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All Journal Vidya Karya Pharmascience Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Majalah Farmasi dan Farmakologi (Trends in Pharmacy and Pharmaceutical Sciences) SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan JOPS (Journal Of Pharmacy and Science) Jurnal Pengabdian Kepada Masyarakat (Mediteg) Borneo Journal Of Pharmascientech Jurnal Insan Farmasi Indonesia Sasambo Journal of Pharmacy Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Health Research Journal of Indonesia Jurnal Pengabdian Masyarakat Panacea Borneo Journal of Pharmacy Jurnal Sains dan Kesehatan Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan JIFTK (Jurnal Ilmu Farmasi Terapan dan Kesehatan)
Putra, Aditya Maulana Perdana
Program Studi Farmasi Fakultas Matematika Dan Ilmu Pengetahuan Alam, Universitas Lambung Mangkurat, Indonesia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Control & Systems Engineering Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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Kesesuaian Penyimpanan Obat High Alert di Depo Obat Rumah Sakit X di Kalimantan Selatan Tahun 2015 Aditya Maulana Perdana Putra
Jurnal Ilmu Farmasi Terapan dan Kesehatan Vol. 1 No. 1 (2019): Jurnal Ilmu Farmasi Terapan dan Kesehatan Vol.1 No.1 2019
Publisher : Sekolah Tinggi Ilmu Kesehatan IKIFA

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Obat High Alert adalah obat yang memiliki risiko tinggi menyebabkan bahaya besar pada pasien jika tidak digunakan secara tepat. Menurut Permenkes No 58 tahun 2014 Tentang Standar Pelayanan di Rumah Sakit bahwa obat high alert wajib disimpan secara terpisah dari penyimpanan lain dan diberikan penandaan khusus. Tujuan penelitian ini adalah untuk mengetahui Bagaimana Kesesuaian Penyimpanan Obat High Alert dengan List Of ISMP di Depo Obat Rumah Sakit X. Metode penelitian yang digunakan adalah penelitian deskriptif. populasi penelitian adalah depo obat Rumah Sakit X yang berjumlah lima depo. Sampel pada penelitian ini adalah sampel jenuh. Alat penelitian pengumpulan data yang digunakan dalam penelitian ini adalah lembar observasi. Hasil penelitian yang dilakukan seluruh depo obat Rumah Sakit X tidak sesuai dalam penyimpanan obat high alert. diperoleh kesimpulan bahwa penyimpanan Obat high alert di depo Obat Rumah Sakit X yaitu lima depo obat terdapat depo VIP Intan dan depo IGD semua obat high alert sesuai dan tiga depo obat lainnya yaitu depo BPJS Rawat Jalan, depo BPJS Rawat Inap, depo Rawat Jalan Umum tidak sesuai. Untuk penyimpanan Obat Look Alike terdapat dua depo Obat yang tidak sesuai dalam melakukan penyimpanan Obat Look Alike yaitu depo Vip Intan dan depo IGD. Sedangkan pada penyimpanan Obat Sound Alike dari lima depo Obat yang diteliti terdapat hasil hampir semua depo obat tidak sesuai dengan List Of ISMP.
Molecular Docking and In Silico Evaluation of Beluntas (Pluchea indica) Phytochemicals as Potential Angiotensin-Converting Enzyme Inhibitors for Hypertension Treatment Rasjava, Achmad Ramadhanna’il; Akbar, Nabila Hadiah; Arfan, Aulia Rhamdani; Wardani, Dyah Ayu Pramoda; Putra, Aditya Maulana Perdana; Muslimawati, Khoirunnisa; Buih, Putri Helena Junjung; Fakih, Taufik Muhammad
Borneo Journal of Pharmacy Vol. 9 No. 1 (2026): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v9i1.9706

Abstract

Hypertension remains a major global health concern due to its high prevalence and strong association with cardiovascular diseases and kidney failure. A key component of blood pressure regulation is the Angiotensin-Converting Enzyme (ACE), which catalyzes the conversion of Angiotensin I into the vasoconstrictor Angiotensin II, making it a primary target for antihypertensive drugs. Although synthetic ACE inhibitors such as ramiprilat are effective, their use is often associated with adverse effects, highlighting the need for safer alternatives. This study employs molecular docking and in silico analysis to evaluate the potential of phytochemicals from beluntas (Pluchea indica) as natural ACE inhibitors. A total of 110 phytoconstituents were screened for pharmacokinetic properties using ADMET analysis, leading to the selection of 20 ligands for docking simulations. Among these, 4,5-di-O-caffeoylquinic acid exhibited the highest binding affinity (-9.409 kcal/mol), followed by di-O-caffeoylquinic acid (-8.984 kcal/mol) and quercetin-3-O-β-D-galactopyranoside (-8.372 kcal/mol). These compounds demonstrated stronger binding affinities than the ACE natural substrate, Angiotensin I (-7.133 kcal/mol), and the ACE inhibitor, ramiprilat (-8.717 kcal/mol), suggesting their potential as competitive ACE inhibitors. The binding interactions of these compounds were characterized by hydrogen bonding with key catalytic residues (HIS368, GLU368), electrostatic stabilization, and hydrophobic interactions within the enzyme active site. Notably, caffeoylquinic acid derivatives closely mimicked the binding mode of ramiprilat, whereas quercetin glycosides exhibited a distinct interaction pattern, indicating a possible alternative inhibitory mechanism. These findings provide evidence supporting the potential of P. indica phytochemicals as natural ACE inhibitors and warrant further investigation into their therapeutic applications in hypertension management.
Co-Authors Abdul Hadi Achyadi, Ryan Akbar, Nabila Hadiah Ana Ulfah Arfan, Aulia Rhamdani Arnida Arnida Aulia, Desy Buih, Putri Helena Junjung Dahlia Syahrina Darmiani, Siti Deni Setiawan Desy Aulia Difa Intannia Dyah Anggraeni Eka Kumalasari Eka Kumalasari Endang Kurniasih Fadlilaturrahmah Fadlilaturrahmah, Fadlilaturrahmah Fahma Lailani Febrianti, Dwi Rizki Fitria Febrianti Hafizah, Noor Hakim, Ade Syarif Hayatun Izma Helsawati Helsawati Herningtyas Nautika Lingga I Dewa Putu Pramantara Jenah, Rina Astiyani Karani Karani Khalid, Ega Rezkyan Khalifah, Sefa Nur Khoerul Anwar Khoirunnisa Muslimawati Lailani, Fahma Lisdawati, Nani M. Ahlun Nazir M. Arsyad Madani, Al Mahendra, Rachul Ridho Mahrita Mahrita Masran, Ulfah Maudy Namirah Raudatullis Wanda Maya Armianti Mochammad Maulidie Alfiannor Saputera Muhammad Arsyad Muhammad Ikhwan Rizki Muliani, Putri Sari Nabila Hadiah Akbar Nahdha Nahdha Nahdha Nahdiya Rahmah Nahdiya Rahmah Nahdiya Rahmah Nani Lisdawati Nashrul Wathan Nazhipah Isnani Noor Cahaya Noor Rizkiyah Noorcahyati Noorcahyati Novia Ariani Nur Annisa Meilina Nurul Mardiati Okta Muthia Sari Okta Muthia Sari Okta Sari, Okta Putri Helena Junjung Buih Putri Nur Azizah Putri Nur Azizah, Putri Nur Qory Rahmat Nazri Rahmatullah, Satrio Wibowo Rahmawati, Fita Ramadhan, Fery Rasjava, Achmad Ramadhanna’il Risma Dian Ariyani Riza Alfian Rosanti, Diah Aulia Rustifah Rustifah Rustifah, Rustifah Saftia Aryzki Salsabila, Risma Zahra Salwa, Helmina Sandi, Dita Ayulia Dwi Saragih, Triando Hamonangan Sari, Okta Muthia Sari, Ratih Pratiwi Sari, Risa Purnama Sari, Sindwi Rinanda Sari, Sri Oktaviani Silviana, Mega Siska Musiam Siti Darmiani Sofia Sofia, Sofia Susanto, Yugo Syifa Maharani Taufik Muhammad Fakih Titin Nor Tjitradi, Sukhito Yohanes Ulfah Masran Wahyuni, Amaliyah Wardani, Dyah Ayu Pramoda Yusrine Wasiaturrahmah Yusrinie Wasiaturrahmah