu Wardani, Amanda Saphira Wawaimuli Arozal William Jayadi Iskandar Yovita Ananta Yulfina Bisanto Zakiudin Munasir Zuraida Zulkarnain