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Journal : Jaringan Laboratorium Medis

Pengaruh Pemberian Alkohol Peroral Terhadap Nilai Mean Corpuscular Volume, Morfologi Eritrosit Darah Tepi dan Normoblas Sumsum Tulang Rodhi Hartono; Soewono Soewono; Tri Ratnaningsih
Jaringan Laboratorium Medis Vol 1, No 1 (2019): May 2019
Publisher : Poltekkes Kemenkes Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jlm.v1i1.5161

Abstract

A true experimental research with pre-post test control group design was carried out using 36 adult experimental male rats (strain wistar Rattus norvegicus) ,aged 10 weeks with weight of 200-250 grams. Before being given the treatment, the rats blood were taken out around 1,5 cc to measure the MCV value and the erythrocyte morphology. The rats were divided into 6 groups. The first group was the control group and the other five were the treatment group which were treated with different concentration of alcohol continuously for 45 days. After being treated, the rats blood were taken as same as the investigator did previously to examine the MCV value and the erythrocyte morphology, included the removal of right femur to assess morphology and bone marrow normoblast diameter. Results of the study showed that  there was increasing  on  MCV value after the treatment that was proportional to the  alcohol  concentration given (p 0.0000.05), likewise the changing of erythrocyte morphology was in term of acanthocytes  target cells, and stomatocyt . However, these research findings showed that there were no significant different in each group resulting  of the treatment (p 0.817 0.05). Yet,there was an inclination of normoblast diameter. Finally, it can be concluded that consuming oral alcohol continuously increases the MCV value, changing of erythrocyte morphology and bone marrow normoblast.
Pengaruh Pemberian Alkohol Peroral Terhadap Nilai Mean Corpuscular Volume, Morfologi Eritrosit Darah Tepi dan Normoblas Sumsum Tulang Hartono, Rodhi; Soewono, Soewono; Ratnaningsih, Tri
Jaringan Laboratorium Medis Vol. 1 No. 1 (2019): May 2019
Publisher : Poltekkes Kemenkes Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jlm.v1i1.5161

Abstract

A true experimental research with pre-post test control group design was carried out using 36 adult experimental male rats (strain wistar Rattus norvegicus) ,aged 10 weeks with weight of 200-250 grams. Before being given the treatment, the rats blood were taken out around 1,5 cc to measure the MCV value and the erythrocyte morphology. The rats were divided into 6 groups. The first group was the control group and the other five were the treatment group which were treated with different concentration of alcohol continuously for 45 days. After being treated, the rats blood were taken as same as the investigator did previously to examine the MCV value and the erythrocyte morphology, included the removal of right femur to assess morphology and bone marrow normoblast diameter. Results of the study showed that  there was increasing  on  MCV value after the treatment that was proportional to the  alcohol  concentration given (p 0.000<0.05), likewise the changing of erythrocyte morphology was in term of acanthocytes  target cells, and stomatocyt . However, these research findings showed that there were no significant different in each group resulting  of the treatment (p 0.817 > 0.05). Yet,there was an inclination of normoblast diameter. Finally, it can be concluded that consuming oral alcohol continuously increases the MCV value, changing of erythrocyte morphology and bone marrow normoblast.
Co-Authors ADAM FERDIANSYAH Adnan, Muhammad Luthfi Afiahayati Afiahayati, Afiahayati Aflifia Birruni Sabila AGUS AGUS Agustiawan, Agustiawan Amar Akbar Ambarwati, Tri Juningaju Andini, Yusria Annis Catur Adi Antariksa, Putri Mayang Sari Arijadi, Desi Arta Farmawati Astutik, Widya Asysyifa, Azzahra Ayu Sari Ning Ati Br. Karo, Dina Andriani Budi Mulyono Caibigan, Ritchie Natuan Chatarina Umbul Wahyuni Dian Nugraheni Diannisa Ikarumi Dicky Moch Rizal Dicky Moch Rizal Dimas Chaerul Ekty Saputra Donytra Arby Wardhana Dwi Aris Agung Nugrahaningsih Dwi Cahyani Ratna Sari Dyah Aruming Tyas E. Elsa Herdiana Murhandarwati Ellsyana Erdyan Romadeni putri Elna, Nandara Priyanti Eti Nurwening Sholikhah Faisal Ibnu Fardhiasih Dwi Astuti Fatimah, Bunga Futri, Irianna Hadi Prayitno, Hadi Hanggoro Tri Rinonce Harahap, Nur Imma Hari Basuki Notobroto Harmaniati, Harmaniati Heriyanto Putri, Rona Hafida Heriyanto, Moch Junaidy Hilmia Fahma Ibnu, Faizal Ifa Roifah Ima Rahmawati Imam Zainuri Indah Lestari, Indah Indra Lesmana Indra Yulianti Iwan Dwiprahasto Jaya, Sudi Indra La Tabari, Muhammad Fadhlan Lutfi Wahyuni Mahardika Agus Wijayanti Mariadi, M. Meilinawati, Elies Miftahurrahmi, Rofifah Muhammad Sajidin Muliasih, Mulat Mulyadi Mulyadi Mulyati Mulyati Muryadi, Elvaro Islami Niken Satuti Nur Handayani Nilam Purwa Seven, Nilam Nina Widyaningrum Nisa, Afifah Khairu Nurrahma, Bira Arumndari Pagan, Muasir Phann, Raksmey Prajna Paramita, Prajna Putri, Rona Hafida Heriyanto Retnowati, Jajuk Rina Nur Hidayati Rina Susilowati Ristya Widi Endah Yani Riza Anama, Riza Rizki A. Gumilang Rodhi Hartono Rodhi Hartono Rosalia, Sabella Rahmawati, Rhea Santoso, Griselda Elisse Sasangka, Bambang Sismindari . Sitawati, Andini Dyah Siti Indatul Laili siti indatul laili, siti indatul Siti Mas Miranda Soewono Soewono Soewono, Soewono Sunat, Khamron Supargiyono - Supatmini, Erna Suryono Yudha Patria Sutaryo Sutaryo Syarifa, Cut Alima Teguh Triyono Titik Nuryastuti Titis Murti Utami, Titis Tri Peni Tri Peni, Tri Tria Wahyu Ningrum Tristifany, Annisa Tun, Su Sandi Hla Usi Sukorini Usman, Muhammad Alvin Ramadhan Widiyanti, Ayu Tri Widodo, Irianiwati Widya Asmara Widyasari, Vita Wijayanti, Lumastari Ajeng Win, Thinzar Aung Windarwati, Windarwati Windu Santoso, Windu Yanasta Yudo Pratama Yusnaini Yusnaini Zakiyah, Nurul Zakiyah, Nurul Zamroni, Asroful Hulam