Article Per Year (5 Year)
p-Index From 2021 - 2026
2.811
P-Index
This Author published in this journals
All Journal Jurnal Penelitian Farmasi Indonesia Jurnal Sains dan Teknologi Farmasi Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) ALCHEMY Jurnal Penelitian Kimia Jurnal Penelitian Farmasi Indonesia Jurnal Pengabdian Magister Pendidikan IPA Pharmacoscript Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan AS-SHIHA: JURNAL KESEHATAN Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan Journal Of Pharmacy
Noveri Rahmawati
Universitas Muhammadiyah Riau
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Education Energy Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Veterinary

Published : 21 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 21 Documents
Search

 1   2   3 
Isolasi Senyawa Metabolit Sekunder dari Ekstrak Metanol Kulit Batang Bauhinia semibifida Roxb. dan Uji Aktivitas Antioksidan Haiyul Fadhli; Nur Fitria Rohmatul Ummah; Noveri Rahmawati
ALCHEMY Jurnal Penelitian Kimia Vol 17, No 1 (2021): March
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/alchemy.17.1.42268.132-139

Abstract

Kulit batang Bauhinia semibifida Roxb. telah lama digunakan sebagai obat tradisional oleh masyarakat Melayu Lingga, Kepulauan Riau. Penelitian ini bertujuan untuk mengisolasi dan menguji aktivitas antioksidan senyawa metabolit sekunder dari ekstrak metanol kulit batang B. semibifida Roxb. Tiga isolat murni berupa satu senyawa alkaloid (BR1) dan dua senyawa flavonoid (BR2 dan BR3) telah berhasil diisolasi dengan cara ekstraksi menggunakan metode maserasi dan dilanjutkan fraksinasi dengan metode kromatografi kolom. Uji aktivitas antioksidan dilakukan terhadap isolat dengan metode 2,2 difenil-1-pikrilhidrazil (DPPH). Senyawa isolat BR1 menunjukan IC50 >1000 µg/mL dikategorikan tidak aktif sebagai antioksidan, sedangkan senyawa isolat BR2 dan BR3 menunjukan IC50 2,92 µg/mL dan 4,39 µg/mL dikategorikan sangat kuat sebagai antioksidan jika dibandingkan dengan vitamin C sebagai kontrol. Berdasarkan evaluasi aktivitas antioksidan senyawa BR2 adalah senyawa pilihan yang dilanjutkan identifikasi dengan spektroskopi Fourier-Transform Infrared Spectroscopy (FTIR) dan Proton Nuclear Magnetic Resonance (1H-NMR) sehingga diduga senyawa isolat memiliki struktur dasar senyawa flavonoid.Isolation of Secondary Metabolite Compounds of Methanolic Extract of Steam Bark Bauhinia semibifida Roxb. and Their Antioxidant Activites. Stem bark of Bauhinia semibifida Roxb. has been long consumed as a medicinal herb by Lingga Malaya Ethnic. Therefore, this research aimed to isolate and examines the antioxidant activity of secondary metabolites from methanol extract of stembark of Bauhinia semibifida Roxb. Three pure compounds which are an alkaloid (BR1) and two flavonoids (BR2 and BR3) have been isolated by extraction using maceration method followed by fractionation using column chromatography method. Antioxidant activity assay was carried out by 2,2-Diphenyl-1-Picrylhydrazyl (DPPH) method. Compound BR1 showed IC50 >1000 µg/mL categorized as inactive as an antioxidant, while compounds BR2 and BR3 showed IC50 2.92 µg/mL and 4.394 µg/mL, respectively, categorized as very strong as an antioxidant when compared to vitamin C as a control. Based on the evaluation of the antioxidant activity, the BR2 was selected compound and continued to identification by Fourier-Transform Infrared Spectroscopy (FTIR) and Proton Nuclear Magnetic Resonance (1H-NMR) spectroscopy so that the isolate has the basic structure of flavonoid compound.
Co-Authors Amelya Zenidah Amini, Rahmi Amri Bakhtiar Anita Lukman AYU RAHMAWATI Ayu Rahmawati Deddi Prima Putra Delvi Andrianingsih Deni Anggraini Dian Handayani Dwi Pratiwi Dwiki Septian Fina Aryani, Fina Haiyul Fadhli Hari, Dewi Gulyla Haris Nanda Prayoga Hendri Sandi, Nofri Herli, Muhammad Azhari Husnawati Husnawati I Ketut Suada Indah, Indah Kurniawati Indriani, Lusi Irfan, Nawwar Lifiani, Rialita Lusi Indriani Meiriza Djohari, Meiriza Muhammad Arif Muhammad Arif Nani Suhaeni Nawwar Irfan Nesya, Nabilla Fadhia Nofri Mulyanti Novtafia Endri Nur Fitria Rohmatul Ummah Nur Indah Melati Nurbaiti Nurdina Putri Nursyafni Nurul Adzkia Ghearizky Rahma Cintya Faiza Rahma Dona Rahmi Amini Rusnedy, Rahmayati Sartika Murni Sinata, Novia Siti Hafsah Tania Tiara Efendi Tri Nova Lovena