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Djoko Agus Purwanto
Departemen Ilmu Kefarmasian, Fakultas Farmasi Universitas Airlangga, Indonesia
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Journal : JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA

 1 
Pengaruh Suhu dan Jumlah Penyeduhan terhadap Kadar Kafein Terlarut dalam Produk Teh Hijau Kering dengan Metode KCKT Febri Annuryanti; Masruratos Zahroh; Djoko Agus Purwanto
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 5 No. 1 (2018): Jurnal Farmasi dan Ilmu Kefarmasian Indonesia
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (239.328 KB) | DOI: 10.20473/jfiki.v5i12018.30-35

Abstract

Pendahuluan: Teh adalah salah satu minuman yang paling banyak dikonsumsi di dunia dan memiliki khasiat bagi kesehatan. Selain memiliki manfaat, teh juga mengandung kafein yang dapat memberikan efek samping apabila dikonsumsi secara berlebihan. Efek samping yang ditimbulkan diantaranya insomnia, ansietas, takikardia dan napas yang cepat. Oleh karena itu, saat ini diinginkan teh dengan kandungan kafein yang rendah. Tujuan: Penelitian ini bertujuan untuk menentukan efek suhu dan jumlah penyeduhan terhadap konsentrasi kafein yang terlarut dari sampel kering teh hijau. Metode: Pada studi ini digunakan tiga macam suhu (50°C, 70°C, 100°C) dan tiga kali pengulangan penyeduhan. Kafein terlarut dianalisa dengan menggunakan kondisi KCKT sebagai berikut: kolom C-18-μbondapak, fase gerak metanol : air : asam asetat 2% v/v (30:65:5) dengan laju alir 0,45 mL/menit. Deteksi dilakukan pada panjang gelombang 272 nm. Parameter validasi yang dilakukan meliputi selektifitas, linieritas, akurasi, presisi, LOD dan LOQ. Seluruh parameter validasi memenuhi persyaratan yang telah ditetapkan. Hasil: Kadar kafein tertinggi diperoleh pada penyeduhan pertama pada suhu 100oC dan kadar kafein terendah ditemukan pada penyeduhan ketiga pada suhu yang sama. Kesimpulan: Berdasarkan hasil analisis, dapat disimpulkan bahwa suhu dan jumlah penyeduhan dapat mempengaruhi kadar kafein terlarut pada teh hijau.
The Effect of Vitamin C Addition on Epigallocatechin Gallate (EGCG) Stability in Green Tea Solution Alief Putriana Rahman; Djoko Agus Purwanto; Isnaeni Isnaeni
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 6 No. 2 (2019): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v6i22019.62-68

Abstract

Background: Epigallocatechin gallate (EGCG) is the most abundant green tea catechin with a powerful antioxidant effect to prevent cancer cells. EGCG in green tea solution is highly susceptible to degradation, this it is urgent to  increase the stability of EGCG by vitamin C addition. Vitamin C can regenerate radical EGCG to be normal EGCG. Objective: This research aim was to determine percent of decreased level of EGCG before and after vitamin C addition. Methods: This paper was focused on enhancing the stability of EGCG by 1 mg (GTVC1), 1.5 mg (GTVC2), 2 mg (GTVC3), 2.5 mg (GTVC4) and 3 mg (GTVC5) of vitamin C addition to 10 g/L of green tea solution concentration. Evaluations of EGCG were conducted at 0 days, 1 day, 2 days, 3 days, and 4 days of storage time. EGCG was analyzed using thin layer chromatography (TLC) densitometry methods. The stability of EGCG was determined by % of decreased EGCG. Results: Percent of loss of EGCG in GT, GTVC1, GTVC2, GTVC3, GTVC4 and GTVC5 after 4 days storage were 19.93%, 10.89%, 21.08%, 18.18%, 28.56%, and 9.76%, respectively. Conclusion: This study showed that in 4 days storage, the decreased level of EGCG in green tea solution with 3 mg of vitamin C addition (GTVC5) was 9.76% which was smaller than green tea solution without vitamin C addition (GT) which EGCG decreasing 19.93%.
Effect of Guava Powder Addition on Epigallocatechin Gallate (EGCG) Content of Green Tea and Its Antioxidant Activity Hanifah Ridha Rabbani; Djoko Agus Purwanto; Isnaeni Isnaeni
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 6 No. 2 (2019): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v6i22019.85-90

Abstract

Background: Tea (Camelia sinensis) contains polyphenols including epigallocatechin gallate (EGCG) which is acknowledged to have strong antioxidant properties. However, its stability is strongly influenced by environment. In a neutral and alkaline environment, EGCG could undergo degradation and lose its antioxidant property. There are some researches about the effect of combination of green tea and other plants to their antioxidant capacity. Objective: The research aimed to investigate the effect of guava addition to EGCG content of green tea and their antioxidant activity. Methods: The concentration of EGCG was determined by chromatographic analysis using TLC scanner, meanwhile the antioxidant activity was evaluated by its ability in scavenging 2,2-diphenyl-1-picrylhydrazyl (DPPH) using UV-Vis Spectrophotometer. Results: Among all the samples, formula 4 (2 parts of green tea and 3 parts of guava) gave the highest EGCG content (39.03 ± 3.65 mg/g). This was 37.5% higher than the control sample (28.39 ± 2.45 mg/g). Formula 4 also had the best antioxidant activity with IC50 of 1917.32±1.75 ppm, 19% lower than control sample (2356.46 ± 3.16 ppm). Conclusion: The addition of guava powder significantly increased the amount of EGCG in green tea extracts and their antioxidant activity.
The Effect of Decyl Glucoside on Stability and Irritability of Nanostructured Lipid Carriers-Green Tea Extract as Topical Preparations Rufaidah Azzahrah; Noorma Rosita; Djoko Agus Purwanto; Widji Soeratri
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 9 No. 3 (2022): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v9i32022.220-228

Abstract

Background: Green Tea Extract (GTE) is a natural antioxidant compound that can protect the skin from photocarcinogenesis (DNA damage due to ultraviolet exposure). GTE has low stability, which needs a delivery system such as Nanostructured Lipid Carriers (NLC) with decyl glucoside (DG) as a natural surfactant that at the right concentration can produce a significantly small particle size which can improve the stability of the NLC. Objective: To determine the effect of DG usage on the characteristics, physical stability, and irritability of NLC-GTE preparation. Methods: NLC-GTE preparation used the High Shear Homogenization (HSH) method with three formulas, which contained DG 2%, 2.5%, and 3% consecutively. Afterwards, the characteristic and physical stability tests were conducted using the thermal cycling method for three cycles with two different temperatures (48 hours/cycle, 2 - 8°C and 40°C). The irritability test used Hen's Egg Test on the Chorioallantoic Membrane (HET-CAM) method. Results: Characteristic test of organoleptic showed that all formulas were white, odorless, and had a semi-solid consistency. However, the pH, particle size, and polydispersity index values from all formulas were within the normal range of values. The physical stability test result showed that 3% DG was the most stable formula. This formula was within the non-irritating range of values in HET-CAM. Conclusion: NLC-GTE with an increased concentration of DG as a surfactant can improve the characteristics and physical stability of the preparation. F3 (3% DG) is the best formula compared to other formulas and indicates non-irritating in the HET-CAM test.
Characteristic and Physical Stability of Anti-Aging Green Tea Extract (GTE) on NLC with Argan Oil as Liquid Lipid Anita Natalia Suryawijaya; Tutiek Purwanti; Djoko Agus Purwanto; Widji Soeratri
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 9 No. 2 (2022): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v9i22022.115-124

Abstract

Background: Green tea extract is a hydrophilic antioxidant that is difficult to penetrate. A nanostructured lipid carrier (NLC) delivers a system consisting of solid-liquid lipids that can improve penetration. Argan oil is a vegetable oil that can be used as a liquid lipid in NLC, reducing particle size and increasing penetration by hydrating the skin. Objective: To determine the formula of NLC green tea extract (NLC-GTE) with liquid lipid argan oil, which has good characteristics and is stable. Methods: Preparation of NLC-GTE used the High Shear Homogenization with solid lipids (cetyl palmitate-glyceryl stearate) - liquid lipids (argan oil) NLC-GTE1 (50:50), NLC-GTE2 (70:30), and NLC-GTE3 (90:10). Characteristic tests included organoleptic, pH, particle size (PS), and polydispersity index (PI). The physical stability test (organoleptic, pH, PS, and PI) used the thermal cycling method (3 cycles six days). Result: NLC-GTE1 – NLC-GTE2 has an odor of argan oil. NLC-GTE3 has odorless. NLC-GTE1 – NLC-GTE3 has a pH scale from 5.782-5.784; PS ranges from 359.73–432.56 nm; PI ranges from 0.175-0.257. The statistical analysis results showed no significant difference between NLC-GTE1 – NLC-GTE3 in pH and PI, there was a significant difference in PS NLC-GTE1; NLC-GTE2 against NLC-GTE3. Physical stability test NLC-GTE2 – NLC-GTE3 phase separation occurs. The statistical analysis results showed no significant difference in pH values NLC-GTE1 – NLC-GTE3 "‹"‹before and after storage; there was a significant difference in NLC-GTE3 before and after storage. Conclusion: NLC-GTE1 was a formula with good characteristics and stability.
Effect of Alpha-Lipoic Acid on the Characteristics and Physical Stability of NLC-Green Tea Extract Fairuz Yaumil Afra; Widji Soeratri; Djoko Agus Purwanto
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 9 No. 3 (2022): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v9i32022.229-234

Abstract

Background: The addition of alpha-lipoic acid in Nanostructured Lipid Carrier-Green Tea Extract (NLC-GTE) has potential to increase effectiveness of anti-aging preparations. It happened because alpha-lipoic acid can increase stability and antioxidant activity. Objective: Comparing the physical characteristics and stability of NLC-GTE with or without alpha-lipoic acid. Methods: NLC-GTE manufactured using the High Shear Homogenization method. NLC-GTE was divided into two formulas, without the addition of alpha-lipoic acid for F1 and with the addition of alpha-lipoic acid for F2. The characteristics and physical stability were tested, including organoleptic, pH, particle size, and polydispersity index. Stability test was held using the thermal cycling method. Results: Based on characteristic test, it was found that F2 had larger particle size value than F1. The average particle size value of F1 is 313.9 ± 0.76 nm and 423.4 ± 0.75 nm for F2. The F1 and F2 preparations had a polydispersity index value below 0.3, so they were homogeneous. The average pH value of F1 is 5.998 ± 0.01, and F2 is 4.798 ± 0.004. The physical stability test showed a difference before and after the sixth day in particle size and pH, but it was still in the range, so it was safe. However, there was a separation in F1 after day 6. Conclusion: Based on the characteristics and physical stability tests, F1 (without alpha-lipoic acid) and F2 (with alpha-lipoic acid) had differences in particle size and pH. From the physical stability test, it can be concluded that F2 is more stable than F1.
Co-Authors A Fahmy Arif Tsani A. Toto Purnomo Abby Rahmat Kamaruzzaman Achmad Fuad Hafid Achmad Toto Poernomo Achmad Toto Purnomo Adecha Ekalipta Primazafira Adi Utarini Afra, Fairuz Yaumil Agustina, Indri Alief Putriana Rahman Anggita Mirzautika Anita Natalia Suryawijaya Asri Darmawati Asri Darmawati Aty Widyawaruyanti Audrey Gracelia Riwu Augustien, Nora Budi Suharjo Budi Wikeko Christina Destri Corry, Maylisa Natalia Devi Eka Juniarti Dewi Isadiartuti Dewi Melani Hariyadi Edhi, Narendrani Sasmitaning Erwin Astha Triyono Esti Hendradi Fairuz Yaumil Afra Fauziyah, Riska Salfa Febri Annuryanti Guniarti Guniarti Guniarti Hadi Poerwono Hadi Suhardjono Hanifah Ridha Rabbani Hasan, Muhammad Amir Heny K Daryanto Herin Mawarti Hidayati, Agriana Rosmalina I Nyoman Wijaya Ilmi, Hilkatul Innisa, Deana Rohali Ira Widjiastuti Isnaeni Isnaeni Isnaeni Iswajuni, Iswajuni Joewono Soeroso Juni Ekowati Jusak Nugraha Jusak Nugraha Kun Ismiyatin Lahardo, Devanus M. Rasjad Indra Mangestuti Agil Marcellino Rudyanto Masruratos Zahroh Melanny Ika Sulistyowaty Mirzautika, Anggita Muhammad Amin Muslihatin, Wirda Noorma Rosita Nora Augustien Pribadi, Didik Huswo Purwaningsih - Purwitasari, Neny Retno Pudji Rahayu Retno Widyowati Riesta Primaharinastiti Riesta Primaharinastiti, Riesta Rufaidah Azzahrah Saribatiara, Saribatiara Setyabudi Setyabudi Soraya Aulia Sri Iswati Suciati Suciati Sukardiman Susetyowati Susilowati Susilowati Sutini Tiara Sukmawati Toto Sudargo Tri Widiandani Tristiana Erawati Tutiek Purwanti Ujang Sumarwan Wibowo, Nadya Khadijah Wicaksana, Firman Widiwurjani Widji Soeratri Widji Soeratri Yayuk Hartriyanti Yudianingtyas, Deanur Yusniasari, Putri Antika Yusuf, Helmy