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All Journal Jurnal Penelitian Farmasi Indonesia Jurnal Sains dan Teknologi Farmasi Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) ALCHEMY Jurnal Penelitian Kimia Jurnal Penelitian Farmasi Indonesia Jurnal Pengabdian Magister Pendidikan IPA Pharmacoscript Journal of Fundamental and Applied Pharmaceutical Science Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan AS-SHIHA: JURNAL KESEHATAN Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan Journal Of Pharmacy
Noveri Rahmawati
Universitas Muhammadiyah Riau
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Education Energy Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Veterinary

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Rasionalitas Antibiotik Pasien Bronkitis Akut Anak Dengan Metode Gyssens Di RSIA Zainab Kota Pekanbaru Endri, Novtafia; Rahmawati, Ayu; Rahmawati, Noveri; Nesya, Nabilla Fadhia
The Journal Of Pharmacy Vol. 1 No. 1 (2023): Journal Of Pharmacy UMRI
Publisher : LPPM, Universitas Muhammadiyah Riau

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Abstract

According to WHO, as many as 13 million children in the world die every year and most of these deaths are in developing countries, where ISPA is one of the main causes of death by killing as many as 4 million children each year. Bronchitis ranks 6th out of 10 causes of death. However, Indonesia still has no reports on exact figures regarding this disease. This study aims to determine the accuracy of the use of antibiotics in pediatric patients with acute bronchitis based on the Gyssens method at RSIA Zainab Pekanbaru City. This type of research was non-experimental with data collection using a purposive sampling technique retrospectively. The results of the study based on a qualitative evaluation of the use of antibiotics in pediatric acute bronchitis patients at RSIA Zainab Pekanbaru City using the Gyssens method showed the quality of rational use of antibiotics found that 64 patients were declared rational ( category 0) and 5 patients were declared irrational. If possible further research regarding the rationality of using antibiotics in pediatric acute bronchitis patients at RSIA Zainab Pekanbaru City can be carried out using the DDD method or with a prospective approach so that monitoring of the patient's condition progress can be carried out from day to day.
Uji Aktivitas Antioksidan Ekstrak Etanol 70% Daun Pandan Wangi (Pandanus amaryllifolius Roxb) Dengan Metode DPPH Muhammad Arif; Ayu Rahmawati; Noveri Rahmawati; Nursyafni; Indah, Indah Kurniawati
The Journal Of Pharmacy Vol. 2 No. 1 (2024): Journal Of Pharmacy UMRI
Publisher : LPPM, Universitas Muhammadiyah Riau

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Antioxidants and free radicals are topics that are increasingly discussed in the field of health and lifestyle. Free radicals, which result from oxidative stress, are known to play a role in the development of many serious diseases, such as cancer, cardiovascular disorders and premature aging. Antioxidants are able to neutralize free radicals, thus having the potential to prevent or reduce the impact of these diseases. This study aims to evaluate the antioxidant activity of ethanol extract of pandan wangi leaves (Pandanus amaryllifolius Roxb) using the DPPH (2,2-diphenyl-1-picrylhydrazyl) method and determine the IC50 value as an indicator of effectiveness. Experimental methods were used to analyze antioxidant activity, with DPPH assays performed using a UV-Vis spectrophotometer. The results showed that the ethanol extract of pandan leaves had an IC50 value of 180.21 µg/mL, which was slightly lower than vitamin C as a positive control with an IC50 value of 136.03 µg/mL. Nevertheless, the antioxidant activity of pandan leaf extract is still in the moderate category, indicating its potential as a source of natural antioxidants. This study also emphasizes the importance of technical factors, such as temperature, incubation duration, and solvent quality, in influencing the test results. This study opens up opportunities for further development in the optimization of extraction and utilization of pandan wangi leaves as a natural ingredient to fight oxidative stress.
Cytotoxic Activity Testing The Extract of Leaves and Yellow Sirsak Fruit (Annona montana) using Method Brine Shrimp Lethality Test (BSLT) Rahmawati, Noveri; Hari, Dewi Gulyla; Tri Nova Lovena; Nurdina Putri; Rahma Dona; Rahma Cintya Faiza; Amini, Rahmi
The Journal Of Pharmacy Vol. 2 No. 2 (2025): Journal Of Pharmacy UMRI
Publisher : LPPM, Universitas Muhammadiyah Riau

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Abstract

The yellow sirsak plant (Annona montana) is an annonaceae family which has been used by the community as traditional medicine properties such as treating diarrhea, vitamin C deficiency and treating boils. This study aims to determine the cytotoxic activity of the larvae of Artemia salina Leach shrimp by using the BSLT method after giving extracts from the leaves and fruit of yellow sirsak (Annona montana). The results showed that the LC50 value of the n- hexane extract of yellow sirsak leaves was 45,84 µg/mL, the ethyl acetate extract of yellow sirsak leaves was 26,44 µg/mL and the ethanol extract of yellow sirsak leaves was 13,99 µg/mL. The n-hexane extract of yellow sirsak fruit was 31,46 µg/mL, the ethyl acetate extract was 40,45 µg/mL and the ethanol extract of the yellow sirsak fruit was 19,84 µg/mL. The mixture of n-hexane leaves and yellow sirsak fruit was 29,91 µg/mL, the ethyl acetate extract mixture of yellow sirsak leaves and fruit was 21,71 µg/mL and the mixture of ethanol extract and yellow sirsak fruit was 14,75 µg/mL. Based on the research results, it can be concluded that the ethanol extract of yellow sirsak leaves shows the most active cytotoxic activity with an LC50 value of 13,99 µg/mL.
Uji Aktivitas Antiinflamasi Ekstrak Etil Asetat Daun Tumbuhan Akar Kaik-Kaik (Uncaria cordata (Lour.) Merr) pada Tikus Putih (Rattus norvegicus) Jantan Noveri Rahmawati; Gulyla Hari, Dewi; Nurbaiti; Rahmawati, Ayu; Nursyafni; Indriani, Lusi; Lovena, Tri Nova; Arif, Muhammad; Hendri Sandi, Nofri
As-Shiha: Jurnal Kesehatan Vol. 3 No. 1 (2023): As-Shiha: Jurnal Kesehatan
Publisher : Fakultas MIPA dan Kesehatan, Universitas Muhammadiyah Riau

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Antiinflammatory activity of ethyl acetate extracts of the leaves of plant Akar Kaik-kaik Uncaria cordata (Lour.) Merr on white male rats. This research examined the quality of crude drugs and extracts ethyl acetate. It is intended to obtain raw materials which can ultimately ensure uniform pharmacologic effect. Antiinflammatory activity of the ethyl acetate extract were tested using the method of paw edema against white male rats. The research were 15 rats mile which divided into 5 groups. Negative control (Na CMC 1%), positive control (Na diklofenak dose 4,5 mg/kgBB) and extract group ethyl acetat with the dose 100, 200 and 400 mg/kgBB given orally. The volume measurement after subcutaneous injection caragen 1% performed with one hour interval for 5 hours assessing with pletysmometer and calculated the inhibition persen. The result of this study showed that the quality of crude drugs and extract ethyl acetate meet the specified requirements Indonesian Herbal Pharmacopoeia. Ethyl acetate extract has significant anti-inflammatory effects to the negative control at doses of 200 and 400 mg/kgBB while against the positive control did not differ significantly white male rats.
Uji Aktivitas Sitotoksik Ekstrak Kulit Batang Tumbuhan Akar Kaik-Kaik (Uncaria Cordata) (Lour.) Meer Dengan Metode Brine Shrimp Lethality Test (BSLT) Rahmawati, Noveri; Nurbaiti
As-Shiha: Jurnal Kesehatan Vol. 2 No. 2 (2022): As-Shiha: Jurnal Kesehatan
Publisher : Fakultas MIPA dan Kesehatan, Universitas Muhammadiyah Riau

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Abstract

In this study, a cytotoxic test of the root bark extract of kaik-kaik (Uncaria cordata)(Lour.)Merr was carried out using the Brine Shrimp Lethality Test (BSLT) method. The root bark extract of kaik-kaik (Uncaria cordata) (Lour.) Merr was obtained by maceration using n-hexane, ethyl acetate, and ethanol as solvents. The effect of each extract was identified on the percentage of mortality of Artemia salina Leach larvae and a probit analysis was calculated. The results showed that the three extracts provided cytotoxic activity with active categories with LC50 respectively, namely, 45.28 ug / ml, 55.08 ug / ml, 47.09 ug / ml which could be used as candidates for anti-cancer drugs
Uji Aktivitas Antiinflamasi Ekstrak Etanol Daun Tumbuhan Akar Kaik-Kaik (Uncaria cordata (Lour.) Merr) Terhadap Tikus Putih (Rattus norvegicus) Jantan Tri Nova Lovena; Rahmawati, Noveri
As-Shiha: Jurnal Kesehatan Vol. 2 No. 2 (2022): As-Shiha: Jurnal Kesehatan
Publisher : Fakultas MIPA dan Kesehatan, Universitas Muhammadiyah Riau

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The study has been carried out of antiinflammatory activity of ethanol extract leaves of plant akar kaik-kaik (Uncaria cordata (Lour.) Merr of the male white rat (Rattus norvegicus). The ethanol extract was first conducted quality checks extracts include: organoleptic test, Thin Layer Chromatography profiles (TLC), determination of water content, drying shrinkage, and ash content. The results showed the ethanol extract the requirements extracts in general. Further test antiinflammatory activity of the white rat (Rattus norvegicus) males using the paw edema. Animal trials were divided into 5 groups: negative control group Na CMC 1%, a positive control diclofenac sodium 4.5 mg/kg weight of the rat and the ethanol extract dose of 100, 200, and 400 mg/kg weight of the rat, the rats are challenged by a subcutaneous injection of 1% solution of carrageenan into the plantar side of the left hind paw, result showed that the ethanol extract doses of 100, 200 and 400 mg/kg weight of the rat had a significantly antiinflammatory activity (p <0.05).
Pharmacokinetic Prediction, Drug-Like Properties, and Molecular Docking of Bioactive Compounds from Ethanol Extract of Uncaria nervosa Elmer Leaves Rahmawati, Noveri; Herli, Muhammad Azhari; Delvi Andrianingsih; Rahmi Amini
The Journal Of Pharmacy Vol. 3 No. 1 (2025): Journal Of Pharmacy UMRI
Publisher : LPPM, Universitas Muhammadiyah Riau

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Abstract

Uncaria nervosa Elmer leaves are known to contain bioactive compounds with potential as natural drug candidates, yet their pharmacokinetic profiles, drug-likeness, and molecular affinity toward target proteins remain limitedly explored. This study aimed to evaluate the pharmacokinetic properties, drug-likeness, and molecular interaction potential of bioactive compounds from the ethanol extract of Uncaria nervosa leaves. An in silico approach was employed using SwissADME to analyze pharmacokinetic parameters (absorption, distribution metabolism, and excretion) and drug-likeness based on Lipinski’s and Veber’s rules, followed by molecular docking against proteins 6O0K and 2W3L using MOE software. The results showed that most compounds exhibited high gastrointestinal absorption, did not inhibit major CYP enzymes, and several complied with drug-likeness rules. Docking analysis revealed that ceratodictyol displayed the closest binding energy to the positive controls (doxorubicin and obatoclax), indicating strong molecular affinity, while N-formamide showed superior pharmacokinetic and drug-likeness properties. In conclusion, the combination of pharmacokinetic and docking data highlights ceratodictyol as the main candidate supported by N-formamide as a potential compound, suggesting that Uncaria nervosa leaf extract may serve as a promising natural source for anticancer drug development.
Perbandingan Rendemen dan Karakteristik Ekstrak Etanol 70% Daun Uncaria guianensis Berdasarkan Berbagai Metode Ekstraksi Rahmawati, Noveri; Amelya Zenidah; Irfan, Nawwar
The Journal Of Pharmacy Vol. 2 No. 2 (2025): Journal Of Pharmacy UMRI
Publisher : LPPM, Universitas Muhammadiyah Riau

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Abstract

Uncaria guianensis is a medicinal plant from the Rubiaceae family, known for its wide range of pharmacological activities, particularly as an anti-inflammatory and immunomodulator. The leaves are rich in secondary metabolites such as alkaloids, flavonoids, tannins, and triterpenoids, whose potential is strongly influenced by the extraction method employed. This study aimed to compare the yield and characteristics of 70% ethanol extracts of Uncaria guianensis leaves obtained through four extraction methods: maceration, percolation, soxhlet extraction, and sonication. Leaf samples were collected from Kampar Regency, Riau, processed into powdered simplicia, and extracted using 70% ethanol. The results of the study showed that the soxhletation method produced the highest yield, namely 65.16%, followed by the maceration, percolation, and sonication methods with yields of 46.42%; 38.20%; and 35.82%, respectively. Phytochemical screening confirmed that all extracts tested positive for the presence of flavonoids, alkaloids, tannins, saponins, steroids, and triterpenoids. In terms of physicochemical characteristics, the soxhlet extract exhibited the best quality, with the lowest ash content (1.00%) and moisture loss (0.53%). In conclusion, soxhlet extraction is the most effective method for producing 70% ethanol extracts of Uncaria guianensis leaves, both in terms of quantity (yield) and quality (ash content and moisture loss).
Aktivitas Antikoagulan Ekstrak Daun Pucuk Merah (Syzygium myrtifolium Walp.) pada Mencit Putih (Mus musculus L.) Lusi Indriani; Rahmawati, Noveri; Sartika Murni
The Journal Of Pharmacy Vol. 3 No. 1 (2025): Journal Of Pharmacy UMRI
Publisher : LPPM, Universitas Muhammadiyah Riau

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Red shoot leaves are known to contain secondary metabolic compounds such as alkaloids, flavonoids, tannins, triterpenoids, steroids, saponins, and phenolic compounds. Flavonoids are known to have cardioprotective activity, including the ability to inhibit platelet aggregation. This study aims to determine the potential of red shoot leaf extract (Syzygium myrtifolium Walp.) as an anticoagulant. The method used is the determination of coagulation time, carried out on days 0, 3, and 6, following the initial wounding of the mice’s tails. The tail is wounded using a sterile lancet at a distance at 2 cm from the tip, and blood is subsequently absorbed using a capillary tube. Coagulation time is measured by observing the formation of fibrin threads on the broken sections of the capillary tube every 15 seconds. Coagulation time is the time required for the formation of the fibrin thread. The study results on day 6 showed that the 100 mg/KgBW dose group of red shoot leaf ethanol extract demonstrated an effect of increasing coagulation time equivalent to the 100 mg acetosal group. Meanwhile, the 125 mg/KgBW dose group of red shoot leaf ethanol extract showed a stronger effect than the 100 mg acetosal group.
Isolasi Senyawa Metabolit Sekunder dari Ekstrak Metanol Kulit Batang Bauhinia semibifida Roxb. dan Uji Aktivitas Antioksidan Haiyul Fadhli; Nur Fitria Rohmatul Ummah; Noveri Rahmawati
ALCHEMY Jurnal Penelitian Kimia Vol 17, No 1 (2021): March
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/alchemy.17.1.42268.132-139

Abstract

Kulit batang Bauhinia semibifida Roxb. telah lama digunakan sebagai obat tradisional oleh masyarakat Melayu Lingga, Kepulauan Riau. Penelitian ini bertujuan untuk mengisolasi dan menguji aktivitas antioksidan senyawa metabolit sekunder dari ekstrak metanol kulit batang B. semibifida Roxb. Tiga isolat murni berupa satu senyawa alkaloid (BR1) dan dua senyawa flavonoid (BR2 dan BR3) telah berhasil diisolasi dengan cara ekstraksi menggunakan metode maserasi dan dilanjutkan fraksinasi dengan metode kromatografi kolom. Uji aktivitas antioksidan dilakukan terhadap isolat dengan metode 2,2 difenil-1-pikrilhidrazil (DPPH). Senyawa isolat BR1 menunjukan IC50 &gt;1000 µg/mL dikategorikan tidak aktif sebagai antioksidan, sedangkan senyawa isolat BR2 dan BR3 menunjukan IC50 2,92 µg/mL dan 4,39 µg/mL dikategorikan sangat kuat sebagai antioksidan jika dibandingkan dengan vitamin C sebagai kontrol. Berdasarkan evaluasi aktivitas antioksidan senyawa BR2 adalah senyawa pilihan yang dilanjutkan identifikasi dengan spektroskopi Fourier-Transform Infrared Spectroscopy (FTIR) dan Proton Nuclear Magnetic Resonance (1H-NMR) sehingga diduga senyawa isolat memiliki struktur dasar senyawa flavonoid.Isolation of Secondary Metabolite Compounds of Methanolic Extract of Steam Bark Bauhinia semibifida Roxb. and Their Antioxidant Activites. Stem bark of Bauhinia semibifida Roxb. has been long consumed as a medicinal herb by Lingga Malaya Ethnic. Therefore, this research aimed to isolate and examines the antioxidant activity of secondary metabolites from methanol extract of stembark of Bauhinia semibifida Roxb. Three pure compounds which are an alkaloid (BR1) and two flavonoids (BR2 and BR3) have been isolated by extraction using maceration method followed by fractionation using column chromatography method. Antioxidant activity assay was carried out by 2,2-Diphenyl-1-Picrylhydrazyl (DPPH) method. Compound BR1 showed IC50 &gt;1000 µg/mL categorized as inactive as an antioxidant, while compounds BR2 and BR3 showed IC50 2.92 µg/mL and 4.394 µg/mL, respectively, categorized as very strong as an antioxidant when compared to vitamin C as a control. Based on the evaluation of the antioxidant activity, the BR2 was selected compound and continued to identification by Fourier-Transform Infrared Spectroscopy (FTIR) and Proton Nuclear Magnetic Resonance (1H-NMR) spectroscopy so that the isolate has the basic structure of flavonoid compound.
Co-Authors Amelya Zenidah Amini, Rahmi Amri Bakhtiar Anita Lukman Ayu Rahmawati AYU RAHMAWATI Deddi Prima Putra Delvi Andrianingsih Deni Anggraini Dian Handayani Dwi Pratiwi Dwiki Septian Endamora Fina Aryani, Fina Haiyul Fadhli Hari, Dewi Gulyla Haris Nanda Prayoga Herli, Muhammad Azhari Husnawati Husnawati Husnunnisa I Ketut Suada INDAH KURNIAWATI Indriani, Lusi Irfan, Nawwar Khazanah Nurain Nurdin Lusi Indriani Meiriza Djohari, Meiriza Muhammad Arif Muhammad Arif Nani Suhaeni Nawwar Irfan Nesya, Nabilla Fadhia Nofri Hendri Sandi Nofri Mulyanti Novtafia Endri Nur Fitria Rohmatul Ummah Nur Indah Melati Nurbaiti Nurdina Putri Nursyafni Nurul Adzkia Ghearizky Putri Tri Hartini Putri, Nurdina Rahma Cintya Faiza Rahma Dona Rahmi Amini Restu Anisa Putri Rialita Lifiani Rizky Rindiana Rusnedy, Rahmayati Sari Rahmadhani Sartika Murni Sinata, Novia Siti Hafsah Tania Tiara Efendi Tri Nova Lovena