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All Journal Vidya Karya Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Majalah Farmasi dan Farmakologi (Trends in Pharmacy and Pharmaceutical Sciences) SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan JOPS (Journal Of Pharmacy and Science) Jurnal Pengabdian Kepada Masyarakat (Mediteg) Borneo Journal Of Pharmascientech Jurnal Insan Farmasi Indonesia Sasambo Journal of Pharmacy Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Health Research Journal of Indonesia Journal of Pharmaceutical and Sciences. Jurnal Pengabdian Masyarakat Panacea Journal of Community Empowerment Borneo Journal of Pharmacy Jurnal Sains dan Kesehatan Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan JIFTK (Jurnal Ilmu Farmasi Terapan dan Kesehatan) Journal of Pharmascience
Putra, Aditya Maulana Perdana
Program Studi Farmasi Fakultas Matematika Dan Ilmu Pengetahuan Alam, Universitas Lambung Mangkurat, Indonesia
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HUBUNGAN PENGETAHUAN DAN KEBUTUHAN PASIEN TERHADAP INFORMASI OBAT DI APOTEK AMANDIT FARMA BANJARMASIN Ratih Pratiwi Sari; Aditya Maulana Perdana Putra; Ulfah Masran
Jurnal Ilmiah Manuntung Vol 4 No 2 (2018): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v4i2.188

Abstract

The current pharmaceutical service has shifted its orientation from drug oriented to patient oriented with reference to pharmaceutical care. Pharmaceutical service activities are not limited to drug preparation and drug delivery to patients but pharmacy needs to interact or communication with the patient. The purpose of this study was to determine how is the relationship between knowledge and patient needs for drug information at Amandit Farma Pharmacy Banjarmasin. This type of research is descriptive analysis. Sampling was taken on March 9 - April 8, 2018 by giving questionnaires to 250 patients who redeemed the prescription at Amandit Farma Banjarmasin Pharmacy using systematic random sampling method according to exclusion and inclusion criteria. Data analysis using Chi Square 3x3. Based on the results of this study can be known the relationship between knowledge and needs of patients on drug information at Amandit Farma Pharmacy in Banjarmasin is statistically meaningful
PROFIL KUALITAS HIDUP DAN TEKANAN DARAH PASIEN HIPERTENSI RAWAT JALAN DI RSUD ULIN BANJARMASIN Riza Alfian; Nani Lisdawati; Aditya Maulana Perdana Putra; Ratih Pratiwi Sari; Fahma Lailani
Jurnal Ilmiah Manuntung Vol 4 No 2 (2018): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v4i2.189

Abstract

Hypertension is one of the main factors of coronary heart disease and stroke. The prevalence of hypertension in South Kalimantan Province occupied a second prevalence of 30,8%. Hypertension is a chronic disease that requires long-term treatment. Furthermore, long-term treatment of anti-hypertension patients also have the possibility of side effects that also affect the quality of life of patients. Uncontrolled blood pressure can aggravate the incidence of hypertension and develop into a more dangerous disease that affects the quality of life of patients. The purpose of this study was to determine the description of blood pressure and quality of life of outpatient hypertensive patients at RSUD Ulin Banjarmasin. This research was conducted by using survey method. Sampling was done by consecutive sampling method. Samples meeting the inclusion criteria were 61 patients. The sample inclusion criteria were outpatients ages 18-65 with hypertension diagnoses, and were willing to follow the study. Exclusion criteria were patients with uncooperative, illiterate and deaf conditions. Data collection was done by interviewing and filling out the EQ-5D questionnaire. Blood pressure data were taken from medical records. The data of the research are presented in descriptive form. Based on this research can be concluded that the value of systolic blood pressure and diastolic mean of research sample is 153,82 ± 17,62 and 86,16 ± 10,52 mmHg. The study sample was dominated by patients with level II hypertension (52,5%). Furthermore the quality of life of the average sample was dominated by the category of poor quality of life (73,8%).
AKTIVITAS KOMBINASI EKSTRAK BAWANG DAYAK-METFORMIN TERHADAP GULA DARAH MENCIT Aditya Maulana Perdana Putra; Ratih Sari Pratiwi
Jurnal Ilmiah Manuntung Vol 4 No 2 (2018): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v4i2.190

Abstract

Diabetes mellitus is a chronic disease that requires good medical treatment to prevent long-term complications. The proportion of DM patients in Indonesia in 2013 was 3,7 million. Indonesia as one of the countries with the highest diversity has natural resources that can be used as an alternative medicine for diabetes mellitus, one of them is dayak onion. Dayak onions themselves contain compounds that can reduce blood glucose levels. The use of traditional medicine in the community is sometimes combined with chemical drugs. So the purpose of this study was to determine the comparison of the combination activity of dayak onion extract – metformin with single metformin to reduce mice blood sugar induced by alloxan. This research includes experimental research. The test animals used were male white mice which were divided into 2 groups, namely the combination of dayak onion and metformin and the single metformin group. The dose of dayak onion extract used in this study was 100 mg / KgBB and the dose of Metformin used was 45 mg / KgBB. Measurement of glucose levels is carried out every 3 days for 15 days. The decrease in fasting blood glucose from the control group and the test group was analyzed by the General Linear Model test at a 95% confidence level. The results of this study indicate that the combination of dayak onion tuber extract and metformin has better hypoglycemic activity than single metformin. This result can be seen from the average glucose level from day 3 to 15 the combination of dayak onion tuber and metformin is lower than the average glucose level of single metformin. The results of GLM analysis showed the sigvalue <0,05 so it can be concluded that there is a difference in glucose levels between the combination of dayak onion tuber and metformin with a single metformin.
Pola terapi dan outcome therapy pasien penyakit ginjal kronik di Rumah Sakit Ansari Saleh Banjarmasin tahun 2023 Sofia, Sofia; Sari, Okta Muthia; Putra, Aditya Maulana Perdana
Sasambo Journal of Pharmacy Vol. 6 No. 2 (2025): September
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/sjp.v6i2.403

Abstract

Chronic kidney disease is a permanent disease that occurs when the body is unable to maintain the balance of fluids and electrolytes, leading to reduced kidney function. This study quantifies the distribution of therapy profiles among patients with chronic kidney disease, taking into account drug classes, names, doses, and methods of administration. The percentages are calculated based on doctors' statements. This descriptive research used total population sampling as a method for data collection. A total of 55 medical records met the research criteria. The therapy profile that was used most frequently, with a proportion of 13.60%, was the vitamin and mineral group. The medicine name Aminefron® accounted for 8.45% of the results. The prescribed dose was 3x2 capsules per day. The oral route represented the highest percentage of usage, at 55.67%. The doctor's declaration indicated that the percentage of patients who improved was 52.73%, while 38.18% remained sick and 9.09% unfortunately died.
Edukasi Penggunaan Obat Antidiabetes Selama Berpuasa di RSUD Ulin Banjarmasin Muslimawati, Khoirunnisa; Putri Nur Azizah; Aditya Maulana Perdana Putra; Nabila Hadiah Akbar; Putri Helena Junjung Buih
Jurnal Pengabdian Kepada Masyarakat (MEDITEG) Vol. 10 No. 2 (2025): Jurnal Pengabdian Kepada Masyarakat (MEDITEG)
Publisher : Pusat Penelitian dan Pengabdian Kepada Masyarakat (P3M) Politeknik Negeri Tanah Laut (Politala)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34128/mediteg.v10i2.377

Abstract

Diabetes Melitus (DM) merupakan penyakit degeneratif yang dikenal sebagai "Mother of Disease" dan "Silent Killer" karena dapat memicu berbagai komplikasi serta kerap tidak menunjukkan gejala pada tahap awal. Saat Ramadhan, penderita DM menghadapi tantangan dalam mengatur konsumsi obat akibat perubahan waktu makan. Kegiatan ini bertujuan untuk meningkatkan pemahaman pasien lanjut usia di Poli Geriatri RSUD Ulin Banjarmasin tentang penggunaan obat anti diabetes selama berpuasa. Kegiatan dilaksanakan pada Jumat, 14 Maret 2025, dengan 17 peserta. Metode yang digunakan meliputi presentasi PowerPoint dan leaflet, dengan evaluasi menggunakan pre-test dan post-test melalui kuis kartu warna. Hasil pre-test menunjukkan tingkat pengetahuan awal rata-rata sebesar 96,07%, yang kemudian meningkat menjadi 100% pada post-test, di mana semua peserta mampu menjawab seluruh pertanyaan dengan benar. Peningkatan pengetahuan peserta dapat menunjukkan bahwa metode edukasi yang digunakan efektif dalam menyampaikan informasi kesehatan. Hasil ini menunjukkan bahwa edukasi yang diberikan efektif meningkatkan pemahaman pasien terkait penggunaan obat selama berpuasa, dengan dampak praktis berupa peningkatan kemampuan pasien untuk menyesuaikan dosis obat dan mengenali tanda hipoglikemia selama Ramadhan.
Kesesuaian Penyimpanan Obat High Alert di Depo Obat Rumah Sakit X di Kalimantan Selatan Tahun 2015 Aditya Maulana Perdana Putra
Jurnal Ilmu Farmasi Terapan dan Kesehatan Vol. 1 No. 1 (2019): Jurnal Ilmu Farmasi Terapan dan Kesehatan Vol.1 No.1 2019
Publisher : Sekolah Tinggi Ilmu Kesehatan IKIFA

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Obat High Alert adalah obat yang memiliki risiko tinggi menyebabkan bahaya besar pada pasien jika tidak digunakan secara tepat. Menurut Permenkes No 58 tahun 2014 Tentang Standar Pelayanan di Rumah Sakit bahwa obat high alert wajib disimpan secara terpisah dari penyimpanan lain dan diberikan penandaan khusus. Tujuan penelitian ini adalah untuk mengetahui Bagaimana Kesesuaian Penyimpanan Obat High Alert dengan List Of ISMP di Depo Obat Rumah Sakit X. Metode penelitian yang digunakan adalah penelitian deskriptif. populasi penelitian adalah depo obat Rumah Sakit X yang berjumlah lima depo. Sampel pada penelitian ini adalah sampel jenuh. Alat penelitian pengumpulan data yang digunakan dalam penelitian ini adalah lembar observasi. Hasil penelitian yang dilakukan seluruh depo obat Rumah Sakit X tidak sesuai dalam penyimpanan obat high alert. diperoleh kesimpulan bahwa penyimpanan Obat high alert di depo Obat Rumah Sakit X yaitu lima depo obat terdapat depo VIP Intan dan depo IGD semua obat high alert sesuai dan tiga depo obat lainnya yaitu depo BPJS Rawat Jalan, depo BPJS Rawat Inap, depo Rawat Jalan Umum tidak sesuai. Untuk penyimpanan Obat Look Alike terdapat dua depo Obat yang tidak sesuai dalam melakukan penyimpanan Obat Look Alike yaitu depo Vip Intan dan depo IGD. Sedangkan pada penyimpanan Obat Sound Alike dari lima depo Obat yang diteliti terdapat hasil hampir semua depo obat tidak sesuai dengan List Of ISMP.
Uji Kadar Sari Larut Air Dan Kadar Sari Larut Etanol Daun Kumpai Mahung (Eupathorium inulifolium H.B.&K) Dwi Rizki Febrianti; Mahrita Mahrita; Novia Ariani; Aditya Maulana Perdana Putra; Noorcahyati Noorcahyati
Journal of Pharmascience Vol. 6 No. 2 (2019): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v6i2.7346

Abstract

ABSTRAK Penentuan kadar sari larut air dan etanol adalah metode kuantitatif untuk jumlah kandungan senyawa dalam simplisia yang mampu tertarik oleh pelarut. Kedua cara yang hampir sama tersebut didasarkan ada kelarutan senyawa yang terkandung dalam simplisia. Secara turun temurun masyarakat dayak meratus dan dayak amandit menggunakan kumpai mahung (eupathorium inulifolium h.b.&k) sebagai obat diare dan malaria. Masih jarang penelitian menggunakan tanaman ini, sehingga peneliti bertujuan untuk mengetahui kadar sari larut air simplisia serbuk dan ekstrak daun kumpai mahung dengan metode yang telah ditetapkan oleh farmakope herbal. Hasil penelitian kadar sari larut air dan kadar sari larut etanol tanaman kumpai mahung pada serbuk memiliki nilai 19,54% dan 16,13%. Pada ekstrak memiliki nilai 19,53% dan 14,55%. Tumbuhan yang satu family yaitu asteraceae menyebutkan bahwa kadar sari larut air tidak kurang dari 5%, yang berarti hasil memenuhi persyaratan materia medika indonesia.Kata kunci: Sari Larut Air, Sari Larut Etanol, Kumpai Mahung, AsteraceaeABSTRACT Determination of water-soluble and ethanol extract contents is a quantitative method for the amount of compound content in a simplicia that can be attracted by the solvent. Both methods are almost the same based on the solubility of the compounds contained in simplicia. For generations, the Meratus and Amandit Dayak communities use kumpai mahung (Eupathorium inulifolium H.B. & K) as a medicine for diarrhea and malaria. Research is still rare to use this plant, so researchers aim to determine the content of water-soluble extract of simplicia powder and mahung kumpai leaf extract by the method established by herbal pharmacopoeia. The results of the research showed that the concentration of water-soluble extracts and ethanol soluble extracts of this plants on the powder had values of 19.54% and 16.13%. The extracts have values of 19.53% and 14.55%. One family plant, Asteraceae, states that the water-soluble extract content is not less than 5%, which means the results meet the requirements of Indonesian medical material.Keywords:  Water Soluble Extract, Ethanol Soluble Extract
Uji Aktivitas Antioksidan dan Antitirosinase Fraksi n-Butanol Daun Sungkai (Peronema canescens Jack.) Secara Kualitatif Menggunakan Kromatografi Lapis Tipis Fadlilaturrahmah Fadlilaturrahmah; Aditya Maulana Perdana Putra; Muhammad Ikhwan Rizki; Titin Nor
Journal of Pharmascience Vol. 8 No. 2 (2021): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v8i2.11160

Abstract

Kerusakan oksidatif dalam tubuh manusia dapat disebabkan oleh radikal bebas, sehingga menimbulkan berbagai permasalahan. Daun P. canescens memiliki kandungan senyawa fenolik, tanin, alkaloid, steroid, saponin dan flavonoid yang potensial sebagai antioksidan. Tujuan penelitian ini yaitu untuk melakukan uji aktivitas antioksidan dan antitirosinase fraksi n-butanol daun sungkai secara kualittaif menggunakan kromatografi lapis tipis. Metode yang digunakan yaitu preparasi sampel dengan pembuatan simplisia yang kemudian diekstraksi secara maserasi menggunakan etanol 96%. Hasil ekstrak kental kemudian difraksinasi bertingkat dengan pelarut n-heksan, etil asetat, dan n-butanol. Selanjutnya dilakukan skrining fitokimia, uji aktivitas antioksidan, dan antitirosinase secara kualitatif menggunakan kromatografi lapis tipis. Hasil rendemen ekstrak etanol daun P. canescens yaitu sebesar 7,28% sedangkan rendemen fraksi yaitu 24,8%. Skrining fitokimia ekstrak etanol P. canescens mengandung alkaloid, flavonoid, terpenoid, steroid, tanin, saponin, dan fenol. Kesimpulan yang didapatkan dari penelitian ini yaitu fraksi n-butanol daun P. canscens berpotensi memiliki aktivitas antioksidan yang ditandai adanya noda kuning pucat setelah penyemprotan dengan reagen DPPH, serta berpotensi memiliki aktivitas antitirosinase secara kualitatif yang ditandai dengan adanya bercak putih pada plat KLT. Kata Kunci: DPPH, L-DOPA, Asam askorbat, Enzim  Oxidative damage in the human body can be caused by free radicals, causing various problems. P. canescens leaves contain phenolic compounds, tannins, alkaloids, steroids, saponins and flavonoids that have potential as antioxidants. The purpose of this study was to test the antioxidant and antityrosinase activity of the n-butanol fraction of sungkai leaves qualitatively using thin layer chromatography. The method used is sample preparation by making simplicia which is then extracted by maceration using 96% ethanol. The viscous extract was then fractionated with n-hexane, ethyl acetate, and n-butanol as solvents. Furthermore, phytochemical screening, antioxidant activity, and antityrosinase tests were carried out qualitatively using thin layer chromatography. The yield of P. canescens leaf ethanol extract was 7.28%, while the fraction yield was 24.8%. Phytochemical screening of P. canescens ethanol extract containing alkaloids, flavonoids, terpenoids, steroids, tannins, saponins, and phenols. The conclusion obtained from this study is that the n-butanol fraction of P. canscens leaves has the potential to have antioxidant activity which is indicated by a pale yellow stain after spraying with DPPH reagent, and has the potential to have qualitative antityrosinase activity which is indicated by the presence of white spots on the TLC plate.
Molecular Docking Analysis Of Phenolic and Flavonoid Compounds from Eichhornia Crassipes for Antidiabetic Activity Through Interaction with PPAR- γ (5Y2O) and A-Glucosidase (3TOP) Khoirunnisa Muslimawati; Taufik Muhammad Fakih; Nabila Hadiah Akbar; Aditya Maulana Perdana Putra; Nazhipah Isnani
Journal of Pharmascience Vol. 12 No. 2 (2025): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v12i2.23583

Abstract

Diabetes Mellitus Tipe 2 (DMT2), ditandai dengan resistensi insulin dan hiperglikemia. Penelitian ini mengevaluasi potensi 30 senyawa golongan fenolik dan flavonoid dari Eichhornia crassipes sebagai agen antidiabetes melalui studi in silico, meliputi uji toksisitas (ToxTree 3.1.0, ProTox 3), analisis ADME (SwissADME), dan molecular docking (AutoDock 4.2.6). Struktur ligan uji diperoleh dari PubChem, sedangkan reseptor PPAR-γ (PDB ID: 5Y2O) dan α-Glukosidase (PDB ID: 3TOP) diunduh dari RCSB Protein Data Bank. Sebelum docking, analisis toksisitas dan ADME dilakukan. Hasil docking menunjukkan Tricin (flavonoid) berinteraksi baik dengan kedua reseptor dan memiliki nilai energi Gibbs -7.53 kcal/mol untuk PPAR-γ dan -5.19 kcal/mol untuk α-Glukosidase, mendekati ligan asli Pioglitazone (-10.03 kcal/mol) dan Acarbose (-6.86 kcal/mol). Interaksi ligan-reseptor Tricin melibatkan ikatan hidrogen dan kontak hidrofobik dengan residu kunci (misalnya, ARG288 dan TYR pada PPAR- γ, residu GLN1561 dan GLN1372 pada α-Glukosidase), mencerminkan interaksi ligan asli. Prediksi toksisitas mengklasifikasikan Tricin sebagai senyawa dengan risiko toksisitas rendah (Cramer Rules Kelas I, Kroes TTC). Selanjutnya, evaluasi ADME menunjukkan bahwa Tricin memenuhi Lipinski's Rule of Five, yang mengindikasikan penyerapan dan bioavailabilitas oral yang baik. Secara keseluruhan, senyawa Tricin dari E. crassipes menunjukkan potensi signifikan sebagai kandidat agen antidiabetes melalui penghambatan PPAR-γ dan α-Glukosidase yang selanjutnya memerlukan validasi dnegan pengujian in vitro dan in vivo. Kata Kunci: Eichhornia crassipes, Molecular Docking, Antidiabetic, PPAR-γ, α-Glucosidase Type 2 Diabetes Mellitus (T2DM), is characterized by insulin resistance and persistent hyperglycemia. This study investigated the antidiabetic potential of 30 phenolic and flavonoid compounds derived from Eichhornia crassipes using in silico approaches, including toxicity assessments (ToxTree 3.1.0, ProTox 3), ADME analysis (SwissADME), and molecular docking (AutoDock 4.2.6). Ligand structures were retrieved from PubChem, while PPAR-γ (5Y2O) and α-Glucosidase (3TOP) receptors were obtained from the RCSB Protein Data Bank. Toxicity and ADME analyses were conducted prior to molecular docking, which employed the Genetic Algorithm with 50 conformations. Docking results revealed that Tricin (a flavonoid) exhibited strong interactions with both receptors, with Gibbs free energy values of -7.53 kcal/mol for PPAR-γ and -5.19 kcal/mol for α-Glucosidase. These values are comparable to those of the native ligands Pioglitazone (-10.03 kcal/mol) and Acarbose (-6.86 kcal/mol). Tricin formed hydrogen bonds and hydrophobic contacts with key active site residues including, ARG288 and TYR327 in PPAR-γ, GLN1561 and GLN1372 in α-Glucosidase), mirroring the interactions of the native ligands. Toxicity predictions classified Tricin as low risk (Class I Cramer Rules, Kroes TTC). Furthermore, ADME evaluation showed that Tricin (aglycone) is fully compliant with Lipinski's Rule of Five, suggesting favorable properties for oral absorption and bioavailability. In conclusion, Tricin from E. crassipes demonstrates significant potential as an antidiabetic candidate and warrants further in vitro and in vivo validation.
Molecular Docking and In Silico Evaluation of Beluntas (Pluchea indica) Phytochemicals as Potential Angiotensin-Converting Enzyme Inhibitors for Hypertension Treatment Achmad Ramadhanna’il Rasjava; Nabila Hadiah Akbar; Aulia Rhamdani Arfan; Dyah Ayu Pramoda Wardani; Aditya Maulana Perdana Putra; Khoirunnisa Muslimawati; Putri Helena Junjung Buih; Taufik Muhammad Fakih
Borneo Journal of Pharmacy Vol. 9 No. 1 (2026): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v9i1.9706

Abstract

Hypertension remains a major global health concern due to its high prevalence and strong association with cardiovascular diseases and kidney failure. A key component of blood pressure regulation is the Angiotensin-Converting Enzyme (ACE), which catalyzes the conversion of Angiotensin I into the vasoconstrictor Angiotensin II, making it a primary target for antihypertensive drugs. Although synthetic ACE inhibitors such as ramiprilat are effective, their use is often associated with adverse effects, highlighting the need for safer alternatives. This study employs molecular docking and in silico analysis to evaluate the potential of phytochemicals from beluntas (Pluchea indica) as natural ACE inhibitors. A total of 110 phytoconstituents were screened for pharmacokinetic properties using ADMET analysis, leading to the selection of 20 ligands for docking simulations. Among these, 4,5-di-O-caffeoylquinic acid exhibited the highest binding affinity (-9.409 kcal/mol), followed by di-O-caffeoylquinic acid (-8.984 kcal/mol) and quercetin-3-O-β-D-galactopyranoside (-8.372 kcal/mol). These compounds demonstrated stronger binding affinities than the ACE natural substrate, Angiotensin I (-7.133 kcal/mol), and the ACE inhibitor, ramiprilat (-8.717 kcal/mol), suggesting their potential as competitive ACE inhibitors. The binding interactions of these compounds were characterized by hydrogen bonding with key catalytic residues (HIS368, GLU368), electrostatic stabilization, and hydrophobic interactions within the enzyme active site. Notably, caffeoylquinic acid derivatives closely mimicked the binding mode of ramiprilat, whereas quercetin glycosides exhibited a distinct interaction pattern, indicating a possible alternative inhibitory mechanism. These findings provide evidence supporting the potential of P. indica phytochemicals as natural ACE inhibitors and warrant further investigation into their therapeutic applications in hypertension management.
Co-Authors Abdul Hadi Achmad Ramadhanna’il Rasjava Achyadi, Ryan Adhindha Amalia Akbar, Nabila Hadiah Ana Ulfah Anna Khumaira Sari Ariranur Haniffadli Arnida Arnida Aulia Rhamdani Arfan Aulia, Desy Ayulia Dwi Sandi, Dita Buih, Putri Helena Junjung Catherina Adeline Kurniawan Dahlia Syahrina Darmiani, Siti Deni Setiawan Desy Aulia Dhea Juliana Putri Difa Intannia Dyah Anggraeni Dyah Ayu Pramoda Wardani Eka Kumalasari Eka Kumalasari Endang Kurniasih Fadlilaturrahmah Fadlilaturrahmah, Fadlilaturrahmah Fahma Lailani Febrianti, Dwi Rizki Fitria Febrianti Hafizah, Noor Hakim, Ade Syarif Hayatun Izma Helsawati Helsawati Herningtyas Nautika Lingga I Dewa Putu Pramantara Jenah, Rina Astiyani Karani Karani Khalid, Ega Rezkyan Khalifah, Sefa Nur Khoerul Anwar Khoirunnisa Muslimawati Khoirunnisa Muslimawati Lailani, Fahma Lisdawati, Nani M. Ahlun Nazir M. Arsyad Madani, Al Mahendra, Rachul Ridho Mahrita Mahrita Masran, Ulfah Maudy Namirah Raudatullis Wanda Maya Armianti Mochammad Maulidie Alfiannor Saputera Muhammad Arsyad Muhammad Ikhwan Rizki Muhammad Rezki Azni Muliani, Putri Sari Nabila Hadiah Akbar Nahdha Nahdha Nahdha Nahdiya Rahmah Nahdiya Rahmah Nahdiya Rahmah Nani Lisdawati Nashrul Wathan Nazhipah Isnani Noor Cahaya Noor Rizkiyah Noorcahyati Noorcahyati Normaidah, Normaidah Novia Ariani Nur Annisa Meilina Nurul Mardiati Okta Muthia Sari Okta Muthia Sari Okta Sari, Okta Putri Helena Junjung Buih Putri Nur Azizah Putri Nur Azizah Qory Rahmat Nazri Rahmatullah, Satrio Wibowo Rahmawati, Fita Ramadhan, Fery Risma Dian Ariyani Riza Alfian Rosanti, Diah Aulia Rustifah Rustifah Rustifah, Rustifah Saftia Aryzki Salsabila, Risma Zahra Salwa, Helmina Saragih, Triando Hamonangan Sari, Ratih Pratiwi Sari, Risa Purnama Sari, Sindwi Rinanda Sari, Sri Oktaviani Silviana, Mega Siska Musiam Siti Darmiani Sofia Sofia Sofia Sofia, Sofia Susanto, Yugo Syifa Maharani Taufik Muhammad Fakih Titin Nor Tjitradi, Sukhito Yohanes Ulfah Masran Wahyuni, Amaliyah Winda Tamara Yusrine Wasiaturrahmah Yusrinie Wasiaturrahmah