Article Per Year (5 Year)
p-Index From 2021 - 2026
4.75
P-Index
This Author published in this journals
All Journal JURNAL GIZI INDONESIA Nurse Media Journal of Nursing UG Journal Journal of Nutrition College Forum Agribisnis Journal of Consumer Science Mutiara Medika: Jurnal Kedokteran dan Kesehatan The Indonesian Biomedical Journal ELT Forum: Journal of English Language Teaching Journal of Consumer Sciences Jurnal Ilmu Keluarga dan Konsumen Indonesian Contemporary Nursing Journal (ICON Journal) Journal of Innovative Science Education Medica Hospitalia Jurnal Health Sains Diponegoro International Medical Journal (DIMJ) Jurnal Keperawatan Klinis dan Komunitas (Clinical and Community Nursing Journal) Neurona Seroja Husada: Jurnal Kesehatan Masyarakat Jurnal Info Kesehatan Eko-Regional: Jurnal Pembangunan Ekonomi Wilayah
Retnaningsih Retnaningsih
Departemen Ilmu Keluarga dan Konsumen Fakultas Ekologi Manusia Institut Pertanian Bogor
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Dentistry Economics, Econometrics & Finance Education Energy Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

Published : 54 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search
Journal : The Indonesian Biomedical Journal

 1 
The Injected Plasma of Myasthenia Gravis Patient with A Low T-reg Level Caused Clinical Myasthenic Syndromes in Swiss-Webster Mice Pasmanasari, Elta Diah; Purwaningsih, Erni Hernawati; Retnaningsih, Retnaningsih; Purba, Jan Sudir; Octaviana, Fitri
The Indonesian Biomedical Journal Vol 16, No 4 (2024)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v16i4.3086

Abstract

BACKGROUND: Myasthenia gravis (MG) is a rare autoimmune disease affecting neuromuscular junction involvement. The finding that T-reg level in MG patients was lower than that in normal persons leads to the idea that the primary pathology of the disease is T-reg dependent. The T-reg level of MG patients seems to be decreasing compared to that of normal persons. The study was conducted to observe the contribution of T-reg level in plasma injected into Swiss-Webster mice to develop clinically and pathologically myasthenic syndromes.METHODS: Swiss-Webster mice were grouped into three groups: the groups received plasma with normal, low, and high T-reg levels, respectively. The T-reg levels of the mice were measured with flow cytometry analysis and a human regulatory T-cell cocktail for T-cell surface cell marker. The motor function, interleukin (IL)-2, interferon (IFN)-γ, and thymus weight of mice were measured after the injection. Histopathological examination was performed to analyze mice’s muscles and thymus.RESULTS: The result identified that the motor function (2-week treatment group: p=0.021 and 3-week treatment group: p=0.032) and muscle width (p=0.014, p=0.032 and p≤0.001) were significantly lower in the low T-reg level plasma group compared to control and high T-reg level plasma groups. The thymus showed an increase in weight without an increase in the cortex-medulla ratio of the thymus, indicating hyperplasia. Both IL-2 and IFN-γ levels were lower in the low and high T-reg level groups compared with the control group, indicating the autoimmune process.CONCLUSION: Low T-reg level was associated with lower motor function, muscle width, increased thymus weight, as well as lower IL-2 and IFN-γ levels. T-reg level contributed to clinical myasthenic syndromes but not pathological findings. This research method is expected to be a basis for the development of animal models with Swiss-Webster mice.KEYWORDS: animal model, Myasthenia gravis, Swiss-Webster mice
Co-Authors Afina, Siti Agung, Locoporta Aisy, Rihadatul Al Mutanafisa, Tasneem Alfiasari Amalia Khairati Amin Husni Andhitara, Yovita Andhitara, Yovita Andhitara Ani Margawati Ani Ruwani, Ani Anita Saufika Anjani, Gemala Ardhini, Rahmi Arifin Triyanto Arina Hayati Asep Taryana Budisulistyo, Trianggoro Caroline, Maria Daynuri, Daynuri Daynuri, Riri Diah Retno Wahyuningrum Dini Aprilia Dodik Tugasworo Drajat Martianto Dwi Febryanto Endang Gumbira Sa’id Endang Kustiowati Erni Hernawati Purwaningsih, Erni Hernawati Fadila Ramadini Febriantina Dewi Fibria Mustikarini, Fibria Firina Firina Firli Bramantyo, Dion Fitri Octaviana Fitria Handayani Hajijah, Rengganis Novyanti Hamdani, Faishol Handaru Tri Mulyono Hanisa Rahmina Fitriyana Hartono, Jimmy Eko Budi Hartoyo Hartoyo Irni Rahmayani Johan Istiqlaliyah Muflikhati Jaeri, Santoso Jethro Budiman, Jethro Junedi, Rahmat Juswanto, Gerard Kurnianto, Aditya Kurnianto, Aditya Kurnianto Lia Yuliana Lilik Noor Yuliati Martha Irene Kartasurya Megawati Simanjuntak Nana Rochana, Nana Nani Maharani Noni Widiawatie Nuraini Nuraini Pasmanasari, Elta Diah Priambada, Dody Purba, Jan Sudir Puspitawati, Arinta Putri, Ayulia Karisma Putri, Marietta Krisnaya Nandika Putri, Nadya Yona Eka Rahmawati, Dani Rahmayanti Rahmayanti Rahmi Parhati RIA ANGGRAINI Saiful Ridlo Satrioaji, Hari Wahono Sofro, Muchlis AU Achsan Udji Sri Anna Marliyati Subu, Muhammad Arsyad Suhartini Ismail, Suhartini Suryadi Suryadi Suryawati, Herlina Syahrul Syahrul Tamad, Fatiha Sri Utami Tri Rahayu, Fitriani Tri Subekti Trisnaningtyas, Wenny Tsaniadi Prihastomo, Krisna Tugasworo, Dodik ` Ujang Sumarwan W.H, Nugrahaningsih Wahyuni, Ribut Nurul Tri Widaryanti, Widya Bella Widaryati Widaryati Yudiatma, Muh. Firman Yuridis, Melani Sukma