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All Journal HAYATI Journal of Biosciences ACTA VETERINARIA INDONESIANA Hemera Zoa Jurnal Sain Veteriner Tropical Animal Science Journal Buletin Anatomi dan Fisiologi (Bulletin of Anatomy and Physiology) ARSHI Veterinary Letters Jurnal Pusat Inovasi Masyarakat Jurnal Veteriner dan Biomedis Current Biomedicine
Diah Nugrahani Pristihadi
Divisi Farmakologi Dan Toksikologi Veteriner, Sekolah Kedokteran Hewan Dan Biomedis, IPB University, Bogor
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Earth & Planetary Sciences Energy Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Social Sciences Veterinary

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Uji Toksisitas Akut Sari Buah Apel (Malus domestica) pada Mencit (Mus musculus) Ifana, Cindy Anola; Andriyanto; Pristihadi, Diah Nugrahani
Jurnal Veteriner dan Biomedis Vol. 2 No. 1 (2024): Maret
Publisher : Sekolah Kedokteran Hewan dan Biomedis

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jvetbiomed.2.1.22-28.

Abstract

Sari buah apel banyak beredar dan dikonsumsi masyarakat sebagai minuman dengan kandungan nutrisi tinggi. Berbagai potensi sari buah apel sebagai bahan alami perlu didukung oleh informasi mengenai tingkat keamanannya. Tingkat keamanan penggunaan sari buah apel dapat diuji dengan uji toksisitas. Pengujian dilakukan pada 20 ekor mencit betina yang dibagi menjadi 5 kelompok. Kelompok perlakuan dosis 0 g/kg BB diberi aquades, sedangkan kelompok lain diberi sari buah apel dengan dosis pemberian 5, 10, 15, dan 20 g/kg BB dalam dosis tunggal secara peroral. Mortalitas, respon fisiologis, dan gejala klinis diamati selama 14 hari setelah satu kali pemberian sediaan. Parameter lain yang diamati pada penelitian ini yaitu bobot badan, bobot organ absolut, bobot organ relatif, dan makro anatomi organ. Hasil pengujian toksisitas akut pada sari buah apel tidak menyebabkan perbedaan yang nyata terhadap gejala klinis, bobot badan, bobot organ, makroanatomi organ, maupun tingkat kematian. Disimpulkan bahwa sari buah apel termasuk ke dalam sediaan yang bersifat praktis tidak membahayakan.
Penyuluhan Sistem Ternak Sehat dan Bersih sebagai Upaya Meningkatkan Kesehatan Ternak Ruminansia di Desa Gentan, Sukoharjo Ferrando, Indigo; Febrianca, Ivory; Maura Tianska, Radine; Matilda Sianturi, Yemima; Fauzan Akmal, David; Annisa, Reni; Adelaide Vertin, Nadya; Kristianto, Williams Tjong; Pristihadi, Diah Nugrahani
Jurnal Pusat Inovasi Masyarakat Vol. 7 No. 2 (2025): Oktober 2025
Publisher : Direktorat Pengembangan Masyarakat Agromaritim, Institut Pertanian Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jpim.7.2.357-368

Abstract

The Siternas program was implemented by the IPB University KKN-T Team in Gentan Village, Bendosari District, Sukoharjo Regency, as an effort to improve livestock health management among smallholder farmers. The program aimed to provide education and assistance to cattle, goat, and sheep farmers in order to establish a healthier, cleaner, and more productive livestock system. The implementation methods included coordination with the Department of Agriculture and Fisheries, initial observation, preparation of educational materials, and door-to-door extension activities combined with field practices. The program was carried out from July 21–23, 2025, across five hamlets, involving 26 farmers and 206 animals (47 cattle and 159 goats/sheep). The results indicated an increased understanding among farmers of the importance of deworming, proper housing management, and disease prevention. The program also distributed free Albendazole, conducted animal health checks, and demonstrated deworming methods. Challenges included language barriers, farmers’ limited availability, and substandard husbandry practices. Nevertheless, the program effectively raised awareness and encouraged farmers to adopt better health management practices. In conclusion, Siternas proved effective in enhancing farmers’ knowledge, skills, and motivation to maintain livestock health, while sustainability requires continuous mentoring, farmer health groups, and multi-sectoral collaboration.
Effect of subacute administration of orange juice (Citrus sinensis) on duodenal structure in paediatric Sprague-Dawley rats (Rattus novergicus) Teo Qin Yan; Altaff Hendry; Daniel Latief Andre; Muhammad Luthfi Rahman; Win Satya Rudramurti; Nadine Hanifa Permana; Dian Maulia Utami; Diah Nugrahani Pristihadi; Agus Setiyono
ARSHI Veterinary Letters Vol. 8 No. 3 (2024): ARSHI Veterinary Letters - August 2024
Publisher : School of Veterinary Medicine and Biomedical Sciences, Bogor Agricultural University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/avl.8.3.69-70

Abstract

This research investigates the impact of orange juice consumption on the histological structure of the duodenum, a critical site for nutrient absorption and digestion. Focusing on pediatric animals, orange juice (with a pH of 3) was administered to post-weaning rats aged 4 weeks to 6 weeks at dosages ranging from 0g/kg BW to 20g/kg BW over two weeks. Duodenal histopathology was assessed, focusing on parameters such as the quantity of crypts of Lieberkuhn, as well as the length, height, width, and depth of villi (measured in μm). Anatomical pathology examination included measurements of the length and width of the duodenum (also in μm), as well as the color mean (OD). The research findings indicate no significant changes in histo-pathology or anatomy pathology of the duodenum. This suggests that young individuals can adapt to acidic challenges without compromising gastrointestinal health. These findings offer reassurance regarding the short-term consumption of acidic orange juice (with a pH of 3) with minimal risks to intestinal integrity, both during growth and development.
Co-Authors A Boediono A. Boediono Adelaide Vertin, Nadya Adi Winarto Agus Setiyono Al Mukhlas Fikri Alifiana Fitrianingrum Altaff Hendry Amaq Fadholly Amrozi Andre, Daniel Latief Andriyanto Andriyanto . Andriyanto Andriyanto Annisa, Reni Arief Boediono Aulia Andi Mustika Bondan Achmadi Budiariati, Vista C. Sumantri Cece Sumantri Daniel Latief Andre Dian Maulia Utami Dwi Budiono Erli Chandra Fauzan Akmal, David Febrianca, Ivory Fedik Abdul Rantam Ferrando, Indigo Firdaus, Munira Laeli H. Maheshwari Hanum, Nur Aisah Hendry, Altaff HERA MAHESHWARI Ifana, Cindy Anola Iryanto, Anetonia Felicia Karisma Mardatillah Kristianto, Williams Tjong Leo Sapelani Soinbala Lina Noviyanti Sutardi M Fakhrudin Matilda Sianturi, Yemima Maula, Yogi Nikmatul Maura Tianska, Radine Mohammad Miftahurrohman Mokhamad Fahrudin Muhammad Luthfi Rahman N M D Haq N. M. D. Haq Nadine Hanifa Permana Noer Muhammad Dliyaul Haq Noer Muhammad Dliyaul Haq, Noer Muhammad Dliyaul Permana, Nadine Hanifa Purohita, Adwisto Saktika Putri, Imelya Andira Putri, Ramadita Aisyah R. Widyastuti Rahman, Muhammad Luthfi Ridi Arif Rini Widyastuti Risna Anggraeni Rudramurti, Win Satya Safitri, Nadiya Sajidah, Halilah Wafa’ Salsabila, Cyntia Bella Saragih, Mariah Mada Rahma Nauli SATRIYAS ILYAS Sigit Prastowo Teo Qin Yan Titiek Sunartatie Utami, Dian Maulia Wahyudin Wahyudin Wasmen Manalu Win Satya Rudramurti Yan, Teo Qin Yayuk Sri Rahayu