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All Journal Jurnal Kedokteran Brawijaya Jurnal Kesehatan Reproduksi Universa Medicina Indonesian Journal of Medicine Journal of Maternal and Child Health Proceedings of the International Conference on Nursing and Health Sciences Folia Medica Indonesiana
Supriyadi Hari Respati
Bagian Obgin FK UNS/ RSUD Dr. Moewardi, Jl. Kol. Sutarto 132 Surakarta
Biochemistry, Genetics & Molecular Biology Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Public Health

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Effect of cognitive behavioral therapy for serotonin level, depression score and quality of life in cervical cancer patients Soetrisno, Soetrisno; Sulistyowati, Sri; Respati, Supriyadi Hari; Nasrudin, Muhamad
Folia Medica Indonesiana Vol. 52, No. 3
Publisher : Folia Medica Indonesiana

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Abstract

Cervical cancer is the most common cause of death among gynaecological neoplasms. Management of advanced cervical cancer currently has not been able to improve the prognosis. Standard intervention therapy, chemotherapy and radiotherapy, as well as the emerging pain could lead to psychological stress till depression, thus reduce patients' quality of life. CBT for psychological stress and depression is expected to improve the fruitfulness of standard therapy. Serotonin is a neurotransmitter which plays a role in the patophysiology of depression. The aim of this study is to analyze the effect of cognitive behavioral therapy on serotonin level, depression score and quality of life in advanced cervical cancer patient with experimental quasi pre and post test design methods. The samples are 15 subjects in both intervention and control groups. Intervention group was given CBT and standard therapy, while control group was given standard therapy only. Study was held in Department of Obstetric and Gynecologic Dr. Moewardi Hospital Surakarta and Prodia Laboratory, in January to March 2015. Independent variable was advanced cervical cancer patients underwent CBT intervention and dependent variables were serotonin level, depression score and quality of life score. The result, serotonin level and quality of life scores were higher after intervention compared with control, (219.43±33,42 vs 89.57±23.23) and (85.13±14.62 vs 41.86±7.24), respectively. Depression score was lower after intervention than without CBT intervention (11.20±4.94 vs 17.00±4.86) and statistically significant (p < 0.05). So, there were effects of cognitive behavioural therapy on serotonin level, depression score and quality of life score in cervical cancer patients and were statistically significant.
Co-Authors -, Soetrisno - Adhi, Kresno Condro Adiyana, Febrian Andhika Alamsyah, Meuthia Ambar Mudigdo Antonius Budi Giri Bawono, Antonius Budi Giri Aris Sudiyanto Aristin, Okid Parama Astetri, Lini Bachnas, Muhammad Adrianes Bambang Eko Wiyono, Bambang Eko Carissa, Dinda Diffah Hanim Ediningtyas, Atifa Nadira Elita Rahmi Eriana Melinawati Eric Edwin Yuliantara Fitriawan, Ahmad Hermawan Udiyanto Heru Priyanto John Arianto Sondakh, John Arianto Kartikasari, Uswatun Khasanah Karuniawati, Benny Khoeronisa, Siti Kurniawan, Hendro Kusnadi, Noferi Laqif, Abdurahman Mahandaru, Araafi Hariza Miftahus Saadah, Miftahus Mubarokah, Rizka Innayatun Muhammad Adrianes Bachnas MUHAMMAD AGUS SUPRAYUDI Nababan, Ronald Nasrudin, Muhamad Nugroho, Muhammad Anggit Nurinasari, Hafi Nutria Widya Purna Anggraini Nuur, Aliffudin Okid Parama Astirin Pella Todungbua', Prima Derry Pradana, Muhammad Denny Gagah Prasetya, Hanung Pujojati, Ferri Waluyo Wiwoho Rahmawati, Deni Nur Fauzia Rahmawati, Oktantia Dyah Ratna Diana Fransiska Ratnasari Dwi Cahyanti, Ratnasari Dwi Ratnasari, Affi Angelia Ridwan, Robert Rizkiani, Inne Saputra, Ricky Bernadi Sesunan, Arfan Syahfani SITI MARYANI Soetrisno Kasan Wiharjo, Soetrisno Kasan Soetrisno Soetrisno Sri Mulyani Sri Sulistyowati Sulistywati, Sri Uki Retno Budihastuti Wiraswesty, Ika WISNU PRABOWO Yeni Andriani, Yeni Yuliani, Saffana Oka