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All Journal Prosiding Seminar Nasional Sains Dan Teknologi Fakultas Teknik As-syifaa Jurnal Farmasi Adi Widya : Jurnal Pengabdian Masyarakat Journal of Dedicators Community JPSCR : Journal of Pharmaceutical Science and Clinical Research Jurnal Farmasi Indonesia Journal Syifa Sciences and Clinical Research (JSSCR) Jurnal Biomedika Abdimas UNWAHAS : Jurnal Pengabdian Masyarakat UNWAHAS Intan Husada : Jurnal Ilmiah Keperawatan Jurnal Farmasi Jurnal Farmasi dan Sains Indonesia (JFSI) Journal of Fundamental and Applied Pharmaceutical Science Jurnal Pengabdian kepada Masyarakat Jurnal Buana Farma Indonesian Journal of Pharmaceutical Education Media Farmasi Indonesia Indonesian Journal of Pharmacy and Natural Product Parapemikir Jurnal Ilmiah Farmasi Prosiding Seminar Nasional Unimus
Reslely Harjanti
Program Studi S1 Farmasi, Fakultas Farmasi, Universitas Setia Budi Jl. LetJend.Sutoyo Mojosongo, Solo 57127.
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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PENGARUH VARIASI KONSENTRASI AVICEL PH 101 DAN LAKTOSA SEBAGAI HOST DALAM PEMBUATAN TABLET CAMPURAN INTERAKTIF GLIMEPIRID MENGGUNAKAN METODE KEMPA LANGSUNG Nugroho, Muhammad Agung; Kuncahyo, Ilham; Harjanti, Reslely
Jurnal Farmasi & Sains Indonesia Vol 8 No 2 (2025)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol8no2p80-91

Abstract

Glimepirid is an antidiabetic drug from the sulfonylurea class with low solubility, thus requiring a formulation approach to improve its bioavailability. This study aimed to examine the effect of varying concentrations of avicel pH 101 and lactose as carrier (host) materials on the physical properties and dissolution profile of glimepirid tablets prepared using the direct compression method. Three formulas were developed with avicel pH 101:lactose ratios: F1 (1:0.5), F2 (1:1), and F3 (1.5:1). Quality evaluation included tests of granule flow properties (angle of repose and flow time) and physical tablet tests (content uniformity, hardness, friability, disintegration time, and dissolution) based on the Indonesian Pharmacopoeia. ANOVA statistical analysis showed significant differences between formulas (p < 0.05). The results indicated that variations in avicel pH 101 and lactose concentrations affected the physical quality and dissolution profile of the tablets. Formula 1 had the fastest disintegration time and the highest drug release. Formula 2 demonstrated the best content uniformity, good powder flow, and stable dissolution. Formula 3 produced the hardest tablets with the lowest friability but required longer disintegration time. Formula 2 was considered the most optimal and is recommended for further development of glimepirid tablets.
Co-Authors - Supriyadi Amanda Duta Wijaya Ana Indrayati Angeline Tamara Anita Nilawati Astiti Noer Cahyati Ayu Bainunniza Ayu Wikandita, Kharisma Benedikta Coo Mogi Bunga Fitri Hariyani Dewi Ekowati Dewi Purnamasari, Nur Aini Dyonisius Andang Arif Wibawa Dzulhija, Aleyda Freshananda Endang Sri Rejeki Fitri Jati Rukmana Freshananda Dzulhija, Aleyda Gregorius Prima Indra Budianto, Gregorius Prima Indra Gunawan Pamudji Hariyani, Bunga Fitri Ilham Kuncahyo Ilham Kuncahyo, Ilham Indra Meilina Yusefa Intan Pratiwi Jason Merari Peranginangin Mamik Ponco Rahayu Ni Wayan Devy Indah Lestari Nilawati, Anita Noela Riski Riani Sumbung Nugroho, Muhammad Agung NURAINI HARMASTUTI Nurrohim, Suci Padusitrada Padusitrada Pratiwi, Intan Priyanto, Widodo Pudiastuti R.S.P R.F.X Premihadi Putra Rahmatudina, Farikha Ratno Agung Samsumaharto Sandra Eka Purna Sari Sari, Sandra Eka Purna Sarimanah, Jamilah Sarimanah, Jamilah Sawal, Rizky Ardian Hartanto Senja, Salsadella Juwita SEPTINA DYAH NUGRAENI Sesilia Putri Nandita Siti Aisiyah Siti Aisiyah Siti Aisiyah Siti Aisyah Siti Aisyah Suhartinah Suhartinah Suhartinah Suhartinah, Suhartinah Sulastri   Titik Sunarni Titik Sunarni Vivin Nopiyanti Widodo Priyanto Widyasti, Jena Hayu Yari Mukti Wibowo