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Devi Permatasari
Jurusan Akuntansi, Fakultas Ekonomi Universitas Islam Sultan Agung Semarang Indonesia Jl. Raya Kaligawe Km. 04 Semarang 50112
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Journal : Science and Technology Indonesia

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Evaluation of Bioactive Compounds, Antioxidant, and Anti-Diabetic Activities in Hexane and Supercritical Carbon Dioxide Extracts of Sweet Potato (Ipomoea batatas L.) Leaves Nasori, Achmad Sofian; Wiguna, Bangkit; Rahayu, Maya Damayanti; Permatasari, Devi; Kazfia, Hananda; Muhamaludin; Rosyidin, Ahmad Khulafaur; Dewi, Rizna Triana; Fu, Minghai; Atmaji, Priyo; Aji, Galih Kusuma
Science and Technology Indonesia Vol. 10 No. 1 (2025): January
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2025.10.1.250-261

Abstract

Sweet potato leaves are a rich source of bioactive compounds with potential health benefits. Advanced methods are being explored to harness these beneficial compounds efficiently. Applying the supercritical carbon dioxide (SCO2) technique, as an environmentally friendly extraction technique, offers many advantages over traditional solvent extraction. This study, therefore, aimed to investigate the effect of SCO2 extraction on the bioactive properties of sweet potato leaves, focusing on antioxidant and anti-diabetic activities. Then, the SCO2 extracts were compared with the hexane extract. A completely random design was used, performing 3 pressures (2000, 3000, and 4000 Psi) and 3 temperatures (40, 50, and 60°C) for the SCO2 extraction. In addition, a maceration using hexane solvent was performed in a shaker for 24 hours. Total polyphenol and flavonoid concentrations were quantified, and gas chromatography-mass spectrometry (GCMS) analyses were used to identify the extracted bioactive compounds. Antioxidant and anti-diabetic activities were also assessed. This yield of SCO2 extraction ranged from 0.49% to 0.89%, which was significantly lower in yield, polyphenol, flavonoid concentration, and antioxidant activity compared to hexane extract (P<0.05). Despite the lower yield, this study observed a higher concentration of bioactive terpenoids such as phytol, caryophyllene oxide, and squalene. In terms of anti-diabetic activity, the extracts at SCO2-specific conditions (4000 Psi 40°C, 3000 Psi 60°C, 3000 Psi 40°C, and 60°C, 2000 Psi 60°C) exhibited potent alpha-glucosidase inhibition, with IC50 values comparable to acarbose, and hexane extract. Dipeptidyl peptidase 4 (DPP4) inhibition was the highest in the hexane extract (p < 0.05), followed by SCO2 extracts. Thus, these findings highlight new possibilities for developing anti-diabetic agents derived from sweet potato leaves using the green SCO2 extraction technique.
Co-Authors Agustiningrum, Ratna Ajeng Intan Nur Rahmawati Aji, Galih Kusuma Akhmad Rifqi Azis, Akhmad Rifqi Anisa Widiawati Ariani, Indri Arif Fatahillah Ayu, Adinda Blasius Boli Lasan Damis Damis Dhian, Arlina Dina Sonia Elsera, Chori Emma Lilianti, Emma Esri Rusminingsih - Fitriana Noor Khayati Fu, Minghai Handayani, Sri Happy, Aulia Hasrianti, Hasrianti Hendar Hendrawan, Jajang Imam Ariffudin Ishmah, Nurul Faridatul Kara, Yunita Frederika Kazfia, Hananda Khairul Bariyyah Kusumaningrum, Puput Risti Leny Latifah Luluk Muhimatul Ifada Luthfinuddin, Hafiski Makin, Gregorius Leraboleng Marwanti Maulida, Haliza Salma Maya Indriastuti Muhamaludin Mutoharoh, Mutoharoh Nadzifah, Laila Ummi Najihah, Naila Nasori, Achmad Sofian Nora Yuniar Setyaputri Novi Mayasari Nur Pamuji, Intan Mardatillah Ohoiwirin, Yuliana Pambudi, Parid Rilo Pangestu, Bangkit Priyo Atmaji Putri, Rini Sahni Qoni’ah, Marifatul Rahayu, Maya Damayanti Ramadlan, Raynal Fira Retnawati Retnawati Retno Anggraini Rizna Triana Dewi Rosyidin, Ahmad Khulafaur Salsabila, Khairiah Santoso, Shifa Aliffiana Sari, Eva Kartika Wulan Sari, Eva Kartika Wulan Sina Putriningsih, Rahma Sinta, Amelia Kumala Soejanto, Laily Tiarani Soniya, Soniya Sri Sat Titi Hamranani Sri Sulistyowati Suciana, Fitri Suharmawan, Wahid Sulistyawati, Intan Sumarsono Sumarsono Susanti, Romia Hari Susi Setiawani Suyami, S Tiarani Soenjanto, Laily Totok Sudiyanto, Totok Tyas, Rini Nurcahyaning Ulhaq, M. Naufal Wahyuningsih, Dita Tri Wiguna, Bangkit Wisesa, Prisca Kikha Candra Yomi Romlah, Oom Yulina Ismiyanti, Yulina ‪Arlina Dhian Sulistyowati‬