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All Journal Jurnal Penelitian Farmasi Indonesia Jurnal Sains dan Teknologi Farmasi Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) ALCHEMY Jurnal Penelitian Kimia Jurnal Penelitian Farmasi Indonesia Pharmacoscript Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan AS-SHIHA: JURNAL KESEHATAN Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan Journal Of Pharmacy
Noveri Rahmawati
Universitas Muhammadiyah Riau
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Education Energy Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Veterinary

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PENGARUH PEMBERIAN EKSTRAK ETANOL DAUN TUMBUHAN AKAR KAIK-KAIK (Uncaria cordata (Lour.)Merr) TERHADAP KADAR TRIGLISERIDA SERUM TIKUS PUTIH (Rattus norvegicus) JANTAN Meiriza Djohari; Dwi Pratiwi; Novia Sinata; Noveri Rahmawati
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 9 No. 2 (2023): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v9i2.679

Abstract

Hypertriglyceridemia is a condition when there is an increase in triglyceride levels in the blood. Hypertriglyceridemia can cause heart problems. One of the plants that can be used as medicine is the root plant kaik-kaik (Uncaria cordata (lour.) Merr). This study aims to determine the effect of giving ethanol extract of kaik-kaik (Uncaria cordata (lour.) Merr) leaves on serum triglyceride levels of male white rats (Rattus norvegicus). The parameters used were serum triglyceride levels of male white rats induced by high fat feed, namely quail egg yolk as much as 10 ml/kgBB. This study used 18 male white rats which were divided into 6 groups with 3 rats per group. The normal group was fed only with rats and Na CMC suspension, the negative group was given high-fat feed induction and Na CMC suspension. The positive group was given high-fat feed induction and 0.9 mg/kgBB of atorvastatin suspension. The treatment group was given high-fat feed and a suspension of ethanol extract of kaik-kaik root leaves at doses of 100, 200, and 400 mg/kgBB as much as 1% of body weight given orally. The method used was colorimetric enzymatic using a Mindray® photometer (BA-88A) at a wavelength of 510 nm. Triglyceride level data on days 0, 15, 22 and 29 were analyzed by one-way ANOVA test and repeated ANOVA. The results showed that the ethanol extract of kaik-kaik root (Uncaria cordata (Lour.) Merr) leaves at doses of 100, 200 and 400 mg/kgBB had an effect in reducing serum triglyceride levels of male white rats (Rattus norvegicus) indicated by differences. which was significant (p <0.05) with negative control and showed activity to decrease triglyceride levels which was not significantly different (p> 0.05) with atorvastatin.
Rasionalitas Antibiotik Pasien Bronkitis Akut Anak Dengan Metode Gyssens Di RSIA Zainab Kota Pekanbaru Endri, Novtafia; Rahmawati, Ayu; Rahmawati, Noveri; Nesya, Nabilla Fadhia
The Journal Of Pharmacy Vol. 1 No. 1 (2023): Journal Of Pharmacy UMRI
Publisher : LPPM, Universitas Muhammadiyah Riau

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Abstract

According to WHO, as many as 13 million children in the world die every year and most of these deaths are in developing countries, where ISPA is one of the main causes of death by killing as many as 4 million children each year. Bronchitis ranks 6th out of 10 causes of death. However, Indonesia still has no reports on exact figures regarding this disease. This study aims to determine the accuracy of the use of antibiotics in pediatric patients with acute bronchitis based on the Gyssens method at RSIA Zainab Pekanbaru City. This type of research was non-experimental with data collection using a purposive sampling technique retrospectively. The results of the study based on a qualitative evaluation of the use of antibiotics in pediatric acute bronchitis patients at RSIA Zainab Pekanbaru City using the Gyssens method showed the quality of rational use of antibiotics found that 64 patients were declared rational ( category 0) and 5 patients were declared irrational. If possible further research regarding the rationality of using antibiotics in pediatric acute bronchitis patients at RSIA Zainab Pekanbaru City can be carried out using the DDD method or with a prospective approach so that monitoring of the patient's condition progress can be carried out from day to day.
Uji Aktivitas Antioksidan Ekstrak Etanol 70% Daun Pandan Wangi (Pandanus amaryllifolius Roxb) Dengan Metode DPPH Muhammad Arif; Ayu Rahmawati; Noveri Rahmawati; Nursyafni; Indah, Indah Kurniawati
The Journal Of Pharmacy Vol. 2 No. 1 (2024): Journal Of Pharmacy UMRI
Publisher : LPPM, Universitas Muhammadiyah Riau

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Abstract

Antioxidants and free radicals are topics that are increasingly discussed in the field of health and lifestyle. Free radicals, which result from oxidative stress, are known to play a role in the development of many serious diseases, such as cancer, cardiovascular disorders and premature aging. Antioxidants are able to neutralize free radicals, thus having the potential to prevent or reduce the impact of these diseases. This study aims to evaluate the antioxidant activity of ethanol extract of pandan wangi leaves (Pandanus amaryllifolius Roxb) using the DPPH (2,2-diphenyl-1-picrylhydrazyl) method and determine the IC50 value as an indicator of effectiveness. Experimental methods were used to analyze antioxidant activity, with DPPH assays performed using a UV-Vis spectrophotometer. The results showed that the ethanol extract of pandan leaves had an IC50 value of 180.21 µg/mL, which was slightly lower than vitamin C as a positive control with an IC50 value of 136.03 µg/mL. Nevertheless, the antioxidant activity of pandan leaf extract is still in the moderate category, indicating its potential as a source of natural antioxidants. This study also emphasizes the importance of technical factors, such as temperature, incubation duration, and solvent quality, in influencing the test results. This study opens up opportunities for further development in the optimization of extraction and utilization of pandan wangi leaves as a natural ingredient to fight oxidative stress.
Cytotoxic Activity Testing The Extract of Leaves and Yellow Sirsak Fruit (Annona montana) using Method Brine Shrimp Lethality Test (BSLT) Rahmawati, Noveri; Hari, Dewi Gulyla; Tri Nova Lovena; Nurdina Putri; Rahma Dona; Rahma Cintya Faiza; Amini, Rahmi
The Journal Of Pharmacy Vol. 2 No. 2 (2025): Journal Of Pharmacy UMRI
Publisher : LPPM, Universitas Muhammadiyah Riau

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Abstract

The yellow sirsak plant (Annona montana) is an annonaceae family which has been used by the community as traditional medicine properties such as treating diarrhea, vitamin C deficiency and treating boils. This study aims to determine the cytotoxic activity of the larvae of Artemia salina Leach shrimp by using the BSLT method after giving extracts from the leaves and fruit of yellow sirsak (Annona montana). The results showed that the LC50 value of the n- hexane extract of yellow sirsak leaves was 45,84 µg/mL, the ethyl acetate extract of yellow sirsak leaves was 26,44 µg/mL and the ethanol extract of yellow sirsak leaves was 13,99 µg/mL. The n-hexane extract of yellow sirsak fruit was 31,46 µg/mL, the ethyl acetate extract was 40,45 µg/mL and the ethanol extract of the yellow sirsak fruit was 19,84 µg/mL. The mixture of n-hexane leaves and yellow sirsak fruit was 29,91 µg/mL, the ethyl acetate extract mixture of yellow sirsak leaves and fruit was 21,71 µg/mL and the mixture of ethanol extract and yellow sirsak fruit was 14,75 µg/mL. Based on the research results, it can be concluded that the ethanol extract of yellow sirsak leaves shows the most active cytotoxic activity with an LC50 value of 13,99 µg/mL.
Uji Aktivitas Antiinflamasi Ekstrak Etil Asetat Daun Tumbuhan Akar Kaik-Kaik (Uncaria cordata (Lour.) Merr) pada Tikus Putih (Rattus norvegicus) Jantan Noveri Rahmawati; Gulyla Hari, Dewi; Nurbaiti; Rahmawati, Ayu; Nursyafni; Indriani, Lusi; Lovena, Tri Nova; Arif, Muhammad; Hendri Sandi, Nofri
As-Shiha: Jurnal Kesehatan Vol. 3 No. 1 (2023): As-Shiha: Jurnal Kesehatan
Publisher : Fakultas MIPA dan Kesehatan, Universitas Muhammadiyah Riau

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Abstract

Antiinflammatory activity of ethyl acetate extracts of the leaves of plant Akar Kaik-kaik Uncaria cordata (Lour.) Merr on white male rats. This research examined the quality of crude drugs and extracts ethyl acetate. It is intended to obtain raw materials which can ultimately ensure uniform pharmacologic effect. Antiinflammatory activity of the ethyl acetate extract were tested using the method of paw edema against white male rats. The research were 15 rats mile which divided into 5 groups. Negative control (Na CMC 1%), positive control (Na diklofenak dose 4,5 mg/kgBB) and extract group ethyl acetat with the dose 100, 200 and 400 mg/kgBB given orally. The volume measurement after subcutaneous injection caragen 1% performed with one hour interval for 5 hours assessing with pletysmometer and calculated the inhibition persen. The result of this study showed that the quality of crude drugs and extract ethyl acetate meet the specified requirements Indonesian Herbal Pharmacopoeia. Ethyl acetate extract has significant anti-inflammatory effects to the negative control at doses of 200 and 400 mg/kgBB while against the positive control did not differ significantly white male rats.
Uji Aktivitas Sitotoksik Ekstrak Kulit Batang Tumbuhan Akar Kaik-Kaik (Uncaria Cordata) (Lour.) Meer Dengan Metode Brine Shrimp Lethality Test (BSLT) Rahmawati, Noveri; Nurbaiti
As-Shiha: Jurnal Kesehatan Vol. 2 No. 2 (2022): As-Shiha: Jurnal Kesehatan
Publisher : Fakultas MIPA dan Kesehatan, Universitas Muhammadiyah Riau

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Abstract

In this study, a cytotoxic test of the root bark extract of kaik-kaik (Uncaria cordata)(Lour.)Merr was carried out using the Brine Shrimp Lethality Test (BSLT) method. The root bark extract of kaik-kaik (Uncaria cordata) (Lour.) Merr was obtained by maceration using n-hexane, ethyl acetate, and ethanol as solvents. The effect of each extract was identified on the percentage of mortality of Artemia salina Leach larvae and a probit analysis was calculated. The results showed that the three extracts provided cytotoxic activity with active categories with LC50 respectively, namely, 45.28 ug / ml, 55.08 ug / ml, 47.09 ug / ml which could be used as candidates for anti-cancer drugs
Uji Aktivitas Antiinflamasi Ekstrak Etanol Daun Tumbuhan Akar Kaik-Kaik (Uncaria cordata (Lour.) Merr) Terhadap Tikus Putih (Rattus norvegicus) Jantan Tri Nova Lovena; Rahmawati, Noveri
As-Shiha: Jurnal Kesehatan Vol. 2 No. 2 (2022): As-Shiha: Jurnal Kesehatan
Publisher : Fakultas MIPA dan Kesehatan, Universitas Muhammadiyah Riau

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Abstract

The study has been carried out of antiinflammatory activity of ethanol extract leaves of plant akar kaik-kaik (Uncaria cordata (Lour.) Merr of the male white rat (Rattus norvegicus). The ethanol extract was first conducted quality checks extracts include: organoleptic test, Thin Layer Chromatography profiles (TLC), determination of water content, drying shrinkage, and ash content. The results showed the ethanol extract the requirements extracts in general. Further test antiinflammatory activity of the white rat (Rattus norvegicus) males using the paw edema. Animal trials were divided into 5 groups: negative control group Na CMC 1%, a positive control diclofenac sodium 4.5 mg/kg weight of the rat and the ethanol extract dose of 100, 200, and 400 mg/kg weight of the rat, the rats are challenged by a subcutaneous injection of 1% solution of carrageenan into the plantar side of the left hind paw, result showed that the ethanol extract doses of 100, 200 and 400 mg/kg weight of the rat had a significantly antiinflammatory activity (p <0.05).
Co-Authors Amini, Rahmi Amri Bakhtiar Anita Lukman Ayu Rahmawati AYU RAHMAWATI Deddi Prima Putra Deni Anggraini Dian Handayani Dwi Pratiwi Dwiki Septian Fina Aryani, Fina Gulyla Hari, Dewi Haiyul Fadhli Hari, Dewi Gulyla Haris Nanda Prayoga Hendri Sandi, Nofri Husnawati Husnawati I Ketut Suada Indah, Indah Kurniawati Indriani, Lusi Lovena, Tri Nova Meiriza Djohari, Meiriza Muhammad Arif Muhammad Arif Nani Suhaeni Nesya, Nabilla Fadhia Nofri Mulyanti Novtafia Endri Nur Fitria Rohmatul Ummah Nur Indah Melati Nurbaiti Nurdina Putri Nursyafni Rahma Cintya Faiza Rahma Dona Rusnedy, Rahmayati Sinata, Novia Siti Hafsah Tania Tiara Efendi Tri Nova Lovena