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All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN MEDIA MEDIKA INDONESIANA JURNAL GIZI INDONESIA Jurnal Kedokteran Diponegoro Journal of Nutrition College Jurnal Biotek Medisiana Indonesia Jurnal Kesehatan The Indonesian Biomedical Journal Media Medika Muda Medica Hospitalia Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) World Nutrition Journal Medica Arteriana (Med-Art) Indonesian Journal of Applied Research (IJAR) Diponegoro International Medical Journal (DIMJ) Jurnal Kesehatan dr. Soebandi
Banundari Rachmawati
Department Of Clinical Pathology, Faculty Of Medicine, Universitas Diponegoro, Semarang
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Environmental Science Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health

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Journal : SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN

 1 
Effectiveness of Brown Algae Extract to Reduce Serum Malondialdehyde and Protein Carbonyl Levels in Streptozotocin-Induced Sprague Dawley Rats Batubara, Lusiana; Kristina, Tri N.; Rachmawati, Banundari
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 7, No 2 (2016): December 2016
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (334.148 KB) | DOI: 10.30659/sainsmed.v7i2.1172

Abstract

Introduction: Brown algae (Sargassum duplicatum) contains bioactive compound with natural antioxidant that may potentially decrease lipid peroxidation and protein oxidation process in diabetes mellitus. Objective: to prove the effectiveness of brown algae extract administration (150mg/kgBW; 300mg/kgBW and 450 mg/kGBW respectively) in reducing serum MDA and PCO levels in streptozotocin-induced sprague dawley rat. Methods: This experiment study used the post test only control group design. Twenty eight (28) Sprague dawley rats induced with Streptozotocin (STZ) 40 mg/kgBW (i.p) were divided into four groups (n=7). The first group was diabetic non treated group (control). The second to fourth groups were the diabetic rats which given brown algae extract (150mg/kgBW; 300mg/kgBW and 450 mg/kgBW respectively) for 30 days. Serum MDA and PCO levels were examined by using ELISA method. Data were analyzed using one way ANOVA.Results: There were no significant differences in serum MDA levels among groups (p=0,405). However, serum PCO level in group administered with 450mg/kgBW of brown algae extract decreased significantly compared to control group (p=0.001), group administered with 150mg/kgBW (p=0.001) and 300mg/kgBW (p=0,037). Conclusion: Administration of brown algae extract did not decrease serum MDA levels significantly. Administration of 450mg/kgBW brown algae extract is effective to decrease serum PCO level significantly.
Co-Authors Agung Aji Prasetyo, Agung Aji Ahmad Reza Ajoekesoema, Tanti Andreas Arie Setiawan Andrew Johan Aryu Candra Asri Ragil Kemuning Asti, Herniah Basti Andriyoko Budi Mulyono Corrie Abednego Crisdayani, Carissa Putri Cynthia Citra Darmono SS Devi Ermawati Dian Widyaningrum Dian Widyaningrum Djuara P Lubis Driyah, Srilaning Dwi Retnoningrum Dwi Retnoningrum Edi Dharmana Edward Kurnia Setiawan Limijadi Edward Kurnia Setiawan Limijadi Edward Kurnia Setiawan Limijadi, Edward Kurnia Setiawan Edwin Basyar Elida Soviana Febe Christianto Fifin Luthfia Rahmi Hardhono Susanto Herniah Asti Wulanjani Hertanto Wahyu Subagio Ida Parwati Ignatius Riwanto, Ignatius Indranila Kustarini Samsuria Indriani Silvia Innawati Jusup Kartika, Nadini Kurniawati, Dewi M Lestari, Sarah Syifa Lisyani Budipardigdo Suromo Luciana Sutanto Lusiana Batubara Mabruratussania Maherdika Mahmudah Hidayati Meita Hendrianingtyas Meita Hendrianingtyas Melkior Krisna Arondaya MI Diah P Mila Niqi Itami Muchlis Ahsan Udji Sofro Muh Agus Barliyan Muji Rahayu Nadini Kartika Niken Puruhita Novita Indayanie Novitasari, Sherly Nyoman Suci Widyastiti Permatasari, Narulita Dyah Prihartiwi Purnamasari Probosuseno Probosuseno, Probosuseno Purnama, Yugi Hari Chandra Purwanto AP Putri Theresia LA Bancin Resty Ryadinency Retnaningsih - Ria Triwardhani Riansari, Anugrah Riwanto Samsuria, Indranila K Sanjaya Santoso Santoso Jaeri Santoso Jaeri Setiawan L, Edward Kurnia Soeharyo Hadisaputro Sofyan Harahap Subandhini Arika Pradati Suhartono, Suhartono Suharyo Hadisaputro Sukartini, Ninik Sulistiana Jhon Desel Surohadi, Natra D. Syaravina, Elita Theresia Ilyan Tjokorda Gde Dalem Pemayun Tri Indah Winarni Tri N. Kristina, Tri N. Triwardhani, Ria Tulaar, Angela B. M. Wardhani, Avriana Pety Wibisono, Agoes Wicaksono, Maulana Akbar Wicaksono, Muhammad Agung Wibowo Yenny Yulianti Yoanita Pratiwi Budiwiyono Yuswo Supatmo