Article Per Year (5 Year)
p-Index From 2021 - 2026
2.319
P-Index
This Author published in this journals
All Journal ILMU KELAUTAN: Indonesian Journal of Marine Sciences JURNAL PENGABDIAN KEPADA MASYARAKAT The Indonesian Biomedical Journal Pro Food Jurnal Penelitian Kesehatan Suara Forikes Jurnal Sains Teknologi dan Lingkungan (JSTL) Jurnal Ilmu Kefarmasian Indonesia Scripta Biologica Jurnal Gema Ngabdi Jurnal Abdi Insani Jurnal Kesehatan Tambusai Journal of Multidisciplinary Applied Natural Science Sasambo Journal of Pharmacy INDRA: Jurnal Pengabdian kepada Masyarakat Jurnal Warta Desa (JWD) Prosiding Konferensi Nasional PKM-CSR Jurnal Pijar MIPA Jurnal Pendidikan dan Pengabdian Masyarakat Jurnal Kefarmasian Indonesia Lombok Medical Journal Klinik: Jurnal Ilmiah Kedokteran dan Kesehatan
Candra Dwipayana Hamdin
Program Studi Farmasi, Fakultas Kedokteran, Universitas Mataram, Mataram, Indonesia
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

Published : 28 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 28 Documents
Search

 1   2   3 
Dual Antifungal and Immunoregulatory Actions of Topical Silver Nanoparticles from Piper ornatum Extract in Cutaneous Candida albicans Infection Dewi, Firli Rahmah Primula; `Mustofa, Laila Al Azizi; Hamdin, Candra Dwipayana; Geraldi, Almando; Lim, Vuanghao; Pramudya, Manikya; Hayati, Alfiah; Hajar, Versa Rachmania
Journal of Multidisciplinary Applied Natural Science Articles in Press
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.374

Abstract

Cutaneous Candida albicans infection is characterized by persistent inflammation, epidermal damage, and dysregulated immune responses. Silver nanoparticles (AgNPs) have emerged as promising antifungal agents with additional immunomodulatory properties; however, their effects on skin pathology and local immune responses during candidiasis remain incompletely defined. This study aimed to investigate the therapeutic effects of a topical AgNP-based cream in a murine model of C. albicans–induced skin infection. AgNPs were green-synthesized using an aqueous leaf extract of Piper ornatum. A murine model of cutaneous C. albicans infection was established, and infected mice were treated topically with AgNP-based cream formulations at concentrations of 4% or 6%. Disease severity was assessed through macroscopic skin evaluation and histopathological analysis. Immune modulation was examined by flow cytometric analysis of CD4⁺ T-cell subsets expressing TNFα and IL-17, as well as CD11b⁺ myeloid cells expressing IL-6 and IL-10. Untreated infected mice exhibited severe cutaneous pathology, including persistent erythema, erosive lesions, epidermal hyperkeratosis, and acanthosis. These changes were accompanied by marked immune dysregulation, characterized by expansion of CD4⁺IL-17⁺ T-cells, suppression of TNFα-producing CD4⁺ T-cells, increased IL-6 expression, and reduced IL-10 production in CD11b⁺ myeloid cells. Topical AgNP treatment significantly ameliorated macroscopic and histological skin damage, restoring epidermal architecture toward normal. Immunologically, AgNP therapy attenuated pathological Th17 responses, reduced IL-6-producing myeloid cells, enhanced IL-10 expression, and maintained TNFα at controlled levels. Both AgNP concentrations were effective, with the 4% AgNP formulation showing slightly superior normalization of epidermal thickness and inflammatory markers. Overall, topical AgNP-based cream effectively alleviated cutaneous C. albicans infection by combining antifungal activity with coordinated immunomodulation of both adaptive and innate immune responses. By suppressing excessive IL-17– and IL-6–driven inflammation while promoting regulatory immune pathways, AgNP treatment supports tissue repair and immune homeostasis, highlighting its potential as a therapeutic strategy for cutaneous candidiasis.
Review Artikel: Pengaruh Sistem Emulsi Lipid terhadap Farmakokinetika Obat Lipofili Ghina Salsabila; Candra Dwipayana Hamdin; Karlina Dwi Febrianingsih; Naya Wahyu Anindiya; Febriana Putri Rohmayani; Haulya Razkianita; Siti Maesarah; Sabila Rosyada; Puji Elok Dzakirah
Jurnal Ilmiah Kedokteran dan Kesehatan Vol. 5 No. 3 (2026): September: Jurnal Ilmiah Kedokteran dan Kesehatan
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/klinik.v5i3.6945

Abstract

Lipophilic drugs have low water solubility and often exhibit inconsistent absorption profiles, which can lead to suboptimal therapeutic outcomes in clinical use. Lipid-based drug delivery systems have emerged as a promising and widely studied formulation strategy because they are able to significantly enhance the solubility, bioavailability, and systemic distribution of lipophilic drugs. This study aims to identify how various lipid emulsion systems modify the pharmacokinetic profile of lipophilic drugs, compare the differences in effects among different types of emulsions, and highlight the key formulation characteristics that contribute to these pharmacokinetic parameter changes. The study was conducted through a comprehensive literature review of national and international scientific articles published between 2015 and 2025. The results indicate that lipid emulsion systems modify pharmacokinetics primarily through increased drug dissolution, accelerated absorption processes, reduced first-pass metabolism, and facilitation of lymphatic transport pathways. These mechanisms consistently result in increased Cmax, AUC, and overall bioavailability. The formulation characteristics that strongly influence these outcomes include nano-sized droplet distribution, lipid type selection, surfactant and co-surfactant composition, amorphous drug form, and the physical stability of the emulsion system.
The Potency of Atorvastatin Nanoparticles Implementation in Human: A Pharmacokinetic Perspective from Basic to Clinical Literature Review Candra Dwipayana Hamdin; Vania Aisyah Aulia Syahda Haris; Steve Pratama Tanjaya; Shafira Khansa Haiba; Faolananda Qurrota A'yun
Lombok Medical Journal Vol. 5 No. 2 (2026): Lombok Medical Journal
Publisher : Faculty of Medicine, Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/e9cn9w04

Abstract

Atorvastatin is a biopharmaceutics classification system class II drug with good permeability but low solubility, thereby limiting its bioavailability and therapeutic efficacy. This study aims to analyze the effect of particle size reduction on the pharmacokinetic parameters (Cmax, Tmax, AUC, t½) of atorvastatin in various drug delivery systems and thepotency of its implementation in human through a literature review approach. Literature screening was conducted using online databases including Google Scholar, PubMed, ScienceDirect, and Springer Open, with inclusion criteria of national and international articles published in the last 10 years discussing atorvastatin formulations with various particle sizes and their pharmacokinetic parameters. Analysis of the 11 selected articles showed that nano-based delivery systems can increase the bioavailability of atorvastatin compared to conventional formulations. The results confirmed that particle size reductionthrough nanotechnology approaches increased the dissolution rate, membrane permeability, and absorption efficiency, thereby optimizing the pharmacokinetic profile of atorvastatin. This review provides evidence that nano-scale formulation strategies have a consistent positive impact on the bioavailability of atorvastatin. Despite these promising preclinical findings, the implementation of atorvastatin nanoparticles in humans remains limited due to the absence of clinical trials, although their potency to improve bioavailability and reduce dose-dependent toxicity at lower doses offers a strong rationale for futuretranslational research.
Edukasi Literasi Dini Obat Herbal bagi Siswa Sekolah Dasar dalam Rangka Optimalisasi Pemanfaatan Tanaman Keluarga (Toga) Candra Dwipayana Hamdin; Febriana Putri Rohmayani; Naya Wahyu Anindiya; Sabita Tarinda
Jurnal Pendidikan dan Pengabdian Masyarakat Vol. 9 No. 1 (2026): Februari
Publisher : FKIP Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppm.v9i1.10657

Abstract

Indonesia memiliki potensi besar dalam pemanfaatan tanaman obat keluarga (TOGA), namun literasi masyarakat, khususnya anak-anak, masih rendah. Kegiatan pengabdian kepada masyarakat ini bertujuan untuk meningkatkan literasi dini siswa sekolah dasar terhadap obat herbal melalui edukasi interaktif dan praktik langsung. Program dilaksanakan di SDN 2 Bentek, Kabupaten Lombok Utara, dengan melibatkan 30 siswa kelas VI. Metode yang digunakan adalah quasi-experimental one group pretest-posttest design untuk menilai efektivitas edukasi terhadap peningkatan pengetahuan. Kegiatan terdiri atas penyuluhan mengenai jenis dan manfaat tanaman obat, demonstrasi pembuatan jamu tradisional, serta praktik penanaman TOGA di lingkungan sekolah. Hasil menunjukkan adanya peningkatan signifikan skor pengetahuan siswa dari hasil pretest ke posttest, dengan sebagian besar siswa mampu menjawab benar ≥80% soal setelah intervensi. Selain itu, observasi partisipatif menunjukkan peningkatan antusiasme dan kemampuan siswa dalam mengenal serta menjelaskan manfaat tanaman obat. Kegiatan ini membuktikan bahwa edukasi berbasis praktik langsung efektif dalam menanamkan kebiasaan memanfaatkan tanaman obat secara bijak sejak usia dini. Program DOCIL (Duta Obat Cilik Lombok) diharapkan menjadi model edukasi berkelanjutan dalam memperkuat literasi kesehatan dan pelestarian kearifan lokal berbasis TOGA.
Edukasi Hipertensi melalui Sosialisasi Pemanfaatan Tanaman Herbal Brucea Javanica (L) Merr pada Masyarakat Pesisir Lingkungan Bangsal Tanjung Karang Sabita Tarinda; Siti Maesarah; Zaskia Rizky Maulana; Vania Aisyah Aulia Syahda Haris; Candra Dwipayana Hamdin
Jurnal Pendidikan dan Pengabdian Masyarakat Vol. 9 No. 2 (2026): Mei
Publisher : FKIP Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppm.v9i2.11320

Abstract

Hipertensi merupakan faktor risiko utama penyakit kardiovaskular yang menjadi penyebab kematian tertinggi di dunia. Tingginya angka kejadian hipertensi umumnya terjadi pada masyarakat pesisir, khususnya di pulau Lombok, yang memiliki kebiasaan pola konsumsi garam yang tinggi yang berpotensi meningkatkan risiko hipertensi. Kegiatan pengabdian kepada masyarakat ini bertujuan untuk meningkatkan pengetahuan dan kesadaran masyarakat mengenai hipertensi serta pemanfaatan tanaman herbal Brucea javanica (L.) Merr sebagai alternatif terapi antihipertensi. Kegiatan dilaksanakan di Lingkungan Bangsal, Kelurahan Tanjung Karang, Kecamatan Sekarbela, Mataram, dengan desain quasi-eksperimental menggunakan pendekatan one group pretest–posttest. Peserta berjumlah 20 orang masyarakat pesisir dengan mayoritas perempuan dan rata-rata usia 52 tahun. Intervensi dilakukan melalui ceramah interaktif, diskusi, serta demonstrasi pemanfaatan Brucea javanica. Evaluasi dilakukan menggunakan instrumen pretest dan posttest yang telah tervalidasi. Hasil menunjukkan rata-rata nilai pretest sebesar 91 dan meningkat menjadi 98 pada posttest, dengan nilai p < 0,05, yang menandakan adanya peningkatan pengetahuan yang signifikan setelah sosialisasi. Sebanyak 7 peserta mengalami peningkatan nilai, sementara 13 peserta mempertahankan nilai yang sudah tinggi, dan tidak terdapat penurunan nilai. Selain peningkatan pengetahuan, peserta menunjukkan antusiasme dan partisipasi aktif selama kegiatan berlangsung. Dengan demikian, kegiatan sosialisasi ini terbukti efektif dalam meningkatkan pengetahuan masyarakat terkait hipertensi dan berpotensi menjadi strategi promotif dan preventif dalam pengendalian hipertensi pada masyarakat pesisir.
ARTIKEL REVIEW : ANALISIS PARAMETER FARMAKOKINETIKA PACLITAXEL DALAM BEBERAPA SEDIAAN NANO-BASED DRUG DELIVERY SYSTEMS Jingga Rusyesyah Padli; Adila Rizkika; Dhea Syafitri Dwiyanti; Dzakiyyah Sulthanah Ahmad; Hudaynu Patya Putri; Gusti Ayu Pratitha Devinta Putri; M. M. Samdya Aripansy; Risma Fitriani; Candra Dwipayana Hamdin
Jurnal Kesehatan Tambusai Vol. 7 No. 2 (2026): JUNI 2026
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v7i2.58197

Abstract

Paclitaxel merupakan agen kemoterapi yang banyak digunakan pada berbagai jenis kanker, namun penggunaannya masih terbatas oleh kelarutan yang rendah, toksisitas sistemik yang berisiko menimbulkan efek samping serius. Berbagai sistem penghantaran obat berbasis nanopartikel telah dikembangkan untuk mengatasi keterbatasan tersebut, termasuk Solid Lipid Nanoparticles (SLN), nanopartikel berbasis PLGA, mesoporous silica nanoparticles, SPIONs, micellar systems, PEGylated nanoparticles, porous starch nanoparticles, hingga prodrug berbasis glukosa. Penelitian ini bertujuan untuk menganalisis dan membandingkan profil farmakokinetika paclitaxel dalam berbagai sistem nanopartikel dengan formulasi paclitaxel konvensional. Metode yang digunakan adalah systematic narrative review terhadap artikel publikasi 10 tahun terakhir (2015–2025) dari database online. Parameter yang dianalisis meliputi Cmax, Tmax, AUC, t½, klirens, volume distribusi, dan mean residence time (MRT). Hasil analisis menunjukkan bahwa nanoformulasi paclitaxel secara konsisten meningkatkan paparan sistemik (AUC), waktu paruh, dan bioavailabilitas, serta menurunkan klirens dibandingkan formulasi konvensional. Selain itu, nanoformulasi mampu meningkatkan akumulasi obat pada jaringan target dan mengurangi toksisitas sistemik. Kesimpulannya, sistem penghantaran paclitaxel berbasis nanopartikel memberikan perbaikan bermakna terhadap profil farmakokinetika dan berpotensi meningkatkan efektivitas serta keamanan terapi kanker.
Translating Nanoparticle-Based Drug Delivery Systems for Natural Products into Clinical Practice: A Pharmacokinetic Perspective Candra Dwipayana Hamdin; Zaskia Rizky Maulana; Silhiyatun Mayada; Lalu Rifqi Azami
Lombok Medical Journal Vol. 5 No. 3 (2026): Lombok Medical Journal
Publisher : Faculty of Medicine, Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/t3ng7e65

Abstract

Secondary metabolites derived from natural products, such as alkaloids,flavonoids, and polyphenols, have promising pharmacological activities, but their clinical use in humans is often restricted by poor solubility, limited gastrointestinal absorption, rapid metabolism, and low systemic bioavailability. Nanoparticle- and formulation-based delivery systems have been developed to address these pharmacokinetic limitations and improvethe therapeutic feasibility of natural product-derived compounds. This literature review discusses the pharmacokinetic enhancement of selected secondary metabolites using nanosuspensions, polymeric nanoparticles, lipid-polymer hybrid nanoparticles, micelles, nanosponges, phytosome-based systems, and nano-sized water-soluble formulations, with emphasis on their potential relevance for human clinical translation. The reviewed studies show improvements in AUC, Cmax, Tmax, half-life, bioavailability, systemic exposure, and tissue distribution compared with conventional formulations. In addition to preclinical evidence, human pharmacokinetic studies on quercetin phytosome, berberine phytosome, and nano-sized curcumin formulation suggest that formulation strategies may improve systemic exposure in humans. These findings support the potential role of nanoparticle and formulation-based delivery systems as translational tools for improving the clinical utility of natural product-derived secondary metabolites. Nevertheless, further studies in patient populations are required to confirm clinical efficacy, long-term safety, and therapeutic relevance.
ARTICLE REVIEW : PERBANDINGAN FARMAKOKINETIKA OMEPRAZOLE, PANTOPRAZOLE DAN ESOMEPRAZOLE SEBAGAI OBAT GOLONGAN PPI Baiq Citra Azzahra Qotrunnada; Diouf Maulana Dwi Putranto; Fawwaz Aqila Putri; Halimatussakdiyah Halimatussakdiyah; Nadia Magfira Nurmalasanti; Sabita Tarinda; Syahrani Febrianti; Wiwin Azariani; Candra Dwipayana Hamdin
Jurnal Kesehatan Tambusai Vol. 7 No. 3 (2026): SEPTEMBER 2026
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v7i3.60201

Abstract

Proton Pump Inhibitor (PPI) seperti omeprazole, pantoprazole, dan esomeprazole banyak digunakan dalam terapi GERD, tukak peptikum, dan infeksi Helicobacter pylori. Efektivitas PPI dipengaruhi oleh parameter farmakokinetik, terutama bioavailabilitas, metabolisme melalui CYP2C19, serta variabilitas antarindividu. Artikel review ini bertujuan membandingkan karakteristik farmakokinetika ketiga PPI dan menjelaskan implikasi klinisnya terhadap efektivitas serta keamanan terapi. Metode yang digunakan adalah kualitatif non-eksperimental dengan desain kajian literatur (literature review) dari jurnal nasional dan internasional tahun 2015–2025 melalui Google Scholar, PubMed, ScienceDirect, dan Publish or Perish, dengan inklusi artikel klinis manusia yang melaporkan Cmax, Tmax, AUC, dan bioavailabilitas. Hasil kajian menunjukkan esomeprazole memiliki bioavailabilitas lebih tinggi dan lebih stabil, serta variabilitas metabolik paling rendah sehingga memberikan kontrol asam yang lebih cepat dan konsisten. Pantoprazole menunjukkan bioavailabilitas stabil dan risiko interaksi obat terendah karena afinitas kecil terhadap CYP2C19, menjadikannya pilihan aman pada pasien polifarmasi. Omeprazole memiliki variabilitas farmakokinetik terbesar akibat ketergantungan tinggi pada metabolisme CYP2C19, sehingga responsnya paling dipengaruhi polimorfisme genetik dan gangguan fungsi hati. Polimorfisme CYP2C19 meningkatkan AUC dan durasi efek terutama pada omeprazole, serta lebih kecil pada pantoprazole dan esomeprazole. Secara keseluruhan, pemilihan PPI ideal harus mempertimbangkan parameter farmakokinetika, status metabolik pasien, kondisi klinis, dan risiko interaksi obat untuk mencapai terapi yang efektif dan aman.
Co-Authors Adila Rizkika Agus Dwi Ananto, Agus Aini, Siti Rahmatul Alamanda, Baiq Irzana Putri Alfiah Hayati Almando Geraldi Almira Amini Alsifah Nurhidayati Amini, Almira Ananta, Muhammad Naufal Farras Andriliana Trihastuty Arief Nurrochmad Baiq Citra Azzahra Qotrunnada Baiq Ressa Puspita Rizma Candra Eka Puspitasari Dandiko Galanova Dandiko Galanova Devy Shandra Purwati Dhea Syafitri Dwiyanti Dheni Cahyo Dheny Cahyo Saputro Diouf Maulana Dwi Putranto Dyke Gita Wirasisya Dzakiyyah Sulthanah Ahmad Faolananda Qurrota A&#039;yun Faturrahman Fawwaz Aqila Putri Febriana Putri Rohmayani Febriana Putri Rohmayani Firli Rahmah Primula Dewi Ghina Salsabila Gusti Ayu Pratitha Devinta Putri Gusti Ayu Putu Sri Erwinayanti Hajar, Versa Rachmania Halimatussakdiyah Halimatussakdiyah Handa Muliasari Hasina, Raisya Haulya Razkianita Hudaynu Patya Putri I MADE SUDARMA Ida Bagus Putra Manuaba Ika Puspitasari Ima Arum Lestarini Iman Surya Pratama Ivan Mambaul Munir Jingga Rusyesyah Padli Karlina Dwi Febrianingsih Kattari, Raisah Putri Lalu Rifqi Azami Lim, Vuanghao Lisnasari, Baiq Risky Wahyu M. M. Samdya Aripansy Mahacita Andanalusia Mahdiyyah Husna Nihar Manikya Pramudya Muhsinul Ihsan Muhsinul Ihsan Mujiburrohman Mujiburrohman Nadia Magfira Nurmalasanti Nadya Arianita Turisia Naya Wahyu Anindiya Naya Wahyu Anindiya Ni Made Amelia Ratnata Dewi Ningsih, Fitriani Putri Eka Puji Elok Dzakirah Putri, Dheden Nurhani Bija Raisya Hasina Retno Zahara Ria Hapsari Risma Fitriani Riza Rusyiana Romi Juniawan Sabila Rosyada Sabita Tarinda Sabita Tarinda Saputra, Yoga Dwi Shafira Khansa Haiba Silhiyatun Mayada Sinta wahyu utami Siti Maesarah Siti Maesarah Siti Rahmatul Aini Siti Rahmatul Aini Steve Pratama Tanjaya Syahrani Febrianti Ulya, Tuhfatul Vania Aisyah Aulia Syahda Haris Vania Aisyah Aulia Syahda Haris Wahida Hajrin Widia Nila Risnadewi Windah Anugrah Subaidah Wiwin Azariani Yazid Maula Zaskia Rizky Maulana Zaskia Rizky Maulana `Mustofa, Laila Al Azizi