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All Journal Vidya Karya Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Majalah Farmasi dan Farmakologi (Trends in Pharmacy and Pharmaceutical Sciences) SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan JOPS (Journal Of Pharmacy and Science) Jurnal Pengabdian Kepada Masyarakat (Mediteg) Borneo Journal Of Pharmascientech Jurnal Insan Farmasi Indonesia Sasambo Journal of Pharmacy Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Health Research Journal of Indonesia Journal of Pharmaceutical and Sciences. Jurnal Pengabdian Masyarakat Panacea Journal of Community Empowerment Borneo Journal of Pharmacy Jurnal Sains dan Kesehatan Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan JIFTK (Jurnal Ilmu Farmasi Terapan dan Kesehatan) Journal of Pharmascience
Putra, Aditya Maulana Perdana
Program Studi Farmasi Fakultas Matematika Dan Ilmu Pengetahuan Alam, Universitas Lambung Mangkurat, Indonesia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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In Silico Evaluation of Kaempferol, Gallic Acid, and Stigmasterol from Lagerstroemia speciosa as Multi-Target Antidiabetic Agents: Molecular Docking and Dynamics Simulation Study Aditya Maulana Perdana Putra; Catherina Adeline Kurniawan; Anna Khumaira Sari; Nabila Hadiah Akbar; Khoirunnisa Muslimawati; Okta Muthia Sari; Dita Ayulia Dwi Sandi; Normaidah Normaidah; Putri Helena Junjung Buih; Ariranur Haniffadli
Borneo Journal of Pharmacy Vol. 9 No. 2 (2026): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v9i2.9720

Abstract

Diabetes mellitus (DM) is a chronic metabolic disorder that leads to severe complications and continues to increase in prevalence worldwide. Although Lagerstroemia speciosa is a well-recognized antidiabetic medicinal plant, most in silico studies have focused exclusively on its major constituent, leaving the antidiabetic potential of its other phytochemicals largely unexplored. This study investigated the multi-target antidiabetic potential of phytochemicals derived from L. speciosa leaves using an in silico approach targeting three key enzymes: aldose reductase, glucokinase, and glycogen synthase kinase 3-beta (GSK3-β). A total of 62 compounds were screened by molecular docking with AutoDock Vina, followed by toxicity predictions using ProTox-II and ToxTree. The top ligand for each target, kaempferol (aldose reductase), gallic acid (glucokinase), and stigmasterol (GSK3-β), was selected for further evaluation through molecular dynamics simulations using GROMACS 2016.3 for 100 ns. Structural and interaction stability were assessed through RMSD, RMSF, SASA, Rg, and RDF analyses. Binding free energies were calculated using the MM/PBSA method via g_mmpbsa. The results indicated that stigmasterol exhibited the most favorable MM/PBSA binding free energy (–133.377 kJ/mol), followed by kaempferol (–65.714 kJ/mol) and gallic acid (–45.629 kJ/mol). However, this favorable energy was dominated by nonspecific van der Waals contributions, consistent with the diffuse interaction patterns and low hydrogen-bond occupancy (4.24%) for stigmasterol. Kaempferol exhibited the highest hydrogen-bond occupancy (64.38%), indicating a stable, consistent interaction with its target enzyme. Rg and RDF analyses confirmed the compactness and specific atomic interactions of the kaempferol and gallic acid complexes.
WASPADA KEDALUWARSA TERSEMBUNYI: SOSIALISASI PENENTUAN BEYOND USE DATE (BUD) DI APOTEK Ratih Pratiwi Sari; Aditya Maulana Perdana Putra; Muhammad Rezki Azni; Winda Tamara
Journal of Community Empowerment Vol 5, No 1 (2026): Maret
Publisher : Universitas Muhammadiyah Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/jce.v5i1.38582

Abstract

ABSTRAK                                                                                     Kurangnya pemahaman masyarakat mengenai perbedaan antara Expired Date (ED) dan Beyond Use Date (BUD) berisiko terhadap keamanan terapi obat di rumah. Kegiatan promosi kesehatan ini bertujuan untuk meningkatkan pemahaman dan keterampilan praktis pengunjung Apotek Melia HKSN Banjarmasin dalam membedakan konsep ED dan BUD, serta mampu menetapkan batas aman penggunaan berbagai sediaan farmasi. Tahapan promosi Kesehatan ini diawali dengan fase persiapan melalui observasi situasi mitra dan penyusunan kuesioner. Pelaksanaan kegiatan dilakukan secara tatap muka pada 14 sampai dengan 16 Oktober 2025 dengan melibatkan 19 responden dari berbagai latar belakang pendidikan. Metode intervensi menggunakan media leaflet yang disertai edukasi persuasif, sesi diskusi, serta simulasi langsung terhadap perhitungan BUD sediaan obat. Evaluasi keberhasilan kegiatan diukur segera setelah intervensi melalui perbandingan skor pre-test dan post-test yang erdiri dari 10 butir pertanyaan kuesioner benar-salah. Hasil menunjukkan peningkatan literasi kesehatan yang signifikan, dimana 15 responden (78,9%) mengalami kenaikan skor pengetahuan. Penguatan pemahaman paling substantif ditemukan pada sediaan sirup kering (dari 32% menjadi 89%) dan puyer yang mencapai Tingkat pemahaman sempurna yaitu 100%. Promosi Kesehatan ini terbukti efektif dalam memberdayakan Masyarakat dalam menjaga mutu dan keamanan obat yang disimpan di lingkungan keluarga.Kata kunci: Beyond Use Date; Apotek; Sediaan Farmasi; Edukasi Obat. ABSTRACTThe public's lack of understanding regarding the difference between Expired Date (ED) and Beyond Use Date (BUD) poses a risk to the safety of home drug therapy. This health promotion activity aims to improve the understanding and practical skills of visitors to the Melia HKSN Banjarmasin Pharmacy in differentiating the concepts of ED and BUD, as well as being able to determine the safe limits for the use of various pharmaceutical preparations. The health promotion stage begins with a preparation phase through observation of partner situations and the preparation of questionnaires. The activity was implemented face-to-face from October 14 to 16, 2025, involving 19 respondents from various educational backgrounds. The intervention method used leaflets accompanied by persuasive education, discussion sessions, and direct simulations of calculating BUD for drug preparations. Evaluation of the activity's success was measured immediately after the intervention by comparing pre-test and post-test scores consisting of 10 true-false questionnaire questions. The results showed a significant increase in health literacy, where 15 respondents (78.9%) experienced an increase in knowledge scores. The most substantial increase in understanding was found in dry syrup preparations (from 32% to 89%) and powders, which achieved a perfect understanding level of 100%. This health promotion program has proven effective in empowering communities to maintain the quality and safety of medicines stored within the family.Keywords: Beyond Use Date; Pharmacy; Pharmaceutical Preparations; Drug Education.
Therapy Profile and Drug Use Analysis of Chronic Kidney Disease Patients Hospitalized at Dr. H. M. Ansari Saleh Hospital: Profil Terapi dan Analisis Penggunaan Obat Pasien Chronic Kidney Disease Rawat Inap Rumah Sakit dr. H. M. Ansari Saleh Okta Muthia Sari; Aditya Maulana Perdana Putra; Putri Nur Azizah; Sofia Sofia
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 9 No. 2 (2023): (October 2023)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2023.v9.i2.16488

Abstract

Background: Therapy in chronic kidney disease aims to slow down the prognosis of the disease. Objectives: Describe the types of classes and names of most drugs in treating chronic kidney disease patients based on the stage of the disease. As well as analysing the use of renal risk drugs in patients with chronic kidney disease. Material and Methods: This descriptive research will be carried out in May-June 2023. The population of this study was the entire medical record of inpatient chronic kidney disease patients at Ansari Saleh Hospital. Data analysis was performed uni variat for the study of patient characteristics and therapy profiles, while the analysis of the use of renal risk medications refers to the 2019 renal handbook. Results: A total of 51 medical records were analysed. The top five drug classes based on stages 4 and 5 include diuretics, cephalosporin antibiotics, vitamins, trace elements, angiotensin II receptor blockers, and insulin. The top five drugs received by patients based on disease stages 4 and 5 consist of furosemide, ceftriaxone, aminefron®, candesartan, and insulin aspart. Renal risk drugs found in studies include drugs that need dose adjustment, are lisinopril, ramipril, cefixime, cefotaxime, meropenem, levofloxacin, ciprofloxacin, bisoprolol, diltiazem, and simvastatin. At the same time, renal-risk drugs that need to be avoided are hydrochlorothiazide and spironolactone. Conclusions: Furosemide diuretics are the most widely used therapy in stages 4 and 5. Hospitalised chronic kidney disease patients receive some renal risk drugs that, in the literature, need dose adjustment, and some need to be avoided.
Studi Perbandingan Antara Maserasi dan Accelerated Solvent Extraction (ASE) terhadap Hasil Ekstrak Daun Kalangkala (Litsea angulata) Nabila Hadiah Akbar; Putri Helena Junjung Buih; Khoirunnisa Muslimawati; Aditya Maulana Perdana Putra; Adhindha Amalia; Dhea Juliana Putri
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1305

Abstract

Kalangkala (Litsea angulata) is an endemic plant of Kalimantan that has long been used in local traditional medicine to manage various health conditions. Phytochemical reports indicate that Kalangkala contains diverse secondary metabolites, including phenolics, flavonoids, alkaloids, tannins, saponins, terpenoids, steroids, and carotenoids. Therefore, selecting an appropriate extraction method is essential to maximize metabolite recovery while minimizing degradation. This experimental study compared the extraction yield of Kalangkala leaf extract obtained using maceration and ASE (Accelerated Solvent Extraction) methods. Each method was performed in three replicates and the percentage yield was calculated. Maceration produced yields of 2.10-2.18%, whereas ASE produced higher yields of 13.25-14.01%. the mean yield of maceration was 2.14 ± 0.04% (95% Cl: 2.04-2.24), while ASE achieved 13.64 ± 0.38% (95%Cl: 12.69-14.58). A two-tailed Welch’s t-test confirmed a statistically significant difference between methods (p = 0.00032), with a mean difference of 11.49% (95% Cl: 10.56-12.42). In conclusion, ASE provided a higher extraction yield than maceration under the conditions evaluated in this study.
Co-Authors Abdul Hadi Achmad Ramadhanna’il Rasjava Achyadi, Ryan Adhindha Amalia Akbar, Nabila Hadiah Ana Ulfah Anna Khumaira Sari Ariranur Haniffadli Arnida Arnida Aulia Rhamdani Arfan Aulia, Desy Ayulia Dwi Sandi, Dita Buih, Putri Helena Junjung Catherina Adeline Kurniawan Dahlia Syahrina Darmiani, Siti Deni Setiawan Desy Aulia Dhea Juliana Putri Difa Intannia Dyah Anggraeni Dyah Ayu Pramoda Wardani Eka Kumalasari Eka Kumalasari Endang Kurniasih Fadlilaturrahmah Fadlilaturrahmah, Fadlilaturrahmah Fahma Lailani Febrianti, Dwi Rizki Fitria Febrianti Hafizah, Noor Hakim, Ade Syarif Hayatun Izma Helsawati Helsawati Herningtyas Nautika Lingga I Dewa Putu Pramantara Jenah, Rina Astiyani Karani Karani Khalid, Ega Rezkyan Khalifah, Sefa Nur Khoerul Anwar Khoirunnisa Muslimawati Khoirunnisa Muslimawati Lailani, Fahma Lisdawati, Nani M. Ahlun Nazir M. Arsyad Madani, Al Mahendra, Rachul Ridho Mahrita Mahrita Masran, Ulfah Maudy Namirah Raudatullis Wanda Maya Armianti Mochammad Maulidie Alfiannor Saputera Muhammad Arsyad Muhammad Ikhwan Rizki Muhammad Rezki Azni Muliani, Putri Sari Nabila Hadiah Akbar Nahdha Nahdha Nahdha Nahdiya Rahmah Nahdiya Rahmah Nahdiya Rahmah Nani Lisdawati Nashrul Wathan Nazhipah Isnani Noor Cahaya Noor Rizkiyah Noorcahyati Noorcahyati Normaidah, Normaidah Novia Ariani Nur Annisa Meilina Nurul Mardiati Okta Muthia Sari Okta Muthia Sari Okta Sari, Okta Putri Helena Junjung Buih Putri Nur Azizah Putri Nur Azizah Qory Rahmat Nazri Rahmatullah, Satrio Wibowo Rahmawati, Fita Ramadhan, Fery Risma Dian Ariyani Riza Alfian Rosanti, Diah Aulia Rustifah Rustifah Rustifah, Rustifah Saftia Aryzki Salsabila, Risma Zahra Salwa, Helmina Saragih, Triando Hamonangan Sari, Ratih Pratiwi Sari, Risa Purnama Sari, Sindwi Rinanda Sari, Sri Oktaviani Silviana, Mega Siska Musiam Siti Darmiani Sofia Sofia Sofia Sofia, Sofia Susanto, Yugo Syifa Maharani Taufik Muhammad Fakih Titin Nor Tjitradi, Sukhito Yohanes Ulfah Masran Wahyuni, Amaliyah Winda Tamara Yusrine Wasiaturrahmah Yusrinie Wasiaturrahmah