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Journal : Science and Technology Indonesia

Cholesterol-Lowering Effects of Turmeric Effervescent Dosage in Preventing Atherosclerosis Pomalango, Zulkifli B.; Paneo, Mohamad Aprianto; Pakaya, Nasrun; Aman, La Ode; Hutuba, Ariani H.
Science and Technology Indonesia Vol. 10 No. 2 (2025): April
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2025.10.2.482-492

Abstract

This study aims to evaluate the cholesterol-lowering effects of turmeric (Curcuma domestica) in an effervescent powder drink formulation to prevent atherosclerosis. The effervescent preparation was produced using standard effervescent techniques, with organoleptic tests revealing an orange color, the characteristic aroma of turmeric, and a slightly sweet taste. The formulation’s pH was approximately 5.9, with a flowability test result of 14 seconds, a powder angle of repose of 30°, and a dissolution time of  4 minutes and 20 seconds. Curcumin shows potential as an anticholesterol as a preventive measure of atherosclerosis disease  through molecular docking testing using autodock-vina. Qualitative test on turmeric effervescent with Sprektrofotometer UV-VIS, Scanning Electon Microscopy (SEM) and Fourier Transform Infrared Spectroscopy (FTIR). Cholesterol testing was conducted on mice induced with cholesterol using margarine over a one-week period, resulting in increased cholesterol levels of maximum 290 mg/dL. Following administration of the converted turmeric dosage, cholesterol levels significantly maximum decreased in the first week to  165 mg/dL. By the second week, further reductions were observed, with cholesterol levels maximum dropping to 143 mg/dL. These results suggest that turmeric effervescent formulation exhibits promising cholesterol-lowering properties and may contribute to the prevention of atherosclerosis
Co-Authors A. Unga, Rani Orelia Ahmad Kadir Kilo Aiyi Asnawi Aiyi Asnawi Akram La Kilo Aldevi Trisnawati Adam Alecia Febriani Putri Arfan Arfan Ariani H. Hutuba Arviani Arviani Asisah, Asisah Astin Lukum Astria Endesei Bumulo, Nuraini Dandi Saputra Halidi Deasy Natalia Botutihe Dilapanga, Windi Djuwarno, Endah Nurrowinta Domu, Siti Afdianti Dr. Apt. Hamsidar Hasan S.Si.,M.Si Ellin Febrina Erni Mohamad Faramita Hiola Haris Munandar Hendri Iyabu Hendri Iyabu Ibrahim, Indriyanti Ishak Isa Jafar La Kilo Karim, Fadila Kasmawati, Henny Kostiawan Sukamto, Kostiawan La Alio La Alio Lukman A. R. Laliyo Madania, Madania Magfirah Nur Cahyani Mahdalena Sy Pakaya mahdalena sy. pakaya Mangara Sihaloho Mardjan Paputungan Mega Fatimah Rosana Mohamad Adam Mustapa Mohamad Aprianto Paneo Mu'thi Andy Suryadi Muhammad Taupik Multiani S. Latif Musa, Weny J.A. Muttaqin, Fauzan Zein Najmah, Najmah Nasrun Pakaya Netty Ino Ischak Nita Suleman Nur Fadillah Pulukadang Nur Rayani Nur Riska Apriana Nurfadilah M. Kasim Nurhayati Bialangi Nurvita Abdullah Opir Rumape Otoluwa, Sri Yulanda Pahrun, Abdul Wahab Pakaya, Devina A.p Rayani, Nur Ruslin, Ruslin Sabihi, Ismail Sabora, Ririn S. Sahami, Ulin Saleh, Sri Deltalia Suchi Wulandari Dai Suleman Duengo Suryadi, A Mu'thi Andy Syamsul Bahri Teti Sutriyati Tuloli Tuloli, Tety Umar, Ahmat Sudir Wayan Ayu Puje Astuti Weny J.A. Musa Widayanti . Widy Susanti Abdulkadir Wiwin Rewini Kunusa Wiwit Zuriati Uno Wiwit Zuriati Uno Yuszda K Salimi Yuszda K. Salimi Yuzda K Salimi Zaenul Wathoni Zulkifli B. Pomalango